KEGG   Loxodonta africana (African savanna elephant): 100655176
Entry
100655176         CDS       T04351                                 

Gene name
CACNA1A
Definition
(RefSeq) LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A
  KO
K04344  voltage-dependent calcium channel P/Q type alpha-1A
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav04010  MAPK signaling pathway
lav04020  Calcium signaling pathway
lav04721  Synaptic vesicle cycle
lav04723  Retrograde endocannabinoid signaling
lav04724  Glutamatergic synapse
lav04725  Cholinergic synapse
lav04726  Serotonergic synapse
lav04727  GABAergic synapse
lav04728  Dopaminergic synapse
lav04730  Long-term depression
lav04742  Taste transduction
lav04930  Type II diabetes mellitus
lav05017  Spinocerebellar ataxia
lav05032  Morphine addiction
lav05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100655176 (CACNA1A)
   04020 Calcium signaling pathway
    100655176 (CACNA1A)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    100655176 (CACNA1A)
   04727 GABAergic synapse
    100655176 (CACNA1A)
   04725 Cholinergic synapse
    100655176 (CACNA1A)
   04728 Dopaminergic synapse
    100655176 (CACNA1A)
   04726 Serotonergic synapse
    100655176 (CACNA1A)
   04730 Long-term depression
    100655176 (CACNA1A)
   04723 Retrograde endocannabinoid signaling
    100655176 (CACNA1A)
   04721 Synaptic vesicle cycle
    100655176 (CACNA1A)
  09157 Sensory system
   04742 Taste transduction
    100655176 (CACNA1A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    100655176 (CACNA1A)
  09165 Substance dependence
   05032 Morphine addiction
    100655176 (CACNA1A)
   05033 Nicotine addiction
    100655176 (CACNA1A)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100655176 (CACNA1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:lav04040]
    100655176 (CACNA1A)
Ion channels [BR:lav04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   100655176 (CACNA1A)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 100655176
NCBI-ProteinID: XP_023408094
LinkDB
Position
Unknown
AA seq 2165 aa
MEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAF
LKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRATIKKSKTDLLNP
EEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSL
VALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDC
GVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIIS
LLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYD
GIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQ
KLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKTTKSVWEQRTSEMRKQNLLASREALYN
ELDPDERWKASYARHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAE
DFLRKQARYHDRTRDPSAQXGLDARRPWAGSQETELGREGPYGRESDHHTREGLEQPGFW
EGEAERGQGCGPPTGRHPSPAGAQQRRAAAAPPRTGADGGVPAGHRPHRRPGXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXARAMRERERTAWPRTYDTEARRDDKERRHRRRKE
NQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESVNPHDSLGHSGLP
QSPAKMGNSTDPEPVPPPPTMATNPQNAASRRMPNNPGNPSNPGPPKTPENSLIVTNPSS
TQTNSAKTARKPDHTAVDIPPACPAPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDPGE
DGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFDMCILMVIAMSSIALAAEDPVQPNAP
RNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTG
NSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFA
VVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLT
LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIII
TFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTI
MAMIALNTIVLMMKFYGASLAYENALRVFNIVFTSLFSLECVLKVLAFGILNYFRDAWNI
FDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKAL
PYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRS
ATGEAWHNIMLSCLSGKPCDKNSGILTPDCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMD
NFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYPDMYQMLRHMSPPLGLGKKCPAR
VAYQRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWP
NLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRME
PPSPTQEGGPGQNALPSTQLDPGGGLMAHEGGIKESPSWVTQRAQEMFQKTGTWSPERGP
PTDMPNSQPNSQSVRCERWAGDGYSDSEHYXPMEGQARAASMPPYMLSPQTISDTSPMKR
SASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRGHRASERSLGRYTDVDTGLGTDLSM
TTQSGDLPSKDRDQERGRPKDRKHRQHHHHHHHHPPPPDKERYSQERPDHSRARARDQRW
SRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRK
AGALGPPQQQQQVARPGRAATSGPRRYPGPAAEPLAGEWPPTGGRGSSRSPGMERRALGP
ARSESPRSCRHTRWPAPRPHTSEGPPGPRHHGYYHDYDEADGLGGRREEGGAYDTPPPAR
HTSSGAGRSPRTPRAAGPDCASPSRHGRRLPNGYYPAQGLPRPRXPGSRKGLHEPYSETD
EDDWC
NT seq 6498 nt   +upstreamnt  +downstreamnt
atggaagggtggactgatctcctgtacaatagcaacgatgcctcagggaacacttggaac
tggttgtacttcatccctctcatcatcattggctccttttttatgctgaacctcgtgctg
ggtgtgctgtcaggggagtttgccaaagaaagggagcgggtggagaaccggcgggctttt
ctgaagctgaggcggcagcagcagattgaaagagagctcaatgggtacatggagtggatc
tcgaaagcagaagaggtgatcctcgccgaggacgaaaccgacggagagcagaggcatccc
tttgatggagctctgcggagagccaccataaagaaaagcaagacagacctgctcaaccct
gaagaggctgaagatcagctggccgatatcgcctctgtggggtctcctttcgctcgagcc
agcattaaaagtgccaagctggagaactcgactttttttcacaaaaaggagaggaggatg
cgtttctacatccgccgcatggtcaaaactcaggccttctactggactgtgctcagtctg
gtagccctcaacacgctgtgtgttgctatcgttcactacaaccagcccgagtggctctcc
gacttcctctactatgcagaattcattttcttaggactctttatgtccgaaatgtttata
aaaatgtatgggctcgggacgcggccttacttccactcttccttcaactgctttgactgt
ggggttatcatcgggagcatcttcgaggtcatctgggccgtcataaaacctggcacatcc
tttggaatcagcgtgttacgagctctcaggttattgcgtattttcaaagtcacaaagtac
tgggcgtctctcaggaacctggtcgtctctcttctcaactccatgaaatccatcatcagc
ctgttgttcctccttttcctctttattgtagtcttcgcccttttgggaatgcagctcttt
ggcggccagtttaattttgatgaaggaacgcctcctaccaactttgacacttttccagca
gcaataatgacggtgtttcagatcctgacaggcgaggactggaacgaggttatgtatgac
ggcatcaagtcccaggggggcgtgcagggcggcatggtgttttccatctacttcatcgtg
ctgacgctcttcgggaactacaccctcctgaatgtgttcttggccatcgccgtggacaac
ctggccaacgcccaggagctcaccaaggatgaacaagaagaagaagaggcagccaaccaa
aaacttgccctacagaaagccaaggaggtggcagaagtgagtcctctgtccgcagccaac
atgtccatagctgtgaaagaacaacagaagaatcagaagacgaccaagtccgtgtgggaa
cagcggaccagcgagatgcggaagcagaacctgctggccagccgggaggccctgtacaac
gagctggatcccgatgagcgctggaaggcctcctacgcccggcacttgcggcctgacatg
aagacgcacttggaccggccgctggtagttgacccccaggagaaccgcaacaacaacacc
aacaagagccgggcagccgagcccacggtggaccagcgcctcggccagcagcgtgccgag
gacttcctcaggaaacaggcccgctaccacgaccggacccgggaccccagcgcccagngg
ggcctggacgcccggaggccctgggctggcagccaggagaccgagctgggccgggagggt
ccttatggccgcgagtcggaccaccacacccgggagggcctagagcagccggggttctgg
gagggcgaggctgagcggggccaaggctgcggaccccccaccgggaggcacccctcaccg
gcaggggcccagcagagaagagccgcagcagctccgccccgcacaggggctgacggggga
gtccccgcaggccaccggccccaccggaggccaggggannnnnnnnnnnnnnnnnnnnnn
nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn
nnnnnnnnnnnnnnnnnngcgagggccatgcgagagcgagagcgcacggcatggcctcgc
acatatgacacagaagcccggagggatgacaaggagcggcggcatcggcggaggaaagag
aaccagggctccggggtccctgtgtcgggccccaacctgtcgaccacccggccgatccag
caagacctgggccgccaagacccgccgctggctgaggacattgacaacatgaagaacaac
aagctggccaccgcagagtccgtcaatccccatgacagccttggccactccggcctgccc
cagagtccagccaagatgggtaacagcaccgaccctgagcccgtgccacccccgcccacc
atggccaccaacccccagaacgccgccagccgccggatgcccaacaacccggggaacccg
tccaaccccggcccccccaagacccccgagaacagccttatcgtcaccaaccccagcagc
acccagaccaactcagctaagactgccagaaagcccgaccacaccgcggtggacatcccc
cctgcctgcccggcccccctcaaccacactgttgtccaagtgaacaaaaacgccaaccca
gacccactgccaaaaaaggaggaagagaagaaggaggaggaggaagacgaccccggggaa
gatggccctaagcccatgcccccctacagctccatgtttatcctgtccacgaccaacccc
cttcgccgcctgtgccattacatcctaaatctgcgctacttcgatatgtgcatccttatg
gtcatcgccatgagcagcatcgccctggccgccgaggaccccgtgcagcccaacgcgcca
cggaacaatgtgctgcggtattttgactacgtttttacaggcgtctttacgtttgagatg
gtgatcaagatgatcgacctggggctcgtcctgcaccagggcgcctacttccgcgacctg
tggaacattctcgacttcattgtggtcagtggggccctggtggcctttgccttcactggc
aacagcaaaggaaaggacatcaacacgattaaatccctccgagtcctccgggtgctacga
cctcttaaaaccatcaagcggttgccaaagctcaaggccgtgtttgactgtgtggtgaac
tccctgaagaatgtcttcaacatcctcatcgtctacatgcttttcatgttcatcttcgcc
gtggtggccgtgcagctcttcaaggggaagttcttccactgcacggatgaatccaaggag
ttcgagaaagactgccgcggcaagtatctcctctatgagaagaacgaggtgaaagcccgg
gaccgagagtggaagaagtatgagttccattacgacaacgtgctgtgggctctgctgacc
ctcttcaccgtgtccacaggggaaggctggccacaggtcctcaagcactcggtggatgcc
accttcgagaaccagggccccagccccgggtaccgcatggagatgtccatcttctatgtc
gtctactttgtggtgttccccttcttctttgtcaacattttcgtggccttgatcatcatc
accttccaggagcagggggacaagatgatggaggaatacagcctggagaaaaatgagagg
gcctgcatcgactttgccatcagcgccaagccgctgacgcgccacatgcctcagaacaag
cagagtttccagtaccgcatgtggcagttcgtggtgtccccacccttcgagtacaccatc
atggccatgatcgccctcaacactatcgtgctcatgatgaagttctacggggcctcgctt
gcttatgaaaacgctctaagagtgttcaacatcgtcttcacctccctcttctctctggaa
tgtgtgctgaaagtcttggcttttgggattctgaattatttccgcgatgcctggaacatc
ttcgactttgtgactgttctgggcagcatcaccgacatcctcgtgactgagtttgggaat
aacttcatcaatctgagcttcctccgcctcttccgagctgcccggctcatcaaactcctt
cgtcagggttacaccatccgcattcttctctggacctttgtgcagtccttcaaggccctg
ccgtatgtctgtctgttgattgccatgcttttcttcatctacgccatcatcggaatgcag
gtgtttggcaacattggcattgacgtggaggacgaggacagtgatgaagatgagttccaa
atcactgagcataataacttccggaccttcttccaggccctcatgcttctcttccggagc
gccaccggggaggcttggcacaacatcatgctgtcctgccttagcgggaagccatgtgat
aaaaactctggcatcctgactcccgactgtggcaacgaattcgcgtatttttacttcgtt
tccttcatcttcctctgctcgtttctgatgctgaacctctttgtcgccgtcatcatggac
aacttcgagtacctcacccgcgactcctccatcctgggccctcaccacctggatgagtac
gtgcgtgtctgggctgagtacgaccccgcagcttggggccgcatgccctacccggacatg
tatcagatgctgagacacatgtctccgcccctgggtctggggaagaagtgtccggccaga
gtggcctaccagaggcttctgcggatggacctgccggtcgctgatgacaacaccgtccac
ttcaattccaccctcatggcactgatccgaacggccctagacatcaagattgccaagggt
ggagctgacaagcagcagatggatgctgagctacggaaggagatgatggccatttggccc
aacctgtcccagaagacactggacctgctggtcacacctcataagtccacggacctgacg
gtggggaagatctacgccgccatgatgatcatggagtactaccggcaaagcaaggccaag
aagctacaggccatgcgcgaggagcagaaccggacacccctcatgttccagcgcatggag
cccccatctccgacgcaggagggtgggcctggccagaatgccctcccctccactcagctg
gacccaggaggaggcctgatggcccatgaaggtggcatcaaggagagcccatcctgggtg
acccagcgggcccaggagatgttccagaagacgggcacatggagcccggagcgggggcca
cccaccgacatgcccaacagccagcccaactctcagtctgtgagatgcgagagatgggca
ggagatggctactccgacagtgagcactacnctcccatggaaggccaggcccgggccgcc
tccatgcccccctatatgctgtccccccagaccatctcagacaccagccccatgaagcgc
tcggcctcagtgctgggccctaaggcccggcgcctggacgattactccctggaacgggtg
ccaccagaggagaaccagcggcaccaccagcggcgccgagaccggggccaccgtgcctcc
gagcgctccctgggccgctacaccgacgtggacacaggcttgggcacagacctgagcatg
accactcagtccggggaccttccatcgaaggatcgagaccaggagcggggccggcccaag
gacaggaagcaccgccagcaccaccaccaccaccaccaccatcccccgccccctgacaag
gagcgctacagccaggagcggcccgaccacagccgggccagggccagggaccagcgctgg
tcccgctcccccagcgagggccgagagcacatggcacaccggcagggcagtagttccgta
agtggaagcccagccccctcaacatctggtaccagcactccgcggcggggacgccgccag
cttccccagaccccctccaccccccggccacacgtgtcctattcccccgtgatccgtaag
gccggcgccttggggcccccacagcaacagcagcaggtggcgcggccaggccgtgcggcc
acgagcggcccacggaggtacccgggccccgcggccgagcctctggccggggagtggccg
cccacggggggccgcggcagcagccgctcgccagggatggagcggcgggccctgggcccg
gcccggagcgagtccccgaggtcctgtcgccacacccggtggccggcaccccgcccgcac
acgtccgaggggcctccagggccccggcaccacggctactaccacgactacgacgaggcc
gacggcctgggcggcaggcgtgaggagggcggggcctacgacacaccaccccccgcgcga
cacacgtcctcgggcgcggggcgctcgcccaggactccccgggccgcgggcccggactgc
gcctcgccttcccggcacggccggcggctccccaacggctattacccggcccaaggactg
cccaggccccgcnggccgggctcccggaaaggcttgcacgaaccctacagcgagaccgac
gaggacgactggtgctaa

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