KEGG ORTHOLOGY: K23605

ORTHOLOGY: K23605

Entry

K23605                      KO

Symbol

SMAD3

Name

mothers against decapentaplegic homolog 3

Pathway

map04068

FoxO signaling pathway

map04110

Cell cycle

map04144

Endocytosis

map04218

Cellular senescence

map04310

Wnt signaling pathway

map04350

TGF-beta signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04659

Th17 cell differentiation

map04933

AGE-RAGE signaling pathway in diabetic complications

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05220

Chronic myeloid leukemia

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05321

Inflammatory bowel disease

map05415

Diabetic cardiomyopathy

Disease

H00800

Loeys-Dietz syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04350 TGF-beta signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04390 Hippo signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04371 Apelin signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04068 FoxO signaling pathway
    K23605  SMAD3; mothers against decapentaplegic homolog 3
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09143 Cell growth and death
   04110 Cell cycle
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04218 Cellular senescence
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   04550 Signaling pathways regulating pluripotency of stem cells
    K23605  SMAD3; mothers against decapentaplegic homolog 3
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K23605  SMAD3; mothers against decapentaplegic homolog 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05212 Pancreatic cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05225 Hepatocellular carcinoma
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05226 Gastric cancer
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05220 Chronic myeloid leukemia
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K23605  SMAD3; mothers against decapentaplegic homolog 3
   05161 Hepatitis B
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09163 Immune disease
   05321 Inflammatory bowel disease
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K23605  SMAD3; mothers against decapentaplegic homolog 3
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K23605  SMAD3; mothers against decapentaplegic homolog 3

Other DBs

GO:

0070410

Genes

HSA:	4088(SMAD3)

PTR:	748161(SMAD3)

PPS:	100993322(SMAD3)

GGO:	109025264(SMAD3)

PON:	100448249(SMAD3)

NLE:	100583279(SMAD3)

HMH:	116482351(SMAD3)

MCC:	711355(SMAD3)

MCF:	102146086(SMAD3)

MTHB:

126957972

MNI:	105488126(SMAD3)

CSAB:

103245436(SMAD3)

CATY:

105600979(SMAD3)

PANU:

101013089(SMAD3)

TGE:	112628064(SMAD3)

MLEU:

105530839(SMAD3)

RRO:	104662580(SMAD3)

RBB:	108514714(SMAD3)

TFN:	117070466(SMAD3)

PTEH:

111548349(SMAD3)

CANG:

105510522(SMAD3)

CJC:	100393808(SMAD3)

SBQ:	101039593(SMAD3)

CIMI:

108282687(SMAD3)

CSYR:

103267025(SMAD3)

MMUR:

105857966(SMAD3)

LCAT:

123631693(SMAD3)

PCOQ:

105821424(SMAD3)

OGA:	100962223(SMAD3)

MMU:	17127(Smad3)

MCAL:

110301346(Smad3)

MPAH:

110327577(Smad3)

RNO:	25631(Smad3)

MCOC:

116073193(Smad3)

ANU:	117699022(Smad3)

MUN:	110557887(Smad3)

CGE:	100759220(Smad3)

MAUA:

101831942(Smad3)

PROB:

127231871(Smad3)

PLEU:

114691539(Smad3)

MORG:

121466030(Smad3)

MFOT:

126507403

AAMP:

119809845(Smad3)

NGI:	103736807(Smad3)

HGL:	101713378(Smad3)

CPOC:

100731807(Smad3)

CCAN:

109701514(Smad3)

DORD:

105981178(Smad3)

DSP:	122114693(Smad3)

PLOP:

125341157(Smad3)

NCAR:

124973148

MMMA:

107137992(Smad3)

OCU:

100346303

OPI:	101532983(SMAD3)

TUP:	102473158(SMAD3)

GVR:	103590291(SMAD3)

CFA:	610902(SMAD3)

CLUD:

112675712(SMAD3)

VVP:	112929830(SMAD3)

VLG:	121482745(SMAD3)

NPO:	129506293(SMAD3)

AML:	100479304(SMAD3)

UMR:	103679154(SMAD3)

UAH:	113240893(SMAD3)

UAR:	123800821(SMAD3)

ELK:

111153179

LLV:

125105231

MPUF:

101677980(SMAD3)

MNP:	131999550(SMAD3)

MLK:	131835965(SMAD3)

NVS:	122894006(SMAD3)

ORO:	101367515(SMAD3)

EJU:	114206573(SMAD3)

ZCA:	113909118(SMAD3)

MLX:	118003430(SMAD3)

NSU:	110583782(SMAD3)

LWW:	102730318(SMAD3)

FCA:	101101387(SMAD3)

PYU:	121041878(SMAD3)

PCOO:

112855310(SMAD3)

PBG:	122468477(SMAD3)

PVIV:

125168330(SMAD3)

LRUF:

124508465

PTG:	102971888(SMAD3)

PPAD:

109262802(SMAD3)

PUC:

125910090

AJU:

106980367

HHV:	120221278(SMAD3)

BTA:	515125(SMAD3)

BOM:	102282627(SMAD3)

BIU:	109564704(SMAD3)

BBUB:

102400710(SMAD3)

BBIS:

104984671(SMAD3)

CHX:	102169293(SMAD3)

OAS:	443169(SMAD3)

BTAX:

128054493(SMAD3)

ODA:	120852520 120860896

CCAD:

122443073(SMAD3)

MBEZ:

129562707(SMAD3)

SSC:	397260(SMAD3)

CFR:	102523073(SMAD3)

CBAI:

105069467(SMAD3)

CDK:	105093274(SMAD3)

VPC:	102531396(SMAD3)

BACU:

103019152(SMAD3)

BMUS:

118890561(SMAD3)

LVE:	103085090(SMAD3)

OOR:	101288074(SMAD3)

DLE:	111177751(SMAD3)

PCAD:

102989819(SMAD3)

PSIU:

116749508(SMAD3)

NASI:

112393136(SMAD3)

ECB:	100033845(SMAD3)

EPZ:	103549637(SMAD3)

EAI:	106840608(SMAD3)

MYB:	102259468(SMAD3)

MYD:	102769241(SMAD3)

MMYO:

118654312(SMAD3)

MLF:	102427892(SMAD3)

PKL:	118718916(SMAD3)

EFUS:

103283787(SMAD3)

MNA:	107525935(SMAD3)

SHON:

118992343(SMAD3)

AJM:	119057106(SMAD3)

PDIC:

114491384(SMAD3)

PHAS:

123808094(SMAD3)

MMF:	118638472(SMAD3)

PPAM:

129064154(SMAD3)

HAI:	109385242(SMAD3)

RFQ:	117023095(SMAD3)

PALE:

102895268(SMAD3)

PGIG:

120604483(SMAD3)

PVP:	105309746(SMAD3)

RAY:	107508935(SMAD3)

MJV:	108404778(SMAD3)

TOD:	119238777(SMAD3)

SARA:

101544572(SMAD3)

TMU:

101344857

ETF:	105979476(SMAD3)

DNM:	101447050(SMAD3)

MDO:	100018703(SMAD3)

GAS:	123238038(SMAD3)

SHR:	100923201(SMAD3)

AFZ:

127551234

PCW:	110205871(SMAD3)

OAA:	100085963(SMAD3)

GGA:	395132(SMAD3)

PCOC:

116225477(SMAD3)

MGP:	100544037(SMAD3)

CJO:	107318915(SMAD3)

TPAI:

128075634(SMAD3)

LMUT:

125698353(SMAD3)

NMEL:

110403531(SMAD3)

APLA:

101801230(SMAD3)

ACYG:

106043666(SMAD3)

CATA:

118259701(SMAD3)

AFUL:

116493384(SMAD3)

LSR:	110483002(SMAD3)

SCAN:

103816118(SMAD3)

PMOA:

120509187(SMAD3)

OTC:	121343454(SMAD3)

PRUF:

121354426(SMAD3)

GFR:	102040325(SMAD3)

FAB:	101806307(SMAD3)

OMA:	130257201(SMAD3)

PHI:	102110827(SMAD3)

PMAJ:

107209417(SMAD3)

CCAE:

111933962(SMAD3)

CCW:	104683877(SMAD3)

CBRC:

103618994(SMAD3)

ETL:

114065087

ZAB:	102062056(SMAD3)

ACHL:

103808962(SMAD3)

SVG:	106852157(SMAD3)

MMEA:

130577137(SMAD3)

HRT:	120758627(SMAD3)

FPG:	101924726(SMAD3)

FCH:	102053568(SMAD3)

CLV:	102095468(SMAD3)

EGZ:	104125236(SMAD3)

NNI:	104017045(SMAD3)

PLET:

104619719

EHS:

104512398

PCAO:

104041105

ACUN:

113484131(SMAD3)

TALA:

104364371(SMAD3)

PADL:

103914749(SMAD3)

AFOR:

103899850(SMAD3)

ACHC:

115341832(SMAD3)

HALD:

104313355

HLE:	104834616(SMAD3)

AGEN:

126043772

GCL:

127020450

CCRI:

104168596(SMAD3)

CSTI:

104554289

CMAC:

104484640(SMAD3)

MUI:	104536758(SMAD3)

BREG:

104641766(SMAD3)

FGA:

104075123

GSTE:

104262979(SMAD3)

LDI:	104354424(SMAD3)

MNB:

103771741

OHA:	104339268(SMAD3)

NNT:	104410023(SMAD3)

SHAB:

115612729(SMAD3)

DPUB:

104303269(SMAD3)

PGUU:

104467786(SMAD3)

ACAR:

104523354

CPEA:

104386652(SMAD3)

AVIT:

104272721(SMAD3)

CVF:	104288041(SMAD3)

RTD:	128914494(SMAD3)

CUCA:

104065164(SMAD3)

TEO:	104372989(SMAD3)

BRHI:

104494348

AAM:	106487670(SMAD3)

AROW:

112970414(SMAD3)

NPD:	112948290(SMAD3)

TGT:	104568338(SMAD3)

DNE:	112996267(SMAD3)

SCAM:

104139223(SMAD3)

ASN:	102379863(SMAD3)

AMJ:	102564680(SMAD3)

CPOO:

109309204(SMAD3)

GGN:	109288422(SMAD3)

PSS:	102449871(SMAD3)

CMY:	102946629(SMAD3)

CCAY:

125643757(SMAD3)

DCC:	119862604(SMAD3)

CPIC:

101949856(SMAD3)

TST:	117883753(SMAD3)

CABI:

116815741(SMAD3)

MRV:	120373294(SMAD3)

ASAO:

132762413(SMAD3)

SUND:

121934446(SMAD3)

PBI:	103067237(SMAD3)

PMUR:

107283914(SMAD3)

CTIG:

120320154(SMAD3)

TSR:

106547616

PGUT:

117676182(SMAD3)

APRI:

131184526(SMAD3)

PTEX:

113442052(SMAD3)

NSS:	113415620(SMAD3)

VKO:	123030741(SMAD3)

PMUA:

114584162(SMAD3)

PRAF:

128401263(SMAD3)

ZVI:	118083703 118093281(SMAD3)

HCG:	128335215(SMAD3)

GJA:	107105564(SMAD3)

STOW:

125424670

EMC:	129345284(SMAD3)

XLA:	108712801(smad3.S) 378633(smad3.L)

XTR:	493272(smad3)

NPR:	108784107(SMAD3)

RTEM:

120931101(SMAD3)

BBUF:

120986029(SMAD3)

BGAR:

122927488(SMAD3)

MUO:	115459943(SMAD3)

GSH:	117348646(SMAD3)

DRE:	326283(smad3b) 58092(smad3a)

SRX:	107738715 107740443 107755098

SANH:

107663972 107686302 107700375

SGH:	107553101 107563442(smad3) 107583760

CCAR:

109063125 109092667 109109148

CAUA:

113052344 113061447 113097371 113106009 113118366

CGIB:

127934301 127961960 127977271 128016895

PTET:

122322927(smad3b) 122328908 122348825(smad3a)

LROH:

127168307(smad3a) 127180610(smad3b)

OMC:	131524007(smad3b) 131544049(smad3a)

PPRM:

120460054 120487810(smad3b) 120491009(smad3a)

RKG:	130087891(smad3b) 130099612(smad3a)

MAMB:

125254113(smad3b) 125264790(smad3a)

CIDE:

127499865 127516003

MASI:

127417240 127449385 127453845 127456001

TROS:

130553876(smad3a) 130562701(smad3b)

TDW:	130420052(smad3a) 130435214(smad3b)

MANU:

129419215(smad3b) 129444055(smad3a)

IPU:	108259569(smad3a) 124627989

IFU:	128602863(smad3a) 128606710(smad3b)

PHYP:

113534580(smad3) 113540926

SMEO:

124379665(smad3a) 124395661(smad3b)

TFD:	113652352(smad3b) 125145338(smad3a)

TVC:	132838542(smad3a) 132851229(smad3b)

AMEX:

103027004 103027811

CMAO:

118817497(smad3a) 118817717(smad3b)

EEE:	113574086 113585069

CHAR:

105892538(smad3b) 105906487(smad3a)

TRU:

101074868

TFS:	130517732(smad3a)

LCO:	104922325(smad3) 104927744

NCC:	104949845 104967854(smad3)

TBEN:

117471175 117491556(smad3b)

CGOB:

115005681 115009849(smad3)

PGEO:

117448076(smad3b) 117464805(smad3a)

GACU:

117538911(smad3b) 117549346(smad3a)

EMAC:

134862973 134879793(smad3b)

ELY:	117258017 117262313(smad3b)

EFO:	125880698 125887698(smad3b)

PLEP:

121946943(smad3a) 121950283(smad3b) 121964791

SLUC:

116038466(smad3b) 116043529(smad3a)

ECRA:

117949314(smad3b) 117950315(smad3a)

ESP:	116694001(smad3) 116704516

PFLV:

114557607 114559543

GAT:	120809216(smad3b) 120812609(smad3a)

PPUG:

119196208(smad3b) 119198624

AFB:	129107736(smad3b) 129108459(smad3a)

CLUM:

117728634 117731879(smad3b)

PSWI:

130193273 130195103(smad3b)

MSAM:

119890083(smad3a) 119893375(smad3b)

SCHU:

122862259(smad3a) 122875137(smad3b)

CUD:	121507938(smad3a) 121515062(smad3b)

ALAT:

119018224 119024552(smad3b)

MZE:	101480714 101485832 101486706(smad3)

ONL:	100692385 100695277(smad3)

OAU:	116323982(smad3a) 116326157(smad3b)

OLA:

101169523

OML:	112160873(smad3a)

CSAI:

133444189(smad3b) 133459688(smad3a)

XMA:	102218118(smad3) 102235393

XCO:	114142996 114156401(smad3)

XHE:	116718553 116732435(smad3)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122835161(smad3b) 122841641

PPRL:

129369520

CVG:	107097788 107100800(smad3)

CTUL:

119780404(smad3b) 119799095(smad3a)

GMU:	124867172(smad3a)

NFU:	107388715(smad3)

KMR:	108230182(smad3b) 108237917(smad3a)

ALIM:

106512958 106521204(smad3)

NWH:	119415770(smad3b) 119423984

AOCE:

111573031 111573169(smad3)

MCEP:

125005272(smad3a) 125014785(smad3b)

CSEM:

103379082 103380246(smad3)

POV:	109624649(smad3) 109637282

SSEN:

122772534 122775907(smad3b)

HHIP:

117756333(smad3a) 117763466(smad3b)

HSP:	118106013(smad3a) 118109592(smad3b)

SMAU:

118302389 118315953(smad3b)

LCF:	108886506(smad3b) 108887878(smad3a)

SDU:	111228425(smad3) 111238627

SLAL:

111661150 111666993(smad3)

XGL:	120789455 120793560(smad3b)

HCQ:	109514412 109519458(smad3)

SSCV:

125967049 125971153

SBIA:

133498492 133502017(smad3b)

PEE:	133399165(smad3a) 133402363(smad3b)

PTAO:

133470963 133478470(smad3b)

BPEC:

110174509(smad3)

MALB:

109963341 109971207(smad3)

BSPL:

114852068(smad3a) 114857452(smad3b)

SJO:	128359272(smad3b) 128381257(smad3a)

STRU:

115166794 115192958(smad3)

OTW:	112235777 112238080(smad3b)

OMY:	110526791 118945776(smad3b)

OGO:	124028264 124035481

OKI:	109883786 109888272

OKE:	118374231(smad3b) 127927370

SNH:	120038266 120049742(smad3a)

CCLU:

121547132(smad3b)

ELS:	105005850(smad3) 105013596

SFM:	108934681(smad3)

PKI:	111845594(smad3)

AANG:

118215823(smad3b)

LOC:	102692333(smad3)

PSPA:

121294921 121299241

ARUT:

117428208 117429671

PSEX:

120541663(smad3b)

LCM:	102356317(SMAD3)

CMK:	103189587(smad3b)

CPLA:

122540896(smad3b)

HOC:	132834303(smad3b)

LERI:

129712736(smad3b)

PMRN:

116939938(SMAD3) 116941967

LRJ:	133343779 133346652(SMAD3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	577345(Sp-Smad2/3)

LPIC:

129255841

APLC:

110975164

AJC:

117122661

SKO:	100313734(Smad2/3)

DME:	Dmel_CG2262(Smox)

DER:

6550310

DSE:

6620171

DSI:	Dsimw501_GD24642(Dsim_GD24642)

DYA:	Dyak_GE17479

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14415

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109406828 115258462 115258472 115258619

CQU:	CpipJ_CPIJ004833

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

TCA:

DPA:

ATD:

NVL:

APLN:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212475

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105380548 105383797

PGW:

CFEL:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM033930

ZNE:

SGRE:

IEL:

FCD:

DPX:	DAPPUDRAFT_314805

DMK:

116928768

PVM:	113821366 113828262

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:	111696358 111704855

LSM:

TCF:

PPOI:

DSV:

RSAN:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

129584616 129588689 129602832

BMY:	BM_BM9173(Bma-daf-8)

LOA:	LOAG_07582

TSP:

Tsp_05943

HRO:	HELRODRAFT_185435

LGI:	LOTGIDRAFT_189014

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105337701 105337984 117688158

CVN:	111112841 111112940

CANU:

128171544 128173082 128173169

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

ADF:	107337755(AdiSmad2/3)

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_49742

AQU:

105312557

» show all

Reference

PMID:9464505

Authors

Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y

Title

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers.

Journal

Cancer Lett 122:157-63 (1998)
DOI:10.1016/s0304-3835(97)00384-4

Sequence

[hsa:4088]

LinkDB

DBGET integrated database retrieval system