KEGG   Mus caroli (Ryukyu mouse): 110287491
Entry
110287491         CDS       T05910                                 

Gene name
Irs4
Definition
(RefSeq) insulin receptor substrate 4
  KO
K17446  insulin receptor substrate 4
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04022  cGMP-PKG signaling pathway
mcal04068  FoxO signaling pathway
mcal04140  Autophagy - animal
mcal04152  AMPK signaling pathway
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04910  Insulin signaling pathway
mcal04920  Adipocytokine signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04930  Type II diabetes mellitus
mcal04935  Growth hormone synthesis, secretion and action
mcal05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    110287491 (Irs4)
   04022 cGMP-PKG signaling pathway
    110287491 (Irs4)
   04152 AMPK signaling pathway
    110287491 (Irs4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110287491 (Irs4)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    110287491 (Irs4)
   04923 Regulation of lipolysis in adipocytes
    110287491 (Irs4)
   04920 Adipocytokine signaling pathway
    110287491 (Irs4)
   04935 Growth hormone synthesis, secretion and action
    110287491 (Irs4)
  09149 Aging
   04211 Longevity regulating pathway
    110287491 (Irs4)
   04213 Longevity regulating pathway - multiple species
    110287491 (Irs4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110287491 (Irs4)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110287491 (Irs4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:mcal04990]
    110287491 (Irs4)
Domain-containing proteins not elsewhere classified [BR:mcal04990]
 Phosphotyrosine binding (PTB) domain-containing proteins
  IRS related family proteins
   110287491 (Irs4)
SSDB
Motif
Pfam: IRS PH_11 PH_8
Other DBs
NCBI-GeneID: 110287491
NCBI-ProteinID: XP_021009754
Ensembl: MGP_CAROLIEiJ_G0033460
UniProt: A0A6P5P104
LinkDB
Position
X
AA seq 1217 aa
MASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTA
TGSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFR
HSVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAM
VAENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVV
KPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRS
TVIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRR
HLGLLPLEPGGWLRRYGLEQFCRLRAIREREEMLFTRRFISPREPPPPFRRGTGHLPRAR
RSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAREASGSSSGNTEEKDKEHEEGNRGDY
IPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSGGGQGSGGQGAGGGNQCSGNGQGT
AGGHGSGGGGHGSGGGQRPGDGHGSGGGKNSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQ
QQTLPPPPPPPPAAGATGGKGKSGGRFRLYFCADRGTKERKEAKEVRDMETPGGVPRGAY
RARAFDEDEDDPYVPMRPGVAAPLACSSDYMPMAPQNSSASTKRHSRSPFEDSRGYMMMF
PRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDYMFMAPGAGAIPKNPPNAQGGSSSKSWS
SYFSLPSPIQSSPLGQSDHSEYVPMLPGKFLGSGLHKEAPFSLGTKTVSSKPSTEASFSK
PEDKGSSAKPSDDVTPMNKAKEPNHLPFIAKESQGKAKPLNPTQEQREAASSRDYINIDF
IKRERLVLPSSAQGLPDMRGVITDPAPTAFSGYLNVEFGVPFPNPTIRLSDLLRVLPGAN
SIPLAGTRWPFPGSAIGSIVEAGEYIEVIFNPAMTPAMSFADSAICYDAQTGQIYVVDPF
SECCMDVSLSPGRCSEPPPVARLRREEAQERRRPQSRSQSLFASTGAAVSAFPTDSLDRD
FPAASAVIAAPAEAPLLAVSRALAVVSALAAAPSIGDVFAGFRAAAGVDSASARGFQPVA
GAQAVREFQDLAAGWNPGALNHEARGEDLAAGAAAPPPPPRQIWVLRPQERADSEDDDDD
DDDIYVRMDFARRDYRK
NT seq 3654 nt   +upstreamnt  +downstreamnt
atggcgagttgctccttctctggccaccaagcgcttaggagactgagagcctcagcagca
gcagcagcctccgcagctctagcagcagtggcgaccaccccgctcctttcctcgggaacc
cggaccgcactcattgggaccgggtcgtcctgtccgggagccatgtggctctccacagcc
actggctcccggtcagactcggaatccgaagaggaggacctccccgtcggggatgaagtc
tgcaaacgcggctacctgaggaagcagaagcatgggcataggcgttacttcgtgctcaaa
ctcgagaccgcagacgctccagctcgactcgaatactaccgaaatgccaggaagttccgg
cacagtgtccgcgccgcggcggctgcagcagaggcggccgcctccggtgctgcggtcccc
gcgctcatcccaccgcggcgcgtgatcatcctgtaccaatgcttctccgtgagccagcgc
gccgatgccaggtaccgacacctcattgccctttttacccaggacgaatacttcgcgatg
gtggccgagaacgagtcggaacaagaaagctggtacttgctcctcagccgcctcatcctc
gagagcaagcgccgccgctgcggcacgctaggcgcactgccggacggagagccggcagcc
ctggcggccgcagcggcggcggagccacccttctacaaagatgtgtggcaggtagtagtg
aaacccagggggctggggcacagaaaagagctgagcggcgtgttccggctgtgtcttacc
gacgaagaggtagtgtttgtaaggctcaataccgaagtggccagtgtggtcgtccagctg
ctgagcattcgtcgctgtgggcactcggagcagtacttcttcttggaagtcggcagatcc
actgtcataggtccgggggagctgtggatgcaagtggatgactccgtggtggcccaaaat
atgcatgagttgtttctggagaagatgagagccttgtgcgcagatgaatacagagcccga
tgccgcagctacagcatcagtattggcgcccacctgttaaccctgctgtccactaggagg
cacctgggcttgctcccgctggagcctggtggctggctcagaagatacggcttggagcag
ttttgccgcctcagagctatccgtgagagggaagagatgctattcaccaggcgcttcatc
tcacccagagagcctccgcctccctttaggcgaggaacagggcacctgcccagagcccgc
aggtccaggagagccgcgtcagtaccacccagccttttccgacgctctgcacctagcccg
ggacggatcccacagcctgaagatgttcccaacgacagagcccgtgaagcctccggttcc
agttctggcaacactgaagaaaaagacaaggagcatgaggaaggaaaccgaggtgattac
atacctatgaacaactggggctcaggaaatggccggggctcaggagggggacggggctca
agtggccaaggttccagtagccagggctcaggtgggagacagggatctggaggtggccag
ggctcaggaggccagggtgccggaggaggaaaccagtgttcaggaaatggccagggcaca
gcaggtggccatggctcaggtggaggtggccatggctcaggcggtggccagagacctgga
gatggtcatggctcaggtggtggcaagaactcaggaagtgggaaaaattctgacgatggt
gaccgtggaaaatctgtgaagaaaagatcctactttggtaaattcactcaaagcaagcag
cagcaaacactgcctccacccccaccgccaccgccagcagctggagcaactggtggcaaa
gggaagtctgggggaagattccgactttatttttgcgcagacagaggcacaaaagaacgc
aaagaagccaaagaggtgagagatatggagaccccaggaggtgttccccggggggcttac
agagccagagctttcgatgaagatgaggatgacccgtatgtgccaatgagaccaggggtg
gctgctcctcttgcgtgttccagtgattatatgccaatggctcctcaaaattcctctgct
tcaacaaagcgccactctcggtcaccctttgaagactccagggggtacatgatgatgttt
cccagagtgagccccccaccacctgtgccaagtgctccgaaagcaccggacaccaataaa
ggggatgactcaaaggacaatgacagtgacagtgattacatgtttatggctcccggagca
ggtgcgattcctaaaaatcctcccaatgcgcagggaggctcttcctccaaaagctggagc
tcttatttctctctgccaagtcctattcagagttcacctttgggacagagtgaccacagt
gagtatgttcctatgttacctgggaaattcctggggagcggtctacacaaagaagccccc
tttagcctgggcaccaaaactgtgtcttcaaagccttcaactgaggcgtcattctcaaaa
cctgaagataaggggtcatctgcaaagccttcagatgatgtgaccccaatgaacaaggct
aaggaacctaaccaccttccttttattgcaaaagaaagtcaaggaaaggccaaaccgcta
aaccccacacaggagcagagagaagctgctagctcccgtgactatatcaacattgacttt
attaagagagagcgccttgtgctaccttcctctgctcaaggactgccagacatgcggggc
gtaattactgaccccgcacccacagctttttctggctacctgaatgttgaattcggggtg
cccttcccaaatccaacaatccgcctctcagatcttttaagagttctaccaggtgccaac
tccatccctctggccggtactaggtggcccttcccaggcagtgctataggtagcattgtg
gaagcgggagaatacattgaagttattttcaacccggctatgacaccagccatgtctttt
gctgacagtgccatttgctatgatgctcaaacaggtcaaatctatgtcgtcgacccattt
tctgagtgctgtatggacgtttctctctctcctggtcgatgctctgaaccgccacctgta
gctaggctgcggcgggaggaagctcaggagagaagacgcccacaaagccgctcccaaagt
ttatttgccagcactggagccgctgtctcggctttcccgactgacagcttggacagagac
tttcccgccgcttctgcggtgattgctgcaccagctgaggcgcctctcttggcagtgagc
cgggctttagccgtggtctctgcgctcgcagcggcccccagcattggcgacgtctttgca
ggcttccgcgctgcggcaggagttgactccgcctccgctcgcgggttccaacctgttgcg
ggtgcccaggctgtaagagaattccaggaccttgcggcaggctggaatcctggagccctt
aaccacgaggcccgaggtgaggacctggccgccggcgcagcggctcccccgccgccacct
cgccagatttgggtgctgagaccccaagagagagcggattctgaggacgacgacgatgat
gacgacgacatttacgtgagaatggactttgccagacgagactacaggaagtga

KEGG   Mus caroli (Ryukyu mouse): 110292727
Entry
110292727         CDS       T05910                                 

Gene name
Irs1
Definition
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04022  cGMP-PKG signaling pathway
mcal04068  FoxO signaling pathway
mcal04140  Autophagy - animal
mcal04150  mTOR signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04152  AMPK signaling pathway
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04722  Neurotrophin signaling pathway
mcal04910  Insulin signaling pathway
mcal04920  Adipocytokine signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04930  Type II diabetes mellitus
mcal04931  Insulin resistance
mcal04932  Non-alcoholic fatty liver disease
mcal04935  Growth hormone synthesis, secretion and action
mcal04960  Aldosterone-regulated sodium reabsorption
mcal05010  Alzheimer disease
mcal05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    110292727 (Irs1)
   04022 cGMP-PKG signaling pathway
    110292727 (Irs1)
   04151 PI3K-Akt signaling pathway
    110292727 (Irs1)
   04152 AMPK signaling pathway
    110292727 (Irs1)
   04150 mTOR signaling pathway
    110292727 (Irs1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110292727 (Irs1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    110292727 (Irs1)
   04923 Regulation of lipolysis in adipocytes
    110292727 (Irs1)
   04920 Adipocytokine signaling pathway
    110292727 (Irs1)
   04935 Growth hormone synthesis, secretion and action
    110292727 (Irs1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110292727 (Irs1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    110292727 (Irs1)
  09149 Aging
   04211 Longevity regulating pathway
    110292727 (Irs1)
   04213 Longevity regulating pathway - multiple species
    110292727 (Irs1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    110292727 (Irs1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110292727 (Irs1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110292727 (Irs1)
   04932 Non-alcoholic fatty liver disease
    110292727 (Irs1)
   04931 Insulin resistance
    110292727 (Irs1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:mcal04990]
    110292727 (Irs1)
Domain-containing proteins not elsewhere classified [BR:mcal04990]
 Phosphotyrosine binding (PTB) domain-containing proteins
  IRS related family proteins
   110292727 (Irs1)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 110292727
NCBI-ProteinID: XP_021015916
Ensembl: MGP_CAROLIEiJ_G0014324
UniProt: A0A6P5PKI9
LinkDB
Position
1
AA seq 1230 aa
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH
HDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRL
CLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVV
AQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRT
ESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRL
HPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGF
ISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYIL
SRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSV
ASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTS
NLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMM
MSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKL
LPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGAR
HQHLRLSSSSGRLRYTTTAEDSSSSTSSDSLGGGYCGARPESNLTHPHHHVLQPHLPRKV
DTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQ
PGYLAGPATSRSSPSVRCPPPLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIG
PAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASL
PRPTGAAPPPSSTASSSVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAK
VIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGSEDVKRHSSASFENV
WLRPGDVGGVSKESAPVCGAAGGLEKSLNYIDLDLAKERSQDCPSQQQSLPPPPPHQPLG
SNEGNSPRRSSEDLSNYASISFQKQPEDHQ
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcaagccctccggataccgatggcttctcagacgtgcgcaaggtgggctacctgcgc
aaacccaagagtatgcataagcgctttttcgtgctgcgggcggccagcgaggccgggggc
ccagcgcgcctggagtattatgagaatgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaac
aagcatctggtggctctctacacccgagacgaacactttgccattgcggcggatagcgag
gctgagcaagacagctggtaccaggctcttctgcagctgcataatcgggcaaaggcccac
catgacggggctggaggaggctgcggtggtagctgcagcggcagctctggcgttggagag
gcaggagaggacttgagctatgacacgggtccaggacccgcgttcaaggaggtctggcag
gttatcctgaaacccaagggcctgggtcagacaaagaacctgattggcatctaccgcctc
tgcctgaccagcaagaccatcagctttgtgaagctgaactccgaggcagccgctgtggtg
ctgcagctgatgaacatcagacgctgtggccactcagagaacttcttcttcatcgaggtg
gggcgttccgctgtgacagggcctggcgaattctggatgcaagtggatgactccgtggtg
gcccagaacatgcatgagaccattctagaggccatgcgggccatgagcgatgagtttcgc
cctcgcagcaaaagccagtcttcatccagttgctccaatcccatcagcgttcccctgcgc
aggcaccatctcaacaaccctccacccagccaggtgggactgactcggagatctcgaact
gagagcatcactgccacctcccctgccagtatggtgggtgggaaaccaggttccttccgg
gtgcgtgcctccagcgatggcgaaggcaccatgtcccgtccagcatcagtggatggcagt
cctgtgagccctagcaccaacaggacccacgcccatcggcatcgaggcagctccaggctg
caccccccactcaaccacagccgctccatccccatgccttcttcgcgatgctcaccttca
gccaccagcccagtgagtctgtcatctagtagtaccagtggccatggctccacttcagac
tgtctcttcccaaggcgctctagtgcttccgtgtccggttcgcctagcgatggcggtttc
atctcttctgatgagtatggttctagtccctgcgatttccgaagttccttccgcagtgtc
accccagattccctggggcacaccccaccagccaggggtgaggaggagctgagcaattat
atctgcatgggtggcaagggagcctccaccttggctgctcccaatggccactacattttg
tccaggggtggcaacggccatcgctacatcccaggtgctaacttggggacaagcccagcg
ctgcctggagatgaagccgcgggtgcagcagatctggataaccggtttcgaaagagaact
cactccgcaggcacatctcctaccatttcccatcagaagaccccctcacagtcttcagtg
gcttctattgaggaatatacagagatgatgcccgctgcctacccaccaggaggtggcagt
ggaggccgactgcccggctaccggcattccgccttcgtgcccacccactcctatcccgaa
gagggtctagagatgcaccacttggaacgtcgtggaggccaccaccgtccagacacctcc
aacctccacactgatgatggctacatgcccatgtctcctggggtggctccagtgcccagc
aaccgcaaaggaaatggggactatatgcccatgagccccaagagtgtatctgccccacag
cagatcattaaccccatcagacgccacccacagagagtggaccccaatggctacatgatg
atgtcacccagtggtagttgctcccctgacattggaggtgggtccagcagcagtagcagc
atcagtgcagccccttctgggagcagctatgggaagccatggacaaatggagtagggggg
caccatactcatgcccttcctcatgccaaacctcctgttgagagtggtggcggtaagctc
ttgccttgcacaggtgactacatgaacatgtccccagtgggagattccaacaccagcagc
ccctcagaatgctactatggcccagaagatccccagcacaagccggtcctctcttactac
tcattgccaaggtcctttaagcacacccagcgccctggagagccagaggagggtgccagg
caccagcatcttcgtctctcttctagctctggacgccttcgctataccacaactgccgaa
gattcctcctcttctaccagcagcgacagtctgggtgggggttactgtggggctaggcca
gagtctaacctcacacatccccaccaccatgtcttgcagccccacctgcctcgaaaggta
gacacagctgcacagaccaacagccgcctggctcgacccacaaggctgtccttgggggat
cccaaggcaagcaccttaccccgggttcgagagcagcaacagcagcaacagtcttccctg
caccctcccgagcccaaaagcccaggagaatatgtgaatattgaattcgggagcggccag
cctggctatttagctggccctgcaacttcccgtagctctccttcagttcgatgtccaccc
ccgctccacccagctcctagagaagagactggctcggaagagtacatgaacatggacttg
gggccaggccggagggcaacctggcaggagagtggtggagttgagttgggcagaataggc
cctgcacctccagggtctgctacggtttgcaggccaacccgttcggtgccaaatagccgt
ggtgactacatgaccatgcagataggttgtcctcgtcaaagctatgtggatacctctcca
gtggccccagtcagctatgctgacatgcggacaggcattgctgcagagaaggcgagcctg
cctagacccacaggagctgctcctcctccatcctccacagcctcttcttctgttacacct
caaggagccaccgctgagcaagctactcactcttccttgctgggaggccctcagggacct
gggggcatgagtgcattcaccagggtgaacctcagtcccaaccataaccagagtgccaaa
gtgattcgcgcagacactcaagggtgccggaggaggcatagctctgagaccttctcagca
cctactcgggctggcaatacggtgccctttggagcaggggctgcagtagggggcagcggt
ggtggtggtggcggcagtgaggatgtaaaacgccacagctctgcatcctttgagaatgtg
tggctgagacctggggatgtagggggagtctccaaggagtcggctccagtgtgtggggct
gctgggggtttggagaagagtcttaactacatagacctggatttggccaaggagcgctct
caggactgcccctctcaacagcagtccctaccaccccctccccctcaccagcccttaggc
agcaatgagggcaactccccaagacgctccagtgaggatttaagcaactatgccagcatc
agcttccagaagcagccagaggatcatcaatag

KEGG   Mus caroli (Ryukyu mouse): 110293997
Entry
110293997         CDS       T05910                                 

Definition
(RefSeq) insulin receptor substrate 1-like
  KO
K17445  insulin receptor substrate 3
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04022  cGMP-PKG signaling pathway
mcal04068  FoxO signaling pathway
mcal04140  Autophagy - animal
mcal04152  AMPK signaling pathway
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04910  Insulin signaling pathway
mcal04920  Adipocytokine signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04930  Type II diabetes mellitus
mcal04935  Growth hormone synthesis, secretion and action
mcal05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    110293997
   04022 cGMP-PKG signaling pathway
    110293997
   04152 AMPK signaling pathway
    110293997
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110293997
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    110293997
   04923 Regulation of lipolysis in adipocytes
    110293997
   04920 Adipocytokine signaling pathway
    110293997
   04935 Growth hormone synthesis, secretion and action
    110293997
  09149 Aging
   04211 Longevity regulating pathway
    110293997
   04213 Longevity regulating pathway - multiple species
    110293997
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110293997
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110293997
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:mcal04990]
    110293997
Domain-containing proteins not elsewhere classified [BR:mcal04990]
 Phosphotyrosine binding (PTB) domain-containing proteins
  IRS related family proteins
   110293997
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 110293997
NCBI-ProteinID: XP_021017589
Ensembl: MGP_CAROLIEiJ_G0027887
UniProt: A0A6P5PN45
LinkDB
Position
5
AA seq 494 aa
MKPAGTGPTVSSGGESTDMSLGSPFPWPCPPDVRLCGHLRKQKSQRRRFFVLRADPPRLE
CYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAE
QQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAQGLSS
GSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAP
IGPGELWLQAPDAVVAQSIHETVLAAMKRLGSNAAGKAEPPQGNSPKSVPAAPTPTPYEI
PASAAQARSPSDQAKQDYFKPLERMGSTHSYKGLDLGGNYITMGVRNDYVHMGGGEAGDY
MWMAPPGLPPTPARADPNKQLEDCESTEYVPMNRFLPGPFYYELKARESDLGHPGAHCSL
RDRWRPTVAQPRCSQGSELSGDYMSIPDYVGTDSARLGSLDSCLNYVDLDLVPPLEVSGA
APGKNPHSYASIKF
NT seq 1485 nt   +upstreamnt  +downstreamnt
atgaagcctgcaggtacgggccccacagtctcctccgggggcgagtccaccgacatgtcc
ctcggctcaccgtttccttggccctgcccgcccgacgtgcggctctgtggccatctgagg
aagcagaagtcccagcgccgccgctttttcgtgctgcgcgctgacccaccacgcctggag
tgctacgagagcgagaagaagttcttggccagcggctgccgcccacctagaccccggcgt
accgttagcctggagggtgcctgcactattagcaagcgcgcagatgcccgtcagcgccac
ctgatcgtcatctataccagcgacagcagcctgggcgtggcggcggccagcgaagcagag
cagcaagcatggtacagcgccctgctcgaggtgcgcgccaccgccgcagcagctgctgct
actgctatgggtttcagtccccaagaggcccctgagtcttggatcttcgccccattccag
gacgtctggcctgtgacactgcggtccaaggggctggggagagcacaaggcctgagcagc
ggcagctatcgcctgtgcctgggttctggggccctgagccttctgcgaaagccaggaagc
aaaggttccagagacagccgggcaacaccaccaccagtcctgcgcttgtccttgctcagt
gtgcgccgctgcggccacgcagactcttttttcttcctggaactcgggcgctcagcgccc
attggtcctggtgagctatggctgcaggcccctgatgcagtggtggcccaaagcattcac
gagacagtcctggctgccatgaagcggctagggagcaatgcagctggcaaagctgagcca
ccacagggaaattctccaaagagtgttcctgcagctcctaccccgacaccatatgaaatc
cctgcatcggcagcacaagcaagaagccccagtgatcaagcaaagcaggactacttcaag
cccctggaaaggatggggtcaacacactcctacaagggactagatctgggcgggaactac
atcaccatgggagtcaggaatgactatgtccacatggggggaggagaagcaggtgactat
atgtggatggcgcccccaggccttcctcccacccctgccagggcagatcctaataagcag
cttgaggattgtgagagcacagagtatgtacccatgaatagatttttacccgggcctttt
tactacgagctcaaggccagggagtctgatcttgggcatccgggtgcccactgtagtctg
agagacagatggagacccacagtggctcagccccgctgttcccaagggtcagagctctct
ggggactacatgtccatccctgactacgtaggaacggacagtgctaggctggggtctctg
gacagctgcctcaactatgtggacctggacctggtccctcccctggaggtttctggagca
gccccagggaagaatccacatagctatgccagcatcaagttctag

KEGG   Mus caroli (Ryukyu mouse): 110300614
Entry
110300614         CDS       T05910                                 

Gene name
Irs2
Definition
(RefSeq) insulin receptor substrate 2
  KO
K07187  insulin receptor substrate 2
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04022  cGMP-PKG signaling pathway
mcal04068  FoxO signaling pathway
mcal04140  Autophagy - animal
mcal04152  AMPK signaling pathway
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04910  Insulin signaling pathway
mcal04920  Adipocytokine signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04930  Type II diabetes mellitus
mcal04931  Insulin resistance
mcal04932  Non-alcoholic fatty liver disease
mcal04935  Growth hormone synthesis, secretion and action
mcal05010  Alzheimer disease
mcal05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    110300614 (Irs2)
   04022 cGMP-PKG signaling pathway
    110300614 (Irs2)
   04152 AMPK signaling pathway
    110300614 (Irs2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110300614 (Irs2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    110300614 (Irs2)
   04923 Regulation of lipolysis in adipocytes
    110300614 (Irs2)
   04920 Adipocytokine signaling pathway
    110300614 (Irs2)
   04935 Growth hormone synthesis, secretion and action
    110300614 (Irs2)
  09149 Aging
   04211 Longevity regulating pathway
    110300614 (Irs2)
   04213 Longevity regulating pathway - multiple species
    110300614 (Irs2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    110300614 (Irs2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110300614 (Irs2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110300614 (Irs2)
   04932 Non-alcoholic fatty liver disease
    110300614 (Irs2)
   04931 Insulin resistance
    110300614 (Irs2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:mcal04990]
    110300614 (Irs2)
Domain-containing proteins not elsewhere classified [BR:mcal04990]
 Phosphotyrosine binding (PTB) domain-containing proteins
  IRS related family proteins
   110300614 (Irs2)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 110300614
NCBI-ProteinID: XP_021026522
Ensembl: MGP_CAROLIEiJ_G0030813
UniProt: A0A6P5Q9L7
LinkDB
Position
8
AA seq 1324 aa
MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA
SAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDN
YGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLM
NIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPR
SKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRT
ASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGG
ALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSS
GSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMS
MDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRAT
FSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRS
GGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYK
ASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALR
GGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGT
FGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYP
LPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD
SRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSL
QQPLPPAPGELYRLPPASPATSQGPTVGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPP
KPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSET
FSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAV
PPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQ
HPQPGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEAT
VVKE
NT seq 3975 nt   +upstreamnt  +downstreamnt
atggctagcgcgcccctgcctgggccccccgcatcggcgggcggggacggcccgaacctc
aataacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag
aagcacggccacaagcgctttttcgtgctgcgcggccccggcacgggcggcgacgaggca
tccgcggctggggggtcgccgccgcagcctccgcggctggagtactacgagagcgagaag
aagtggaggagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgtctgaac
atcaacaagcgtgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag
tacttcgctgtagcggcggagaacgagcaggagcaggagggctggtaccgcgcactcacc
gacttggtcagcgaaggccgctctggcgaggggggctcgggcaccaccggcggctcttgc
agcgcctctctcccgggagtcctgggcggctcagcgggcgccgctggctgcgatgacaac
tacgggctcgtgacacccgccacggccgtctaccgcgaggtgtggcaggtgaacctgaaa
cctaagggactgggccagagcaagaacctgactggtgtataccgcctatgcctgtctgcg
cgcaccatcggcttcgtgaagctcaattgcgaacagccgtcggtgacgctgcagcttatg
aacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgttcggcc
gtcaccggtcccggggagttgtggatgcaagccgacgactcggtggtggcgcagaacatc
catgagaccatcctggaggctatgaaggcactcaaagagctcttcgagttccggcctcgc
agcaagagtcagtcgtccgggtcgtcagccacgcatcccatcagcgtgccgggcgcgcgc
cgccaccaccacctagtcaacctaccccctagccagaccggcctggtgcgtcgctcgcgc
actgacagcctggctgccacccccccagcagccaagtgcacttcgtgccgggttcgtacg
gccagcgagggcgacggcggcgcggcaggcggggccgggacggcaggaggcaggccgatg
tcggtggcagggagccccctgagtcccgggccggtgcgcgcgccccttagccgctcgcac
accctgagcgccggctgcggaggccgcccgagcaaagtgactctggcgccggcaggggga
gccctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgcctgcagccacc
agccctggcagcctgtcctccagcagtgggcacggctcgggctcctacccgctgcctcct
ggctcccacccgcacctgcctcatccactgcatcacccccaaggccagcgtccgtccagc
ggtagtgcctccgcctcgggctcccccagcgacccgggtttcatgtcccttgacgagtat
ggctccagccctggcgacctgagagccttcagtagccacaggagcaacacacccgagtca
atcgcggagaccccgccagccagagatggcagtgggggcgaactctatgggtacatgagc
atggatagacccctgagccactgtggccgcccttaccgtagggtctcaggggatggggcc
caggacctggatagaggactgaggaagaggacttactccctaaccacgcctgccaggcag
cggcaggtacctcagccttcctctgcctctctagatgaatacactctcatgagggccacc
ttctctggcagttcaggtcgcctctgcccatccttccctgcgtcctctcccaaagtggcc
tacaacccttacccagaggactatggagacattgagattggttctcacaagagttccagc
agtaacctgggagcagatgatggctacatgcccatgacccctggggcagcccttaggagt
ggtggtcccaatagctgcaagagcgatgactacatgcccatgagccccaccagcgtgtct
gctcccaaacagattctgcagccacgcttggcagcggccttgcccccttccggagcagcc
gtgccagcacccccttcaggggtgggcaggaccttcccagtaaacggaggtggctacaaa
gccagctccccagcggagagctccccagaagatagtgggtacatgcgaatgtggtgtggc
tccaagctgtctatggagaacccagaccctaagctactccccaacggggactacctcaac
atgtcccccagcgaggcaggcactgcagggaccccacctgacttctcagcagctttgcgt
ggaggcagtgaaggcctcaaaggcatccccggccactgctacagctctttgccccgctct
tataaggctccctgttcctgcagcggagacaatgaccagtatgtgctcatgagctcccct
gtgggccggatcttggaagaggagagactggagccccaggccaccccaggggctggcacc
tttggggcagctggtggtagtcatacccagcctcatcactcagcagtgccttcctccatg
aggccgagtgccatcggtggccgccctgagggcttcctgggccagcgctgtcgggcagtg
cggcccacacgcctatcactagagggactgcagacccttcccagcatgcaagagtaccct
ctacccacagagcccaagagccctggcgagtatatcaacattgactttggtgaggcaggt
acccgtctgtctccgcctgcccccccactactggcatccgcagcctcatcttcttcactg
ctctcagccagtagtcctgcttcatccctgggttcaggtaccccaggcaccagcagcgac
agccggcagcgctctccactctctgactatatgaacctggacttcagttctcccaagtcc
cctaagcctagcacccgcagtggggacacagtaggctccatggatggccttctctctcca
gaggcttcatccccatacccaccactgcctccacgtccttccacttccccttcctcctta
cagcagcctctgccacctgccccgggagaactataccgcctgcctccagcatcacctgcc
acttcccagggtcccactgttggctcctcaatgtcctctgagcctggggataatggtgac
tataccgagatggcctttggtgtggctgcaaccccgcctcaacctatcgtggcaccccca
aagccagaaggtgcccgagtggccagtcccacttcgggcttgaagcggctaagtctcatg
gatcaggtatccggggtggaggccttccttcaagtcagccagccccctgacccccaccgg
ggtgctaaggtcatccgtgcagacccacaggggggacgtcgtcgccacagttcagagacc
ttttcctctaccaccaccgtcaccccagtgtccccatcctttgcccacaattccaagcgc
cacaattcggcctctgtggaaaatgtctcactcaggaaaagcagtgaaggcagcagcacc
ctgggaggaggtgatgagccacccacatccccaggacaggcacagcccttggtggctgtg
cccccagtgccacaggctaggccgtggaatccaggtcagcccggagctttgattggctgt
cctggaggcagcagttctcccatgcgcagagagacctccgtgggtttccagaacggcctc
aactatatcgccatcgatgtgagaggtgagcaggggtccttggcgcagtctcagccgcag
catccgcagccaggagacaagaactcctggagccggacccgtagccttggggggctcctc
ggcaccgtcggaggctctggcgccagcggagtgtgtgggggtccaggcactggagctttg
ccctctgccagcacctatgcaagcatcgacttcctgtcccatcacttgaaggaagccaca
gtcgtgaaagagtga

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