KEGG   PATHWAY: lav04962
lav04962                    Pathway                                

Vasopressin-regulated water reabsorption - Loxodonta africana (African savanna elephant)
In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.
Organismal Systems; Excretory system
Pathway map
lav04962  Vasopressin-regulated water reabsorption

Loxodonta africana (African savanna elephant) [GN:lav]
100667788  LOW QUALITY PROTEIN: neurophysin 2-like [KO:K05242]
100677315  AVPR2; vasopressin V2 receptor [KO:K04228]
100655206  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100669226  neuroendocrine secretory protein 55-like [KO:K04632]
100653532  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
100674724  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:]
100663448  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
100654098  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
100676447  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
100677099  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
100675162  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100653565  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100673694  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100666211  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100670574  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100677344  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100675079  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100676260  RAB11A; ras-related protein Rab-11A [KO:K07904]
100664220  RAB11B; ras-related protein Rab-11B [KO:K07905]
100670700  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100656983  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
100673565  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100664711  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X3 [KO:K10415]
100665421  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100659457  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
100661369  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
100660499  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
100657546  dynein light chain 1, cytoplasmic-like [KO:K10418]
100656316  DCTN1; LOW QUALITY PROTEIN: dynactin subunit 1 [KO:K04648]
100655036  DCTN2; dynactin subunit 2 isoform X2 [KO:K10424]
100673543  DCTN4; dynactin subunit 4 [KO:K10426]
100671785  DCTN5; dynactin subunit 5 [KO:K10427]
100670622  DCTN6; dynactin subunit 6 [KO:K10428]
100672461  VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
100659266  NSF; vesicle-fusing ATPase [KO:K06027] [EC:]
100662887  STX4; syntaxin-4 isoform X2 [KO:K13502]
100676912  RAB5A; ras-related protein Rab-5A [KO:K07887]
100668413  RAB5B; ras-related protein Rab-5B [KO:K07888]
100669020  RAB5C; ras-related protein Rab-5C [KO:K07889]
100676682  AQP4; aquaporin-4 isoform X1 [KO:K09866]
100676691  AQP3; aquaporin-3 [KO:K09876]
C00001  H2O
C00575  3',5'-Cyclic AMP
Boone M, Deen PM
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Arch 456:1005-24 (2008)
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
Localization and trafficking of aquaporin 2 in the kidney.
Histochem Cell Biol 130:197-209 (2008)
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D
Physiology and pathophysiology of renal aquaporins.
J Am Soc Nephrol 10:647-63 (1999)
Marples D, Frokiaer J, Nielsen S
Long-term regulation of aquaporins in the kidney.
Am J Physiol 276:F331-9 (1999)
Ward DT, Hammond TG, Harris HW
Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.
Annu Rev Physiol 61:683-97 (1999)
Fenton RA, Moeller HB
Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.
Prog Brain Res 170:571-9 (2008)
Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA
Aquaporins in the kidney: from molecules to medicine.
Physiol Rev 82:205-44 (2002)
Deen PM, van Balkom BW, Kamsteeg EJ
Routing of the aquaporin-2 water channel in health and disease.
Eur J Cell Biol 79:523-30 (2000)
Bonilla-Felix M
Development of water transport in the collecting duct.
Am J Physiol Renal Physiol 287:F1093-101 (2004)
Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
Physiol Genomics 32:229-53 (2008)
Nguyen MK, Nielsen S, Kurtz I
Molecular pathogenesis of nephrogenic diabetes insipidus.
Clin Exp Nephrol 7:9-17 (2003)
lav04144  Endocytosis
lav04530  Tight junction
KO pathway

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