KEGG   Lipotes vexillifer (Yangtze River dolphin): 103087933
Entry
103087933         CDS       T03090                                 

Gene name
RAF1
Definition
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
lve  Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve01521  EGFR tyrosine kinase inhibitor resistance
lve01522  Endocrine resistance
lve04010  MAPK signaling pathway
lve04012  ErbB signaling pathway
lve04014  Ras signaling pathway
lve04015  Rap1 signaling pathway
lve04022  cGMP-PKG signaling pathway
lve04024  cAMP signaling pathway
lve04062  Chemokine signaling pathway
lve04068  FoxO signaling pathway
lve04071  Sphingolipid signaling pathway
lve04072  Phospholipase D signaling pathway
lve04140  Autophagy - animal
lve04150  mTOR signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04210  Apoptosis
lve04218  Cellular senescence
lve04270  Vascular smooth muscle contraction
lve04360  Axon guidance
lve04370  VEGF signaling pathway
lve04371  Apelin signaling pathway
lve04510  Focal adhesion
lve04540  Gap junction
lve04550  Signaling pathways regulating pluripotency of stem cells
lve04613  Neutrophil extracellular trap formation
lve04625  C-type lectin receptor signaling pathway
lve04630  JAK-STAT signaling pathway
lve04650  Natural killer cell mediated cytotoxicity
lve04660  T cell receptor signaling pathway
lve04662  B cell receptor signaling pathway
lve04664  Fc epsilon RI signaling pathway
lve04666  Fc gamma R-mediated phagocytosis
lve04720  Long-term potentiation
lve04722  Neurotrophin signaling pathway
lve04726  Serotonergic synapse
lve04730  Long-term depression
lve04810  Regulation of actin cytoskeleton
lve04910  Insulin signaling pathway
lve04912  GnRH signaling pathway
lve04914  Progesterone-mediated oocyte maturation
lve04915  Estrogen signaling pathway
lve04916  Melanogenesis
lve04917  Prolactin signaling pathway
lve04919  Thyroid hormone signaling pathway
lve04921  Oxytocin signaling pathway
lve04926  Relaxin signaling pathway
lve04928  Parathyroid hormone synthesis, secretion and action
lve04929  GnRH secretion
lve04935  Growth hormone synthesis, secretion and action
lve05010  Alzheimer disease
lve05022  Pathways of neurodegeneration - multiple diseases
lve05034  Alcoholism
lve05132  Salmonella infection
lve05152  Tuberculosis
lve05160  Hepatitis C
lve05161  Hepatitis B
lve05163  Human cytomegalovirus infection
lve05164  Influenza A
lve05165  Human papillomavirus infection
lve05167  Kaposi sarcoma-associated herpesvirus infection
lve05170  Human immunodeficiency virus 1 infection
lve05200  Pathways in cancer
lve05205  Proteoglycans in cancer
lve05206  MicroRNAs in cancer
lve05210  Colorectal cancer
lve05211  Renal cell carcinoma
lve05212  Pancreatic cancer
lve05213  Endometrial cancer
lve05214  Glioma
lve05215  Prostate cancer
lve05218  Melanoma
lve05219  Bladder cancer
lve05220  Chronic myeloid leukemia
lve05221  Acute myeloid leukemia
lve05223  Non-small cell lung cancer
lve05224  Breast cancer
lve05225  Hepatocellular carcinoma
lve05226  Gastric cancer
lve05230  Central carbon metabolism in cancer
lve05231  Choline metabolism in cancer
lve05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:lve00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103087933 (RAF1)
   04012 ErbB signaling pathway
    103087933 (RAF1)
   04014 Ras signaling pathway
    103087933 (RAF1)
   04015 Rap1 signaling pathway
    103087933 (RAF1)
   04370 VEGF signaling pathway
    103087933 (RAF1)
   04371 Apelin signaling pathway
    103087933 (RAF1)
   04630 JAK-STAT signaling pathway
    103087933 (RAF1)
   04068 FoxO signaling pathway
    103087933 (RAF1)
   04072 Phospholipase D signaling pathway
    103087933 (RAF1)
   04071 Sphingolipid signaling pathway
    103087933 (RAF1)
   04024 cAMP signaling pathway
    103087933 (RAF1)
   04022 cGMP-PKG signaling pathway
    103087933 (RAF1)
   04151 PI3K-Akt signaling pathway
    103087933 (RAF1)
   04150 mTOR signaling pathway
    103087933 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103087933 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    103087933 (RAF1)
   04218 Cellular senescence
    103087933 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103087933 (RAF1)
   04540 Gap junction
    103087933 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103087933 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103087933 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613  Neutrophil extracellular trap formation
    103087933 (RAF1)
   04625 C-type lectin receptor signaling pathway
    103087933 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    103087933 (RAF1)
   04660 T cell receptor signaling pathway
    103087933 (RAF1)
   04662 B cell receptor signaling pathway
    103087933 (RAF1)
   04664 Fc epsilon RI signaling pathway
    103087933 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    103087933 (RAF1)
   04062 Chemokine signaling pathway
    103087933 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103087933 (RAF1)
   04929 GnRH secretion
    103087933 (RAF1)
   04912 GnRH signaling pathway
    103087933 (RAF1)
   04915 Estrogen signaling pathway
    103087933 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    103087933 (RAF1)
   04917 Prolactin signaling pathway
    103087933 (RAF1)
   04921 Oxytocin signaling pathway
    103087933 (RAF1)
   04926 Relaxin signaling pathway
    103087933 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    103087933 (RAF1)
   04919 Thyroid hormone signaling pathway
    103087933 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    103087933 (RAF1)
   04916 Melanogenesis
    103087933 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103087933 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    103087933 (RAF1)
   04720 Long-term potentiation
    103087933 (RAF1)
   04730 Long-term depression
    103087933 (RAF1)
   04722 Neurotrophin signaling pathway
    103087933 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    103087933 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103087933 (RAF1)
   05206 MicroRNAs in cancer
    103087933 (RAF1)
   05205 Proteoglycans in cancer
    103087933 (RAF1)
   05230 Central carbon metabolism in cancer
    103087933 (RAF1)
   05231 Choline metabolism in cancer
    103087933 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103087933 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103087933 (RAF1)
   05212 Pancreatic cancer
    103087933 (RAF1)
   05225 Hepatocellular carcinoma
    103087933 (RAF1)
   05226 Gastric cancer
    103087933 (RAF1)
   05214 Glioma
    103087933 (RAF1)
   05221 Acute myeloid leukemia
    103087933 (RAF1)
   05220 Chronic myeloid leukemia
    103087933 (RAF1)
   05218 Melanoma
    103087933 (RAF1)
   05211 Renal cell carcinoma
    103087933 (RAF1)
   05219 Bladder cancer
    103087933 (RAF1)
   05215 Prostate cancer
    103087933 (RAF1)
   05213 Endometrial cancer
    103087933 (RAF1)
   05224 Breast cancer
    103087933 (RAF1)
   05223 Non-small cell lung cancer
    103087933 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103087933 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    103087933 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    103087933 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103087933 (RAF1)
   05152 Tuberculosis
    103087933 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103087933 (RAF1)
   05161 Hepatitis B
    103087933 (RAF1)
   05160 Hepatitis C
    103087933 (RAF1)
   05164 Influenza A
    103087933 (RAF1)
   05163 Human cytomegalovirus infection
    103087933 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103087933 (RAF1)
   05165 Human papillomavirus infection
    103087933 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103087933 (RAF1)
   01522 Endocrine resistance
    103087933 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lve01001]
    103087933 (RAF1)
Enzymes [BR:lve01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103087933 (RAF1)
Protein kinases [BR:lve01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103087933 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 103087933
NCBI-ProteinID: XP_007461619
UniProt: A0A340XQI5
LinkDB
Position
Un
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHGESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSSTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHISNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagatgct
gtgtttgatggccccagctgcatctcccctacaatagttcagcagtttggctatcagcgt
cgggcatcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtt
tttttgccaaacaagcaaagaacagtggtcaatgtgcggaatgggatgagcttgcatgac
tgccttatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagttttcaga
cttctccacgaacacaagggtaaaaaagcacgtttagattggaatactgatgctgcctcg
ttgattggagaggaacttcaagtagatttcctggatcatgttccactcacaactcacaac
tttgctcggaagaccttcctgaaacttgccttctgtgacatctgtcagaagttcctgcta
aatgggtttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgctgttcccaaattccact
gttggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccatgctttcacattc
aacacctccagcccctcctctgaaggttccctctcccagaggcagaggtctacgtccaca
cctaatgtccacatggtcagcaccaccttgcccgtggacagcaggatgattgaggatgca
attcgaagtcacggtgaatcagcctcaccttcagccttgtccagcagtcccaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccggcacagagagagcgggcaccg
ggatccagcacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
ggaactgtttataagggcaagtggcatggagacgttgcagtaaagattctaaaggttgtt
gaccccacaccagagcagttccaggccttcagaaatgaagtggctgtccttcgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctataaacacctgcacgtccaggagaccaagttc
cagatgttccagttgattgacattgcccggcagacggctcagggaatggactacttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacaacccaccggctccatcttgtggatggccccagaggtgattcgaatgcaa
gacaataacccgttcagcttccagtccgacgtctactcttacggcatcgtgctgtacgag
cttatgacgggggagctgccctactcccacatcagcaaccgcgatcagatcatcttcatg
gtaggccgagggtacgcctccccagaccttagtaagctgtacaagaactgccccaaagca
atgaagaggctggtagccgactgtgtgaagaaagttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccataccgaggacatcaatgcctgcacgctgacc
acatcccctcgattgcctgtcttctag

DBGET integrated database retrieval system