Loxodonta africana (African savanna elephant): 100653532 Help Entry 100653532         CDS       T04351                                  Gene name ADCY6 Definition (RefSeq) adenylate cyclase type 6 isoform X1   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04742   Taste transduction lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04924   Renin secretion lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04961   Endocrine and other factor-regulated calcium reabsorption lav04962   Vasopressin-regulated water reabsorption lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100653532 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100653532 (ADCY6)    04371 Apelin signaling pathway     100653532 (ADCY6)    04072 Phospholipase D signaling pathway     100653532 (ADCY6)    04024 cAMP signaling pathway     100653532 (ADCY6)    04022 cGMP-PKG signaling pathway     100653532 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100653532 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     100653532 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100653532 (ADCY6)    04062 Chemokine signaling pathway     100653532 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     100653532 (ADCY6)    04923 Regulation of lipolysis in adipocytes     100653532 (ADCY6)    04912 GnRH signaling pathway     100653532 (ADCY6)    04913 Ovarian steroidogenesis     100653532 (ADCY6)    04915 Estrogen signaling pathway     100653532 (ADCY6)    04914 Progesterone-mediated oocyte maturation     100653532 (ADCY6)    04921 Oxytocin signaling pathway     100653532 (ADCY6)    04926 Relaxin signaling pathway     100653532 (ADCY6)    04935 Growth hormone synthesis, secretion and action     100653532 (ADCY6)    04918 Thyroid hormone synthesis     100653532 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     100653532 (ADCY6)    04916 Melanogenesis     100653532 (ADCY6)    04924 Renin secretion     100653532 (ADCY6)    04925 Aldosterone synthesis and secretion     100653532 (ADCY6)    04927 Cortisol synthesis and secretion     100653532 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100653532 (ADCY6)    04270 Vascular smooth muscle contraction     100653532 (ADCY6)   09154 Digestive system    04970 Salivary secretion     100653532 (ADCY6)    04971 Gastric acid secretion     100653532 (ADCY6)    04972 Pancreatic secretion     100653532 (ADCY6)    04976 Bile secretion     100653532 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     100653532 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     100653532 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     100653532 (ADCY6)    04727 GABAergic synapse     100653532 (ADCY6)    04725 Cholinergic synapse     100653532 (ADCY6)    04723 Retrograde endocannabinoid signaling     100653532 (ADCY6)   09157 Sensory system    04742 Taste transduction     100653532 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     100653532 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     100653532 (ADCY6)    04213 Longevity regulating pathway - multiple species     100653532 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     100653532 (ADCY6)    04714 Thermogenesis     100653532 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100653532 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     100653532 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100653532 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100653532 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100653532 (ADCY6)    05163 Human cytomegalovirus infection     100653532 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100653532 (ADCY6) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100653532 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc DUF1053 HNOBA TBK1_ULD Shisa Motif Other DBs NCBI-GeneID:  100653532 NCBI-ProteinID:  XP_023411593 LinkDB All DBs Position Unknown AA seq 1180 aa AA seqDB search MVVLIPSPSFPPSSMSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRTSGLCTPHYMSCL QDAEPPSPTPAAPPRCPWQEEGFIRRGGPGKGTELGLRAVALGFEDTEATVAVGVAELAP NMVPRSKGSCWHRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLA FHAVPARPQPAYVALLACAATLFVALMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGAL AATPHSPSVGLWCPVFFVYITYTLLPIRMRAAVFSGLGLSTLHLILAWQLNRGDAFLWKQ LGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQ HVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTGLASQCTAQELVMTLNELF ARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVN VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLEYLNGDY EVELGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDR AFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRF LLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPHSTLMLGIYASTFLLL LITVLTCAVYSCGSLFPKALQHLSRNIVRSRAHSTAVGIFSVLLVFTSATANMFTCNHTP IRTCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTAPTCNFPEYFVGNMLLSLLASS VFLHISSIGKLAMILVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA PGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL NEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLME QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQV TTDLYQVLASKGYQLECRGVVKVKGKGEMTTYFLNGGPSS NT seq 3543 nt NT seq  +upstreamnt  +downstreamnt atggtggtattaataccatctccttcctttcctcccagcagcatgtcgtggtttagtggc ctcctggttcccaaagtggatgaacggaaaacagcctggggtgaacgcaatgggcaaaag cgtccgcgccgcgggacacggaccagtggcctctgcacgccccactatatgagctgcctc caggatgcagagcctcccagccctactcctgcagctccccctcggtgcccctggcaggaa gaaggcttcatccgcaggggtggcccaggcaagggcacagagctggggctgcgggcggtg gccctgggctttgaggacacagaggcaacagtggcggtaggggtggccgagctggcgccc aacatggtgccgaggagcaagggatcctgctggcaccgtctggtgcaggtattccagtca aagcagttccgctctgccaaactggagcgcctgtaccagcggtacttcttccagatgaac cagagcagcctgacgctgctgatggcggtgctggtactgctcacggctgtgctgctggcc ttccacgccgtgcctgcccgccctcagcctgcctacgtggccctgctggcctgtgctgcc accctcttcgtggctctcatggtggtgtgtaaccgacatagctttcgccaggactccatg tgggtggtgagctacgtggtgctaggcatcctggcagctgtgcaggttgggggggccctg gcagccacccctcacagcccctctgtaggcctctggtgccctgtgttctttgtctacatc acctacacgctcctacccatccgcatgagggcggccgtcttcagtggcctgggtctctcc accctgcatttgatcttggcctggcaactcaaccgtggagatgccttcctctggaagcag ctcggtgccaacgtactgcttttcctctgcaccaatgtcattggcatctgcacacactac ccggctgaggtgtctcagcgccaggcctttcaggagacccgtggctacatccaggcccgg ctgcacctgcagcatgagaatcggcagcaggagcggctgctgctgtcagtgttgccccag catgttgccatggagatgaaagaagacatcaacactaaaaaagaagacatgatgttccac aagatctacatccagaagcatgacaacgtcagcatactgtttgctgacatcgaaggcttc accggcttggcctcccagtgcaccgcacaagagctggtcatgaccctgaatgagctcttc gcccgctttgacaagctggccgcggaaaatcattgcctgaggatcaagattttaggggat tgctactactgtgtgtcagggctgccggaggcccgggcagaccatgcccactgctgtgtg gagatgggaatggacatgatcgaggccatctcgctggtgcgcgaagtgacaggtgtgaat gtgaatatgcgcgtgggcatccacagtgggcgtgtgcactgcggtgtcctcggccttcgg aaatggcagtttgatgtgtggtccaatgatgtgaccctggccaaccacatggaggccggg ggccgggccggccgcatccacatcactcgggccacgctggagtacctgaatggggactac gaggtggagttgggccgaggtggggagcgcaacgcatacctcaaggagcagcacattgag accttcctcatcctgggcgccagccagaagcggaaagaggagaaggccatgctggccaag ttgcaacggacacgggccaactccatggaggggctgatgccacgctgggtgcccgaccgt gccttttcccgtaccaaggactccaaagctttccgccagatgggcattgatgattccagc aaagacaaccggggtgcccaagacgccctgaaccccgaggatgaggtagacgagttcctg ggccgtgccattgatgcacgtagcattgaccagctccgcaaggaccacgtgcgccggttc ctgctcaccttccagagagaagaccttgagaagaagtactcgcggaaggtggatccccgc ttcggagcctacgttgcctgtgccttgttggtcttctgctttatctgcttcatccagctc ctcgtcttcccacactcaaccctgatgcttgggatctatgccagtaccttcctgctgttg ctgatcactgtgctgacctgtgctgtgtactcttgtggttcactgttccctaaggccctg caacatctgtcccgcaatatcgtccgctctcgggcacacagcactgcggttggcatcttt tcagttctgcttgtcttcacctctgccactgccaacatgttcacctgtaaccacaccccc atccggacctgtgcagcccggatgctgaatttaacacctgccgacatcaccgcctgccac ctgcagcagctcaattactctctgggcctggatgctcccctgtgtgagggcaccgcacct acctgcaacttccccgagtacttcgttggaaacatgctactgagtctcttggccagctct gtcttcctacatatcagcagcatcgggaagttggccatgatccttgtcctggggctcatc tatttggtgctgcttctgctgggtcccccggccaccatctttgacaactatgacctactg cttggtgtccatggcttagcttcttccaacgagaccttcgatgggctagactgcccagct cccgggagggtggcactcaagtatatgacccctgtgattctgctggtgtttgccctggcg ctctatctgcatgcccagcaggtggagtcaactgcccgcttggacttcctctggaaactg caggcaacaggggagaaggaggagatggaagagctccaggcctacaaccggcgactgctg cacaacatcctgcccaaggatgtggccgcccactttctggcccgcgagcgccggaatgat gagctttactatcagtcctgtgagtgtgtggctgtcatgtttgcttccatcgccaacttc tctgagttttatgtggagctggaggcaaacaacgagggcgtagagtgcctacggctgctc aacgagatcatcgcggactttgatgagatcatcagtgaggagcggttccggcagctggag aaaatcaagacaattggcagcacctacatggctgcctcggggctgaacgccagcacctac gatcaggtgggccgctcccacatcactgcccttgccgactatgccatgcggctcatggag cagatgaagcacatcaatgagcactccttcaacaatttccagatgaagattggactgaac atgggcccagtcgtagcaggtgtcattggggctcggaagccgcagtatgacatctggggg aacacagtgaatgtctctagccgtatggacagcacaggggttcctgaccgaatccaggtg accacggacctgtaccaggttttagcctccaagggctaccagctggagtgtcgaggggtg gtcaaggtgaagggcaagggggagatgaccacctacttcctcaatgggggccccagcagt tag

Loxodonta africana (African savanna elephant): 100653771 Help Entry 100653771         CDS       T04351                                  Gene name ADCY7 Definition (RefSeq) adenylate cyclase type 7 isoform X1   KO K08047   adenylate cyclase 7 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100653771 (ADCY7)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100653771 (ADCY7)    04371 Apelin signaling pathway     100653771 (ADCY7)    04020 Calcium signaling pathway     100653771 (ADCY7)    04072 Phospholipase D signaling pathway     100653771 (ADCY7)    04024 cAMP signaling pathway     100653771 (ADCY7)    04022 cGMP-PKG signaling pathway     100653771 (ADCY7)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100653771 (ADCY7)   09144 Cellular community - eukaryotes    04540 Gap junction     100653771 (ADCY7)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100653771 (ADCY7)    04062 Chemokine signaling pathway     100653771 (ADCY7)   09152 Endocrine system    04911 Insulin secretion     100653771 (ADCY7)    04923 Regulation of lipolysis in adipocytes     100653771 (ADCY7)    04912 GnRH signaling pathway     100653771 (ADCY7)    04913 Ovarian steroidogenesis     100653771 (ADCY7)    04915 Estrogen signaling pathway     100653771 (ADCY7)    04914 Progesterone-mediated oocyte maturation     100653771 (ADCY7)    04921 Oxytocin signaling pathway     100653771 (ADCY7)    04926 Relaxin signaling pathway     100653771 (ADCY7)    04935 Growth hormone synthesis, secretion and action     100653771 (ADCY7)    04918 Thyroid hormone synthesis     100653771 (ADCY7)    04928 Parathyroid hormone synthesis, secretion and action     100653771 (ADCY7)    04916 Melanogenesis     100653771 (ADCY7)    04925 Aldosterone synthesis and secretion     100653771 (ADCY7)    04927 Cortisol synthesis and secretion     100653771 (ADCY7)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100653771 (ADCY7)    04270 Vascular smooth muscle contraction     100653771 (ADCY7)   09154 Digestive system    04970 Salivary secretion     100653771 (ADCY7)    04971 Gastric acid secretion     100653771 (ADCY7)    04972 Pancreatic secretion     100653771 (ADCY7)    04976 Bile secretion     100653771 (ADCY7)   09156 Nervous system    04724 Glutamatergic synapse     100653771 (ADCY7)    04727 GABAergic synapse     100653771 (ADCY7)    04725 Cholinergic synapse     100653771 (ADCY7)    04723 Retrograde endocannabinoid signaling     100653771 (ADCY7)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100653771 (ADCY7)   09149 Aging    04211 Longevity regulating pathway     100653771 (ADCY7)    04213 Longevity regulating pathway - multiple species     100653771 (ADCY7)   09159 Environmental adaptation    04713 Circadian entrainment     100653771 (ADCY7)    04714 Thermogenesis     100653771 (ADCY7)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100653771 (ADCY7)   09165 Substance dependence    05032 Morphine addiction     100653771 (ADCY7)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100653771 (ADCY7)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100653771 (ADCY7)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100653771 (ADCY7)    05163 Human cytomegalovirus infection     100653771 (ADCY7)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100653771 (ADCY7) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100653771 (ADCY7) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N DUF1053 Motif Other DBs NCBI-GeneID:  100653771 NCBI-ProteinID:  XP_023411382 LinkDB All DBs Position Unknown AA seq 1090 aa AA seqDB search MPAKGRYFLNEGEEGPDQDALYERYSLTSQRGPLLLTFLLVAIAACTALIVIEFINWDPS KLKTLLGTAVVVLVVFVALYLLVYVDCLVRRGLRALALLTWACLMTLGYVLLYDSRMKGA CSWEQVPFFLFVIFVVYTLLPFSMWGAVAVGVVSTVSHLLVLGILLGAHKMPSDHIVLKL LANAIIFLCGNLTGAFHKHRMQDASRDLFTYTVKCIQVRSKLRIEKRQQENLLLSVLPAH ISMGMKLAIIERLKEHRDRRYMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL VVMLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCEAIKQ VREATGVDINMRVGIHSGNVLCGVIGLLKWQYDVWSHDVSLANRMEASGVPGRVHITEAT LNHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPCQHLPRPKGDAALKMRA SVRMTRYLESWGAARPFAHLNHRESVSVSETPDPNSRRPRAIPLRRHRTPDKSASLKGRS EDDSYNDEMWSAIEGLTSTRCGPPHSCAAAPRFCCSRSDDFHTCTWVSIFQEKGLEREYR LAPIPRARHYFACAGLVFLCILLIHVLLMPRMAALGVSFGLVACVLGLVLGLSFADQFLR CCPAWGMLRAISERVETQSLLRVSLAIVTISSLLTIAIISLPLLPVPALGPPGGNETSRN TVSSQTSCELLLHYTSSCILGFIACSVFLWMSLELKFVLLTVALVAYLVLFNISPCWQWA CCSHSLGNLTESNGTLSSSCPWSDLKTMINFYLVLFYVTLVMLSMQTDYYCRLDCLWKKK FKKEQEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKV FYTECDINKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVTSGHE NQDLERQHAQIGIMVEFSLALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYD IWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELTTYFVCTD TAKFQGLGLN NT seq 3273 nt NT seq  +upstreamnt  +downstreamnt atgccagccaaggggcgctatttcctcaacgagggtgaggagggcccagaccaggatgcg ctgtatgagaggtatagcctcaccagccagcgcgggccgctgctgctcacattcctgctg gtggctatcgcggcctgcactgccctcatcgtcatcgagttcatcaactgggacccctcc aaactcaagactctcctggggacggcggtcgtggtgcttgtcgtgtttgttgccctctac ctgctggtgtatgtcgactgccttgtgcggcgggggctcagggccctggcgctgctcacc tgggcctgcctcatgacgctgggttacgtgctgctgtacgactcacggatgaagggggcc tgctcctgggagcaggtgcccttcttcctgtttgtcatcttcgtggtgtacacgctgctg cccttcagcatgtggggggccgtcgcagtgggggtcgtctccactgtctcccacctcctc gtgctcggcatcctcctgggggcccacaagatgcctagtgaccacatagtgctgaagctg ctggccaatgccatcatcttcttgtgtgggaacctgactggcgccttccacaagcaccgg atgcaggatgcctccagagacctgttcacctacactgtgaagtgcatccaggtccggagc aagctgcgcatcgagaagcggcagcaggagaacctgctgctctcggtgctgccagcccac atctccatgggcatgaagctggccatcattgagcgcctcaaggagcacagggaccgccgc tacatgcccgacaacaacttccacagcctgtatgtcaagcggcaccagaacgtcagcatc ctctacgcagacattgtgggcttcacgcagctggccagtgactgctcccccaaggagctg gtggtgatgcttaacgagctctttggaaagttcgaccagattgccaaggccaacgagtgc atgcggatcaagatcctgggtgactgctattactgcgtgtcgggcctgcctgtgtccctg cccactcatgcccggaactgcgtgaagatggggctggacatgtgtgaggccatcaagcag gtgcgggaggccacgggtgtggacatcaacatgcgcgtgggcatccactccgggaacgtg ctgtgcggtgtcatcgggctgctcaagtggcagtatgacgtatggtcccacgacgtgtcc ctggccaacaggatggaggcatctggagtccccggccgggtgcacatcacggaggcgacg ctgaaccacctggacaaggcgtacgaagtggaggatgggcacgggcagcagagggacccc tacctgaaggagatgaatatccgcacctacctggtcatcgacccccggagccagcagcca cctccgccctgccagcacctccccaggcccaagggggacgcagctctgaagatgcgggcg tcagtgcggatgacccgctacctggagtcctggggtgccgcgcggcccttcgcgcacctc aaccatcgcgagagcgtgagcgtcagtgagacccctgaccccaacagccggaggcccagg gccattcctttgcggcgccaccggaccccagacaaaagtgcgtctctcaaggggcggtcg gaggatgactcctacaacgatgagatgtggtcggccatcgaggggctcacttccacaagg tgtggcccccctcactcctgtgctgccgcccccaggttctgctgctccaggtcagatgac ttccacacctgcacctgggtgtccatcttccaggagaagggccttgagcgagagtaccgc ctggcacccatcccccgggcccgccactacttcgcctgtgccggcctcgtcttcctctgc atcctgctcatccatgtcctgctgatgcccaggatggcggctctgggtgtgtcctttggg ctggtggcctgtgtgctggggctagtgctgggcctgtcctttgctgatcagttcttgagg tgctgcccagcctgggggatgctccgggccatctctgagagggtggagacacagtccctg ctgagggtgtccctggccatcgtgaccatcagcagcctgctcaccattgccatcatcagc ctgccgctgctccctgtcccagcactgggaccacctggtgggaacgagacgagccggaac actgtgagcagccagacctcatgtgagctgctgctgcattacaccagcagctgcatcctg ggcttcattgcttgctccgtcttcttgtggatgagcctggagctgaagttcgtgctgctg accgtggccttggtggcctacctggtgctctttaacatctctccgtgctggcagtgggcc tgctgcagccacagcctgggcaacctcacggagagcaacggcaccctcagctcctcttgt ccatggagtgatctgaagacaatgattaatttctacctggttctgttctatgtcaccctc gtcatgctctccatgcagactgactactactgccgtctggactgtttgtggaagaagaag ttcaagaaggagcaggaggagtttgagaccatggagaatgtgaaccgccttcttctggag aacgtcctgccagcccatgtggccgcccacttcattggcgacaagttaaatgaggactgg taccaccagtcgtatgactgcgtctgtgtcatgtttgcgtccgtgccggatttcaaagtg ttctataccgagtgcgacatcaacaaggaagggctggagtgcctgcgcctgctgaacgag atcattgcggactttgacgagctgctgttaaagcccaagttcagtggggtggagaagatc aagaccatcggcagcacatacatggcagcagcggggctcagcgtcacctcagggcatgag aaccaggacctggagcggcagcacgcccagatcggcatcatggtggagttcagcctcgcc ctgatgagcaagctggacggcatcaacaggcactccttcaactccttccgcctccgtgtc ggcataaaccatgggcccgtgattgctggggtgatcggggcgcggaaacctcagtatgac atctggggaaacacggtcaatgttgccagccgaatggagagcactggggaacttgggaaa atccaggttactgaggagacatgcaccatcctgcagggactgggctactcctgtgagtgc cgcggactgattaacgtcaaaggcaagggcgaactgacgacttacttcgtctgcacagac actgccaagttccaagggctggggctgaactga

Loxodonta africana (African savanna elephant): 100661616 Help Entry 100661616         CDS       T04351                                  Gene name ADCY8 Definition (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04720   Long-term potentiation lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04742   Taste transduction lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100661616 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100661616 (ADCY8)    04371 Apelin signaling pathway     100661616 (ADCY8)    04020 Calcium signaling pathway     100661616 (ADCY8)    04072 Phospholipase D signaling pathway     100661616 (ADCY8)    04024 cAMP signaling pathway     100661616 (ADCY8)    04022 cGMP-PKG signaling pathway     100661616 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100661616 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     100661616 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100661616 (ADCY8)    04062 Chemokine signaling pathway     100661616 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     100661616 (ADCY8)    04923 Regulation of lipolysis in adipocytes     100661616 (ADCY8)    04912 GnRH signaling pathway     100661616 (ADCY8)    04913 Ovarian steroidogenesis     100661616 (ADCY8)    04915 Estrogen signaling pathway     100661616 (ADCY8)    04914 Progesterone-mediated oocyte maturation     100661616 (ADCY8)    04921 Oxytocin signaling pathway     100661616 (ADCY8)    04926 Relaxin signaling pathway     100661616 (ADCY8)    04935 Growth hormone synthesis, secretion and action     100661616 (ADCY8)    04918 Thyroid hormone synthesis     100661616 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     100661616 (ADCY8)    04916 Melanogenesis     100661616 (ADCY8)    04925 Aldosterone synthesis and secretion     100661616 (ADCY8)    04927 Cortisol synthesis and secretion     100661616 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100661616 (ADCY8)    04270 Vascular smooth muscle contraction     100661616 (ADCY8)   09154 Digestive system    04970 Salivary secretion     100661616 (ADCY8)    04971 Gastric acid secretion     100661616 (ADCY8)    04972 Pancreatic secretion     100661616 (ADCY8)    04976 Bile secretion     100661616 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     100661616 (ADCY8)    04727 GABAergic synapse     100661616 (ADCY8)    04725 Cholinergic synapse     100661616 (ADCY8)    04720 Long-term potentiation     100661616 (ADCY8)    04723 Retrograde endocannabinoid signaling     100661616 (ADCY8)   09157 Sensory system    04742 Taste transduction     100661616 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     100661616 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     100661616 (ADCY8)    04213 Longevity regulating pathway - multiple species     100661616 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     100661616 (ADCY8)    04714 Thermogenesis     100661616 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100661616 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     100661616 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100661616 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100661616 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100661616 (ADCY8)    05163 Human cytomegalovirus infection     100661616 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100661616 (ADCY8) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100661616 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N TBK1_ULD Motif Other DBs NCBI-GeneID:  100661616 NCBI-ProteinID:  XP_010586798 LinkDB All DBs Position Unknown AA seq 1067 aa AA seqDB search MNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQY SGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQV ILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLE TENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFT NLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVE MGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGG IPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKE SVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGP EEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLL FITAIQSLLPSSRVMPLAIQFSVLIMLHSALVLITTAEDYKCLPLVLRKTCCWINETYLA RNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAM VTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLL MAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFL EKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLSE DRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWDHLCALADFSLALSESIQEINKHSFNN FELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQG FAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLN RQRQKQLLNENNNTGIIKAHYNRRTLLTPSGPEPGAQAEGTDKSDLP NT seq 3204 nt NT seq  +upstreamnt  +downstreamnt atgaacgtgctggacgtgctgactaaactcaccctcttggttctccacttgagcctggcc tcggcacccatggacccgctcaagggcattctgttgggtttcttcaccggcatcgaggtg gtaatctgcgccctggtggtggtcaggaaggacaccacctcacacacgtacctgcagtac agcggcgtggtcacctgggtggccatgaccacccaaatcctggcagcaggccttggctat gggctcctgggtgacggcatcggttacgtgctcttcacgctcttcgccacctacagcatg ctgccgctgcccctcacctgggccatcctggccggcctgggcacctcgctgctccaggtg atcctccaagtggtcatccccagactggcggtcatttccatcaaccaggtggtggcccag gcagtgttattcatgtgtatgaacacagctgggatcttcatcagttacctgtcagaccgg gcccagcgccaagccttcctggagactcggaggtgtgtggaggccaggctgcgcctggaa acagagaaccagagacaggagcggcttgtgctgtctgtgctccccaggtttgttgtcctg gaaatgatcaacgacatgactaatgtggaagacgagcacctgcagcaccagttccaccgg atctacatccaccgctatgagaatgtcagtattcttttcgcagatgttaaaggatttacc aacctctccacgaccttgtctgctcaggagctggtcaggatgctcaacgagctctttgcc agatttgatcgcctggcccatgagcatcactgtcttcgcattaaaatcctgggagactgc tactattgcgtttccggacttcctgaaccccgccaggaccacgcccactgctgtgttgaa atgggcctcagcatgattaaaaccatcaggtatgtgcgatcaaggacaaagcatgacgtt gacatgcggattggaatccactcaggctcagtgctctgtggcgtgttgggcctgcggaag tggcagtttgatgtctggtcttgggatgtggacattgcgaacaaactcgaatctggagga atccctgggaggattcacatttccaaggccacactggactgcctcaatggtgactacaat gtggaagaggggcacggtaaagagaggaatgaattcctgaggaagcataatatagagacc tatttaattaagcagcctgaggacagtctgctgtctttgcccgaagacattgtcaaggag tcggtgagctcctcggacaggagaaacagtggagcaaccttcacagaagggtcctggagc cccgagctgccctttgataacatagtggggaaacagaacactctggctgccctaacaaga aattcaataaatctgcttccaaaccatctcgcacaagctttgcatgtccagtcggggcct gaggaaattaacaagagaatagaacataccatcgacttgcggagtggcgataaattgcga agagagcatatcaagccattctcactgatgtttaaagactccagcctggagcacaagtac tctcaaatgagggatgaagtattcaagtcaaacttggtctgtgcatttatcgttcttcta ttcatcacggcaatccaaagtttgcttccttcttcaagggtgatgccgttggccatccag ttttccgttctgattatgctgcactcggctctggtcctcatcaccacagcagaggattat aagtgcttgcccctcgtccttcggaaaacttgctgttggattaatgagacctatttggca cggaatgtcatcatctttgcatccatcttgattaatttcctgggtgccatcctaaatatc ctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaattcctcagct gtgtttacagatatctgctcctacccagagtatttcgtcttcacgggtgtgttggccatg gtgacctgtgcggtattcctgcgacttaactccgtcctgaagctagccgtgctactgatt atgatcgccatctatgccctactgaccgaaaccatctatgcaggcctctttctgcgttat gacaacctgaaccacagtggagaagatttcctggggaccaaggaggcatcgctcctgcta atggccatgttcctccttgctgtgttctaccatggacagcagctggagtacaccgcccgc ctggacttcctgtggcgagtgcaggccaaggaggagatcaacgagatgaaggagctgagg gaacacaacgagaacatgctccggaacatcctgcccagccacgtggcccgccacttcctg gagaaagaccgggacaacgaggagctgtattctcagtcctatgatgctgttggggtgatg ttcgcctccattccagggtttgccgacttttactcccagactgaaatgaacaaccaagga gtggaatgcctgcgcttgctgaatgagatcattgctgacttcgatgaattgctcagcgag gaccggtttcaagacattgaaaaaatcaagaccattggcagcacctacatggcagtgtca ggcctgtcacctgaaaaacagcaatgtgaagacaagtgggatcatctgtgtgccctggcc gacttctctctcgccctgtctgaaagcatacaggagatcaacaagcattcgttcaacaac ttcgagctgcggatcggcatcagccatggctcagtggtagctggcgttattggcgctaag aaaccccagtatgacatttggggcaaaaccgtgaacctggccagccgaatggatagcaca ggggtcagcggcaggatccaagtcccagaggagacctatctcatcctgaaagaccagggc tttgccttcgactaccgaggggagatctatgtgaagggcatcagtgaacaggaaggaaaa atcaaaacatactttctcctgggaagagtccagcccaacccattcatcctgcccccaaga agactgcccgggcaatactccttggccgcggtcgtcctcgggctcgtgcagtccctcaac aggcaaaggcagaagcagctcctcaacgagaataacaacacggggatcatcaaggcccat tacaaccggcggactttgttaactcccagtgggcccgagcccggagcccaagccgaaggc accgacaaatccgatttgccataa

Loxodonta africana (African savanna elephant): 100663448 Help Entry 100663448         CDS       T04351                                  Gene name ADCY9 Definition (RefSeq) LOW QUALITY PROTEIN: adenylate cyclase type 9   KO K08049   adenylate cyclase 9 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04961   Endocrine and other factor-regulated calcium reabsorption lav04962   Vasopressin-regulated water reabsorption lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100663448 (ADCY9)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100663448 (ADCY9)    04371 Apelin signaling pathway     100663448 (ADCY9)    04020 Calcium signaling pathway     100663448 (ADCY9)    04072 Phospholipase D signaling pathway     100663448 (ADCY9)    04024 cAMP signaling pathway     100663448 (ADCY9)    04022 cGMP-PKG signaling pathway     100663448 (ADCY9)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100663448 (ADCY9)   09144 Cellular community - eukaryotes    04540 Gap junction     100663448 (ADCY9)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100663448 (ADCY9)    04062 Chemokine signaling pathway     100663448 (ADCY9)   09152 Endocrine system    04911 Insulin secretion     100663448 (ADCY9)    04923 Regulation of lipolysis in adipocytes     100663448 (ADCY9)    04912 GnRH signaling pathway     100663448 (ADCY9)    04913 Ovarian steroidogenesis     100663448 (ADCY9)    04915 Estrogen signaling pathway     100663448 (ADCY9)    04914 Progesterone-mediated oocyte maturation     100663448 (ADCY9)    04921 Oxytocin signaling pathway     100663448 (ADCY9)    04926 Relaxin signaling pathway     100663448 (ADCY9)    04935 Growth hormone synthesis, secretion and action     100663448 (ADCY9)    04918 Thyroid hormone synthesis     100663448 (ADCY9)    04928 Parathyroid hormone synthesis, secretion and action     100663448 (ADCY9)    04916 Melanogenesis     100663448 (ADCY9)    04925 Aldosterone synthesis and secretion     100663448 (ADCY9)    04927 Cortisol synthesis and secretion     100663448 (ADCY9)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100663448 (ADCY9)    04270 Vascular smooth muscle contraction     100663448 (ADCY9)   09154 Digestive system    04970 Salivary secretion     100663448 (ADCY9)    04971 Gastric acid secretion     100663448 (ADCY9)    04972 Pancreatic secretion     100663448 (ADCY9)    04976 Bile secretion     100663448 (ADCY9)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     100663448 (ADCY9)    04961 Endocrine and other factor-regulated calcium reabsorption     100663448 (ADCY9)   09156 Nervous system    04724 Glutamatergic synapse     100663448 (ADCY9)    04727 GABAergic synapse     100663448 (ADCY9)    04725 Cholinergic synapse     100663448 (ADCY9)    04723 Retrograde endocannabinoid signaling     100663448 (ADCY9)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100663448 (ADCY9)   09149 Aging    04211 Longevity regulating pathway     100663448 (ADCY9)    04213 Longevity regulating pathway - multiple species     100663448 (ADCY9)   09159 Environmental adaptation    04713 Circadian entrainment     100663448 (ADCY9)    04714 Thermogenesis     100663448 (ADCY9)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100663448 (ADCY9)   09165 Substance dependence    05032 Morphine addiction     100663448 (ADCY9)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100663448 (ADCY9)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100663448 (ADCY9)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100663448 (ADCY9)    05163 Human cytomegalovirus infection     100663448 (ADCY9)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100663448 (ADCY9) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100663448 (ADCY9) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N Motif Other DBs NCBI-GeneID:  100663448 NCBI-ProteinID:  XP_003417791 LinkDB All DBs Position Unknown AA seq 1344 aa AA seqDB search MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSGSHPKHCKYSISSSCSSSGDS GGAPRRVGVGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACMERCFPQTRRRFRYAL FYIGFRLLAPGVSTFAGHMQSRLGVLVGPALIFFFTFSFTFTRLYARHYVCTALVLTLLV FILTLALQFQVLTPLSGRADSSNHTPTVSPHSTCLSQVGSFSMCIEVLLLLYTVMHLPLY LSLFLGVAYSILFETFGHHFRDADCFPPVWGALHWELLSRALLHLCIHAIGVHLLIMSQV RSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDDDSENSVKRHPTS SPKNKKKKFSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLSDLSW SLQPLVXETQVXEISTLGDCYYCVAGCLEARGNHAYCCIEMGLADQAIQQFCQEKKNGEM GCRVHGHVLCGLWGCGVKFNWGNDVNWANLMEQLGVAGKVHISESTAKYLDDRYEMEDGK VFERLGQSVVADQLKGLKTYLISGQRAKESHCSCSEALLSGLKVIGGSQGSSGPRLQGTA SPGSVSDLAQTVKTFDNLKTCLSCGITFAPKSEAGAEGGAVQNGCQDEHKNSSKASGGPN SKAQNGLLSPPPEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFV DVIKEDSLMKDYFFKPPINQFSLNFLDQELERTYRTSYQEEVIKNSPVKTFASATFSSLL DVFLSTTVFLVLSVTCFLKYRATALSPPPAALAIFGVALVLEVLSLVVSVRMVFFLEDVM LCTKRLLEWIAGWLPRHFIGAILVSLPALAVYSHVTSEFETNIHFTTFVCSAILIAVVQY CNFCQLSSWMRSSLATIVGAGPLLLLYISLCPDSSIIIAHLDAVQNFSSQGSPCSGSLPH DSRKPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQAD WLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQCQDSSHPQEHLQILFEFAKEMMRVV DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS EESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCIDNGIVPQHQLSISPDIRVQVDGS IGRSPTDEIANLVPSVQNLDRASLSSDSSTQAKDVHLSSKRPWREPVRAEESCRFSKAME KSDCEEVGLEEANELTKLNVSGSL NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt atggcttccccgccccaccagcagctgctgcatcaccacagcaccgaggtgagctgcgac tccagcggagacagcaacagcgtgcgggtcaaaatcaaccccaagcagctctcatctgga agccaccccaagcactgcaagtacagcatctcctccagctgcagcagttcgggggactcc gggggcgcgccccggagggtgggcgtcgggggccgcctgcgccggcagaagaagctgccg cagctgttcgagagagcctccagccgctggtgggaccccaaattcgactcggtgaacctg gaggaggcgtgcatggagcgctgcttcccgcaaacccggcgccgcttccgctatgcgctc ttctacatcggctttcgcctgcttgctcctggagtgtctacttttgcgggccacatgcaa tccagactgggggtcttggtaggccctgcccttattttcttttttaccttctcttttacc ttcaccagactgtacgcccggcactacgtgtgcaccgcgctggtgctcactctcttggtg ttcatcctcactctggccttgcagtttcaggttttgacgcctctctcaggacgcgctgac agctccaatcacacacccacagtcagcccccactccacctgcttgtctcaagtggggagc ttctccatgtgcatcgaagtgctccttttgctgtacactgtcatgcacttacctttgtat ttgagcctgttcctgggagtggcctattctattctctttgagacctttggccaccatttc cgagatgcagactgcttccctccggtgtggggagccctgcactgggagctgctgagcagg gccttgctccacctctgcattcacgccatcggggtccacctgctcatcatgtcccaggtg aggtccaggagcactttcctcaaggtggggcagtccattatgcacgggaaggatctggaa gtagaaaaagccctcaaagagagaatgatccactctgtgatgcccagaatcatcgctgat gacttaatgaaacagggtgatgatgacagtgagaattctgtcaaaaggcaccccacctcg agccccaagaacaagaagaagaaattttctatacagaaagcgcctatagccttccgccct tttaaaatgcagcagatcgaagaggtcagcattttgtttgcagacattgtgggcttcacc aagatgagtgccaacaagtccgcgcatgccctggtagggcttctcagcgacttgtcgtgg tctctccaaccgcttgtgtgagagacacaagtgtgagagatcagcacgttgggtgactgt tactattgtgtggcagggtgtctcgaagcccggggaaaccatgcctactgctgcatcgaa atgggcttggctgatcaagccatccaacagttctgccaggaaaaaaagaatggtgaaatg ggttgtcgggttcacgggcacgttttgtgtgggctctggggttgcggagttaaattcaac tggggtaatgatgtgaattgggccaacctcatggagcagctgggagtggctggcaaggtc cacatttccgagtccactgcaaaatacttagatgatcggtacgaaatggaagacgggaag gtgtttgagcgcctgggccagagtgtggtggctgaccagttgaaaggtctgaagacatac ctgatatcgggtcagagagcgaaggagtctcattgcagctgttcagaggccttgctttct ggcctcaaggtcattggcggctcccaggggtcttcaggccctaggttacaggggacagca tcaccagggagtgtcagtgacttggcacagactgtcaaaacctttgataaccttaagacc tgcctttcatgtggaattacgtttgctccaaaatctgaagctggtgcagaaggaggagca gtccaaaatggctgtcaagacgagcataaaaacagcagcaaggcttctggaggacctaat tccaaagcccagaatggacttctgagccctccaccagaggagaagcttaccaacagtcag acctccctgtgtgagatcctacaggaaaagggaaggtgggcaggggtgagcttggaccaa tctgccctccttccgttgagattcaagaatatccgggagaaaacagatgcccattttgtt gatgttattaaagaagatagcctgatgaaagattatttttttaaaccacccattaatcag ttcagcttgaacttcttggaccaggagctagagcgaacctacaggaccagctaccaagaa gaggtcataaagaattctcccgtgaagacttttgccagtgccaccttcagttcccttctg gatgtgtttctgtcaacaactgtgtttctagtcctctccgtcacctgcttcctgaagtac agggccaccgccttgtccccaccgcctgctgccctggccatctttggtgtggccctggtg ctggaggtgctctccctcgttgtctctgtcaggatggtgttcttcctggaagatgtcatg ttgtgtaccaagcgcctgctggagtggatcgccggctggcttcctcgtcacttcatcgga gcaatcctggtgtcactccctgcccttgccgtctattcccatgtcacctctgagtttgag acaaacattcattttaccacgttcgtgtgctcagccatcctcatcgctgtcgtgcagtac tgcaacttctgccagctcagctcctggatgcggtcctcgctggccaccattgttggggct gggcccctgctcctgctttatatctccctgtgtccagacagttccataataattgcacac cttgatgcagtacagaatttcagttcccaggggagtccctgcagtggctcactgccacat gacagcaggaagccagccagtctgattggccaggaggtggttctcgtcttctttcttctg ctcctcctggtctggttcctgaaccgagagttcgaagtcagctaccgcttacactaccat ggcgacgtggaagcggaccttcaccgcaccaagatccagagcatgcgagaccaggctgac tggctgctgagaaacatcattccttaccatgtggccgagcagctcaaggtgtctcagacc tattccaagaaccatgacagtggaggggtcatcttcgccagcatcgtcaacttcagcgaa ttctacgaggagaactacgaggggggcaaggagtgctaccgggtcctcaacgaactcatt ggggactttgacgagctcctaagcaagccggactacagcagcattgagaagatcaagacc attggggcgacctacatggctgcctcggggctgaacacggctcagtgccaggatagcagc cacccgcaggaacacctgcagatcctgttcgagtttgccaaggagatgatgcgtgtggtg gatgacttcaataacaacatgttgtggttcaacttcaaactccgtgtcggcttcaaccat gggcccctgactgcaggggtcatcggcaccacaaagctgctgtacgatatctggggggac acggtcaacattgccagcaggatggataccactggggtagaatgccgcattcaggtgagt gaagagagctaccgggtcctgagcaagatgggctatgactttgactacagagggacagtg aatgtcaaggggaaaggtcaaatgaagacctacctctaccccaagtgtatagacaacggg atcgtgcctcaacaccagctgtccatctccccggacatccgggtccaggtggacgggagc atcgggcggtcacccactgatgagatcgccaacctggtgccttctgtacagaatttggac agggcgtctctgagttccgatagcagcacacaggccaaggatgtccacctgtcttctaag aggccctggagggagcctgtcagagcagaagagagttgccgcttcagcaaagccatggag aaaagcgactgtgaggaagtagggctggaggaagccaatgagctcaccaagctcaatgtc tccgggagcttgtga

Loxodonta africana (African savanna elephant): 100670244 Help Entry 100670244         CDS       T04351                                  Gene name ADCY5 Definition (RefSeq) LOW QUALITY PROTEIN: adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04726   Serotonergic synapse lav04727   GABAergic synapse lav04728   Dopaminergic synapse lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04924   Renin secretion lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05012   Parkinson disease lav05030   Cocaine addiction lav05031   Amphetamine addiction lav05032   Morphine addiction lav05034   Alcoholism lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100670244 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100670244 (ADCY5)    04371 Apelin signaling pathway     100670244 (ADCY5)    04072 Phospholipase D signaling pathway     100670244 (ADCY5)    04024 cAMP signaling pathway     100670244 (ADCY5)    04022 cGMP-PKG signaling pathway     100670244 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100670244 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     100670244 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100670244 (ADCY5)    04062 Chemokine signaling pathway     100670244 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     100670244 (ADCY5)    04923 Regulation of lipolysis in adipocytes     100670244 (ADCY5)    04912 GnRH signaling pathway     100670244 (ADCY5)    04913 Ovarian steroidogenesis     100670244 (ADCY5)    04915 Estrogen signaling pathway     100670244 (ADCY5)    04914 Progesterone-mediated oocyte maturation     100670244 (ADCY5)    04921 Oxytocin signaling pathway     100670244 (ADCY5)    04926 Relaxin signaling pathway     100670244 (ADCY5)    04935 Growth hormone synthesis, secretion and action     100670244 (ADCY5)    04918 Thyroid hormone synthesis     100670244 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     100670244 (ADCY5)    04916 Melanogenesis     100670244 (ADCY5)    04924 Renin secretion     100670244 (ADCY5)    04925 Aldosterone synthesis and secretion     100670244 (ADCY5)    04927 Cortisol synthesis and secretion     100670244 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100670244 (ADCY5)    04270 Vascular smooth muscle contraction     100670244 (ADCY5)   09154 Digestive system    04970 Salivary secretion     100670244 (ADCY5)    04971 Gastric acid secretion     100670244 (ADCY5)    04972 Pancreatic secretion     100670244 (ADCY5)    04976 Bile secretion     100670244 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     100670244 (ADCY5)    04727 GABAergic synapse     100670244 (ADCY5)    04725 Cholinergic synapse     100670244 (ADCY5)    04728 Dopaminergic synapse     100670244 (ADCY5)    04726 Serotonergic synapse     100670244 (ADCY5)    04723 Retrograde endocannabinoid signaling     100670244 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100670244 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     100670244 (ADCY5)    04213 Longevity regulating pathway - multiple species     100670244 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     100670244 (ADCY5)    04714 Thermogenesis     100670244 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100670244 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     100670244 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     100670244 (ADCY5)    05031 Amphetamine addiction     100670244 (ADCY5)    05032 Morphine addiction     100670244 (ADCY5)    05034 Alcoholism     100670244 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100670244 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100670244 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100670244 (ADCY5)    05163 Human cytomegalovirus infection     100670244 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100670244 (ADCY5) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100670244 (ADCY5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc DUF1053 HNOBA TBK1_ULD Motif Other DBs NCBI-GeneID:  100670244 NCBI-ProteinID:  XP_003413007 LinkDB All DBs Position Unknown AA seq 1261 aa AA seqDB search MSRTKSVSPPGYAAQTAAAPAPRGGPEHRSAWGEADPRANGYPHPPGGSARGSTKKPGGA VTPQQRQRLASRWRGDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR GAAGGGSTRAPSAGGGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRATDDLEAGAVED GEGSGDGGSSAGSDAGPGAKLSLGACCLALLQVNRSKKFPSDQLKRLYQRYFLRPERLNQ SSLTMLMAVLVLVCLVMPFHAARPPLQLPYLAVLATAVGVIVIMAVLCNRAAFHQDHMGL ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVVSGVLLSAL HLAIALRANSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN RQRANSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI TIVPHSVFMLSFYLTCFLLLILVVFVSVIYSCVKLFPAPLQTLSRKIVRSKMNSTLVGVF TITLVFLSAFVNMFMCNSKDLFSCLGDEHNVSVSQINACHVVESAFNYSLGEEQGFCGSP WPNCNFPEYFTYSVVLSMLACSVFLQMSCIGKLVLMLAIELIYVLVVEVPGVTLFDNADL LVTANAIDLNNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY DKVGRTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL S NT seq 3786 nt NT seq  +upstreamnt  +downstreamnt atgtcccgcactaaaagcgtcagccccccgggctacgcggcgcagacagcggcggcgccc gcgccccggggaggccccgaacaccgctcggcgtggggagaggccgatccccgtgccaat ggctaccctcacccccctgggggctcggcccgcggctccaccaagaagcccgggggggcc gtgaccccccagcagcggcagcgcctggccagccgctggcgcggcgacgacgacgacgat cctccgctgagcggcgacgaccccctggccgggggcttcggcttcagcttccgctccaag tccgcctggcaggagcgtggcggcgacgactgcggtcggggcagccgccggcagcggcgg ggcgcggcaggcgggggcagcacccgggcgccctctgcgggtggcggcggcggctccgcg gcggcggcggccgcagccggcggcaccgaggtgcgaccccgctcggtggagctgggcctg gaggagcggcggggcaagggccgcgccaccgacgacctggaggccggcgccgtcgaggac ggcgaggggtccggggatggcggcagctccgcgggctcggacgcgggtcccggcgcgaaa ctgtcgctgggcgcctgctgcctggccctgctgcaggtaaaccgctccaagaagttccca tcggaccagctgaagcggctgtaccagcgctactttcttcgccctgaacgcctgaaccag agcagcctcaccatgctcatggcagtgctggtgctcgtgtgtctggtcatgcctttccac gcggcgcggcccccgctccagctgccctacctggccgtgctggccaccgccgtgggcgtc atcgtcatcatggccgtgctctgcaaccgcgccgctttccaccaagaccatatgggcctc gcctgctacgcgctcatcgccgtcgtgctggcggtccaggtggtgggcctgctgctgccc cagccgcgcagcgcctcggagggcatctggtggaccgtgttcttcatctacaccatctat acgctgctgccggtgcgcatgcgggcggcggtggtcagcggggtgctcctgtctgccctt cacctggccatcgccctgcgtgccaactctcaggaccagttcctgctcaagcagctggtc tccaatgtcctcattttctcctgcaccaacatcgtgggggtctgcacccactacccggcc gaggtctcccagagacaggcctttcaggagacccgggagtgcatccaggcgcggctccac tcgcagcgggagaaccagcagcaggagcggctcctgctgtctgtccttccccggcatgtt gccatggagatgaaagcagacatcaacgccaagcaagaggatatgatgtttcacaagatt tacatccagaaacatgacaacgtgagcatcctgtttgctgatatcgagggcttcaccagc ctggcatcccagtgcactgcacaggagctggtcatgaccctcaacgagctctttgcccgc ttcgacaagctggctgcggagaatcactgtttacgtattaagatcctgggggactgttac tactgcgtctcggggctgcctgaagcgagggccgaccatgcccactgctgcgtggagatg ggcatggatatgattgaggccatctcgttggtccgggaggtgactggggtgaacgtgaac atgcgcgtgggaattcacagcgggcgagtacactgcggtgtccttggtctcaggaagtgg cagttcgacgtctggtctaacgacgtcacgctggccaaccacatggaggctggaggcaag gcgggacgcatacacatcaccaaggccacactcaactacctgaatggagactatgaggtg gagccgggctgtgggggcgagcgcaacgcctacctcaaggagcacagtattgagaccttc ctcatcctgcgctgcacccagaagcggaaagaagagaaggccatgatcgccaagatgaat cgccagagagccaactccattgggcataacccgccacactggggcgctgagcgccccttc tacaaccacctgggtggcaaccaggtctccaaggagatgaagcggatgggctttgaagac cccaaggacaagaacgcccaggaaagtgcgaaccccgaggacgaagtggatgagtttctg gggcgggccatcgacgccaggagcatcgacaggctgcgctctgagcatgtccgcaaattc ctcttgaccttcagggagcctgacttagagaagaagtattccaagcaggtggacgaccgg tttggtgcctacgtggcatgtgcctctcttgtcttcctcttcatttgcttcgtccagatc accatcgtgccccactccgtgttcatgttgagtttctacctgacctgcttcctgctgctg atcttggtggtatttgtgtcggtgatctactcctgcgtgaagctcttcccagccccactg cagaccctctccaggaagattgtgcggtccaagatgaacagcaccctggtcggggtgttc accatcaccctggtgttcctgtcagcttttgtcaacatgttcatgtgcaactccaaggac ctgttcagctgcctgggcgacgagcacaacgtcagtgtgagccagatcaacgcgtgccac gtggtggagtcagccttcaactacagcctaggcgaggagcagggcttctgcggcagcccc tggcccaactgcaacttccccgagtacttcacctacagcgtggtgctcagcatgctggcc tgctccgtgttcctgcagatgagctgcatcgggaagctggtgctcatgctcgccatcgag ctcatctacgtgctcgtcgtcgaggtgcctggcgtcacgctgtttgacaatgcggacctg ctggtcaccgccaacgccatagatctgaacaacaacgggacctcccagtgccctgagcac gcgaccaaggtggcgctgaaggtggtgacccccatcatcatctcagtcttcgtgctggcc ctgtacctgcacgctcagcaggtggagtccactgctcgcctggacttcctctggaaactg caggctacagaggagaaggaggagatggaggagctacaggcatataaccggcggctgctg cacaacatcctgcccaaggacgtggctgcccacttcctggcccgcgagcgccggaacgac gagctctactaccagtcatgtgagtgcgtggccgtcatgttcgcctccatcgccaacttc tccgagttctacgtggagctggaggccaacaacgagggagttgagtgcctgcggctgctc aacgagatcattgcagacttcgacgagatcatcagcgaggatcggttcaggcagctggaa aagatcaagaccatcggcagtacctacatggctgcctcgggcctcaatgattccacctat gacaaggtgggcaggacccacatcaaggctctggctgacttcgccatgaagctgatggac caaatgaagtacatcaacgagcactccttcaacaacttccagatgaagatcgggctcaac atcggccctgtggtggctggggtgatcggggctcgcaagcctcagtacgacatctggggc aatacggtgaatgtggccagccgcatggacagcaccggtgtgcctgaccgcatccaggtc accacagacatgtaccaggtgctggctgccaacacataccagctggagtgccggggtgtg gtcaaggtcaagggcaaaggcgagatgatgacctacttcctcaatggagggcccccgctc agttag

Loxodonta africana (African savanna elephant): 100671072 Help Entry 100671072         CDS       T04351                                  Gene name ADCY1 Definition (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04720   Long-term potentiation lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05142   Chagas disease lav05146   Amoebiasis lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100671072 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100671072 (ADCY1)    04371 Apelin signaling pathway     100671072 (ADCY1)    04020 Calcium signaling pathway     100671072 (ADCY1)    04072 Phospholipase D signaling pathway     100671072 (ADCY1)    04024 cAMP signaling pathway     100671072 (ADCY1)    04022 cGMP-PKG signaling pathway     100671072 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100671072 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     100671072 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100671072 (ADCY1)    04062 Chemokine signaling pathway     100671072 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     100671072 (ADCY1)    04923 Regulation of lipolysis in adipocytes     100671072 (ADCY1)    04912 GnRH signaling pathway     100671072 (ADCY1)    04913 Ovarian steroidogenesis     100671072 (ADCY1)    04915 Estrogen signaling pathway     100671072 (ADCY1)    04914 Progesterone-mediated oocyte maturation     100671072 (ADCY1)    04921 Oxytocin signaling pathway     100671072 (ADCY1)    04926 Relaxin signaling pathway     100671072 (ADCY1)    04935 Growth hormone synthesis, secretion and action     100671072 (ADCY1)    04918 Thyroid hormone synthesis     100671072 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     100671072 (ADCY1)    04916 Melanogenesis     100671072 (ADCY1)    04925 Aldosterone synthesis and secretion     100671072 (ADCY1)    04927 Cortisol synthesis and secretion     100671072 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100671072 (ADCY1)    04270 Vascular smooth muscle contraction     100671072 (ADCY1)   09154 Digestive system    04970 Salivary secretion     100671072 (ADCY1)    04971 Gastric acid secretion     100671072 (ADCY1)    04972 Pancreatic secretion     100671072 (ADCY1)    04976 Bile secretion     100671072 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     100671072 (ADCY1)    04727 GABAergic synapse     100671072 (ADCY1)    04725 Cholinergic synapse     100671072 (ADCY1)    04720 Long-term potentiation     100671072 (ADCY1)    04723 Retrograde endocannabinoid signaling     100671072 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100671072 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     100671072 (ADCY1)    04213 Longevity regulating pathway - multiple species     100671072 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     100671072 (ADCY1)    04714 Thermogenesis     100671072 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100671072 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     100671072 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100671072 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100671072 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100671072 (ADCY1)    05163 Human cytomegalovirus infection     100671072 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     100671072 (ADCY1)    05142 Chagas disease     100671072 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100671072 (ADCY1) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100671072 (ADCY1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N DUF1053 HNOBA Motif Other DBs NCBI-GeneID:  100671072 NCBI-ProteinID:  XP_023399960 LinkDB All DBs Position Unknown AA seq 1011 aa AA seqDB search MQQISKLTLFFSLTFALLCCPFALGGSASAHAAGSAAAQQGVWQLLLVTFVSYALLPVPS LLAIGFGLVVAASHLLVSATLVPAKRPCLWRTLGANALLFVSVNMYGAFVRILTERSQRK AFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDN VSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLT QPKTDHAHCCVEMGLDMIDTITSVAEATEVNLNMRVGLHTGRVLCGVLGLRKWQYDVWSN DVTLANVMEAAGLPGKVHITKTTLECLNGDYEVEPGYGHERNSFLKTHNIKTFFIVPSHR RKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRT ASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLRYKHVEREQKY HKLQDEYFTSAVGLALILAALLGLVYLLIIPQNLVALVLLVFCICFLVACIMYLHITRVQ CFPGCLTIQIRTTLCIFIVVLIYSVAQGCMVGCMPWAWRSSPNSSLMVLLPRGRSTALPT SPCTSVPHALLCCLVGTLTLATFLRVPSWPKTLLLLVLTMLSVLMLGLSGPTGAAGGRAV SLPSYEPILAILLFSCALGLHSRQVDLKLRLDYLWAMQAEEERDDMEKVKLDNKRILFNL LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI IADFDELMEKDFYKDLEKIKTIGSTYMAAVGLAPTAGAKAEKSITSHLSVLADFAIEMFD VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQV TEEVHRLLKGCSYQFMCRGKVSVKGKGEMLTYFLEGRIDGSGSQTRSLNMERKMCPYRKA GLQTRLATSCPPVPSVAGFSVQAGLGAVQSTGLPSQPTLQYLPSRAAVKEA NT seq 3036 nt NT seq  +upstreamnt  +downstreamnt atgcagcagatcagcaagctcacgctgttcttcagccttaccttcgcgctgctctgctgt ccctttgcgttgggcggttccgccagtgcccacgctgcggggtcggcggctgcccaacag ggcgtctggcagctccttttggtcactttcgtgtcctatgccctgctgcccgtgcccagc ctgctggctatcggctttgggcttgtggtggccgcatctcacttgctggtctccgccacc ttggtccccgccaagcgcccatgtctctggaggacgcttggagccaacgccctgctcttc gtcagtgtgaacatgtatggggccttcgtgcggatcctgaccgagcgctcccagaggaag gctttcctgcaggcccgcaactgcatcgaggacaggctgaggctggaagatgagaatgag aagcaggagcggctcctgatgagtctcctgccccgcaacgttgccatggagatgaaggag gattttctgaaaccccctgagaggattttccataaaatttacatccagagacatgacaac gtgagcattctgtttgcagacattgtgggcttcacggggctggcgtcccagtgcacagcc caggagctggtgaaacttctgaatgagctcttcgggaagtttgatgagctagccacggag aaccactgccggcggatcaagatcctgggggactgctattactgcgtgtcgggcctcacc cagcccaagactgaccacgcccactgctgtgtggagatggggcttgacatgattgatacc atcacatctgtggctgaggccactgaggtgaacctgaacatgcgtgtggggctgcacaca ggccgggtgctctgtggggtgctgggcctgcgcaagtggcagtacgatgtatggtccaat gatgtgaccctagccaacgtcatggaagccgccggcctgccagggaaggttcatatcaca aagacgaccctagagtgcttgaatggggactacgaggtagaaccgggttatggacatgag aggaacagtttcttgaaaactcataatatcaaaacattttttattgtgccatcccatcgg cgaaagatatttccaggactgattctctcagatataaaaccagccaaaaggatgaagttc aaaactgtctgctacctgctggtgcagctcatgcattgccggaagatgttcaaggccgag atccccttctccaacgtcatgacgtgtgaggacgatgacaagcggagggcgttgagaaca gcctcagaaaaactcagaaaccggtcatctttctccaccaatgttgtctacaccacgcct ggcactcgtgtcaacagatacatcagccgcctcttggaggcccggcaaacagagttggag atggcagacttgaacttctttaccctgaggtacaagcacgttgaacgagaacaaaagtac cacaagcttcaagacgagtacttcaccagtgctgttggtcttgcactcattctagctgcc ttacttggccttgtctaccttctcataatcccacagaacctggtcgctttggtcctgctt gtgttctgcatttgcttcttggtggcatgtatcatgtatctgcacatcacacgagtccag tgttttccagggtgcctgacgattcagatccgtaccaccttgtgtatcttcatcgtggtc ttaatctattcagtggcccaaggatgtatggtgggctgcatgccctgggcctggcgctcg agccccaacagctccctgatggtcctcttgcccagaggccgcagcactgcgctgcccact tcgccctgtacgtcggtgccccatgccctgctctgctgcctcgtgggcaccctcacactg gccaccttcctgcgcgtcccctcctggcccaagacgctcctcctgctagtgctcaccatg ctgtctgtcctcatgctggggctcagcgggcccacaggagcagctggcggccgtgctgtc tccttgcccagctatgagcccatcttggccatcctgctcttctcctgcgcactgggcctg cactccaggcaggtggacctcaagctgcggctggactacctctgggccatgcaggcagaa gaggagcgtgatgacatggagaaggtcaaactggacaacaagaggatcctcttcaacctc ttaccagcccatgtggcccagcacttcctcatgtcaaatcccagaaacatggacctctat taccagtcatactcacaagtgggtgtcatgttcgcttccatccccaacttcaatgacttc tacattgagctggatggcaacaacatgggggtggagtgtctgcgcctcctgaacgagatt atcgccgactttgatgagctcatggagaaagacttttataaggacctagagaagataaag accatcgggagcacatacatggcggctgtggggctggcacccacggcgggggccaaggct gagaagtccatcacctcccaccttagtgtacttgcggactttgccatcgagatgtttgac gtactggatgaaatcaactatcagtcatacaatgactttgtcctccgtgtgggcattaat gtcggccccgtggtggctggggtgatcggagcccggaggcctcagtacgacatctggggc aacacggtcaacgtggccagccgcatggacagcaccggggtccagggcaagattcaggtg acagaggaagttcaccggctgctgaaagggtgcagctaccagttcatgtgcagaggaaaa gtcagtgtcaagggcaaaggtgaaatgctgacatacttcctagagggaaggattgatgga agtggctcccaaaccaggtctttaaacatggagcggaaaatgtgtccttacaggaaagcc ggcctccagaccagactggccaccagctgccccccggtgcccagtgtggctggcttctca gtccaagcggggctgggggctgtgcagagcacaggcctcccttcacagcccactctccag tacctcccctccagagcagctgtgaaggaggcttag

Loxodonta africana (African savanna elephant): 100673570 Help Entry 100673570         CDS       T04351                                  Gene name ADCY2 Definition (RefSeq) LOW QUALITY PROTEIN: adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04922   Glucagon signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100673570 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100673570 (ADCY2)    04371 Apelin signaling pathway     100673570 (ADCY2)    04020 Calcium signaling pathway     100673570 (ADCY2)    04072 Phospholipase D signaling pathway     100673570 (ADCY2)    04024 cAMP signaling pathway     100673570 (ADCY2)    04022 cGMP-PKG signaling pathway     100673570 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100673570 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     100673570 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100673570 (ADCY2)    04062 Chemokine signaling pathway     100673570 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     100673570 (ADCY2)    04922 Glucagon signaling pathway     100673570 (ADCY2)    04923 Regulation of lipolysis in adipocytes     100673570 (ADCY2)    04912 GnRH signaling pathway     100673570 (ADCY2)    04913 Ovarian steroidogenesis     100673570 (ADCY2)    04915 Estrogen signaling pathway     100673570 (ADCY2)    04914 Progesterone-mediated oocyte maturation     100673570 (ADCY2)    04921 Oxytocin signaling pathway     100673570 (ADCY2)    04926 Relaxin signaling pathway     100673570 (ADCY2)    04935 Growth hormone synthesis, secretion and action     100673570 (ADCY2)    04918 Thyroid hormone synthesis     100673570 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     100673570 (ADCY2)    04916 Melanogenesis     100673570 (ADCY2)    04925 Aldosterone synthesis and secretion     100673570 (ADCY2)    04927 Cortisol synthesis and secretion     100673570 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100673570 (ADCY2)    04270 Vascular smooth muscle contraction     100673570 (ADCY2)   09154 Digestive system    04970 Salivary secretion     100673570 (ADCY2)    04971 Gastric acid secretion     100673570 (ADCY2)    04972 Pancreatic secretion     100673570 (ADCY2)    04976 Bile secretion     100673570 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     100673570 (ADCY2)    04727 GABAergic synapse     100673570 (ADCY2)    04725 Cholinergic synapse     100673570 (ADCY2)    04723 Retrograde endocannabinoid signaling     100673570 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100673570 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     100673570 (ADCY2)    04213 Longevity regulating pathway - multiple species     100673570 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     100673570 (ADCY2)    04714 Thermogenesis     100673570 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100673570 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     100673570 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100673570 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100673570 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100673570 (ADCY2)    05163 Human cytomegalovirus infection     100673570 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100673570 (ADCY2) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100673570 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N HNOBA Motif Other DBs NCBI-GeneID:  100673570 NCBI-ProteinID:  XP_010586365 LinkDB All DBs Position Unknown AA seq 1089 aa AA seqDB search MWREAMRRRRYLRDGAEAAAGGGRPRSGDWLYESYYCMSQQHPLIVFLLLIVMGACLALL AVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGY LFMCFGGTVSPWDQVSFFLFIIFGGNTMLPFNMRDAIIASVLTSASXTIVLSVCLSATPG TREHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQER LLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRL ASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMG LDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP GRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHT LDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGRHNFQNRTLRT KSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLFFYNKILEKEYRATALPAFKY YVTCACLIFFCIFLVQILVLPKTTILGLSFGAAFLSLTFILFVCFAGQLLRCSKKASTLL RWLLKSSGIIANRPWPRVSLTVITTAIVLTMAVFNMFFLSNPEEAIPPTANTSNTSFPAS NDQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMTAALVGYNTILLHTHA HVLDGYSQVLFQRPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKKER EEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKEFYTE SDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQELAQE PERQYLHIGTMVEFAFALVAKLEAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWG NTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCSCRGIINVKGKGELKTYFVNTEMSR SLSQSNLAS NT seq 3270 nt NT seq  +upstreamnt  +downstreamnt atgtggcgggaggcgatgcggcggcgccgctacctgcgggacggcgccgaggcggcggcg ggcggcgggcggccgcgctccggggactggctctacgagtcctactactgcatgagccag cagcacccgctcatcgtcttcctgctgctcatcgtcatgggcgcctgcctggccctgctc gccgtcttcttcgcgctcgggctggaggtggaagaccatgtggcatttttaataacggtt cccacggccctggcaatcttcttcgcgatatttatccttgtctgcattgagtccgtgttt aagaagctgctccgtcttttctctttggtgatatggatatgtcttgttgccatgggatac ctgttcatgtgttttggaggcaccgtctctccttgggaccaggtgtccttcttcctcttc atcatttttggggggaacaccatgctgcccttcaacatgcgagatgccatcatcgccagc gtcctcacctccgcctcgnacaccatcgtgctcagcgtctgcctgtctgcgacgccgggg accagggagcacttggtctggcagatactggccaacgtgatcattttcatctgcgggaac ctggcgggcgcctaccacaagcatctcatggagctggctctgcagcagacctatcaggac acctgtaattgtatcaagtcccgcatcaagttggagtttgaaaaacgtcagcaggagcgt cttctcctctccttgctgccagctcatatagccatggaaatgaaagctgagatcatccag aggctacagggccccaaagcgggacagatggagaacaccaacaacttccacaacctgtac gtcaagaggcacaccaatgtcagcatcttgtacgctgacattgtcgggttcacgcggctg gcgagtgactgctccccaggagagcttgtccacatgctgaatgaactctttgggaagttt gatcagattgcaaaggagaacgaatgcatgagaataaagattctaggagactgctactac tgcgtgtctggcctccccatatcactccccaaccacgccaagaactgtgtgaaaatggga ttggacatgtgcgaagccatcaagaaagtgagggatgccaccggagtcgacatcaacatg cgtgtgggcgtgcactctgggaatgtgctctgtggcgtgatcgggctgcagaagtggcag tacgatgtgtggtcacatgacgtcacgctcgccaaccacatggaagccggaggggtcccc gggcgtgttcacatttcttcggtgaccttggagcacttgaatggagcttacaaggtggaa gagggagacggtgatatcagggacccgtatttaaaacagcacctggtgaaaacctacttt gtcatcaaccccaagggagaacgacggagcccccagcacctcttccggccccgccacacc ctggacggagccaagatgagggcatctgtgcgcatgacccggtacttggagtcctgggga gcagccaagcccttcgcacacctgcaccacagggacagcatgaccaccgagaacggcaag atcagcaccacggatgtaccaatgggccggcataattttcagaatcgcactttaagaacc aagtcacaaaagaaaagatttgaagaagaattgaatgaaaggatgatccaagccattgac ggaatcaatgctcagaagcagtggctcaaatccgaagacatccagagaatctcgctattt ttctacaataaaatactggaaaaagaataccgagcaacggccctgccagcattcaagtac tacgtgacctgcgcctgcctcatcttcttctgcatcttcctcgtgcagatcctcgtgtta cccaaaaccaccatcctgggactttcctttggagctgcatttctctcactcaccttcatc ctgttcgtctgcttcgctgggcagcttctgcggtgcagtaagaaggcatccaccttgctc aggtggctcctgaagtcgtcgggcatcatcgccaaccggccctggccgcgggtctccctc actgtcatcaccacagccatcgtcctgaccatggccgtgttcaacatgtttttcctgagc aatccagaagaagctatccctccaactgccaatacatcgaacacaagttttcctgcctca aacgatcaggtggctattcttcgtgcgcaaaatttgtttttcctcccgtactttatatac agctgcatcctgggactgatctcctgctcggtgttcctgcgggtgaactatgagctgaag atgctaatcatgacggccgccttggtgggctacaacaccatcctgctccacactcatgcc cacgtgctggacggctacagccaggtcttattccagagaccaggcatttggaaagactta aagaccatgggctccgtgtctctctttatattcttcatcacactgcttgtcctgggtcgg cagaatgaatattactgtaggttagatttcctgtggaagaacaagttcaaaaaagagcgg gaggagatcgagaccatggagaacctgaaccgcgtgctgctggagaatgtgcttcccgcc cacgtggctgagcacttcctggcacggagcctgaagaacgaggacctgtaccaccaatcc tatgattgtgtctgcgtcatgtttgcctccatcccagatttcaaagaattttacaccgaa tcagatgtgaacaaggagggcttggagtgccttcggctcctgaacgagatcattgctgat tttgatgatctgttgtccaagccgaaattcagtggagtagaaaagatcaagaccatcggc agcacatacatggcggcgacgggtctgagcgcggtgcccagccaggagcttgcccaggag ccagagaggcagtacctgcacattggcaccatggtggaatttgccttcgcgctggtggcg aagttggaggccatcaacaagcactccttcaacgacttcaagctgcgagtgggtattaac cacgggcctgtaatcgctggtgtaattggcgctcagaaaccacagtatgacatttggggc aacaccgtcaatgtggccagtcggatggacagcacgggcgtcctggataaaatacaggtg actgaggaaacaagccttgtcctccagaccctcgggtacacctgctcctgtcgagggata atcaacgtgaaaggcaaaggggagctgaagacgtactttgtgaacacggagatgtcccgg tctctctcccagagcaacctggcgtcctga

Loxodonta africana (African savanna elephant): 100674724 Help Entry 100674724         CDS       T04351                                  Gene name ADCY3 Definition (RefSeq) adenylate cyclase type 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04740   Olfactory transduction lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04962   Vasopressin-regulated water reabsorption lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100674724 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100674724 (ADCY3)    04371 Apelin signaling pathway     100674724 (ADCY3)    04020 Calcium signaling pathway     100674724 (ADCY3)    04072 Phospholipase D signaling pathway     100674724 (ADCY3)    04024 cAMP signaling pathway     100674724 (ADCY3)    04022 cGMP-PKG signaling pathway     100674724 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100674724 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     100674724 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100674724 (ADCY3)    04062 Chemokine signaling pathway     100674724 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     100674724 (ADCY3)    04923 Regulation of lipolysis in adipocytes     100674724 (ADCY3)    04912 GnRH signaling pathway     100674724 (ADCY3)    04913 Ovarian steroidogenesis     100674724 (ADCY3)    04915 Estrogen signaling pathway     100674724 (ADCY3)    04914 Progesterone-mediated oocyte maturation     100674724 (ADCY3)    04921 Oxytocin signaling pathway     100674724 (ADCY3)    04926 Relaxin signaling pathway     100674724 (ADCY3)    04935 Growth hormone synthesis, secretion and action     100674724 (ADCY3)    04918 Thyroid hormone synthesis     100674724 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     100674724 (ADCY3)    04916 Melanogenesis     100674724 (ADCY3)    04925 Aldosterone synthesis and secretion     100674724 (ADCY3)    04927 Cortisol synthesis and secretion     100674724 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100674724 (ADCY3)    04270 Vascular smooth muscle contraction     100674724 (ADCY3)   09154 Digestive system    04970 Salivary secretion     100674724 (ADCY3)    04971 Gastric acid secretion     100674724 (ADCY3)    04972 Pancreatic secretion     100674724 (ADCY3)    04976 Bile secretion     100674724 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     100674724 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     100674724 (ADCY3)    04727 GABAergic synapse     100674724 (ADCY3)    04725 Cholinergic synapse     100674724 (ADCY3)    04723 Retrograde endocannabinoid signaling     100674724 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     100674724 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     100674724 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     100674724 (ADCY3)    04213 Longevity regulating pathway - multiple species     100674724 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     100674724 (ADCY3)    04714 Thermogenesis     100674724 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100674724 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     100674724 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100674724 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100674724 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100674724 (ADCY3)    05163 Human cytomegalovirus infection     100674724 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100674724 (ADCY3) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100674724 (ADCY3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA NCE101 Motif Other DBs NCBI-GeneID:  100674724 NCBI-ProteinID:  XP_003411966 LinkDB All DBs Position Unknown AA seq 1142 aa AA seqDB search MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRAVGRTHEISVRSSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSKDMLAPLIVAGIGLVLDII LFVLCKKGVLPDRVTRKVVPYLLWLLITAQIFSYLGLNFAQAHTASDTVGWQAFFIFSFF ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDQLKGIQLLREILANVFLYLCAIIVG IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMESGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPPFSKPSSPALIETKEPDGITTG SISEEAEEHDAQADNPSFPNPRRRLHLQDLADRVVDASEDEHELNQLLNEALLERESAQV VKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPGLMTNYV TFVVGEVLLLVLTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVV DMLSCLQYYTGPSNRTTGMEEQDGCVANPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLL VTGAVAVINLYAWCPIFDEYDHRRFREHEVPITLEKMQVSSAPGLNGTDRLPLMPSKYSM TVMMFVMLLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVANMLPEHVAR HFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSL LDNPKFRIITKIKTIGSTYMAASGVTPDVNTNGFTGSNKEEKSEKERWQHLADLADFALA MKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGN IQVVEETQAILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKPAAFPNGSSVTLPHQVVD NS NT seq 3429 nt NT seq  +upstreamnt  +downstreamnt atgcctcggaatcagggcttctctgatcccgagtactcagctgagtactcggctgaatac tccgtcagcctgccctctgaccctgatcgagcggtgggccggacccatgaaatctccgtc cggagctcggggtcttgcctctgcctgcctcgcttcatgcggctgaccttcgtgcctgag tccttggagaacctctaccagacgtacttcaaaaggcagcgccatgagaccctgctggtg ctggtggttttcgcagccctcttcgactgctacgtggtggtcatgtgcgccgtggtcttc tccaaagacatgctggcgcccctcatcgtggccgggattggactggtgttggacatcatc cttttcgtgctctgcaaaaagggggtgctccctgaccgggtcacccgcaaagtggtgccc tacctgctgtggctgctgataacagcccagatcttctcctacctgggcctgaactttgcc caggcccacacagccagcgacacggtgggttggcaggccttcttcatcttctccttcttc atcacgctgcccctcagtctcagccccatcgtgatcatctcagttgtctcctgcgttgta cacacgcttgtcttgggggtcaccgtggcccagcagcagcaggaccagctaaaggggatc cagttgctgagggagatcctggccaacgtcttcctctacctgtgtgccatcatcgtgggc atcatgtcttactacatggcagaccgcaagcaccgcaaggccttcctggaggctcgccag tcgctggaagtgaagatgaacctggaagagcagagccagcagcaggagaaccttatgctt tccatcctgcccaagcacgtggctgacgagatgttgaaggacatgaagaaagatgagagc cagaaggaccagcagcagttcaacaccatgtacatgtaccgtcacgagaacgtcagcatc ctctttgctgatatcgtgggcttcacccagctgtcctctgcctgcagtgcgcaggagcta gtgaagcttctcaacgagctctttgcccgctttgacaagctggcagcgaaataccaccag ctgcggattaagatcctgggtgactgttactactgcatctgtggcctgcctgactaccgg gaggaccacgctgtctgctccatcctcatggggctggccatggtggaggccatctcgtat gtgcgggagaagacaaagactggggtggacatgcgtgtgggggtgcacacgggcaccgtg ttgggtggcgtcctgggccagaagcgctggcagtatgatgtgtggtccaccgacgtcacc gtggccaacaagatggagtcaggcggcatcccagggcgcgtgcatatctcccagagcacc atggactgcctgaaaggagagtttgacgtggagccaggcgatggaggcagccgctgcgat tacctggaggagaagggcatcgaaacctacctcatcattgcatccaagccagaggtgaag aaaacagccacccaaaatggcctcaacggctcggccctgccaaatggagcaccacctttc tcaaagcccagctctcctgccctcatcgagaccaaggagcctgatgggatcaccaccgga tctatatcggaggaggctgaggagcatgatgcccaggcagacaacccctcattccccaac ccccgtcggaggctgcaccttcaggacctggctgatcgcgtggtggacgcctctgaggac gaacatgagcttaaccagctgctcaacgaggccctgctggagcgagagtctgcacaggta gtaaagaagagaaacaccttcctcctgtccatgcggtttatggacccggaaatggaaacc cgctactcggtggagaaggaaaagcagagtggggccgccttcagctgctcctgcgttgtc ctactctgtacagcgctggtcgagatactcatcgaccccgggctaatgacaaactacgtg acctttgtggttggggaggttctgctcctggtcttgacaatctgctcgctggctgccatc tttccccgggcctttcctaagaagctcgtggctttctcaacatggatcgaccggacccgc tgggccaggaacacctgggccatgttagccatcttcattctggttatggcaaacgttgtg gacatgcttagctgtctccagtactacacggggcccagcaacaggactacagggatggag gagcaggacggctgcgtggcgaaccccaagtactacaactatgttgctgtgctgtccctc atcgccaccatcatgctggtgcaggtcagccacatggtgaagctcacactcatgctgctc gtcacaggcgcggtggccgtcatcaacctctatgcctggtgccccatctttgatgaatac gaccacagacgttttcgggagcatgaggttcccatcaccttagagaagatgcaggtatct tctgcccctgggctcaatgggaccgacaggctgcccctgatgccttccaagtactcaatg acagtgatgatgttcgtcatgctgctgagcttttactacttctcccgccacgtggaaaaa ctggcacggaccctgttcttgtggaagattgaggtccatgaccagaaggaacgtgtttat gagatgcgacgctggaatgaggccttggtcgccaacatgttgcctgagcacgtggcccgc catttcctgggttccaagaagagagatgaggagctgtacagccagtcttacgatgagatt ggagtcatgtttgcttccttgcccaactttgctgacttctacacagaggagagcatcaat aacggtggcattgagtgtctacgctttctcaatgaaatcatctcagatttcgactctctc ctggacaatcccaaatttcggatcattaccaagatcaaaaccattggcagtacctatatg gcagcttcaggagtcaccccagatgtcaacaccaacggttttactggctccaacaaggag gaaaagtcggagaaggagcgctggcagcacctggctgatctggctgactttgcactggcc atgaaggacacgcttacaaacatcaacaaccagtccttcaacaacttcatgctgcgcata ggcatgaacaaaggaggggtactggctggcgtcattggagcccggaagccacactacgac atctggggcaatacagtcaatgtagccagcaggatggagtccacgggggtcatgggcaac atccaggtagtagaagaaacacaagccattctccgagagtacggtttccgcttcgtgagg cgaggtcctatctttgtgaaggggaagggggagctgctgacctttttcctgaaggggcgc gataagccagctgccttcccgaatggctcctctgtcacactgccccaccaggtggtagac aactcctga

Loxodonta africana (African savanna elephant): 100675525 Help Entry 100675525         CDS       T04351                                  Gene name ADCY4 Definition (RefSeq) adenylate cyclase type 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism lav  Loxodonta africana (African savanna elephant) Pathway lav00230   Purine metabolism lav01100   Metabolic pathways lav01522   Endocrine resistance lav04015   Rap1 signaling pathway lav04020   Calcium signaling pathway lav04022   cGMP-PKG signaling pathway lav04024   cAMP signaling pathway lav04062   Chemokine signaling pathway lav04072   Phospholipase D signaling pathway lav04114   Oocyte meiosis lav04211   Longevity regulating pathway lav04213   Longevity regulating pathway - multiple species lav04261   Adrenergic signaling in cardiomyocytes lav04270   Vascular smooth muscle contraction lav04371   Apelin signaling pathway lav04540   Gap junction lav04611   Platelet activation lav04713   Circadian entrainment lav04714   Thermogenesis lav04723   Retrograde endocannabinoid signaling lav04724   Glutamatergic synapse lav04725   Cholinergic synapse lav04727   GABAergic synapse lav04742   Taste transduction lav04750   Inflammatory mediator regulation of TRP channels lav04911   Insulin secretion lav04912   GnRH signaling pathway lav04913   Ovarian steroidogenesis lav04914   Progesterone-mediated oocyte maturation lav04915   Estrogen signaling pathway lav04916   Melanogenesis lav04918   Thyroid hormone synthesis lav04921   Oxytocin signaling pathway lav04923   Regulation of lipolysis in adipocytes lav04925   Aldosterone synthesis and secretion lav04926   Relaxin signaling pathway lav04927   Cortisol synthesis and secretion lav04928   Parathyroid hormone synthesis, secretion and action lav04934   Cushing syndrome lav04935   Growth hormone synthesis, secretion and action lav04970   Salivary secretion lav04971   Gastric acid secretion lav04972   Pancreatic secretion lav04976   Bile secretion lav05032   Morphine addiction lav05163   Human cytomegalovirus infection lav05166   Human T-cell leukemia virus 1 infection lav05200   Pathways in cancer lav05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:lav00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100675525 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100675525 (ADCY4)    04371 Apelin signaling pathway     100675525 (ADCY4)    04020 Calcium signaling pathway     100675525 (ADCY4)    04072 Phospholipase D signaling pathway     100675525 (ADCY4)    04024 cAMP signaling pathway     100675525 (ADCY4)    04022 cGMP-PKG signaling pathway     100675525 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100675525 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     100675525 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100675525 (ADCY4)    04062 Chemokine signaling pathway     100675525 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     100675525 (ADCY4)    04923 Regulation of lipolysis in adipocytes     100675525 (ADCY4)    04912 GnRH signaling pathway     100675525 (ADCY4)    04913 Ovarian steroidogenesis     100675525 (ADCY4)    04915 Estrogen signaling pathway     100675525 (ADCY4)    04914 Progesterone-mediated oocyte maturation     100675525 (ADCY4)    04921 Oxytocin signaling pathway     100675525 (ADCY4)    04926 Relaxin signaling pathway     100675525 (ADCY4)    04935 Growth hormone synthesis, secretion and action     100675525 (ADCY4)    04918 Thyroid hormone synthesis     100675525 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     100675525 (ADCY4)    04916 Melanogenesis     100675525 (ADCY4)    04925 Aldosterone synthesis and secretion     100675525 (ADCY4)    04927 Cortisol synthesis and secretion     100675525 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100675525 (ADCY4)    04270 Vascular smooth muscle contraction     100675525 (ADCY4)   09154 Digestive system    04970 Salivary secretion     100675525 (ADCY4)    04971 Gastric acid secretion     100675525 (ADCY4)    04972 Pancreatic secretion     100675525 (ADCY4)    04976 Bile secretion     100675525 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     100675525 (ADCY4)    04727 GABAergic synapse     100675525 (ADCY4)    04725 Cholinergic synapse     100675525 (ADCY4)    04723 Retrograde endocannabinoid signaling     100675525 (ADCY4)   09157 Sensory system    04742 Taste transduction     100675525 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     100675525 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     100675525 (ADCY4)    04213 Longevity regulating pathway - multiple species     100675525 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     100675525 (ADCY4)    04714 Thermogenesis     100675525 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100675525 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     100675525 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100675525 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100675525 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100675525 (ADCY4)    05163 Human cytomegalovirus infection     100675525 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100675525 (ADCY4) Enzymes [BR:lav01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100675525 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N CD52 Motif Other DBs NCBI-GeneID:  100675525 NCBI-ProteinID:  XP_010598850 LinkDB All DBs Position Unknown AA seq 1075 aa AA seqDB search MAGLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALVALFAVSWASGRELASDPG FLTTVVCALGGFSLLLGLASCEQRLQRWTRPLSGLVWAALLALGHGFLFTGGVVSAWDQV SFFLFVIFTVYAMLPLGMRDAAAAGLVSSLSHLLALGLYLGPQPDSRPALLPQLVANAVL FLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEDEKGTAGGLLSSLEGPKMRPSLLMTRY LESWGAAKPFAHLSHIDSPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKF FQVIEQLNSQKQWKQSKDFNPLTLYFRKKEMEKEYRLSALPAFKYYAACTFLVFLSNFII QMLVTNRPPALAITYSITFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGLVATRPG LRVALGTATLKPLSPYLLLQFLLPASSNCPFRAANVSAMAFNLSWELPGSLPLISVPYSM HCCVLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSDCLIARLYMGSLDSRP GVLKEPKLMGVISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLL ENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLL NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEF AVALGCKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGV LGKIQVTEETARALQSLGYTCYRRGIIKVKGKGQLCTYFLNTDLTRAGPPSATLG NT seq 3228 nt NT seq  +upstreamnt  +downstreamnt atggccggcctcttcagtcctcggccgccccccagcgaagacctcttctacgagacctac tacagcctaagccagcagtacccgctgctgctactgctgctggtaatcgtgctctgcgcg ctggtggcgctgttcgccgtctcctgggccagcggcagggagctggcctctgacccgggc ttcctgaccaccgtggtgtgcgcactgggcggcttctcgctgctgctggggctggcttcc tgcgagcagcgactgcagcgctggacgcgtcccctgtctggcctggtgtgggccgcgctg cttgcgctaggccacggcttcctattcaccgggggcgtggtcagtgcttgggaccaggtg tccttctttctcttcgttatcttcacggtgtacgccatgttgcccctgggtatgcgggac gccgccgccgcgggcctcgtctcctcactctctcacctgcttgcccttggactgtacctt gggccccagccagactcacggccagcgctgctgccccagctagtggcaaatgcggtgctg ttcctgtgcgggaacgtggctggagcgtaccacaaggcgctgatggagcgcgcgctgcgt gccacgttccgggaggcgctcagctccctacactcacgccggcggctggacaccgagaag aagcaccaggaacaccttctcttgtccatccttcctgcctacctggcccgagagatgaag gcagagatcatggcccggctgcaggctggacaggggtcacggcctgagagcaccaacaat ttccacagcctctatgtcaagaggcaccagggagtcagcgtgctgtatgcggacatagtg ggcttcacacgactagccagcgagtgctcccccaaggagctggtgctcatgctcaatgaa ctctttggcaagttcgaccagattgccaaggagcatgagtgcatgcggatcaagattctg ggagactgttactactgtgtctctgggttgcccctctccttgccagaccatgccatcaac tgtgtgcgcatggggctggacatgtgccgggccatcaggaaacttcgggcagccaccggc gtggacatcaacatgcgtgtgggcgtgcactcgggcagtgtgctctgtggagtcattggc ttgcagaaatggcaatatgatgtctggtcccatgatgtcaccctggccaaccacatggag gcaggcggtgtgccaggacgagtgcacatcacaggggccaccctggccctgctggcaggg gcttatgctgtggaggatgcagccatggaacaccgggacccataccttcgggagctaggg gagcctacctacctggtcatcgatccccgggctgaggaggatgagaagggcactgcagga gggttgttgtcctctctggagggccccaagatgcgtccatcactgctgatgacccgctat ctggagtcctggggtgcagccaagccttttgctcacctgagccacatagacagccctgta tccacctccacccctctcccggagaaggccctagcttccttcagcccccagtggagcctg gaccggagccgtaccccccggggactagatgatgaactagacactggggatgccaagttc ttccaggtcatcgagcagctcaactctcagaaacagtggaaacaatcgaaggatttcaac ccactgacactgtacttcagaaagaaggagatggagaaggagtaccggctctctgcactc cccgccttcaaatactatgcagcctgcaccttcctggtttttctctccaatttcatcatc cagatgctggtgacaaacaggcctccagctctggccatcacctatagcatcaccttcctc ctcttcctcctcctcctctttgtctgcttctcagagcacctgacgaggtgtgtcctgaaa ggccccaagatgctgcactggctgcctgcactgtctggcctggtggccacgcggcccggc ttgcgagtcgccctgggcacggccacccttaagcccttatctccttatctcctactgcag ttcctcttaccagcatcatccaactgccctttccgggctgccaatgtgtccgccatggct ttcaacctctcctgggagcttcctgggtccttgcctctcatcagtgtcccgtactccatg cactgctgtgttctgggtttcctctcctgctcccttttcctacacatgagcttcgaattg aagctgctgctgctcctgctgtggctggcagcctcctgctccctcttcctgcactcccat gcctggctgtctgactgcctcatcgcccgcctctatatgggttccttggactccaggcca ggggtgctgaaggagcccaaactgatgggagtcatctctttcttcatctttttcttcacc ctcctcgtcctggctcggcagaatgagtattactgccgcctggacttcctgtggaagaag aagctgaggcaggagagagaagagacagagacaatggagaaccttactcggctgctcttg gagaatgtgctccctgcacacgtggccccccagttcattggccaaaaccggcgcaatgag gacctctaccaccagtcctatgagtgtgtttgtgtcctcttcgcctcagtcccggacttc aaggagttttactctgaatccaacatcaaccacgaggggctggagtgtctgcgactgctc aacgagataattgctgattttgatgagctgctctccaagcccaagttcagtggggtagag aaaatcaaaaccatcggcagcacctacatggcagccacaggtttaaatgccacctctgga caggatgcacagcaggatgctgaacgaagttgcagccaccttggcaccatggtggaattt gcagtggctctggggtgtaaactggatgtcatcaacaagcactcattcaacaacttccgc ctgcgtgtggggttgaaccatggaccagtagtggctggtgtgattggagcccaaaagcca caatatgacatctggggcaacacagtgaatgtggccagccgcatggagagtacaggggtc ctgggcaagatccaagtgactgaggagacagcccgggccctgcaatccctgggctatacc tgctacaggcggggcatcatcaaagtcaaaggcaaagggcagctttgcacatactttctg aacacagacttaacacgcgctggacccccctcagccaccctaggctaa

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