KEGG   ORTHOLOGY: K24309
Entry
K24309                      KO                                     

Name
TET2_3
Definition
methylcytosine dioxygenase TET2/3 [EC:1.14.11.-]
Disease
H01481  Myelodysplastic syndrome
H01892  Peripheral T cell lymphoma
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K24309  TET2_3; methylcytosine dioxygenase TET2/3
   03036 Chromosome and associated proteins
    K24309  TET2_3; methylcytosine dioxygenase TET2/3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.-  
     K24309  TET2_3; methylcytosine dioxygenase TET2/3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K24309  TET2_3; methylcytosine dioxygenase TET2/3
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    K24309  TET2_3; methylcytosine dioxygenase TET2/3
Genes
HSA: 200424(TET3) 54790(TET2)
PTR: 459329(TET3) 471263(TET2)
PPS: 100967275(TET3) 100985863(TET2)
GGO: 101128074(TET2) 101140089(TET3)
PON: 100438711(TET2) 100442848(TET3)
NLE: 100582842(TET3) 100604843(TET2)
MCC: 694137(TET2) 707759(TET3)
MCF: 102122788(TET2) 102146434(TET3)
CSAB: 103220042(TET3) 103236067(TET2)
RRO: 104668766(TET2) 104676849(TET3)
RBB: 108521863(TET3) 108529613(TET2)
CJC: 100403244(TET3) 100407516(TET2)
SBQ: 101028390(TET2) 101028776(TET3)
MMU: 194388(Tet3) 214133(Tet2)
MCAL: 110291600(Tet2) 110296048(Tet3)
MPAH: 110316501(Tet3) 110320561(Tet2)
RNO: 310859(Tet2) 680576(Tet3)
MUN: 110562569(Tet2) 110566855(Tet3)
CGE: 100769509(Tet3) 100769811(Tet2)
NGI: 103740608(Tet2) 103749944(Tet3)
HGL: 101710771(Tet3) 101722412(Tet2)
CCAN: 109688138(Tet3) 109698496(Tet2)
OCU: 100339579(TET2) 100350148(TET3)
TUP: 102476879(TET2) 102477884(TET3)
CFA: 478499(TET2) 483109(TET3)
VVP: 112916731(TET3) 112934197(TET2)
AML: 100469957(TET2) 100480248(TET3)
UMR: 103661712(TET2) 103671399(TET3)
UAH: 113243822(TET3) 113255522(TET2)
ORO: 101374488(TET3) 101378267(TET2)
FCA: 101083580(TET3) 101092848(TET2)
PTG: 102960254(TET3) 102960342(TET2)
PPAD: 109247616(TET2) 109262972(TET3)
AJU: 106966496(TET2) 106967737(TET3)
BTA: 101904937(TET3) 538481(TET2)
BOM: 102276920(TET3) 102287204(TET2)
BIU: 109560281(TET2) 109565923(TET3)
BBUB: 102398208(TET3) 102405717(TET2)
CHX: 102184732(TET3) 102191595(TET2)
OAS: 101104996(TET2) 101105649(TET3)
SSC: 100520484(TET3) 100521465(TET2)
CFR: 102506052(TET2) 102506860(TET3)
CDK: 105089572(TET2) 105096566(TET3)
BACU: 102998384(TET3) 103014051(TET2)
LVE: 103079040(TET3) 103090176(TET2)
OOR: 101270552(TET3) 101272595(TET2)
DLE: 111169121(TET3) 111171470(TET2)
PCAD: 102978846(TET3) 102982309(TET2)
ECB: 100057820(TET3) 100073065(TET2)
EPZ: 103558398(TET2) 103559864(TET3)
EAI: 106823862(TET3) 106842085(TET2)
MYB: 102255490(TET3) 102261093(TET2)
MYD: 102756019(TET3) 102773712(TET2)
MNA: 107529266(TET3) 107545507(TET2)
HAI: 109371211(TET3) 109377031(TET2)
DRO: 112302954(TET3) 112317846(TET2)
PALE: 102883587(TET2) 102884458(TET3)
RAY: 107502894(TET3) 107512419(TET2)
MJV: 108386480(TET3) 108397333(TET2)
LAV: 100671009(TET3) 100674717(TET2)
MDO: 100013110(TET2) 100617359(TET3)
SHR: 100914493(TET2) 100916608(TET3)
PCW: 110199787(TET2) 110222636(TET3)
OAA: 100079592(TET2) 103167955(TET3)
GGA: 422540(TET2) 425829(TET3)
MGP: 100539143(TET3) 100544333(TET2)
CJO: 107313300(TET2) 107323691(TET3)
NMEL: 110387222(TET3) 110397478(TET2)
APLA: 101797266(TET2)
ACYG: 106045311(TET2) 106047649(TET3)
TGU: 100228365(TET2) 115498126(TET3)
LSR: 110471159(TET2) 110480184(TET3)
SCAN: 103824907(TET3) 103826019(TET2)
GFR: 102037031(TET2) 102044775(TET3)
FAB: 101817204(TET2) 101822076(TET3)
PHI: 102105215(TET3) 102107468(TET2)
PMAJ: 107199274(TET3) 107202979(TET2)
CCAE: 111927752(TET2) 111938773(TET3)
CCW: 104697108(TET2)
ETL: 114060749(TET2) 114071512(TET3)
FPG: 101913593(TET3) 101913943(TET2)
FCH: 102046196(TET3) 102047169(TET2)
CLV: 102089745(TET3) 102095484(TET2)
EGZ: 104126583(TET2) 104130376(TET3)
NNI: 104021176(TET2)
ACUN: 113479521(TET2) 113488026
PADL: 103919528(TET2)
AAM: 106492014(TET2)
ASN: 102368709(TET2) 102380670(TET3)
AMJ: 102564733(TET2) 102575499(TET3)
PSS: 102453997(TET3) 102462102(TET2)
CMY: 102930294(TET3) 102946068(TET2)
CPIC: 101930793(TET3) 101946912(TET2)
ACS: 100552284(tet2) 100555822(tet3)
PVT: 110072087(TET3) 110080471(TET2)
PBI: 103054028(TET3) 103057861(TET2)
PMUR: 107283256(TET3)
TSR: 106552164(TET3)
PMUA: 114602655(TET3) 114603859(TET2)
GJA: 107120329(TET3) 107125656(TET2)
XLA: 108706731(tet2.S) 108710731(tet2.L) 108711530(tet3.L) 108712780(tet3.S)
XTR: 100036628(tet3) 100380145(tet2)
NPR: 108785428(TET2) 108793891(TET3)
DRE: 101887161(tet2) 103283056(tet3)
CCAR: 109052757
IPU: 108255510(tet3) 108263772(tet2)
PHYP: 113524609(tet2) 113536954(tet3)
AMEX: 103046012 103046434(tet2)
EEE: 113585328(tet2) 113587361
TRU: 101068038 101073625(tet2)
LCO: 104925995(tet3) 104926967(tet2)
NCC: 104965096(tet2)
MZE: 101464948 101470589(tet2)
ONL: 102079559(tet3) 102082021(tet2)
OLA: 101165814 101170986(tet2)
XMA: 102222313(tet3) 102236515(tet2)
XCO: 114144979(tet2) 114154028(tet3)
PRET: 103466474(tet2) 103469756(tet3)
CVG: 107095860(tet2) 107101442
NFU: 107375277(tet2) 107393527(tet3)
KMR: 108230985(tet2) 108234976(tet3)
ALIM: 106517051(tet2) 106524728(tet3)
AOCE: 111567143(tet2) 111572277
CSEM: 103383528(tet2) 103397467
POV: 109633800(tet3) 109638351(tet2)
LCF: 108878340 108896534(tet2)
SDU: 111226959(tet3) 111236619(tet2)
SLAL: 111647925(tet3) 111670419(tet2)
HCQ: 109511104(tet2) 109524987
BPEC: 110163340 110165368(tet2)
MALB: 109954754 109961312(tet2)
ELS: 105014352(tet3) 105021066(tet2)
SFM: 108924487(tet2) 108940376
PKI: 111837235(tet2) 111844155(tet3)
LCM: 102346742(TET2) 102350737(TET3)
CMK: 103177662(tet2)
BFO: 118411024
SPU: 580376
APLC: 110977987
SKO: 100366356
DME: Dmel_CG43444(Tet)
DER: 6546372
DSE: 6610523
DSI: Dsimw501_GD13372(Dsim_GD13372)
DAN: 6493110
DSR: 110185335
DPE: 6599610
DMN: 108151565
DWI: 6639345
DAZ: 108613259
DNV: 108651546
DHE: 111597607
DVI: 6623063
MDE: 101900516
LCQ: 111674877
AAG: 5573007
AME: 412878
BIM: 100742067
BTER: 100642293
CCAL: 108629950
OBB: 114879355
SOC: 105201110
MPHA: 105832348
AEC: 105145855
ACEP: 105618945
PBAR: 105434147
VEM: 105570560
HST: 105189647
DQU: 106750706
CFO: 105258876
LHU: 105670607
PGC: 109855178
OBO: 105283671
PCF: 106793296
NVI: 100114438
CSOL: 105362988
MDL: 103575228
TCA: 103312925
DPA: 109535782
ATD: 109596041
NVL: 108564764
BMOR: 101743969
BMAN: 114240805
PMAC: 106710979
PRAP: 110993496
HAW: 110374536
TNL: 113502725
PXY: 105385720
API: 100159694
DNX: 107173867
AGS: 114129200
RMD: 113554993
BTAB: 109029641
CLEC: 106665216
ZNE: 110838460
FCD: 110862326
PVM: 113824054
PCAN: 112563243
MYI: 110453899
OBI: 106871070
LAK: 106173631
 » show all
Reference
  Authors
Mohamedali AM, Smith AE, Gaken J, Lea NC, Mian SA, Westwood NB, Strupp C, Gattermann N, Germing U, Mufti GJ
  Title
Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome.
  Journal
J Clin Oncol 27:4002-6 (2009)
DOI:10.1200/JCO.2009.22.6985
  Sequence
[hsa:54790]
Reference
  Authors
Liu N, Wang M, Deng W, Schmidt CS, Qin W, Leonhardt H, Spada F
  Title
Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules.
  Journal
PLoS One 8:e62755 (2013)
DOI:10.1371/journal.pone.0062755
  Sequence
[mmu:194388]
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