KEGG   PATHWAY: map04214
Entry
map04214                    Pathway                                

Name
Apoptosis - fly
Description
Apoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organisms, playing a crucial role in removing excess unwanted cells without stimulation of an immune response. Caspases are the central components of the apoptotic response. In Drosophila, Dark promotes activation of the initiator caspase Dronc. Drosophila inhibitor of apoptosis protein 1 (DIAP1) inhibits Dronc and the effector caspases Drice and Dcp-1. RHG family proteins such as Rpr, Hid, Grim, Sickle, and Jafrac-2 promote cell death, in part by disrupting DIAP1's ability to inhibit caspase activity. Proapoptotic proteins such as caspases and RHG proteins are regulated through multiple pathways. The Drosophila steroid hormone ecdysone mediates cell death by controling the up-regulation of a number of proapoptotic genes. Cytotoxic stress such as DNA damage can activate P53, which in turn induces the expression of RHG genes. Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. Hid, a member of the RHG family, is negatively regulated by the epidermal growth factor (EGF) receptor-dependent survival signaling and positively regulated by the tumor suppressors Hippo, Salvador, and Warts.
Class
Cellular Processes; Cell growth and death
Pathway map
map04214  Apoptosis - fly
map04214

Reference
  Authors
Hay BA, Guo M
  Title
Caspase-dependent cell death in Drosophila.
  Journal
Annu Rev Cell Dev Biol 22:623-50 (2006)
DOI:10.1146/annurev.cellbio.21.012804.093845
Reference
  Authors
Hay BA, Huh JR, Guo M
  Title
The genetics of cell death: approaches, insights and opportunities in Drosophila.
  Journal
Nat Rev Genet 5:911-22 (2004)
DOI:10.1038/nrg1491
Reference
  Authors
Kumar S, Cakouros D
  Title
Transcriptional control of the core cell-death machinery.
  Journal
Trends Biochem Sci 29:193-9 (2004)
DOI:10.1016/j.tibs.2004.02.001
Reference
  Authors
Fuchs Y, Steller H
  Title
Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
  Journal
Nat Rev Mol Cell Biol 16:329-44 (2015)
DOI:10.1038/nrm3999
Reference
  Authors
Arya R, White K
  Title
Cell death in development: Signaling pathways and core mechanisms.
  Journal
Semin Cell Dev Biol 39:12-9 (2015)
DOI:10.1016/j.semcdb.2015.02.001
Reference
  Authors
Danial NN, Korsmeyer SJ
  Title
Cell death: critical control points.
  Journal
Cell 116:205-19 (2004)
DOI:10.1016/S0092-8674(04)00046-7
Reference
  Authors
Gorski S, Marra M
  Title
Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.
  Journal
Physiol Genomics 9:59-69 (2002)
DOI:10.1152/physiolgenomics.00114.2001
Reference
  Authors
Richardson H, Kumar S
  Title
Death to flies: Drosophila as a model system to study programmed cell death.
  Journal
J Immunol Methods 265:21-38 (2002)
DOI:10.1016/S0022-1759(02)00068-6
Reference
  Authors
Kuranaga E
  Title
Caspase signaling in animal development.
  Journal
Dev Growth Differ 53:137-48 (2011)
DOI:10.1111/j.1440-169X.2010.01237.x
Reference
  Authors
Bergmann A, Steller H
  Title
Apoptosis, stem cells, and tissue regeneration.
  Journal
Sci Signal 3:re8 (2010)
DOI:10.1126/scisignal.3145re8
Reference
  Authors
Riedl SJ, Shi Y
  Title
Molecular mechanisms of caspase regulation during apoptosis.
  Journal
Nat Rev Mol Cell Biol 5:897-907 (2004)
DOI:10.1038/nrm1496
Reference
  Authors
Igaki T, Miura M
  Title
Role of Bcl-2 family members in invertebrates.
  Journal
Biochim Biophys Acta 1644:73-81 (2004)
DOI:10.1016/j.bbamcr.2003.09.007
Reference
  Authors
Clavier A, Rincheval-Arnold A, Colin J, Mignotte B, Guenal I
  Title
Apoptosis in Drosophila: which role for mitochondria?
  Journal
Apoptosis 21:239-51 (2016)
DOI:10.1007/s10495-015-1209-y
Reference
  Authors
Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K
  Title
Mitochondrial involvement in cell death of non-mammalian eukaryotes.
  Journal
Biochim Biophys Acta 1813:597-607 (2011)
DOI:10.1016/j.bbamcr.2010.10.008
Reference
  Authors
Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S
  Title
The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
  Journal
Cell Death Dis 5:e1452 (2014)
DOI:10.1038/cddis.2014.403
Reference
  Authors
Kilpatrick ZE, Cakouros D, Kumar S
  Title
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.
  Journal
J Biol Chem 280:11981-6 (2005)
DOI:10.1074/jbc.M413971200
Reference
  Authors
Yu SY, Yoo SJ, Yang L, Zapata C, Srinivasan A, Hay BA, Baker NE
  Title
A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye.
  Journal
Development 129:3269-78 (2002)
Reference
  Authors
McNeill H, Downward J
  Title
Apoptosis: Ras to the rescue in the fly eye.
  Journal
Curr Biol 9:R176-9 (1999)
DOI:10.1016/S0960-9822(99)80107-9
Reference
  Authors
Narasimamurthy R, Geuking P, Ingold K, Willen L, Schneider P, Basler K
  Title
Structure-function analysis of Eiger, the Drosophila TNF homolog.
  Journal
Cell Res 19:392-4 (2009)
DOI:10.1038/cr.2009.16
Reference
  Authors
Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L
  Title
P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
  Journal
PLoS Pathog 9:e1003137 (2013)
DOI:10.1371/journal.ppat.1003137
Reference
  Authors
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M
  Title
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
  Journal
Nat Cell Biol 4:705-10 (2002)
DOI:10.1038/ncb842
Reference
  Authors
Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ
  Title
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
  Journal
PLoS One 4:e5055 (2009)
DOI:10.1371/journal.pone.0005055
Reference
  Authors
Bilak A, Su TT
  Title
Regulation of Drosophila melanogaster pro-apoptotic gene hid.
  Journal
Apoptosis 14:943-9 (2009)
DOI:10.1007/s10495-009-0374-2
Related
pathway
map04391  Hippo signaling pathway - fly
KO pathway
ko04214   
LinkDB

DBGET integrated database retrieval system