Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_04399
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Entry
KPN_04399 CDS
T00566
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
kpn
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00270
Cysteine and methionine metabolism
kpn00450
Selenocompound metabolism
kpn00670
One carbon pool by folate
kpn01100
Metabolic pathways
kpn01110
Biosynthesis of secondary metabolites
kpn01230
Biosynthesis of amino acids
kpn04980
Cobalamin transport and metabolism
Module
kpn_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
kpn00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
KPN_04399 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
KPN_04399 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
KPN_04399 (metH)
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
KPN_04399 (metH)
Enzymes [BR:
kpn01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
KPN_04399 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ABR79754
UniProt:
A6TGS0
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All DBs
Position
4813394..4817077
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLHQQLKERILVLDGGMGTMIQGYRLSEQDFRGERFADWPCDLKGNNDLLVLSK
PEVIREIHDAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTRALAEGGVDLILI
ETVFDTLNAKAAIYAVKEELEALGVDLPLMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LSFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMATQIREWAE
AGFLNIVGGCCGTTPEHIAAMSRAVAGLPPRQLPEIAVACRLAGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWEVIEKGLKCIQGKGIVNSISMKEGVESFIHHAKLVRRYGAAV
VVMAFDEVGQADTRERKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPGELRDAVEDVILNRRDDSTERLLELAEKYRGSKADDGANAQQAEWRTWEVK
KRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIIDL
GVMVPADKILKTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVSALLSDTQRDEFVARTRKEYETVRIQHGRKKPR
TPPVTLAAARENDLAFDWESYTPPVAHRLGVQTVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAQRLFKDANELLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVLTVSHHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQH
DDYNKIMIKAIADRLAEAFAEYLHEKVRKVYWGYAANENLSNEELIRENYQGIRPAPGYP
ACPEHTEKGTIWQLLDVEAHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQV
EDYALRKGMTPAEVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagttgagcaactgcatcagcagttaaaagaacgtattctggttctggat
gggggcatgggcaccatgatccagggctatcgtctgagtgagcaggactttcgcggtgag
cgctttgctgactggccgtgcgacctgaaaggcaacaacgacctgctggtgctcagcaaa
cccgaagtgatccgcgagatccacgacgcctatttcgaggccggcgcggatatcattgag
accaacacctttaactcgacgaccatcgcgatggcggattaccagatggaatccctgtcg
gccgagatcaactttgccgcggcgaagctggcccgcgccagcgccgacgcctggacggcc
cgcacgccggaaaaaccgcgctatgtcgcgggcgtgcttggcccgaccaaccgcaccgcc
tctatctcgcctgatgtgaacgatccggcgttccgtaatattacctttgaccagctggtg
gccgcctatcgcgaatccacccgggcgctggcggaaggcggcgtggatctgatcctgatt
gaaacggtgtttgacaccctgaacgctaaagcggccatctatgcggtgaaagaggagctg
gaggcgttaggcgttgacctgccgctgatgatctccgggaccattaccgatgcctctggc
cgcacgctttccggacagaccaccgaagccttttataactcgctgcgtcacgccgaagcc
ttatcgtttggtctgaactgcgccctcgggccggacgagctgcggcagtacgtccaggag
ctgtcgcgcattgccgaatgctacgtcaccgcgcacccgaacgccggcctgcccaacgcc
ttcggcgaatacgatctggacgccgacaccatggcgacgcaaattcgcgaatgggcggaa
gccggtttcctcaatatcgttggcggctgctgcggtaccaccccggagcatatcgccgcc
atgagccgggcggtagcgggcctgccgccgcgtcagttgccggaaattgcggtggcctgc
cgcctcgccggcctggagccgttgaatatcggcgacgatagcctgttcgttaacgtcggt
gaacgaactaacgtcaccggctcggcgaaatttaagcggctgattaaagaagagaagtac
agcgaagcgctggacgttgcgcgtcagcaggtggaaagcggcgcgcagattatcgatatc
aacatggacgaggggatgctcgacgcggaagcggcgatggtgcgtttccttaacctgatt
gccggcgagccggacattgcccgcgtgccgatcatgattgactcctccaagtgggaagtc
attgaaaagggcctgaaatgtattcagggcaaaggcatcgttaactcgatttcgatgaaa
gagggcgtcgaatcctttatccaccatgcgaaactggttcgccgctacggcgccgcggtg
gtggtgatggccttcgacgaggttggtcaggccgacacccgcgaacgtaaaattgagatt
tgccgtcgcgcctacaaaatcctcaccgaagaggtcggcttcccgccggaagatattatc
ttcgaccccaatatctttgccgtcgccaccggtatcgaagagcataacaactacgcacag
gactttatcggcgcctgcgaagacatcaaacgcgagctgccgcatgcgctaatctccggc
ggggtctccaacgtctccttctccttccgcggtaatgacccggtacgtgaggcgatccac
gccgtattcctctactacgcgatccgcaacggcatggacatggggatcgtcaacgccggt
cagctggccatctatgatgacctcccgggcgagctgcgcgacgcggtcgaagacgtgatc
ctcaaccgccgcgatgacagtaccgaacggttacttgagctggcggaaaaatatcgcggc
agcaaagcggacgacggcgcgaatgcccagcaggcggagtggcgcacctgggaagtgaaa
aaacgcctcgaatattcgctggttaagggcattaccgaatttatcgaacaggacaccgaa
gaagcgcgtcagcaggccgcccgcccgattgaggtcattgaagggccgctgatggacggc
atgaacgtggtcggcgatctgttcggcgaaggcaaaatgttcctgccgcaggtggtgaaa
tccgcccgtgtaatgaaacaggcggtggcctaccttgagccgtttattgaagccagtaaa
gagcagggctccagtaacggcaaaatggtgattgccacggtaaaaggcgacgttcatgac
attggcaaaaacatcgtcggcgtggtgctgcagtgcaataactacgaaatcattgatctt
ggcgtgatggtcccggcggataaaattctcaaaacggccaaagaggtaaacgcggatcta
attggtctttccgggctgattaccccatcgctggacgagatggttaatgtggcgaaagag
atggagcgccagggctttaccatcccgctgctgataggcggcgcgaccacctcgaaagcg
catacggcggtgaaaatcgagcagaactacagcggccccaccgtttacgtacagaacgcc
tcgcgcaccgtcggcgtggtgtctgcgctgctctcggacacgcagcgcgacgagtttgtc
gcccgcacgcgcaaagagtatgaaacggtgcgtatccagcatgggcgtaaaaaaccgcgt
acgccgccggtgacccttgccgccgcgcgggaaaacgatctggcctttgactgggagagc
tacacgccgccggtggctcatcgtctgggagtacagacggtggaagccagtatcgagact
ctgcgcaactacatcgactggacgccgttcttcatgacctggtcgctggcgggtaaatat
ccgcgcattctggaagatgaagtggtaggggaagaggcgcagcgcctgttcaaagacgct
aacgagctgctggataagcttagcgcagagaaaaccctgaacccgcgcggcgtggtgggt
ctgttcccggccaaccgcgtgggcgacgatattgaaatctatcgcgatgaaacccgcacc
cacgtgctgacggtgagccatcatctgcgccagcagacggagaaggttggcttcgccaac
tactgtctcgccgattttgtcgcgccgaagctgagcggcaaggcggactacatcggcgcc
ttcgccgtgaccggcggcctggaagaggacgcgctggcggacgcctatgaagcgcagcat
gatgactataacaagatcatgattaaagccatcgccgatcgcctggcggaggcctttgcc
gagtatctgcatgagaaagtgcgcaaggtttactggggatatgcggccaatgagaacctc
agcaatgaggagcttattcgcgagaactaccaggggatccgaccggcgccgggatatccg
gcctgtccggagcacaccgaaaaggggaccatctggcagctactggacgtcgaagcccat
accggcatgaagctcaccgagtctttcgccatgtggccaggcgcatcggtttccggctgg
tacttcagccatccggacagtaagtacttcgccgtggcgcagatccagcgcgatcaggtc
gaagattacgcgctgcgtaaaggaatgacgccggcggaggtcgagcgctggttagcgcct
aatctgggctatgatgcggactag
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