KEGG   Klebsiella pneumoniae subsp. pneumoniae KPNIH32: KPNIH32_28030
Entry
KPNIH32_28030     CDS       T03468                                 
Name
(GenBank) dihydrofolate reductase
  KO
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Organism
kpg  Klebsiella pneumoniae subsp. pneumoniae KPNIH32
Pathway
kpg00670  One carbon pool by folate
kpg00790  Folate biosynthesis
kpg01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:kpg00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    KPNIH32_28030
   00670 One carbon pool by folate
    KPNIH32_28030
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:kpg01504]
    KPNIH32_28030
Enzymes [BR:kpg01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     KPNIH32_28030
Antimicrobial resistance genes [BR:kpg01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    KPNIH32_28030
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-ProteinID: AIW79612
UniProt: A0A221KLI8
LinkDB
Position
pKPC-def:complement(65309..65782)
AA seq 157 aa
MKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYA
VVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDI
EPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG
NT seq 474 nt   +upstreamnt  +downstreamnt
ttgaaagtatcattgatggctgcgaaagcgaaaaacggcgtgattggttgcggtccagac
ataccctggtccgcgaaaggggagcagctactttttaaagcattgacctacaatcagtgg
cttctggtgggtcgcaagacgtttgaatctatgggcgcactccccaataggaaatacgcg
gtcgttacccgctcaggttggacatcaaatgatgacaatgtagttgtatttcagtcaatc
gaagaggccatggacaggctagctgaattcaccggtcacgttatagtgtctggtggcgga
gaaatttaccgagaaacattacccatggcctctacgctccacttatcgacgatcgacatc
gagccagagggggatgttttcttcccgagtattccaaataccttcgaagttgtttttgag
caacactttacttcaaacattaactattgctatcaaatttggaaaaagggttaa

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