KEGG   Loxodonta africana (African savanna elephant): 100659125
Entry
100659125         CDS       T04351                                 

Gene name
EGFR
Definition
(RefSeq) epidermal growth factor receptor isoform X1
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav01521  EGFR tyrosine kinase inhibitor resistance
lav01522  Endocrine resistance
lav04010  MAPK signaling pathway
lav04012  ErbB signaling pathway
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04066  HIF-1 signaling pathway
lav04068  FoxO signaling pathway
lav04072  Phospholipase D signaling pathway
lav04144  Endocytosis
lav04151  PI3K-Akt signaling pathway
lav04510  Focal adhesion
lav04520  Adherens junction
lav04540  Gap junction
lav04630  JAK-STAT signaling pathway
lav04810  Regulation of actin cytoskeleton
lav04912  GnRH signaling pathway
lav04915  Estrogen signaling pathway
lav04921  Oxytocin signaling pathway
lav04926  Relaxin signaling pathway
lav04928  Parathyroid hormone synthesis, secretion and action
lav04934  Cushing syndrome
lav05160  Hepatitis C
lav05163  Human cytomegalovirus infection
lav05165  Human papillomavirus infection
lav05171  Coronavirus disease - COVID-19
lav05200  Pathways in cancer
lav05205  Proteoglycans in cancer
lav05206  MicroRNAs in cancer
lav05210  Colorectal cancer
lav05212  Pancreatic cancer
lav05213  Endometrial cancer
lav05214  Glioma
lav05215  Prostate cancer
lav05218  Melanoma
lav05219  Bladder cancer
lav05223  Non-small cell lung cancer
lav05224  Breast cancer
lav05225  Hepatocellular carcinoma
lav05226  Gastric cancer
lav05230  Central carbon metabolism in cancer
lav05231  Choline metabolism in cancer
lav05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100659125 (EGFR)
   04012 ErbB signaling pathway
    100659125 (EGFR)
   04014 Ras signaling pathway
    100659125 (EGFR)
   04015 Rap1 signaling pathway
    100659125 (EGFR)
   04630 JAK-STAT signaling pathway
    100659125 (EGFR)
   04066 HIF-1 signaling pathway
    100659125 (EGFR)
   04068 FoxO signaling pathway
    100659125 (EGFR)
   04020 Calcium signaling pathway
    100659125 (EGFR)
   04072 Phospholipase D signaling pathway
    100659125 (EGFR)
   04151 PI3K-Akt signaling pathway
    100659125 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    100659125 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100659125 (EGFR)
   04520 Adherens junction
    100659125 (EGFR)
   04540 Gap junction
    100659125 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100659125 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    100659125 (EGFR)
   04915 Estrogen signaling pathway
    100659125 (EGFR)
   04921 Oxytocin signaling pathway
    100659125 (EGFR)
   04926 Relaxin signaling pathway
    100659125 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    100659125 (EGFR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100659125 (EGFR)
   05206 MicroRNAs in cancer
    100659125 (EGFR)
   05205 Proteoglycans in cancer
    100659125 (EGFR)
   05230 Central carbon metabolism in cancer
    100659125 (EGFR)
   05231 Choline metabolism in cancer
    100659125 (EGFR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100659125 (EGFR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100659125 (EGFR)
   05212 Pancreatic cancer
    100659125 (EGFR)
   05225 Hepatocellular carcinoma
    100659125 (EGFR)
   05226 Gastric cancer
    100659125 (EGFR)
   05214 Glioma
    100659125 (EGFR)
   05218 Melanoma
    100659125 (EGFR)
   05219 Bladder cancer
    100659125 (EGFR)
   05215 Prostate cancer
    100659125 (EGFR)
   05213 Endometrial cancer
    100659125 (EGFR)
   05224 Breast cancer
    100659125 (EGFR)
   05223 Non-small cell lung cancer
    100659125 (EGFR)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100659125 (EGFR)
  09172 Infectious disease: viral
   05160 Hepatitis C
    100659125 (EGFR)
   05171 Coronavirus disease - COVID-19
    100659125 (EGFR)
   05163 Human cytomegalovirus infection
    100659125 (EGFR)
   05165 Human papillomavirus infection
    100659125 (EGFR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100659125 (EGFR)
   01522 Endocrine resistance
    100659125 (EGFR)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100659125 (EGFR)
Protein kinases [BR:lav01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   100659125 (EGFR)
Exosome [BR:lav04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   100659125 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   100659125 (EGFR)
  Exosomal proteins of bladder cancer cells
   100659125 (EGFR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like Kinase-like APH Kdo
Other DBs
NCBI-GeneID: 100659125
NCBI-ProteinID: XP_010585451
LinkDB
Position
Unknown
AA seq 1205 aa
MRPSGAVGATLLVLLATHFQASWALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNLLYENTYALA
VLSNYGANKTGVKELPMRNLQEILTGAVRFSNNPVLCSIETIQWRDIVDSDFISNMSMDL
QSSQASCQKCAPSCPNGSCWGTGEENCQKLTKTICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLICRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPHNYV
VTDHGSCVRSCGSDSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFR
NCTSISGDLHILPVAFKGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPVNKTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRKLCYANTINWKKL
FGTSRQNTKIINNRGEKDCKAVGYVCNPLCSSEGCWGPEPKDCVSCRNVSRGRECVNKCN
ILEGEPREFVEKSECIQCHPECLPQPMNITCTGRGPDSCIKCAHYIDGPHCVKTCPSGIL
GENNTLVWKYADASHVCHLCHPNCTFGCAGPGLEGCATNGPKIPSIATGIVGGLLLLVVM
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPVTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPVCTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMNLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ
QGFFNSPSTSRTPLLNSLSAASNNSTVACVDRNGQSSPIKEDSFLQRYSSDPTGALTEES
IDDSFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVENPEYLNT
TEPACVNSPAYWAQKGNHQISLDNPDYQQDFFPKEAKPNGIFKVPAAENAEYLRVAPPSS
EFIGA
NT seq 3618 nt   +upstreamnt  +downstreamnt
atgcgaccctccggggcagtcggtgccacgctcctggtgctgctggctacgcacttccag
gcgagttgggcgctggaggaaaagaaagtttgccagggcacgagcaacaagcttactcag
ttgggcacttttgaagatcactttctgagcctccagaggatgttcaataactgtgaagtg
gtccttgggaatttggaaattacctacgtgcaaaggaattatgacctgtccttcttaaag
accatccaggaggtcgccggctatgtactcattgccctcaacacagtggagaggattccc
ttggaaaacctgcagattatcagaggaaatctactctatgaaaacacctatgccttggcc
gtcttatccaactatggtgcaaataaaaccggagtaaaggagctgcccatgaggaactta
caggaaatcctgactggtgccgtgagattcagcaacaaccctgtcctctgcagcatagaa
accatccagtggcgagacattgtcgacagtgatttcataagcaatatgtcaatggacttg
cagagcagtcaggccagctgccagaagtgtgctccaagctgtcccaatggaagctgctgg
ggtacgggagaggaaaactgccagaaattgaccaaaaccatctgtgcccagcagtgttct
gggcgctgccgcggcaagtcccccagcgactgctgccacaaccagtgtgccgccggctgc
acaggaccccgagagagtgactgtctgatctgccgaaagtttcgagatgaagccacatgc
aaggacacttgcccgccactgatgctctacaaccccaccacataccagatggatgttaac
ccagagggaaaatacagctttggcgccacatgtgtgaagaagtgcccacataactatgtg
gtgacagaccacgggtcgtgtgtccggtcctgcggttccgacagctatgagatggaggag
gatggagtccgcaagtgtaaaaagtgtgaggggccttgtcgcaaagtttgtaatggcatt
ggaattggtgagtttaaagacacactttccataaatgctacaaatattaaacacttcaga
aattgcacctctatcagtggagaccttcatatcctcccagtagcatttaagggtgactcc
ttcacacgcactccacctctagatccaaaggaactggatattctaaaaaccgtaaaagaa
ataacagggtttttgctgattcaggcttggcctgtaaacaagactgacctccacgctttt
gagaacctagaaatcatacgcggcagaacaaagcaacatggtcagttttctcttgcggtt
gttggcctggacataacgtctttgggattacgctctctcaaggaaataagtgatggagac
gtgataatttcaggaaaccgaaaactgtgctatgcaaatacaataaactggaaaaaacta
tttgggacttcaagacagaacaccaaaattataaacaacagaggcgagaaggactgcaag
gccgtaggctacgtttgtaatcccttgtgctcatcagagggctgctggggcccggaaccc
aaagactgcgtctcctgccgcaatgtcagccgaggccgagagtgtgtgaacaagtgcaat
attctggagggagagccgagggagtttgtggagaaatccgagtgcatacagtgccatcct
gaatgtctgccccagcccatgaatataacctgcacgggacgcggacctgacagctgtata
aagtgtgcccactacatcgacggcccccactgtgtcaagacctgcccatcagggatcctg
ggagaaaacaacaccctggtctggaagtatgcggatgccagtcacgtgtgccacctgtgc
catccaaactgcactttcggctgtgctggaccaggtcttgaaggctgtgcaacgaatggg
cccaagatcccatccatcgccactggaattgtgggtggcctcctcttgttggtggtgatg
gctcttgggattggccttttcatgcgaaggcgccacattgtccggaagcgcacgctgcgc
agactgctgcaggaaagagagctcgttgagccagtgacgcccagtggtgaagctcccaac
caagctctcctgaggatcttaaaggaaacagaatttaagaagatcaaagtgcttggctct
ggggcctttggcactgtgtataagggactctggatcccagaaggagagaaagttaaaatt
cctgtggctatcaaagaattaagagaagccacgtctccaaaagccaacaaagagattctt
gacgaagcctatgtcatggccagtgtggacaatcctcacgtgtgccgcttgctgggtatc
tgtctgacctccacggtccagctcatcacacagctcatgccctttggctgcctcctggac
tatgtccgcgagcacaaggacaacatcggctcccagtacctcctcaactggtgtgtgcag
attgcaaagggcatgaactacctggaagaccgccgcctggtgcaccgcgacctggctgcg
agaaatgtcctggtgaagactccgcagcacgtcaagatcacagatttcgggctggccaaa
ctgcttggtgctgaagagaaggagtaccatgctgaaggaggcaaagttcctattaaatgg
atggctctggaatcaattttacaccgaatttatacccaccaaagtgatgtctggagctac
ggtgtcacagtttgggagttgatgacctttggatccaagccttatgatggaatccctgca
agtgagatctcgtccatcctagagaaaggagagcgccttccgcagccacccgtgtgcacc
atcgatgtgtacatgatcatggtcaagtgctggatgatagatgcagatagtcgcccaaag
ttccgtgagttgatcattgaattctccaaaatggcccgtgaccctcagcgctaccttgtc
attcagggagatgaacgaatgaatctgcccagccctacagactcaaatttttaccgtgcc
ctgatggacgaagaggacatggaagatgtcgtggacgcagacgagtacctcattccacag
caaggattcttcaacagtccttctacatctcgaactcccctcctaaattctctgagcgca
gccagcaacaattccacggtggcttgcgttgatagaaacgggcagagcagtcccatcaag
gaggacagcttcctgcagcggtacagctctgaccccacaggagccttgactgaagagagc
atcgatgacagcttcctgccagtgccagaatacataaaccagtctgttcccaaaaggccc
gcgggctctgtccagaatcccgtctaccacaatcagcctctgaatccagcccccggcaga
gaccctcactaccaaaacccccacagcaatgccgtggagaaccccgagtatctcaacacc
accgagcctgcctgtgtcaacagccccgcctactgggcccagaaaggcaaccaccaaatc
agtctggacaaccccgactaccaacaggacttcttcccgaaggaagccaagccaaacggc
atcttcaaggttcccgcagctgaaaatgctgaatacctaagggttgcaccaccaagcagt
gagtttattggagcctga

KEGG   Loxodonta africana (African savanna elephant): 100670735
Entry
100670735         CDS       T04351                                 

Gene name
PDGFRA
Definition
(RefSeq) platelet-derived growth factor receptor alpha isoform X1
  KO
K04363  platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav01521  EGFR tyrosine kinase inhibitor resistance
lav04010  MAPK signaling pathway
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04072  Phospholipase D signaling pathway
lav04144  Endocytosis
lav04151  PI3K-Akt signaling pathway
lav04510  Focal adhesion
lav04540  Gap junction
lav04630  JAK-STAT signaling pathway
lav04810  Regulation of actin cytoskeleton
lav05163  Human cytomegalovirus infection
lav05200  Pathways in cancer
lav05206  MicroRNAs in cancer
lav05214  Glioma
lav05215  Prostate cancer
lav05218  Melanoma
lav05230  Central carbon metabolism in cancer
lav05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100670735 (PDGFRA)
   04014 Ras signaling pathway
    100670735 (PDGFRA)
   04015 Rap1 signaling pathway
    100670735 (PDGFRA)
   04630 JAK-STAT signaling pathway
    100670735 (PDGFRA)
   04020 Calcium signaling pathway
    100670735 (PDGFRA)
   04072 Phospholipase D signaling pathway
    100670735 (PDGFRA)
   04151 PI3K-Akt signaling pathway
    100670735 (PDGFRA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    100670735 (PDGFRA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100670735 (PDGFRA)
   04540 Gap junction
    100670735 (PDGFRA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100670735 (PDGFRA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100670735 (PDGFRA)
   05206 MicroRNAs in cancer
    100670735 (PDGFRA)
   05230 Central carbon metabolism in cancer
    100670735 (PDGFRA)
   05231 Choline metabolism in cancer
    100670735 (PDGFRA)
  09162 Cancer: specific types
   05214 Glioma
    100670735 (PDGFRA)
   05218 Melanoma
    100670735 (PDGFRA)
   05215 Prostate cancer
    100670735 (PDGFRA)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100670735 (PDGFRA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100670735 (PDGFRA)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100670735 (PDGFRA)
Protein kinases [BR:lav01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   100670735 (PDGFRA)
CD molecules [BR:lav04090]
 Proteins
  100670735 (PDGFRA)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 I-set ig Ig_2 V-set Herpes_gE C2-set_2 Kinase-like LAT DUF3475
Other DBs
NCBI-GeneID: 100670735
NCBI-ProteinID: XP_023410821
LinkDB
Position
Unknown
AA seq 1078 aa
MFPFTGPGLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVNWQYPMSEDENHSVEI
RNEENNSGLFVTVLEVTGASAAHTGLYTCYYNHTLTEENEVKGRRIYIYVPDPDVVFIPL
GMMDYLVITEEDDSAIIPCRTTDPETPVTLLSGDRVVHASYDSKQGFNGTFPVGSYICEA
TIKGKTFQTIPFNVYTLKATSELDLEMEALKTVYKSGEKIEVTCVVFNNEVVDLQWTYPG
EVKGKGVTMLEEIKVPTIKLVYTLTIPKATVKDSGDYECAARQATKEVKEMKKVTISVHE
KGFIEIKPNFSQLEAVNLHEVKHFVVDIKAYPPPRISWLKDNLTLIENLTEITTDVDRIQ
EIRYRSKLKLIRAKEEDSGHYTIVVQNEDDVKSYTFELLTQVPSSILDLVDDHHGSTGVQ
TVKCMAAGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGQVTFT
KVEETIAVRCLAKNLLGVENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQ
KPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGT
AYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIY
IITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDY
MDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLT
LLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVS
KGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKS
GYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLK
SDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPED
EDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
NT seq 3237 nt   +upstreamnt  +downstreamnt
atgtttccttttacagggccggggctaatactctgccagctttcactaccctccatcctt
ccaaatgaaaatgaaaaggttgtgcagctgaattcctccttttctctgagatgctttggg
gagagtgaagtgaactggcagtaccccatgtctgaagatgagaaccacagtgtggaaatc
cgaaacgaggaaaacaacagtggcctttttgtgacagtgctggaagtgaccggtgcctcg
gcggcccacacaggactgtacacttgctactacaaccacactctgacagaagaaaatgag
gtcaaaggcaggcgtatttatatctacgtgccggacccagacgtagtcttcatacctctg
ggaatgatggattatttggtcatcacggaggaggatgattctgccatcataccctgccga
acgactgaccctgagaccccagtcaccttactcagtggcgatagggtggttcatgcctcc
tatgacagcaaacagggctttaacggaactttccctgtggggtcctacatctgtgaggcc
accatcaaagggaagacgttccagaccatcccttttaacgtgtatactttaaaagcaaca
tcagaacttgacctagaaatggaagctcttaaaactgtgtataaatcaggggagaagatt
gaggtcacttgtgtagtctttaacaatgaagtggttgaccttcagtggacttaccctgga
gaagtgaaaggcaaaggtgtcacaatgctcgaggaaatcaaggttccaaccatcaagctg
gtgtacactttgacaatccccaaggccacagtgaaagacagtggagattacgaatgtgct
gcccgccaggccaccaaggaggtcaaagaaatgaagaaagtcaccatttctgttcatgag
aaaggattcattgaaatcaaacccaacttcagccagttggaagctgtcaacctgcatgaa
gtcaaacattttgtggtggacataaaggcctaccctcctcctaggatatcctggctgaag
gacaacctgacgctgattgaaaacctgaccgagatcactactgatgtagacaggattcag
gagataaggtatcgaagtaaattaaagctgatccgtgctaaggaagaagacagtggccat
tatactattgtagttcaaaatgaagatgatgtgaagagctatacttttgaactattaact
caagttccctcctctattctggacttggttgatgaccaccatggctctactggggtgcag
actgtgaagtgcatggcagcaggaacccctcttcctgacattgagtggatgatttgcaag
gatattaaaaaatgcaataatgaaacttcatggacgattttggccaacaatgtctcaaac
atcatcactgaaatccactcccgagaccggagtaccgtggagggccaagttactttcacc
aaagtagaggagaccattgcagttcgatgcctggctaagaatcttcttggggtggagaac
cgagagctgaagctcgtggctcccactctgcgttctgaactcactgtggcggctgcagtc
ttggtgctattggtgattgtgatcatctcacttattgtcctggtcgtcatttggaaacag
aaaccgaggtatgaaattcgttggagggtcattgaatcaatcagccctgatggacatgaa
tatatttatgtggaccccatgcagctgccttatgactccagatgggagtttccaagagat
ggactagtgcttggtcgtatcctgggatctggtgcctttgggaaagtggttgaaggaacg
gcctatggattaagccgttctcagcctgtgatgaaagtagcagtgaagatgctaaaaccc
acagccagatccagtgaaaaacaagctctcatgtctgaactgaagattatgactcacctg
gggccacatttaaacattgtaaacttgttgggggcctgtaccaaatcaggacccatttac
atcatcactgagtactgcttctatggggatttggtcaattatttgcataagaatagagac
agctttctgagtcaccacccagagaagccaaagaaagagttggacatctttggattgaac
cccgctgatgaaagcacacggagttacgttattttatcttttgaaaacaatggtgactac
atggacatgaaacaagccgataccacacagtatgtccccatgctggaaaggaaagaggtc
tctaagtattcagacatccagagatctttgtatgatcgcccagcctcgtataagaagaaa
tctatgttagactcagaagtcaaaaacctcctctcggatgataactcagaaggccttact
ttgttggatttgttgagcttcacctatcaagttgcccgaggaatggagtttttggcttca
aaaaattgtgtccaccgggacctggctgctcgcaatgtcctcctggctcaggggaaaatt
gtgaagatctgtgactttggcctggccagagatatcatgcatgattctaactacgtgtca
aaaggcagcaccttcctccccgtgaagtggatggctcctgagagcatctttgacaacctc
tacaccaccctgagcgacgtctggtcttatggcatcctgctttgggagatcttctctctt
ggtggcacaccctaccctggcatgatggtggattcgactttttacaataagataaagagt
gggtaccgaatggccaaacccgaccatgccaccagtgaagtctacgagatcatggtgaag
tgctggaacagtgagccagagaagagaccctccttctaccacctgagtgaaattgtggag
aatctgctgcctggacaatataagaagagttatgagaaaattcacctggacttcctgaag
agtgaccatcctgctgtggcacgcatgcgtgtggactctgacaacgcgtacattggcgtc
acctataaaaacgaggaagataagctgaaggactgggagggtggccttgatgagcagaga
ctgagcgcggacagtggctacatcatccctctgcctgacatcgaccctgttcctgaggat
gaagacctgggcaagaggaacagacacagctcacagacctctgaagagagtgctattgag
acaggttccagcagttctacctttatcaagagagaggatgagaccattgaggacatcgac
atgatggacgacattggcatagactcctcagacctggtggaggacagcttcctgtaa

KEGG   Loxodonta africana (African savanna elephant): 100671240
Entry
100671240         CDS       T04351                                 

Gene name
PDGFRB
Definition
(RefSeq) platelet-derived growth factor receptor beta isoform X1
  KO
K05089  platelet-derived growth factor receptor beta [EC:2.7.10.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav01521  EGFR tyrosine kinase inhibitor resistance
lav04010  MAPK signaling pathway
lav04014  Ras signaling pathway
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04072  Phospholipase D signaling pathway
lav04151  PI3K-Akt signaling pathway
lav04510  Focal adhesion
lav04540  Gap junction
lav04630  JAK-STAT signaling pathway
lav04810  Regulation of actin cytoskeleton
lav05165  Human papillomavirus infection
lav05200  Pathways in cancer
lav05206  MicroRNAs in cancer
lav05214  Glioma
lav05215  Prostate cancer
lav05218  Melanoma
lav05230  Central carbon metabolism in cancer
lav05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lav00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100671240 (PDGFRB)
   04014 Ras signaling pathway
    100671240 (PDGFRB)
   04015 Rap1 signaling pathway
    100671240 (PDGFRB)
   04630 JAK-STAT signaling pathway
    100671240 (PDGFRB)
   04020 Calcium signaling pathway
    100671240 (PDGFRB)
   04072 Phospholipase D signaling pathway
    100671240 (PDGFRB)
   04151 PI3K-Akt signaling pathway
    100671240 (PDGFRB)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100671240 (PDGFRB)
   04540 Gap junction
    100671240 (PDGFRB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100671240 (PDGFRB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100671240 (PDGFRB)
   05206 MicroRNAs in cancer
    100671240 (PDGFRB)
   05230 Central carbon metabolism in cancer
    100671240 (PDGFRB)
   05231 Choline metabolism in cancer
    100671240 (PDGFRB)
  09162 Cancer: specific types
   05214 Glioma
    100671240 (PDGFRB)
   05218 Melanoma
    100671240 (PDGFRB)
   05215 Prostate cancer
    100671240 (PDGFRB)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    100671240 (PDGFRB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100671240 (PDGFRB)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100671240 (PDGFRB)
Protein kinases [BR:lav01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   100671240 (PDGFRB)
CD molecules [BR:lav04090]
 Proteins
  100671240 (PDGFRB)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 ig I-set Ig_2 V-set Trypan_PARP
Other DBs
NCBI-GeneID: 100671240
NCBI-ProteinID: XP_003404646
LinkDB
Position
Unknown
AA seq 1126 aa
MKPPGVMPAMVLKGQLLLLPLLLLMGPQASQGLVITPPGPELVLNISSTFILTCSGPAPV
VWERLSQKPPQEVIRTQDGNFSSMLTLTNVTGLDTGEYFCTYNDSHGLEHDERKRLYIFV
PDPTVGFLPTKPEDLFIFLVEVPETIPCRVTDPQLVVTLHEKKVDIPLPIPYDHQRGFSG
IFEDKTYICKTTIGDREVDSDPYYVYSLQVSSINVSVNAVQTVVRQGENITVMCIVTGSE
VVNFGWTYPRMESGRLVEPVTDFLLDVPSHIRSILHIPNAELGDSGTYVCNVSESVNEHQ
DEKAINVTVVESGYLRLLGEMDPVQFADLHRSRTLRVVFEAYPPPTVMWFKDNRTLGDSG
TGEISLSIRNVSETRYVTELTLVRVKVAEAGHYTVRAFHEDAELQLSFQLQVNVPVRVLE
LSESHPASGEQTVRCRGRGMPQPYLTWSTCSDLKRCPHELPPTSLGNSSEEESQLETNVT
YWAEEQEFEVVSTLRLHRVDQPLSVRCTLHNPLGYHMQEVIVVPHSLPFKVVVISAILAL
VVLTVISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLV
LGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPH
LNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHCSDKRHPPSAELYSNALP
VGLPLPSHVSLTGESDGGYMDMSKDELVDYVPMLDMKGDVKYADIESSNYTAPYDNYVPS
APERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVK
ICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGVLLWEIFTLGG
TPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERL
LGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGSRGLHSSLDSSVLYTAVQPNEGDNDYI
IPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQEEPEPDLRPQEELEP
EPEPEPEPEPEPEPEPEPEPEPEPEPEQPLGSGCPGPRAQAADSFL
NT seq 3381 nt   +upstreamnt  +downstreamnt
atgaagcctccaggtgtgatgccagcaatggtcctcaaaggccagttgctgttgttgccc
ctgctgctgctgatgggtccacaggcctctcagggcctggttatcacacccccggggccg
gagcttgtcctcaatatctctagcaccttcattctgacctgctcgggcccagctccagtg
gtatgggaacggctgtcccagaagcccccgcaggaagtgatcaggacccaggatggtaac
ttctccagcatgctgacgctgaccaatgtcactgggctcgacacaggagaatacttttgc
acctacaatgactcccatgggctggagcacgatgagcgaaagcggctctacatctttgtg
ccagatcccaccgtgggtttcctccctaccaaacctgaggacttattcatctttctcgtg
gaagtacctgagacaatcccatgccgggtgacagacccacagctggtggtgacactgcat
gagaagaaagtggatatcccactgccaatcccctatgaccaccaacggggcttctctggt
atctttgaggataagacctacatctgcaaaaccaccatcggggacagggaggtggattct
gacccctattatgtctacagcctccaggtgtcatccatcaatgtgtctgtgaacgcagtg
cagactgtggtccgccagggtgagaacatcaccgtcatgtgcattgtgactggaagcgag
gtcgtcaactttgggtggacatatccccgcatggagagtgggcggctggtggagccagtg
acggacttcctgttagatgtgccctcccacattcgctccatcctgcacattcccaatgcc
gagctgggtgactcaggcacctacgtctgcaatgtgtcggagagtgtgaacgagcatcag
gatgaaaaggcgatcaatgtcactgtggtcgagagcggctatctgcggctgctgggagag
atggaccctgtacaattcgcggatctgcaccggagccgcacactgcgggtggtgttcgag
gcctacccaccacccaccgtcatgtggttcaaggacaaccgcaccctaggtgactccggc
accggcgagatctccctgtccattcgcaatgtgtctgagacccggtacgtgacggaactg
acactggttcgggtgaaggtggctgaggctggccactacaccgtgcgggccttccacgag
gacgctgagttgcagctttccttccagttgcaggtcaacgtccctgtccgtgtgctggag
ctgagtgagagccacccagccagcggcgagcagacagtccgctgtcgtggtcggggcatg
ccccagccgtacctcacctggtctacctgcagcgacctcaagaggtgtccgcacgagctg
ccacccacatccctggggaacagttcggaggaggagagccagctggagactaacgtgacg
tactgggcggaggagcaggagttcgaggtggtgagcacgctgcgcctacaccgcgtggat
cagccgctgtccgtgcgctgcacgctgcacaacccactgggctaccatatgcaggaggtc
atcgtggtgccacattcactgcccttcaaggtggtggtgatctcagccatcctggccctg
gtggtcctcactgtcatctccctcatcatcctgatcatgctctggcagaagaagccacgt
tatgagatccgctggaaggtgatcgagtcagtgagctccgatggacatgagtacatctac
gtggaccccatgcagctgccctatgactccacatgggagctgccgcgggaccagcttgtg
ctgggacgcacccttggctctggggcctttgggcaggtggtggaggccacggcacatggt
ctgagccattctcaggccacaatgaaggtggctgtcaagatgctgaaatccacagcccgt
agcagtgagaaacaagccctcatgtcggagctgaagatcatgagtcatctcgggccccac
ctgaatgtggtcaacctgctgggggcctgcaccaaaggaggacccatctacatcattact
gagtactgccgctacggcgacctggtggactacctgcaccgcaacaaacacaccttcctg
cagcactgctcggacaagcgccacccgcccagcgccgagctctacagcaatgccctgccc
gtcgggctccctctgcccagccatgtgtccctgactggggagagtgacggtggctacatg
gacatgagcaaggatgagttggtggactacgtacccatgctggacatgaaaggggacgtc
aaatatgcagacatcgagtcctccaactacacggccccttatgacaactacgtcccctct
gctcccgagaggacgtgccgggcaactttgatcaatgagtccccagtgcttagttacatg
gaccttgtgggcttcagctaccaggtggccaatggcatggaattcctggcctccaagaac
tgtgtccaccgagacctggcggccaggaacgtgctgatctgtgagggcaagctggtcaag
atctgtgactttggcctggctcgtgacattatgagggactcaaactacatctccaaaggc
agtaccttcctgcctctcaagtggatggcccccgagagcatcttcaacagcctttacacc
accctgagcgacgtgtggtccttcggggtcctactctgggagatcttcaccctgggtggc
accccttacccggagctgcccatgaatgagcaattctacaatgccatcaagcgaggttac
cgcatggcgcagcctgcccacgcgtcagacgagatctacgagatcatgcagaagtgctgg
gaagagaagtttgagattcggccccccttctcccagctggtgctgcttcttgagagactg
ctgggtgagggttacaaaaagaagtaccagcaggtggatgaggagtttctgaggagcgac
cacccagccatccttcgctcccaagcccgcttgcccggatcccgtggcctccactccagc
ttggacagctccgtcctttatactgccgtgcagcccaatgagggtgacaatgactacatc
attcccctgcctgaccccaaacccgaggttgctgatgagggaccattggagggctccccc
agccttgcaagctccactctgaatgaagtcaacacctcctccaccatctcctgtgacagt
cccctggagccccaagaggaaccagagccggaccttcggccccaggaggagctggagccg
gagccggagccggaaccagagccggagccagagccggagccagagccagagccggagccg
gaaccggagccagagccggagcagccactgggttcaggctgcccaggtcctcgggctcag
gcggcggacagcttcctgtag

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