KEGG   PATHWAY: lav04115
lav04115                    Pathway                                

p53 signaling pathway - Loxodonta africana (African savanna elephant)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
lav04115  p53 signaling pathway

Loxodonta africana (African savanna elephant) [GN:lav]
100663914  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:]
100666208  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:]
100661281  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
100658513  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:]
100661448  GORAB; RAB6-interacting golgin [KO:K19748]
104845647  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
100669448  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:]
100658206  MDM4; protein Mdm4 isoform X1 [KO:K10127]
100663725  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100671706  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100669703  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100668070  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100668683  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104847103  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
100655429  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:]
100668342  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100659451  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100668134  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:]
100676629  SFN; 14-3-3 protein sigma [KO:K06644]
100655521  RPRM; protein reprimo [KO:K10128]
100654684  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100659655  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100668529  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:]
100658253  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100655692  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
100653562  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100655495  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
100657715  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100657698  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
104846103  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
104846102  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
100663575  caspase-8 [KO:K04398] [EC:]
100660542  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:]
100662196  BID; BH3-interacting domain death agonist [KO:K04726]
100673560  BAX; apoptosis regulator BAX [KO:K02159]
100677531  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100671262  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
100659905  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
100655646  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100675268  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100667114  TP53I3; LOW QUALITY PROTEIN: quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
100667395  quinone oxidoreductase PIG3-like [KO:K10133] [EC:1.-.-.-]
100659082  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
100669432  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
100658232  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
100669493  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:]
100654286  cytochrome c, testis-specific [KO:K08738]
100657132  cytochrome c [KO:K08738]
100665091  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
100656597  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:]
100672256  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:]
100654018  AIFM2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
100674990  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
100664710  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100660994  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
100655451  CD82; LOW QUALITY PROTEIN: CD82 antigen [KO:K06509]
100667431  THBS1; thrombospondin-1 [KO:K16857]
100674695  SERPINB5; serpin B5 [KO:K10139]
100665802  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100664945  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
100673076  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:]
100656546  SESN1; sestrin-1 isoform X2 [KO:K10141]
100676440  SESN3; sestrin-3 isoform X2 [KO:K10141]
100657842  SESN2; sestrin-2 [KO:K20394]
100660561  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:]
100670924  TSC2; tuberin isoform X4 [KO:K07207]
100659559  STEAP3; LOW QUALITY PROTEIN: metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
100667310  COP1; E3 ubiquitin-protein ligase RFWD2 isoform X1 [KO:K10143] [EC:]
100664562  RCHY1; LOW QUALITY PROTEIN: RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
100660439  CCNG1; LOW QUALITY PROTEIN: cyclin-G1 [KO:K10145]
100660300  CCNG2; cyclin-G2 isoform X1 [KO:K10146]
100658588  PPM1D; protein phosphatase 1D isoform X1 [KO:K10147] [EC:]
100670813  TP73; LOW QUALITY PROTEIN: tumor protein p73 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
lav04110  Cell cycle
lav04210  Apoptosis
lav04218  Cellular senescence
KO pathway

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