KEGG   Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_00045
Entry
KPN_00045         CDS       T00566                                 
Symbol
folA
Name
(GenBank) dihydrofolate reductase type I, trimethoprim resistance
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
kpn  Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00670  One carbon pool by folate
kpn00790  Folate biosynthesis
kpn01100  Metabolic pathways
kpn01240  Biosynthesis of cofactors
Module
kpn_M00126  Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:kpn00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    KPN_00045 (folA)
   00670 One carbon pool by folate
    KPN_00045 (folA)
Enzymes [BR:kpn01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     KPN_00045 (folA)
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-ProteinID: ABR75505
UniProt: A6T4I4
LinkDB
Position
49985..50464
AA seq 159 aa
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI
VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR
NT seq 480 nt   +upstreamnt  +downstreamnt
atgatcagtctgattgcggcgttagcggtagatcgcgtcattggtatggaaaacgccatg
ccatggaacctgcctgccgatctcgcctggttcaaacgcaacacgttaaataagccggtg
gtgatggggcgtctgacctgggaatccattgggcgcccattgccggggcgtaaaaatatc
gtgatcagcagcaaacccggcagcgacgatcgcgtgcagtgggtctcctccgtagaagaa
gcaattgccgcctgcggcgatgtggaagagattatggtgatcggcggcggccgggtgtat
gagcagttcctgccgaaagcgcagaagctctacttgacccatattgatgcggaagtggaa
ggcgatacccatttcccggattacgatccggacgaatgggagtcggtgttcagcgagttt
catgacgccgacgcgcagaactcccatagctactgctttgagatcctcgaacgccgttaa

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