KEGG   PATHWAY: map00121
Entry
map00121                    Pathway                                

Name
Secondary bile acid biosynthesis
Description
The secondary bile acids are derived from the primary bile acids by the enzymatic action of intestinal bacteria through the process of deconjugation and dehydroxylation. The secondary bile acids in humans include deoxycholic acid and lithocholic acid, formed from the 7alpha-dehydroxylation of cholic acid and chenodeoxycholic acid, respectively.
Class
Metabolism; Lipid metabolism
Pathway map
map00121  Secondary bile acid biosynthesis
map00121

Reference
  Authors
Hofmann AF, Hagey LR
  Title
Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.
  Journal
Cell Mol Life Sci 65:2461-83 (2008)
DOI:10.1007/s00018-008-7568-6
Reference
  Authors
Ridlon JM, Kang DJ, Hylemon PB
  Title
Bile salt biotransformations by human intestinal bacteria.
  Journal
J Lipid Res 47:241-59 (2006)
DOI:10.1194/jlr.R500013-JLR200
Reference
  Authors
Ridlon JM, Kang DJ, Hylemon PB
  Title
Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271.
  Journal
Anaerobe 16:137-46 (2010)
DOI:10.1016/j.anaerobe.2009.05.004
Reference
  Authors
Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB
  Title
Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.
  Journal
Biochim Biophys Acta 1781:16-25 (2008)
DOI:10.1016/j.bbalip.2007.10.008
Reference
  Authors
Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF
  Title
A phylogenetic survey of biliary lipids in vertebrates.
  Journal
J Lipid Res 46:2221-32 (2005)
DOI:10.1194/jlr.M500178-JLR200
Related
pathway
map00120  Primary bile acid biosynthesis
KO pathway
ko00121   
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