Loxodonta africana (African savanna elephant): 100660963
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Entry
100660963 CDS
T04351
Definition
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase
KO
K00512
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:
1.14.14.19
1.14.14.32
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav00140
Steroid hormone biosynthesis
lav01100
Metabolic pathways
lav04913
Ovarian steroidogenesis
lav04917
Prolactin signaling pathway
lav04927
Cortisol synthesis and secretion
lav04934
Cushing syndrome
Module
lav_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
lav_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
100660963
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
100660963
04917 Prolactin signaling pathway
100660963
04927 Cortisol synthesis and secretion
100660963
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100660963
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
lav00199
]
100660963
Enzymes [BR:
lav01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
100660963
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
100660963
Cytochrome P450 [BR:
lav00199
]
Cytochrome P450, animal type
CYP17 family
100660963
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
p450
Motif
Other DBs
NCBI-GeneID:
100660963
NCBI-ProteinID:
XP_003409011
UniProt:
G3SPQ2
LinkDB
All DBs
Position
Unknown
AA seq
508 aa
AA seq
DB search
MWELLAVLLLTLVYYFWPKIRRPGAKYPKSLPFLPLVGSLPFLPRHGHPHINFFKLQKKY
GPIYSFRLGTATYVVVGQYQLAREVLIKKGREFSGRPNVLTLAMVSNNQKGVAFADSGPH
WQLHRKLVQAAFTLFKDGHQRLEKIILKEISSLCDFLANQNGQSIDISLPVFLAVTNMIS
MFCFNSSYTYDDPDLHVIKMYNEIILENLDTHSLVDIFPCLKIFPFKSLQMMKNAVKIRS
ELMHKTIEEYKEKFSSDSITNLLDILIQAKMSSDNNNDGPDQDSKMLSQEHIIATMMDIF
GAGVETTTSVMKWTVAFLLHNPQVKKKIQEEIDQNIGFSRTPTLSDRNHLVLLEATIREV
LRIRPIAPLLTPHMASTDSSIGEFTIDKGTNVIINLWALHHSEKEWHQPDQFMPERFLDP
TGCQLISPTLSYLPFGAGPRSCLGEILARQELFLFLSWVLQRFDLEVPDDGQLPSLEGNP
KAVFLISNFKVKVKVREAWREAHAEGSA
NT seq
1527 nt
NT seq
+upstream
nt +downstream
nt
atgtgggagctcttggctgtcttgctgctcaccctagtttattacttttggcccaagata
aggcgccctggtgccaagtaccccaagagcctcccgttcctgcccctggtgggcagcctg
cctttcctccctcgacatggacatcctcacatcaatttcttcaagctgcagaaaaaatat
ggccccatctattcttttcgtctgggtaccgcaacttatgtggttgtcggccagtaccag
ctggccagggaggtgctcatcaagaaaggcagagaattctccgggcgacccaatgtgcta
actctggcaatggtgtcaaacaaccaaaaaggcgtcgcctttgccgacagtggtccccac
tggcagctacatagaaagctggtgcaggctgcgtttaccctgttcaaggacggccaccag
aggctagagaagatcatacttaaggaaatcagctcattatgtgatttcctggccaaccag
aatggacagtctatagatatatcgttacctgtcttcctggctgtgaccaacatgatctcc
atgttctgcttcaactcttcctacacgtatgatgatcctgatctgcatgtcataaaaatg
tacaatgaaatcatcctggagaatctggacacccacagtctggtggatatcttcccctgc
ttgaagattttccccttcaaatccctgcaaatgatgaagaatgctgttaaaatacgaagt
gaactgatgcataaaaccatagaagaatacaaggagaaattcagcagtgactctatcact
aacctgctagacatactgatccaagccaagatgagctcagacaataacaatgatggccca
gaccaggattcaaagatgctttctcaagaacacattattgccaccatgatggacatcttc
ggggctggtgtggagaccactacctctgtgatgaagtggactgtggccttcctgctgcac
aaccctcaggtgaagaaaaagatccaggaggagattgaccagaacataggttttagtcgc
acaccaactctgagtgaccggaaccacctcgttctgctggaggccaccatccgagaggtg
ctacgcatccgacctatagctcccctcctcaccccccacatggcttccactgactccagc
attggtgagtttaccattgacaaaggcacaaatgttatcatcaatttgtgggcactgcat
cacagtgagaaggagtggcaccagccggaccagttcatgcctgagcgcttcttggaccca
accgggtgccagctcatctcaccaacattgagctacttgccctttggggcgggaccccgc
tcctgcctaggtgagatcctggcccgccaggagctcttcctcttcctgtcctgggtgctc
cagaggtttgacctggaggtgccggatgatgggcagctaccctccttggagggcaatccc
aaggcggtctttctgatcagcaacttcaaagtgaaggtcaaggtgcgcgaggcctggagg
gaagcccatgctgagggtagtgcctag
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