Mus caroli (Ryukyu mouse): 110299617 Help Entry 110299617         CDS       T05910                                  Gene name Jak3 Definition (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism mcal  Mus caroli (Ryukyu mouse) Pathway mcal04062   Chemokine signaling pathway mcal04151   PI3K-Akt signaling pathway mcal04217   Necroptosis mcal04550   Signaling pathways regulating pluripotency of stem cells mcal04630   JAK-STAT signaling pathway mcal04658   Th1 and Th2 cell differentiation mcal04659   Th17 cell differentiation mcal05161   Hepatitis B mcal05162   Measles mcal05166   Human T-cell leukemia virus 1 infection mcal05169   Epstein-Barr virus infection mcal05200   Pathways in cancer mcal05203   Viral carcinogenesis mcal05223   Non-small cell lung cancer mcal05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:mcal00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     110299617 (Jak3)    04151 PI3K-Akt signaling pathway     110299617 (Jak3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     110299617 (Jak3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     110299617 (Jak3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     110299617 (Jak3)    04659 Th17 cell differentiation     110299617 (Jak3)    04062 Chemokine signaling pathway     110299617 (Jak3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     110299617 (Jak3)    05203 Viral carcinogenesis     110299617 (Jak3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     110299617 (Jak3)   09163 Immune disease    05340 Primary immunodeficiency     110299617 (Jak3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     110299617 (Jak3)    05161 Hepatitis B     110299617 (Jak3)    05162 Measles     110299617 (Jak3)    05169 Epstein-Barr virus infection     110299617 (Jak3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mcal01001]     110299617 (Jak3) Enzymes [BR:mcal01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      110299617 (Jak3) Protein kinases [BR:mcal01001]  Non-receptor tyrosine kinases   JAK family [OT]    110299617 (Jak3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl APH Kdo pKID Motif Other DBs NCBI-GeneID:  110299617 NCBI-ProteinID:  XP_021025003 Ensembl:  MGP_CAROLIEiJ_G0031199 UniProt:  A0A6P5Q7V6 LinkDB All DBs Position 8 AA seq 1100 aa AA seqDB search MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKA CGILPVYHSLFALATEDFSCWFPPSHIFCIEDVDTQVLVYRLRFYFPDWFGLETCHRFGL RKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQGEFLSLAVLDLAQMAREQAQR PGELLKMVSYKACLPPSLRDVIQGQNFLTRRRIRRTVVLALRRVVACQADRYALMAKYIL DLERLHPAATTETFRVGLPGAQEEPGLLRVAGDNGIAWSSGDQELFQTFCDFPEIVDVSI KQAPRVGPAGEHRLVTVTRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEV APPRLLEEEEELCHGPITLDFAIHKLKAAGSLPGTYILRRSPQDYDSFLLTACVQTPLGP DYKGCLIRQDPSGAFSLVGLSQPHRSLRELLAACWHSGLRVDGAALNLTSCCAPRPKEKS NLIVVRRGCTPAPAPGCSPSCCALTQLSFHTIPVDSLEWHENLGHGSFTKIFHGRRREVV DGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVY LGAIDMYLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNP PFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPA HITSLEPAKKLKFYEDQGQLPALKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSD YELLSDPTPGIPSSRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPL GDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEY LPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVK IADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYC DKSCSPSAEFLRMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPQD RPAFGTLSPQLDALWHGRPG NT seq 3303 nt NT seq  +upstreamnt  +downstreamnt atggcacctccaagtgaggagacacctctgatccctcagcgctcttgcagcctctcatcc tcagaggcaggagccctgcatgtgctccttcctccccggggacctgggcctccccagcga ctgtcattctcttttggggactacttggccgaggatctgtgtgtgcgagctgccaaggcc tgtggcatcctgcctgtttatcattcgcttttcgctctggccactgaggacttctcttgc tggtttcccccaagccacatcttctgcatagaggacgtggacactcaagtcttggtctac aggctacgcttttatttccctgactggtttgggctggagacatgtcaccgctttgggctg cgcaaagatttgaccagtgccatccttgacttacatgttttagaacatctctttgctcag caccgcagtgacctggtgagtgggcgcctcccggtgggccttagcatgaaggaacaggga gagttcctgagcctggccgtgctggacttggcccagatggctcgtgagcaggcccagcgc ccaggagagctgctgaagatggtcagttacaaagcctgtctgccgcccagcctgcgcgat gtgatccagggccagaacttcttgacacgcaggcgcatccgcaggaccgtggtcctggcg ctgcgccgcgtggtcgcctgccaggccgaccgctacgcgctcatggccaagtatattctg gacctggagcggctacatccagcggccaccaccgagaccttccgtgtggggctcccgggc gcccaggaggagccggggcttctgcgtgtggcgggggacaacggcatcgcctggagctcc ggggaccaggagcttttccagaccttctgtgactttccggaaatcgtggatgtcagcatc aagcaggccccacgtgtgggtccggcaggggagcaccggctggtcaccgtcaccaggatg gacggccacatcctggaagcagagtttccggggctgcctgaggcgctgtccttcgtggcc ctcgtggatgggtacttccgcctgatctgcgactccaggcattatttctgcaaggaggtg gcgccgccgcggctgctggaggaggaggaggagctgtgccatggacccatcacgttagac tttgccatccacaagctgaaggccgctggctccctcccaggcacctacattctccgccgt agcccgcaggactatgacagctttcttcttaccgcctgtgtccagactcctcttggcccc gactacaagggctgcctcatccgccaggaccccagtggggctttctccctggttggtctc agccagccgcacagaagcctgcgggagctgcttgcagcctgctggcattccgggcttcga gtagatggcgctgccctgaacctaacatcctgctgcgctcccagacccaaggaaaagtcc aatttgatcgtggtgcgaaggggctgcactccagcgcctgcccctggctgctccccgtcc tgctgtgcactgacacagctgagcttccacacgattccagtggacagcctggagtggcac gagaacctgggtcacggttcttttaccaagatcttccatggccgcaggcgggaggtagtg gatggtgagacacatgactcagaagtcctcctgaaggtcatggactccagacatcggaac tgcatggagtcttttctggaagctgcaagcttgatgagccaagtatcctacccacacctg gtgttactgcacggcgtctgcatggctggagacagcatcatggtgcaggaatttgtgtat ctaggagcaattgacatgtacctgcgcaagcgtggccacctggtgtcagccagctggaaa ctgcaggtgaccaagcagctggcatatgcccttaactacttggaggacaaaggccttcct catggcaacgtctcagcacggaaggtgctcctggctcgcgaggggggtgatgggaatcca cctttcattaagctgagtgatcctggtgtcagtcccactgtgctgagcctggaaatgctc accgacagaataccctgggtggcccccgaatgtctccaggaggctcagacgctcggcttg gaggctgacaagtggggctttggagccaccacgtgggaggtgttcagcgggggacccgcc cacatcacctcgctggagcccgccaaaaagctgaagttctatgaggatcagggacagctg cccgccctcaaatggacagaactggcgggacttatcacacagtgcatggcgtatgatcct ggccggcgcccctccttccgagctatcctcagagacctcaacggcctcattacatcagat tatgagctcctctcagaccccacacctggcatcccgagttcccgagatgagctgtgcggt ggcgcccagctctatgcctgccaggaccccgccatattcgaggagagacaccttaagtac atttctttgttgggcaagggtaactttggcagcgtggagctgtgccgctacgaccccctg ggggacaatacaggacccctggtggcagtgaaacagctacagcacagcgggccagaccag cagagggacttccagcgggagattcagatccttaaggctctgcacagcgacttcatcgtc aagtaccggggagtcagctatgggccaggtcgccagagcctacggttggtgatggagtac ctgcccagcggctgcctgcgggacttcctgcagcgccatcgcgcgcgcctgcacaccgac cgcctactgctgttcgcctggcagatctgcaagggcatggagtacctgggtgcgcgccgc tgcgtgcaccgtgacctggctgcgcgcaacatcctggtggagagcgaggcgcatgtgaag atcgcggacttcggcctcgctaagctgctgcccctgggaaaggattactacgtggtccgc gagcctggccaaagccccatcttttggtatgccccggagtccctatctgacaacatcttc tcccgccaatctgacgtgtggagcttcggagtggtgttgtacgagctcttcacctactgc gacaagagctgcagcccatctgctgagttcctgcgcatgatggggcctgagcgtgaagga cccccgctctgccgcctcctggagctgctggcagagggccgacgcctcccaccacctccc acctgccccaccgaggttcaggaactcatgcagctgtgctgggcgcccagcccgcaggac cggccagccttcggcaccctgagcccccagctggacgcgctgtggcatggaagacccgga tag

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