KEGG   PATHWAY: map04112
Entry
map04112                    Pathway                                

Name
Cell cycle - Caulobacter
Description
Cell cycle progression of Caulobacter crescentus is implemented by an elaborate transcriptional regulatory network. During the life cycle, Caulobacter divides asymmetrically producing two distinct cell types with specialized development programs. The sessile stalked cell immediately initiates a new round of division cycle, whereas the motile swarmer cell remains in the G1 phase for a defined interval before differentiating into the stalked cell and entering into the S phase. The division process is centered around three master regulator proteins, DnaA, GcrA, and CtrA. DnaA and GcrA together drive the synthesis of proteins needed to complete DNA replication. CtrA controls the transcription of a diverse group of genes, which are required for essential morphological, metabolic, and cell cycle events.
Class
Cellular Processes; Cell growth and death
Pathway map
map04112  Cell cycle - Caulobacter
map04112

Other DBs
GO: 0000278
Reference
  Authors
Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams HH
  Title
Architecture and inherent robustness of a bacterial cell-cycle control system.
  Journal
Proc Natl Acad Sci U S A 105:11340-5 (2008)
DOI:10.1073/pnas.0805258105
Reference
  Authors
Curtis PD, Brun YV
  Title
Getting in the loop: regulation of development in Caulobacter crescentus.
  Journal
Microbiol Mol Biol Rev 74:13-41 (2010)
DOI:10.1128/MMBR.00040-09
Reference
  Authors
Skerker JM, Laub MT
  Title
Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus.
  Journal
Nat Rev Microbiol 2:325-37 (2004)
DOI:10.1038/nrmicro864
Reference
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
  Authors
Thanbichler M
  Title
Spatial regulation in Caulobacter crescentus.
  Journal
Curr Opin Microbiol 12:715-21 (2009)
DOI:10.1016/j.mib.2009.09.013
Reference
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
  Authors
Hengge R
  Title
Principles of c-di-GMP signalling in bacteria.
  Journal
Nat Rev Microbiol 7:263-73 (2009)
DOI:10.1038/nrmicro2109
Reference
  Authors
Goley ED, Toro E, McAdams HH, Shapiro L
  Title
Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle.
  Journal
Cold Spring Harb Symp Quant Biol 74:55-64 (2009)
DOI:10.1101/sqb.2009.74.005
Reference
  Authors
Li S, Brazhnik P, Sobral B, Tyson JJ
  Title
Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.
  Journal
PLoS Comput Biol 5:e1000463 (2009)
DOI:10.1371/journal.pcbi.1000463
Related
pathway
map02020  Two-component system
map02030  Bacterial chemotaxis
map02040  Flagellar assembly
KO pathway
ko04112   
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