KEGG   PATHWAY: map05131
Entry
map05131                    Pathway                                

Name
Shigellosis
Description
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
map05131  Shigellosis
map05131

Module
M00363  EHEC pathogenicity signature, Shiga toxin [PATH:map05131]
Disease
H00299  Shigellosis
Reference
  Authors
Schnupf P, Sansonetti PJ
  Title
Shigella Pathogenesis: New Insights through Advanced Methodologies.
  Journal
Microbiol Spectr 7 (2019)
DOI:10.1128/microbiolspec.BAI-0023-2019
Reference
  Authors
Mattock E, Blocker AJ
  Title
How Do the Virulence Factors of Shigella Work Together to Cause Disease?
  Journal
Front Cell Infect Microbiol 7:64 (2017)
DOI:10.3389/fcimb.2017.00064
Reference
  Authors
Ashida H, Mimuro H, Sasakawa C
  Title
Shigella manipulates host immune responses by delivering effector proteins with specific roles.
  Journal
Front Immunol 6:219 (2015)
DOI:10.3389/fimmu.2015.00219
Reference
  Authors
Sasakawa C
  Title
A new paradigm of bacteria-gut interplay brought through the study of Shigella.
  Journal
Proc Jpn Acad Ser B Phys Biol Sci 86:229-43 (2010)
DOI:10.2183/pjab.86.229
Reference
  Authors
Ashida H, Kim M, Sasakawa C
  Title
Manipulation of the host cell death pathway by Shigella.
  Journal
Cell Microbiol 16:1757-66 (2014)
DOI:10.1111/cmi.12367
Reference
  Authors
Siqueira MDS, Ribeiro RM, Travassos LH
  Title
Autophagy and Its Interaction With Intracellular Bacterial Pathogens.
  Journal
Front Immunol 9:935 (2018)
DOI:10.3389/fimmu.2018.00935
Reference
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Related
pathway
map03070  Bacterial secretion system
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04140  Autophagy - animal
map04210  Apoptosis
map04510  Focal adhesion
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04810  Regulation of actin cytoskeleton
KO pathway
ko05131   
LinkDB

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