KEGG T04351: 100655429

KEGG Orthology (KO) [BR:lav00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    100655429 (CDK6)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100655429 (CDK6)
   04115 p53 signaling pathway
    100655429 (CDK6)
   04218 Cellular senescence
    100655429 (CDK6)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100655429 (CDK6)
   05206 MicroRNAs in cancer
    100655429 (CDK6)
   05203 Viral carcinogenesis
    100655429 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100655429 (CDK6)
   05225 Hepatocellular carcinoma
    100655429 (CDK6)
   05214 Glioma
    100655429 (CDK6)
   05220 Chronic myeloid leukemia
    100655429 (CDK6)
   05218 Melanoma
    100655429 (CDK6)
   05224 Breast cancer
    100655429 (CDK6)
   05222 Small cell lung cancer
    100655429 (CDK6)
   05223 Non-small cell lung cancer
    100655429 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100655429 (CDK6)
  09172 Infectious disease: viral
   05160 Hepatitis C
    100655429 (CDK6)
   05164 Influenza A
    100655429 (CDK6)
   05162 Measles
    100655429 (CDK6)
   05163 Human cytomegalovirus infection
    100655429 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100655429 (CDK6)
   05169 Epstein-Barr virus infection
    100655429 (CDK6)
   05165 Human papillomavirus infection
    100655429 (CDK6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    100655429 (CDK6)
Enzymes [BR:lav01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100655429 (CDK6)
Protein kinases [BR:lav01001]
Serine/threonine kinases: CMGC group
  CDK family
   100655429 (CDK6)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like RIO1 FTA2 Seadorna_VP7

Other DBs

NCBI-GeneID:

100655429

NCBI-ProteinID:

XP_003407195

UniProt:

G3TL01

LinkDB

Position

Unknown

AA seq 326 aa
MEKDGLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMLQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSPQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
HDLERCKENLDSHLPPGQNTSELNTA

NT seq 981 nt +upstreamnt +downstreamnt
atggagaaggacggcctgagtcgcgcggaccagcaatacgagtgcgtggcggagatcggg
gagggcgcctatgggaaggtgttcaaggcccgggacttgaagaacggaggccgtttcgtg
gcgctgaagcgtgtgcgggtgcagactggcgaagagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtatgcacagtatcacgaacagacagagaaacgaaactaacattagtgtttgaacat
gttgatcaagacttgaccacttacttggataaggttccggagcctggagtgcccactgaa
accattaaggatatgatgcttcagcttctccgaggtctggactttcttcattctcaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagtggacaaataaaa
ctggctgacttcggcctggcccggatctacagttttcagatggcgcttacgtcagtggtc
gtcacgctgtggtacagagctccagaagtcttgcttcagtccagctacgccacccctgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcctggatgtaattggactcccaggagaa
gaggactggcctagagatgttgctcttcccaggcaggctttccattcaaaatctccccaa
ccaattgagaagtttgtaacagatattgatgaactaggcaaagacctacttctgaagtgt
ctgacattcaatccagcgaaaagaatatctgcctacagtgccctgtctcacccatacttc
cacgacctggagaggtgcaaggagaacctggattcacatctgccgcctggccagaacacc
tcggagctgaacacagcctga

Loxodonta africana (African savanna elephant): 104847103

Entry

104847103 CDS T04351

Gene name

CDK4

Definition

(RefSeq) cyclin-dependent kinase 4

K02089

cyclin-dependent kinase 4 [EC:2.7.11.22]

Organism

lav Loxodonta africana (African savanna elephant)

Pathway

lav01522

Endocrine resistance

lav04110

Cell cycle

lav04115

p53 signaling pathway

lav04151

PI3K-Akt signaling pathway

lav04218

Cellular senescence

lav04530

Tight junction

lav04660

T cell receptor signaling pathway

lav04933

AGE-RAGE signaling pathway in diabetic complications

lav04934

Cushing syndrome

lav05160

Hepatitis C

lav05162

Measles

lav05163

Human cytomegalovirus infection

lav05164

Influenza A

lav05165

Human papillomavirus infection

lav05166

Human T-cell leukemia virus 1 infection

lav05167

Kaposi sarcoma-associated herpesvirus infection

lav05169

Epstein-Barr virus infection

lav05200

Pathways in cancer

lav05203

Viral carcinogenesis

lav05212

Pancreatic cancer

lav05214

Glioma

lav05218

Melanoma

lav05219

Bladder cancer

lav05220

Chronic myeloid leukemia

lav05222

Small cell lung cancer

lav05223

Non-small cell lung cancer

lav05224

Breast cancer

lav05225

Hepatocellular carcinoma

Brite

KEGG Orthology (KO) [BR:lav00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    104847103 (CDK4)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    104847103 (CDK4)
   04115 p53 signaling pathway
    104847103 (CDK4)
   04218 Cellular senescence
    104847103 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    104847103 (CDK4)
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    104847103 (CDK4)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104847103 (CDK4)
   05203 Viral carcinogenesis
    104847103 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    104847103 (CDK4)
   05225 Hepatocellular carcinoma
    104847103 (CDK4)
   05214 Glioma
    104847103 (CDK4)
   05220 Chronic myeloid leukemia
    104847103 (CDK4)
   05218 Melanoma
    104847103 (CDK4)
   05219 Bladder cancer
    104847103 (CDK4)
   05224 Breast cancer
    104847103 (CDK4)
   05222 Small cell lung cancer
    104847103 (CDK4)
   05223 Non-small cell lung cancer
    104847103 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104847103 (CDK4)
   04934 Cushing syndrome
    104847103 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104847103 (CDK4)
   05160 Hepatitis C
    104847103 (CDK4)
   05164 Influenza A
    104847103 (CDK4)
   05162 Measles
    104847103 (CDK4)
   05163 Human cytomegalovirus infection
    104847103 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104847103 (CDK4)
   05169 Epstein-Barr virus infection
    104847103 (CDK4)
   05165 Human papillomavirus infection
    104847103 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    104847103 (CDK4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lav01001]
    104847103 (CDK4)
Enzymes [BR:lav01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     104847103 (CDK4)
Protein kinases [BR:lav01001]
Serine/threonine kinases: CMGC group
  CDK family
   104847103 (CDK4)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like FTA2

Other DBs

NCBI-GeneID:

104847103

NCBI-ProteinID:

XP_010599575

LinkDB

Position

Unknown

AA seq 225 aa
MATPRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGTGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSAYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK

NT seq 675 nt +upstreamnt +downstreamnt
atggccacccctcgatatgagccagtggctgagattggtgtcggtgcctatgggacggtg
tacaaggctcgtgatccccacagtggccactttgtggccctcaagagcgtgagagtcccc
aatggaggaggcactggagggggccttcctatcagcacagttcgtgaagtggccttactg
aggcggctggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccaca
gcccgaactgatcgggaaaccaaggtaaccctggtatttgaacacgtggaccaagatcta
aggacctatctagacaaagcacccccaccaggcttgccagtggagaccatcaaggatcta
atgcgccagtttctaagaggccttgatttcctgcatgccaattgcattgttcaccgagac
ctgaagccagagaacatcctggtgacaagcggtggaaccgtcaagttggctgactttggg
ttggccagaatctacagctaccagatggcacttacacctgtggttgttacactctggtac
cgtgctcctgaggttcttctgcagtctgcatatgcaacccctgtagacatgtggagtgta
ggctgtatcttcgcagagatgtttcgtcggaagcctctcttctgtggaaactctgaagct
gaccagttaggcaaa

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