Loxodonta africana (African savanna elephant): 100659125
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Entry
100659125 CDS
T04351
Gene name
EGFR
Definition
(RefSeq) epidermal growth factor receptor isoform X1
KO
K04361
epidermal growth factor receptor [EC:
2.7.10.1
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav01521
EGFR tyrosine kinase inhibitor resistance
lav01522
Endocrine resistance
lav04010
MAPK signaling pathway
lav04012
ErbB signaling pathway
lav04014
Ras signaling pathway
lav04015
Rap1 signaling pathway
lav04020
Calcium signaling pathway
lav04066
HIF-1 signaling pathway
lav04068
FoxO signaling pathway
lav04072
Phospholipase D signaling pathway
lav04144
Endocytosis
lav04151
PI3K-Akt signaling pathway
lav04510
Focal adhesion
lav04520
Adherens junction
lav04540
Gap junction
lav04630
JAK-STAT signaling pathway
lav04810
Regulation of actin cytoskeleton
lav04912
GnRH signaling pathway
lav04915
Estrogen signaling pathway
lav04921
Oxytocin signaling pathway
lav04926
Relaxin signaling pathway
lav04928
Parathyroid hormone synthesis, secretion and action
lav04934
Cushing syndrome
lav05160
Hepatitis C
lav05163
Human cytomegalovirus infection
lav05165
Human papillomavirus infection
lav05171
Coronavirus disease - COVID-19
lav05200
Pathways in cancer
lav05205
Proteoglycans in cancer
lav05206
MicroRNAs in cancer
lav05210
Colorectal cancer
lav05212
Pancreatic cancer
lav05213
Endometrial cancer
lav05214
Glioma
lav05215
Prostate cancer
lav05218
Melanoma
lav05219
Bladder cancer
lav05223
Non-small cell lung cancer
lav05224
Breast cancer
lav05225
Hepatocellular carcinoma
lav05226
Gastric cancer
lav05230
Central carbon metabolism in cancer
lav05231
Choline metabolism in cancer
lav05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100659125 (EGFR)
04012 ErbB signaling pathway
100659125 (EGFR)
04014 Ras signaling pathway
100659125 (EGFR)
04015 Rap1 signaling pathway
100659125 (EGFR)
04630 JAK-STAT signaling pathway
100659125 (EGFR)
04066 HIF-1 signaling pathway
100659125 (EGFR)
04068 FoxO signaling pathway
100659125 (EGFR)
04020 Calcium signaling pathway
100659125 (EGFR)
04072 Phospholipase D signaling pathway
100659125 (EGFR)
04151 PI3K-Akt signaling pathway
100659125 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
100659125 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100659125 (EGFR)
04520 Adherens junction
100659125 (EGFR)
04540 Gap junction
100659125 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100659125 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
100659125 (EGFR)
04915 Estrogen signaling pathway
100659125 (EGFR)
04921 Oxytocin signaling pathway
100659125 (EGFR)
04926 Relaxin signaling pathway
100659125 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
100659125 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100659125 (EGFR)
05206 MicroRNAs in cancer
100659125 (EGFR)
05205 Proteoglycans in cancer
100659125 (EGFR)
05230 Central carbon metabolism in cancer
100659125 (EGFR)
05231 Choline metabolism in cancer
100659125 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100659125 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
100659125 (EGFR)
05212 Pancreatic cancer
100659125 (EGFR)
05225 Hepatocellular carcinoma
100659125 (EGFR)
05226 Gastric cancer
100659125 (EGFR)
05214 Glioma
100659125 (EGFR)
05218 Melanoma
100659125 (EGFR)
05219 Bladder cancer
100659125 (EGFR)
05215 Prostate cancer
100659125 (EGFR)
05213 Endometrial cancer
100659125 (EGFR)
05224 Breast cancer
100659125 (EGFR)
05223 Non-small cell lung cancer
100659125 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100659125 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
100659125 (EGFR)
05171 Coronavirus disease - COVID-19
100659125 (EGFR)
05163 Human cytomegalovirus infection
100659125 (EGFR)
05165 Human papillomavirus infection
100659125 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100659125 (EGFR)
01522 Endocrine resistance
100659125 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lav01001
]
100659125 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
lav04147
]
100659125 (EGFR)
Enzymes [BR:
lav01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
100659125 (EGFR)
Protein kinases [BR:
lav01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
100659125 (EGFR)
Exosome [BR:
lav04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
100659125 (EGFR)
Exosomal proteins of pancreatic cancer cells
100659125 (EGFR)
Exosomal proteins of bladder cancer cells
100659125 (EGFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
Kinase-like
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
100659125
NCBI-ProteinID:
XP_010585451
LinkDB
All DBs
Position
Unknown
AA seq
1205 aa
AA seq
DB search
MRPSGAVGATLLVLLATHFQASWALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNLLYENTYALA
VLSNYGANKTGVKELPMRNLQEILTGAVRFSNNPVLCSIETIQWRDIVDSDFISNMSMDL
QSSQASCQKCAPSCPNGSCWGTGEENCQKLTKTICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLICRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPHNYV
VTDHGSCVRSCGSDSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFR
NCTSISGDLHILPVAFKGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPVNKTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRKLCYANTINWKKL
FGTSRQNTKIINNRGEKDCKAVGYVCNPLCSSEGCWGPEPKDCVSCRNVSRGRECVNKCN
ILEGEPREFVEKSECIQCHPECLPQPMNITCTGRGPDSCIKCAHYIDGPHCVKTCPSGIL
GENNTLVWKYADASHVCHLCHPNCTFGCAGPGLEGCATNGPKIPSIATGIVGGLLLLVVM
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPVTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPVCTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMNLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ
QGFFNSPSTSRTPLLNSLSAASNNSTVACVDRNGQSSPIKEDSFLQRYSSDPTGALTEES
IDDSFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVENPEYLNT
TEPACVNSPAYWAQKGNHQISLDNPDYQQDFFPKEAKPNGIFKVPAAENAEYLRVAPPSS
EFIGA
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgcgaccctccggggcagtcggtgccacgctcctggtgctgctggctacgcacttccag
gcgagttgggcgctggaggaaaagaaagtttgccagggcacgagcaacaagcttactcag
ttgggcacttttgaagatcactttctgagcctccagaggatgttcaataactgtgaagtg
gtccttgggaatttggaaattacctacgtgcaaaggaattatgacctgtccttcttaaag
accatccaggaggtcgccggctatgtactcattgccctcaacacagtggagaggattccc
ttggaaaacctgcagattatcagaggaaatctactctatgaaaacacctatgccttggcc
gtcttatccaactatggtgcaaataaaaccggagtaaaggagctgcccatgaggaactta
caggaaatcctgactggtgccgtgagattcagcaacaaccctgtcctctgcagcatagaa
accatccagtggcgagacattgtcgacagtgatttcataagcaatatgtcaatggacttg
cagagcagtcaggccagctgccagaagtgtgctccaagctgtcccaatggaagctgctgg
ggtacgggagaggaaaactgccagaaattgaccaaaaccatctgtgcccagcagtgttct
gggcgctgccgcggcaagtcccccagcgactgctgccacaaccagtgtgccgccggctgc
acaggaccccgagagagtgactgtctgatctgccgaaagtttcgagatgaagccacatgc
aaggacacttgcccgccactgatgctctacaaccccaccacataccagatggatgttaac
ccagagggaaaatacagctttggcgccacatgtgtgaagaagtgcccacataactatgtg
gtgacagaccacgggtcgtgtgtccggtcctgcggttccgacagctatgagatggaggag
gatggagtccgcaagtgtaaaaagtgtgaggggccttgtcgcaaagtttgtaatggcatt
ggaattggtgagtttaaagacacactttccataaatgctacaaatattaaacacttcaga
aattgcacctctatcagtggagaccttcatatcctcccagtagcatttaagggtgactcc
ttcacacgcactccacctctagatccaaaggaactggatattctaaaaaccgtaaaagaa
ataacagggtttttgctgattcaggcttggcctgtaaacaagactgacctccacgctttt
gagaacctagaaatcatacgcggcagaacaaagcaacatggtcagttttctcttgcggtt
gttggcctggacataacgtctttgggattacgctctctcaaggaaataagtgatggagac
gtgataatttcaggaaaccgaaaactgtgctatgcaaatacaataaactggaaaaaacta
tttgggacttcaagacagaacaccaaaattataaacaacagaggcgagaaggactgcaag
gccgtaggctacgtttgtaatcccttgtgctcatcagagggctgctggggcccggaaccc
aaagactgcgtctcctgccgcaatgtcagccgaggccgagagtgtgtgaacaagtgcaat
attctggagggagagccgagggagtttgtggagaaatccgagtgcatacagtgccatcct
gaatgtctgccccagcccatgaatataacctgcacgggacgcggacctgacagctgtata
aagtgtgcccactacatcgacggcccccactgtgtcaagacctgcccatcagggatcctg
ggagaaaacaacaccctggtctggaagtatgcggatgccagtcacgtgtgccacctgtgc
catccaaactgcactttcggctgtgctggaccaggtcttgaaggctgtgcaacgaatggg
cccaagatcccatccatcgccactggaattgtgggtggcctcctcttgttggtggtgatg
gctcttgggattggccttttcatgcgaaggcgccacattgtccggaagcgcacgctgcgc
agactgctgcaggaaagagagctcgttgagccagtgacgcccagtggtgaagctcccaac
caagctctcctgaggatcttaaaggaaacagaatttaagaagatcaaagtgcttggctct
ggggcctttggcactgtgtataagggactctggatcccagaaggagagaaagttaaaatt
cctgtggctatcaaagaattaagagaagccacgtctccaaaagccaacaaagagattctt
gacgaagcctatgtcatggccagtgtggacaatcctcacgtgtgccgcttgctgggtatc
tgtctgacctccacggtccagctcatcacacagctcatgccctttggctgcctcctggac
tatgtccgcgagcacaaggacaacatcggctcccagtacctcctcaactggtgtgtgcag
attgcaaagggcatgaactacctggaagaccgccgcctggtgcaccgcgacctggctgcg
agaaatgtcctggtgaagactccgcagcacgtcaagatcacagatttcgggctggccaaa
ctgcttggtgctgaagagaaggagtaccatgctgaaggaggcaaagttcctattaaatgg
atggctctggaatcaattttacaccgaatttatacccaccaaagtgatgtctggagctac
ggtgtcacagtttgggagttgatgacctttggatccaagccttatgatggaatccctgca
agtgagatctcgtccatcctagagaaaggagagcgccttccgcagccacccgtgtgcacc
atcgatgtgtacatgatcatggtcaagtgctggatgatagatgcagatagtcgcccaaag
ttccgtgagttgatcattgaattctccaaaatggcccgtgaccctcagcgctaccttgtc
attcagggagatgaacgaatgaatctgcccagccctacagactcaaatttttaccgtgcc
ctgatggacgaagaggacatggaagatgtcgtggacgcagacgagtacctcattccacag
caaggattcttcaacagtccttctacatctcgaactcccctcctaaattctctgagcgca
gccagcaacaattccacggtggcttgcgttgatagaaacgggcagagcagtcccatcaag
gaggacagcttcctgcagcggtacagctctgaccccacaggagccttgactgaagagagc
atcgatgacagcttcctgccagtgccagaatacataaaccagtctgttcccaaaaggccc
gcgggctctgtccagaatcccgtctaccacaatcagcctctgaatccagcccccggcaga
gaccctcactaccaaaacccccacagcaatgccgtggagaaccccgagtatctcaacacc
accgagcctgcctgtgtcaacagccccgcctactgggcccagaaaggcaaccaccaaatc
agtctggacaaccccgactaccaacaggacttcttcccgaaggaagccaagccaaacggc
atcttcaaggttcccgcagctgaaaatgctgaatacctaagggttgcaccaccaagcagt
gagtttattggagcctga
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integrated database retrieval system
