KEGG   Mus caroli (Ryukyu mouse): 110295755
Entry
110295755         CDS       T05910                                 

Gene name
Cacna1c
Definition
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1C
  KO
K04850  voltage-dependent calcium channel L type alpha-1C
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04010  MAPK signaling pathway
mcal04020  Calcium signaling pathway
mcal04022  cGMP-PKG signaling pathway
mcal04024  cAMP signaling pathway
mcal04260  Cardiac muscle contraction
mcal04261  Adrenergic signaling in cardiomyocytes
mcal04270  Vascular smooth muscle contraction
mcal04713  Circadian entrainment
mcal04720  Long-term potentiation
mcal04723  Retrograde endocannabinoid signaling
mcal04724  Glutamatergic synapse
mcal04725  Cholinergic synapse
mcal04726  Serotonergic synapse
mcal04727  GABAergic synapse
mcal04728  Dopaminergic synapse
mcal04742  Taste transduction
mcal04911  Insulin secretion
mcal04912  GnRH signaling pathway
mcal04921  Oxytocin signaling pathway
mcal04924  Renin secretion
mcal04925  Aldosterone synthesis and secretion
mcal04927  Cortisol synthesis and secretion
mcal04929  GnRH secretion
mcal04930  Type II diabetes mellitus
mcal04934  Cushing syndrome
mcal04935  Growth hormone synthesis, secretion and action
mcal05010  Alzheimer disease
mcal05020  Prion disease
mcal05022  Pathways of neurodegeneration - multiple diseases
mcal05031  Amphetamine addiction
mcal05410  Hypertrophic cardiomyopathy
mcal05412  Arrhythmogenic right ventricular cardiomyopathy
mcal05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110295755 (Cacna1c)
   04020 Calcium signaling pathway
    110295755 (Cacna1c)
   04024 cAMP signaling pathway
    110295755 (Cacna1c)
   04022 cGMP-PKG signaling pathway
    110295755 (Cacna1c)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    110295755 (Cacna1c)
   04929 GnRH secretion
    110295755 (Cacna1c)
   04912 GnRH signaling pathway
    110295755 (Cacna1c)
   04921 Oxytocin signaling pathway
    110295755 (Cacna1c)
   04935 Growth hormone synthesis, secretion and action
    110295755 (Cacna1c)
   04924 Renin secretion
    110295755 (Cacna1c)
   04925 Aldosterone synthesis and secretion
    110295755 (Cacna1c)
   04927 Cortisol synthesis and secretion
    110295755 (Cacna1c)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    110295755 (Cacna1c)
   04261 Adrenergic signaling in cardiomyocytes
    110295755 (Cacna1c)
   04270 Vascular smooth muscle contraction
    110295755 (Cacna1c)
  09156 Nervous system
   04724 Glutamatergic synapse
    110295755 (Cacna1c)
   04727 GABAergic synapse
    110295755 (Cacna1c)
   04725 Cholinergic synapse
    110295755 (Cacna1c)
   04728 Dopaminergic synapse
    110295755 (Cacna1c)
   04726 Serotonergic synapse
    110295755 (Cacna1c)
   04720 Long-term potentiation
    110295755 (Cacna1c)
   04723 Retrograde endocannabinoid signaling
    110295755 (Cacna1c)
  09157 Sensory system
   04742 Taste transduction
    110295755 (Cacna1c)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110295755 (Cacna1c)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110295755 (Cacna1c)
   05020 Prion disease
    110295755 (Cacna1c)
   05022 Pathways of neurodegeneration - multiple diseases
    110295755 (Cacna1c)
  09165 Substance dependence
   05031 Amphetamine addiction
    110295755 (Cacna1c)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    110295755 (Cacna1c)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    110295755 (Cacna1c)
   05414 Dilated cardiomyopathy
    110295755 (Cacna1c)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110295755 (Cacna1c)
   04934 Cushing syndrome
    110295755 (Cacna1c)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:mcal04040]
    110295755 (Cacna1c)
Ion channels [BR:mcal04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   110295755 (Cacna1c)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH Etmic-2 PKD_channel DUF4834
Other DBs
NCBI-GeneID: 110295755
NCBI-ProteinID: XP_021019807
Ensembl: MGP_CAROLIEiJ_G0028788
LinkDB
Position
6
AA seq 2093 aa
MIRAFVQPSTPPYQPLSSHTSEETERKFKGKVVHEAQLNCFYISPGGSNYGSPRPAHANM
NANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPK
KQGGTTATRPPRALLCLTLKNPIRRACISIVEWKSFEIIILLTIFANCVALAIYIPFPED
DSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSA
ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLH
IALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGT
VCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVI
FGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAANHGLSVFRSLMDCRM
RLQGSDAADTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVET
KIMSPLGISVLRCVRLLRIFKITRYAHSYTNLLCEIPIINTLLAIGNLLLLLFLFIIIFS
LLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPG
MLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEK
KQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPREEDEEEPEMPVGPRPRP
LSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED
PVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSL
ISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQF
MFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNV
LAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIF
VGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYF
EYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSD
PWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLS
RGEGIRTLLWTFIKSFQEXRGKEGTTFLXTGERVDYSTIISNTEVAFSNLPSLAQELWLS
DAQFLLVIPPERCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISF
YMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVT
LLRRIXPPXGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLE
QANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL
VGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRA
GGLFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYS
STGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLNSKRCHSR
ESQGATVSQEMFPDETRSVRMSEEAEYCSEPSLLSTDMLSYQEDEHRQLTCPEEDKREIQ
PSPKRSFLRSASLGKLTPRFAALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLR
PIPTLRLEGAESSEKLNSSXPSIHCSSWSEETTACSGXSSMARRARPVSLTVPSQAGAPG
RQFHGSASSLVEAVLISEGLGQFAQDPKFIXVTTQELADACDMTIEEMENAADNILSGGA
QQSPNGTLLPFVNCRDPGQDRAVVPEDESCAYALGRGRSEEALADSRSYVSNL
NT seq 6282 nt   +upstreamnt  +downstreamnt
atgattcgggccttcgttcagccatccacacccccataccagccnctctccagtcacacg
tctgaggaaacagagaggaagttcaagggcaaggtggtacatgaagctcaactcaactgt
ttctacatttctcctggaggttccaactatgggagcccacgcccagctcatgccaacatg
aatgccaatgcagctgcaggacttgctcccgagcacatccctactccaggggcagcactg
tcctggcaggcagccatcgatgccgcccggcaggccaagctcatgggcagtgctggcaac
gcaaccatctctaccgtcagttccacacagcggaagcggcagcagtatgggaaacccaag
aagcaggggggcacaacagccacacggccgccccgggctctgctctgcctgactctgaag
aaccctatccggagggcgtgcataagcattgttgaatggaaatcatttgaaatcattatt
ttactgactatttttgccaattgtgtggccttagcaatctatattccctttccggaagac
gactccaacgccaccaactccaacctggaacgagtggagtatctcttcctcatcattttt
accgtggaagcatttttaaaagtaattgcctacggacttctcttccaccccaacgcatac
ctccgcaacggttggaatttactggattttataattgtggttgtagggctttttagtgca
attttagaacaagcaaccaaagctgatggggccaatgctctaggagggaaaggagctgga
tttgacgtgaaggcactgagagcattccgcgtgctccgtcccctgcgactggtgtccgga
gtcccaagtctccaggtggtcctgaactccatcatcaaggccatggtgcctctgctgcac
atcgctcttcttgtgctcttcgtcatcatcatttatgctattatcggcctggagctcttc
atgggaaagatgcacaagacctgctacaaccaggagggcataatagatgttccagcagaa
gaggacccttccccttgtgctttggagacaggccatgggcgacagtgtcagaacgggacc
gtgtgcaaacctgggtgggatgggcccaagcacggcatcaccaacttcgacaacttcgcc
ttcgccatgctgacggtgttccagtgtatcaccatggagggctggacagacgtgctgtac
tggatgcaagacgctatgggctatgagttgccctgggtgtattttgtcagtctggtcatc
tttggatcctttttcgttctaaatctggttctcggtgttttgagcggggagttttccaaa
gagagggagaaagccaaagcccgaggagatttccagaagcttcgagagaaacagcagcta
gaagaagatctcaaaggctacctggactggatcacccaggcagaagacattgaccctgag
aacgaggacgagggcatggatgaagacaagcctcgaaacatgagcatgcccacaagtgag
actgagtctgtcaacactgaaaacgtggctggaggtgacatcgagggagaaaactgtgga
gccaggcttgccgccaatcacggtctatcagtgttccgttcacttatggactgcagaatg
aggttgcaggggtctgatgctgcagacacagccaataaagccctcctggcccttttcact
gcagaaatgctcctgaagatgtacagcctgggtctgcaggcctattttgtgtccctcttc
aaccgctttgactgtttcattgtgtgtgggggcatcctggagaccatcctggtggagacg
aagatcatgtctcccctgggcatctctgtgctgagatgtgtgcggttgctcaggatcttc
aagatcaccaggtatgcacactcatacacaaacttactgtgtgaaattccgattataaac
actctcctagcgataggcaacttgctgctgctcctcttcctcttcatcatcatcttctcc
ctcctggggatgcagctctttggagggaagttcaacttcgatgagatgcagacccgtagg
agcacgttcgataacttcccgcagtctctcctcactgtgtttcagatcctgaccggggag
gactggaattcggtgatgtatgatgggatcatggcttatggcggcccctcttttccaggg
atgttagtctgtatttacttcatcatcctcttcatctgtggaaattatatcctactgaat
gtgttcttggccattgcggtggacaacctggctgatgcggagagcctgacctcagcccaa
aaggaggaggaagaagagaaggagaggaagaagctggccaggactgccagcccagaaaag
aaacaggaggtgatggagaagccagccgtggaggaaagcaaagaggagaaaattgaactg
aagtccattacagcagatggagaatccccacccactaccaagatcaacatggatgacctc
cagcccagggaagaggatgaagaggagccagagatgcctgtggggccacgcccccggcca
ctgtctgagctgcaccttaaggaaaaggcagttcccatgccggaagccagtgcatttttc
atcttcagcccaaacaacaggttccgcctgcagtgccaccgtattgtcaatgacacgatc
ttcaccaacctcatcctcttcttcattctgctcagcagcatctctctggctgctgaggac
cccgtccagcacacctccttcaggaaccatatcctaggcaatgcagactatgtcttcact
agtatctttacattagaaattatccttaagatgactgcttacggggctttcctgcacaag
ggctctttctgccgaaattacttcaatatcctggacctgctggtggttagcgtgtccctc
atctcctttggcatccagtccagcgcaatcaacgttgtgaagattttacgagtgctgcga
gtccttagacccctgagggccatcaacagggccaaggggctaaagcatgtggttcagtgc
gtgtttgtggccatccggaccatcgggaacatcgtaattgtcaccactctgctgcagttc
atgtttgcctgcattggggtccagctcttcaagggaaagctctatacctgttcggatagt
tctaaacagacggaggcagaatgcaagggtaactatatcacatacaaagatggagaggtt
gatcaccccattatccagcctcgaagctgggagaacagcaagtttgactttgacaatgtt
ttggcagccatgatggctctcttcaccgtctccaccttcgaagggtggccagagctgctg
taccgctccattgactcccacacagaagacaagggccccatctacaactaccgtgtggag
atctccatcttcttcatcatctacatcatcatcattgccttcttcatgatgaacatcttc
gtgggtttcgtcattgtcaccttccaggagcagggggaacaagagtacaagaactgtgag
ctggacaagaaccagagacaatgtgtggaatatgccctcaaggcccgacccttgcgaagg
tacatccccaagaaccagcaccagtacaaagtgtggtacgtggtcaactctacctacttc
gagtatctgatgttcgttctcatcctgctcaacaccatctgcctggccatgcagcactat
ggccagagctgcctcttcaaaatcgccatgaatatactcaacatgcttttcaccggcctc
ttcacggtggagatgatcctgaagctcattgccttcaaacccaagggttactttagtgat
ccctggaatgtttttgacttcctcatcgtcattgggagcataattgatgtcattctcagt
gagactaatccagctgaacatacccaatgctctccctctatgagtgcagaggagaactcc
cgcatctccatcaccttcttccgcctcttccgggtcatgcgcctggtgaagctgctgagc
cgcggggaaggcatccgaaccctgctgtggaccttcatcaagtccttccaggaggngcgt
gggaaggaagggacaaccttcctgnttactggagaacgtgtggactactccaccatcatc
tcaaacaccgaagtcgcgttcagcaacctcccnagtctcgcacaggaactctggctgtca
gatgctcagttccttttggtaattcctcctgaaaggtgtgccaccggagaggcctggcag
gacatcatgctggcctgcatgccaggcaagaagtgtgccccagagtctgagccnagcaac
agcacggaaggggagaccccctgtggcagcagctttgctgtcttctacttcatcagcttc
tacatgctctgtgccttcctgatcatcaacctctttgtagcngttatcatggacaacttt
gactacctgactagggattggtctatcctcggtccccatcacctggatgaattcaagaga
atctgggccgagtatgaccctgaagccaagggtcggatcaaacacttggatgtggtgacc
ctcctccgtcgaattcancccccantgggttttgggaagttgtgtcctcaccgtgtggcc
tgcaaacgcctggtgtccatgaacatgcctctgaacagtgatggcacagtcatgttcaat
gctaccctgtttgccctcgtcaggacagccctgaggatcaaaacagaagggaacctagag
caagccaatgaggagctccgggccatcatcaagaaaatctggaagaggaccagcatgaag
ctgttggaccaggtggtgccccctgcaggcgatgacgaggtcacagtgggcaagttctat
gccaccttcctgatccaagagtacttcaggaaattcaagaagcgaaaagagcaggggctg
gtgggcaagccctcacaaaggaatgcactgtccctccaggctggcttacgcaccttgcat
gacattgggcctgagatccggcgggccatctctggggatctgactgctgaggaggaattg
gacaaggctatgaaggaggcggtgtctgctgcctccgaagacgacatcttcaggagggct
ggaggcctgttcggcaaccatgtcacctactatcagagtgacagcaggggcaacttccct
cagacattcgccacccagcgcccactgcacatcaacaagacagggaacaaccaagctgac
accgagtcaccgtcccatgagaagctggtggactccacgttcacccccagcagctactca
tccacaggctccaatgccaacatcaacaatgccaacaacactgccctgggccgcttcccc
catcccgctggctactccagcactgtcagcaccgtggagggccatgggcctcccttgtcc
cctgctgtccgagtacaggaggcagcatggaagctcaactctaagaggtgccactcccga
gagagccagggagccacggtgagtcaggagatgtttccagatgagacccgcagcgtgagg
atgagtgaagaagccgagtactgcagtgagcccagcctgctctctacagatatgctgtcc
taccaggaggatgaacaccgacaactgacctgcccagaggaggacaagagggagatccag
ccatctccaaagaggagtttccttcgctctgcctctctaggtaaactcacgcctcgcttt
gcagcattggcagtggcaggcttgagccccctcctgcagagaagccattctcctaccaca
ttccccaggccgtgccccacaccccctgtcactccaggcagccggggcaggcccctacgt
cccatccctaccctacggctggagggggcagagtccagcgagaaactcaacagcagctnc
ccatccatccactgtagctcctggtctgaggagactacagcctgtagtgggancagcagc
atggcccggagagcccggcccgtctccctcaccgtgcccagccaggctggagctccaggg
agacagttccatggcagtgccagcagcctggtngaagcggtcttgatttcagaaggactg
ggacagtttgctcaagatcccaagttcatcnaggtcaccacccaggagctggctgacgcc
tgcgacatgacaatagaggagatggagaacgccgcagacaacatcctcagtgggggcgcc
cagcagagccccaacggcaccctcttaccttttgtgaactgcagggacccggggcaggac
agggctgtggtcccagaggacgagagctgcgcatatgccctggggcgaggccggagcgag
gaggcgctcgcggacagcaggtcctacgtcagcaacctgtag

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