KEGG   Loxodonta africana (African savanna elephant): 100669094Help
Entry
100669094         CDS       T04351                                 

Gene name
HK1
Definition
(RefSeq) hexokinase-1 isoform X1
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
lav  Loxodonta africana (African savanna elephant)
Pathway
lav00010  Glycolysis / Gluconeogenesis
lav00051  Fructose and mannose metabolism
lav00052  Galactose metabolism
lav00500  Starch and sucrose metabolism
lav00520  Amino sugar and nucleotide sugar metabolism
lav00524  Neomycin, kanamycin and gentamicin biosynthesis
lav01100  Metabolic pathways
lav01200  Carbon metabolism
lav04066  HIF-1 signaling pathway
lav04910  Insulin signaling pathway
lav04930  Type II diabetes mellitus
lav04973  Carbohydrate digestion and absorption
lav05230  Central carbon metabolism in cancer
Module
lav_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
lav_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Brite
KEGG Orthology (KO) [BR:lav00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    100669094 (HK1)
   00051 Fructose and mannose metabolism
    100669094 (HK1)
   00052 Galactose metabolism
    100669094 (HK1)
   00500 Starch and sucrose metabolism
    100669094 (HK1)
   00520 Amino sugar and nucleotide sugar metabolism
    100669094 (HK1)
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    100669094 (HK1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100669094 (HK1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100669094 (HK1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100669094 (HK1)
 09160 Human Diseases
  09161 Cancers
   05230 Central carbon metabolism in cancer
    100669094 (HK1)
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100669094 (HK1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lav04131]
    100669094 (HK1)
Enzymes [BR:lav01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     100669094 (HK1)
Membrane trafficking [BR:lav04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    100669094 (HK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 CSD UvrD-helicase
Motif
Other DBs
NCBI-GeneID: 100669094
NCBI-ProteinID: XP_003409087
LinkDB All DBs
Position
Unknown
AA seq 919 aa AA seqDB search
MIAAQLLAYYFTELKDDQVKKIDKYLYTMRLSDETLLDIMARFRSEMKSGLSRDSNPTAT
IKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVDHEQHQNVRMESEVYDTPENIIH
GSGSQLFDHVAECLGDFMEKKKIKDKKLPVGFTFSFPCQQSKIDEGILITWTKRFKASGV
EGADVVKLLDKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YIGELVRLILVKMAKEGLLFEGRITPELLTKGKFNTSDVSAIEMNKEGLHNAKEILTRLG
VEPSHDDCISVQHVCAIVTFRSANLVAATLGAILCRLRDNKGTPRLRTTVGVDGSLYKMH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFRLT
KEMLMEVKKRMRAEMELGLKKATHEKATVKMLPSFVRSTPDGTEHGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYTIPIEVMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCKQESLDAGILITWTKGFKATDCVGHDVTTLLKDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMRNIEMVEGTDGQMCINMEWGAFGDNGCLDD
IRTGYDKLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAELCGAGMAA
VVDKIRENRRLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPQCNVSFLLSEDGSGKG
AALITAVGVRLRGEVPPTS
NT seq 2760 nt NT seq  +upstreamnt  +downstreamnt
atgatcgccgcgcagctcctggcctactacttcaccgagctgaaggatgaccaagtcaaa
aagattgacaagtatctctataccatgcggttatccgatgaaactctgttggatatcatg
gctcgcttcaggagtgagatgaagagtggcctctcccgggattctaatccaacagccaca
atcaagatgttgccaacatttgtaaggtccattcctgatggttcagagaagggagatttc
attgccttggatcttggtgggtcttcctttcgaattctacgggtgcaagtggatcacgag
cagcatcaaaatgttcgcatggagtctgaggtttacgacacccccgagaacatcatacac
ggcagtggaagccagctttttgatcacgtcgctgagtgcctgggagacttcatggagaaa
aagaaaatcaaggacaagaaattacctgtgggattcacgttttctttcccctgccaacaa
tccaaaattgatgagggcatcctgatcacctggacaaagagatttaaagcgagtggagta
gagggtgcagatgtggtgaagctgctggacaaagccatcaagaaacgaggggactatgac
gccaacattgtggccgtggtgaacgacacagtggggaccatgatgacctgtggctacgat
gaccagcattgtgaagttggcctgatcattggcactggcaccaatgcttgctacatggag
gaactgaggcacattgacctggtggaaggcgatgaggggaggatgtgcatcaacacggag
tggggggcctttggggacgacgggtccctagaagacatccggaccgagtttgaccgagag
atagaccggggctcccttaatccgggaaagcagttgtttgagaagatggtcagtggcatg
tacatcggggagctggttcgactgatcctggtcaagatggccaaagagggtctcttattt
gaagggcggatcaccccggagctacttaccaaaggaaagttcaacaccagcgatgtgtca
gccatcgaaatgaataaggaaggcctccacaatgccaaagaaatcctgacccgtctggga
gtggaaccgtctcatgacgactgtatttcagtccagcacgtgtgcgccattgtcacgttt
cgctcggccaacctggtggctgcaacgctgggtgccatcttgtgccgccttcgtgataac
aagggcacacccaggctgcggactacggttggtgtcgacggatctctatacaagatgcac
ccacagtattcccggcgtttccacaagaccctgaggcgcctggtgccggactcagatgtg
cgtttcctgctgtcggagagcggcagtggcaagggagccgccatggtgaccgcagtggct
taccgcctggccgagcagcaccggcagatcgaggagaccctggcccacttccgcctcacc
aaggagatgctgatggaggtgaagaagcggatgcgggctgagatggagttgggactgaag
aaggcgacccatgagaaggccactgtcaagatgctgccctcctttgtccggagcactcca
gatgggactgagcacggtgacttcttggccctcgaccttggaggaacgaacttccgcgtc
ctgctggtgaagatccgcagtgggaagaagaggacagtggaaatgcacaacaagatctac
accattcccattgaagtcatgcagggcaccggggaagagctgtttgaccacatcgtttcc
tgcatctccgacttcctggactacatgggcatcaaaggccccagaatgcctttgggcttc
accttctcctttccctgcaagcaggaaagcttggatgcgggtatcttgatcacctggaca
aagggcttcaaggcaactgactgtgtggggcacgatgtaaccaccctactaaaggatgca
ataaaaaggagagaggaatttgacctggacgtggtggctgtggtgaacgacacggtgggc
accatgatgacctgtgcttatgaggagcccacctgtgaggtcggactcatcgtaggaacg
ggcagcaatgcctgctacatggaagaaatgaggaatattgagatggtggaagggactgat
gggcaaatgtgtatcaacatggaatggggtgcctttggggacaacggctgtctggatgat
atccgaacaggctatgataagttggtggatgaatattctctaaacgctgggaaacaaagg
tatgagaagatgatcagcggcatgtacctgggggagatcgtccgcaacatcctgattgac
ttcaccaagaagggatttctcttccgggggcagatctctgagaccctgaagacgcggggc
atctttgagaccaaattcctctctcagatcgagagtgaccgattagcactgctccaggtt
cgggccatcctccagcagctgggactgaacagcacctgtgatgacagtatcctcgtcaag
actgtgtgtggggtcgtgtccaggagagctgcagagctgtgtggcgcagggatggctgct
gtggtagataagatccgtgagaacaggagactggaccatctgaatgtgactgtgggagtg
gacgggacactctacaaacttcatccacacttctccagaatcatgcaccaaaccgtgaag
gaactgtcaccacaatgtaatgtgtccttcctgctgtcagaagatggtagtggcaagggg
gccgccctcatcacggctgtgggtgtgcggctgcgaggagaagtgcccccaaccagctaa

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