Lipotes vexillifer (Yangtze River dolphin): 103087933
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Entry
103087933 CDS
T03090
Gene name
RAF1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
lve
Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve01521
EGFR tyrosine kinase inhibitor resistance
lve01522
Endocrine resistance
lve04010
MAPK signaling pathway
lve04012
ErbB signaling pathway
lve04014
Ras signaling pathway
lve04015
Rap1 signaling pathway
lve04022
cGMP-PKG signaling pathway
lve04024
cAMP signaling pathway
lve04062
Chemokine signaling pathway
lve04068
FoxO signaling pathway
lve04071
Sphingolipid signaling pathway
lve04072
Phospholipase D signaling pathway
lve04140
Autophagy - animal
lve04150
mTOR signaling pathway
lve04151
PI3K-Akt signaling pathway
lve04210
Apoptosis
lve04218
Cellular senescence
lve04270
Vascular smooth muscle contraction
lve04360
Axon guidance
lve04370
VEGF signaling pathway
lve04371
Apelin signaling pathway
lve04510
Focal adhesion
lve04540
Gap junction
lve04550
Signaling pathways regulating pluripotency of stem cells
lve04613
Neutrophil extracellular trap formation
lve04625
C-type lectin receptor signaling pathway
lve04630
JAK-STAT signaling pathway
lve04650
Natural killer cell mediated cytotoxicity
lve04660
T cell receptor signaling pathway
lve04662
B cell receptor signaling pathway
lve04664
Fc epsilon RI signaling pathway
lve04666
Fc gamma R-mediated phagocytosis
lve04720
Long-term potentiation
lve04722
Neurotrophin signaling pathway
lve04726
Serotonergic synapse
lve04730
Long-term depression
lve04810
Regulation of actin cytoskeleton
lve04910
Insulin signaling pathway
lve04912
GnRH signaling pathway
lve04914
Progesterone-mediated oocyte maturation
lve04915
Estrogen signaling pathway
lve04916
Melanogenesis
lve04917
Prolactin signaling pathway
lve04919
Thyroid hormone signaling pathway
lve04921
Oxytocin signaling pathway
lve04926
Relaxin signaling pathway
lve04928
Parathyroid hormone synthesis, secretion and action
lve04929
GnRH secretion
lve04935
Growth hormone synthesis, secretion and action
lve05010
Alzheimer disease
lve05022
Pathways of neurodegeneration - multiple diseases
lve05034
Alcoholism
lve05132
Salmonella infection
lve05152
Tuberculosis
lve05160
Hepatitis C
lve05161
Hepatitis B
lve05163
Human cytomegalovirus infection
lve05164
Influenza A
lve05165
Human papillomavirus infection
lve05167
Kaposi sarcoma-associated herpesvirus infection
lve05170
Human immunodeficiency virus 1 infection
lve05200
Pathways in cancer
lve05205
Proteoglycans in cancer
lve05206
MicroRNAs in cancer
lve05210
Colorectal cancer
lve05211
Renal cell carcinoma
lve05212
Pancreatic cancer
lve05213
Endometrial cancer
lve05214
Glioma
lve05215
Prostate cancer
lve05218
Melanoma
lve05219
Bladder cancer
lve05220
Chronic myeloid leukemia
lve05221
Acute myeloid leukemia
lve05223
Non-small cell lung cancer
lve05224
Breast cancer
lve05225
Hepatocellular carcinoma
lve05226
Gastric cancer
lve05230
Central carbon metabolism in cancer
lve05231
Choline metabolism in cancer
lve05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
lve00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103087933 (RAF1)
04012 ErbB signaling pathway
103087933 (RAF1)
04014 Ras signaling pathway
103087933 (RAF1)
04015 Rap1 signaling pathway
103087933 (RAF1)
04370 VEGF signaling pathway
103087933 (RAF1)
04371 Apelin signaling pathway
103087933 (RAF1)
04630 JAK-STAT signaling pathway
103087933 (RAF1)
04068 FoxO signaling pathway
103087933 (RAF1)
04072 Phospholipase D signaling pathway
103087933 (RAF1)
04071 Sphingolipid signaling pathway
103087933 (RAF1)
04024 cAMP signaling pathway
103087933 (RAF1)
04022 cGMP-PKG signaling pathway
103087933 (RAF1)
04151 PI3K-Akt signaling pathway
103087933 (RAF1)
04150 mTOR signaling pathway
103087933 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103087933 (RAF1)
09143 Cell growth and death
04210 Apoptosis
103087933 (RAF1)
04218 Cellular senescence
103087933 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
103087933 (RAF1)
04540 Gap junction
103087933 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
103087933 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103087933 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
103087933 (RAF1)
04625 C-type lectin receptor signaling pathway
103087933 (RAF1)
04650 Natural killer cell mediated cytotoxicity
103087933 (RAF1)
04660 T cell receptor signaling pathway
103087933 (RAF1)
04662 B cell receptor signaling pathway
103087933 (RAF1)
04664 Fc epsilon RI signaling pathway
103087933 (RAF1)
04666 Fc gamma R-mediated phagocytosis
103087933 (RAF1)
04062 Chemokine signaling pathway
103087933 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
103087933 (RAF1)
04929 GnRH secretion
103087933 (RAF1)
04912 GnRH signaling pathway
103087933 (RAF1)
04915 Estrogen signaling pathway
103087933 (RAF1)
04914 Progesterone-mediated oocyte maturation
103087933 (RAF1)
04917 Prolactin signaling pathway
103087933 (RAF1)
04921 Oxytocin signaling pathway
103087933 (RAF1)
04926 Relaxin signaling pathway
103087933 (RAF1)
04935 Growth hormone synthesis, secretion and action
103087933 (RAF1)
04919 Thyroid hormone signaling pathway
103087933 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
103087933 (RAF1)
04916 Melanogenesis
103087933 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
103087933 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
103087933 (RAF1)
04720 Long-term potentiation
103087933 (RAF1)
04730 Long-term depression
103087933 (RAF1)
04722 Neurotrophin signaling pathway
103087933 (RAF1)
09158 Development and regeneration
04360 Axon guidance
103087933 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103087933 (RAF1)
05206 MicroRNAs in cancer
103087933 (RAF1)
05205 Proteoglycans in cancer
103087933 (RAF1)
05230 Central carbon metabolism in cancer
103087933 (RAF1)
05231 Choline metabolism in cancer
103087933 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103087933 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
103087933 (RAF1)
05212 Pancreatic cancer
103087933 (RAF1)
05225 Hepatocellular carcinoma
103087933 (RAF1)
05226 Gastric cancer
103087933 (RAF1)
05214 Glioma
103087933 (RAF1)
05221 Acute myeloid leukemia
103087933 (RAF1)
05220 Chronic myeloid leukemia
103087933 (RAF1)
05218 Melanoma
103087933 (RAF1)
05211 Renal cell carcinoma
103087933 (RAF1)
05219 Bladder cancer
103087933 (RAF1)
05215 Prostate cancer
103087933 (RAF1)
05213 Endometrial cancer
103087933 (RAF1)
05224 Breast cancer
103087933 (RAF1)
05223 Non-small cell lung cancer
103087933 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
103087933 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
103087933 (RAF1)
09165 Substance dependence
05034 Alcoholism
103087933 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
103087933 (RAF1)
05152 Tuberculosis
103087933 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103087933 (RAF1)
05161 Hepatitis B
103087933 (RAF1)
05160 Hepatitis C
103087933 (RAF1)
05164 Influenza A
103087933 (RAF1)
05163 Human cytomegalovirus infection
103087933 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
103087933 (RAF1)
05165 Human papillomavirus infection
103087933 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103087933 (RAF1)
01522 Endocrine resistance
103087933 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lve01001
]
103087933 (RAF1)
Enzymes [BR:
lve01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103087933 (RAF1)
Protein kinases [BR:
lve01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
103087933 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
103087933
NCBI-ProteinID:
XP_007461619
UniProt:
A0A340XQI5
LinkDB
All DBs
Position
Un
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHGESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSSTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHISNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagatgct
gtgtttgatggccccagctgcatctcccctacaatagttcagcagtttggctatcagcgt
cgggcatcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtt
tttttgccaaacaagcaaagaacagtggtcaatgtgcggaatgggatgagcttgcatgac
tgccttatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagttttcaga
cttctccacgaacacaagggtaaaaaagcacgtttagattggaatactgatgctgcctcg
ttgattggagaggaacttcaagtagatttcctggatcatgttccactcacaactcacaac
tttgctcggaagaccttcctgaaacttgccttctgtgacatctgtcagaagttcctgcta
aatgggtttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgctgttcccaaattccact
gttggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccatgctttcacattc
aacacctccagcccctcctctgaaggttccctctcccagaggcagaggtctacgtccaca
cctaatgtccacatggtcagcaccaccttgcccgtggacagcaggatgattgaggatgca
attcgaagtcacggtgaatcagcctcaccttcagccttgtccagcagtcccaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccggcacagagagagcgggcaccg
ggatccagcacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
ggaactgtttataagggcaagtggcatggagacgttgcagtaaagattctaaaggttgtt
gaccccacaccagagcagttccaggccttcagaaatgaagtggctgtccttcgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctataaacacctgcacgtccaggagaccaagttc
cagatgttccagttgattgacattgcccggcagacggctcagggaatggactacttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacaacccaccggctccatcttgtggatggccccagaggtgattcgaatgcaa
gacaataacccgttcagcttccagtccgacgtctactcttacggcatcgtgctgtacgag
cttatgacgggggagctgccctactcccacatcagcaaccgcgatcagatcatcttcatg
gtaggccgagggtacgcctccccagaccttagtaagctgtacaagaactgccccaaagca
atgaagaggctggtagccgactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccataccgaggacatcaatgcctgcacgctgacc
acatcccctcgattgcctgtcttctag
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