KEGG   Mus caroli (Ryukyu mouse): 110303265
Entry
110303265         CDS       T05910                                 

Gene name
Tbk1
Definition
(RefSeq) serine/threonine-protein kinase TBK1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal04014  Ras signaling pathway
mcal04137  Mitophagy - animal
mcal04140  Autophagy - animal
mcal04620  Toll-like receptor signaling pathway
mcal04621  NOD-like receptor signaling pathway
mcal04622  RIG-I-like receptor signaling pathway
mcal04623  Cytosolic DNA-sensing pathway
mcal04657  IL-17 signaling pathway
mcal05014  Amyotrophic lateral sclerosis
mcal05022  Pathways of neurodegeneration - multiple diseases
mcal05135  Yersinia infection
mcal05160  Hepatitis C
mcal05161  Hepatitis B
mcal05162  Measles
mcal05163  Human cytomegalovirus infection
mcal05164  Influenza A
mcal05165  Human papillomavirus infection
mcal05167  Kaposi sarcoma-associated herpesvirus infection
mcal05168  Herpes simplex virus 1 infection
mcal05169  Epstein-Barr virus infection
mcal05170  Human immunodeficiency virus 1 infection
mcal05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    110303265 (Tbk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110303265 (Tbk1)
   04137 Mitophagy - animal
    110303265 (Tbk1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    110303265 (Tbk1)
   04621 NOD-like receptor signaling pathway
    110303265 (Tbk1)
   04622 RIG-I-like receptor signaling pathway
    110303265 (Tbk1)
   04623 Cytosolic DNA-sensing pathway
    110303265 (Tbk1)
   04657 IL-17 signaling pathway
    110303265 (Tbk1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    110303265 (Tbk1)
   05022 Pathways of neurodegeneration - multiple diseases
    110303265 (Tbk1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    110303265 (Tbk1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    110303265 (Tbk1)
   05161 Hepatitis B
    110303265 (Tbk1)
   05160 Hepatitis C
    110303265 (Tbk1)
   05171 Coronavirus disease - COVID-19
    110303265 (Tbk1)
   05164 Influenza A
    110303265 (Tbk1)
   05162 Measles
    110303265 (Tbk1)
   05168 Herpes simplex virus 1 infection
    110303265 (Tbk1)
   05163 Human cytomegalovirus infection
    110303265 (Tbk1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110303265 (Tbk1)
   05169 Epstein-Barr virus infection
    110303265 (Tbk1)
   05165 Human papillomavirus infection
    110303265 (Tbk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcal01001]
    110303265 (Tbk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcal04131]
    110303265 (Tbk1)
Enzymes [BR:mcal01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     110303265 (Tbk1)
Protein kinases [BR:mcal01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   110303265 (Tbk1)
Membrane trafficking [BR:mcal04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    110303265 (Tbk1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal CEP63 DUF713 Kinase-like ubiquitin BPL_LplA_LipB
Other DBs
NCBI-GeneID: 110303265
NCBI-ProteinID: XP_021029977
Ensembl: MGP_CAROLIEiJ_G0015857
UniProt: A0A6P5QHM4
LinkDB
Position
10
AA seq 729 aa
MQSTPNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFA
ETSDVLHRMVIHVFSLQHMTALKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLV
LELGRLAQHFPKTTEENPIFVTSREQLNSVGLRYEKISLPKIHPRYDLDGDASMAKAVTG
VVCYACRTASTLLLYQELMRKGVRWLIELVKDDYKETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMRVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISNRLSPGGLLADTWAHQE
GTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSH
FSEECVRKYEAFKDKSEEWMRKMLLLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQ
KMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
SGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacccccaaccatctgtggctcctgtctgacatcctaggccagggggccact
gcaaatgtcttccgaggaaggcataagaaaactggtgatctctatgctgtcaaagtattt
aataacataagcttccttcgcccagtggatgtccaaatgagagaatttgaagtgttaaaa
aaactcaatcacaaaaacatcgtcaagttatttgctattgaagaggagacaacaacaaga
cataaagtgcttattatggaattttgtccctgtgggagtttatacactgttttagaggag
ccgtccaatgcttatggacttccagaatcagaatttctaattgttttacgagatgtggtg
ggtgggatgaatcatctccgagagaacggcatagtgcaccgagatatcaagccaggcaac
atcatgcgcgtcataggggaggacggccagtctgtatacaaactcacggatttcggcgcc
gctcgagagctggaggacgatgagcagtttgtgtctctgtacggcacagaagagtacctg
catccggacatgtatgaaagggcagtgctaagaaaggaccatcagaagaagtacggggct
accgttgatctgtggagtgttggagtgacattctaccatgcagccacggggtcgctgccg
tttagacccttcgaggggcctcggaggaacaaagaagtgatgtataaaataatcactggg
aagccgtctggtgcaatatctggagtacagaaagcagaaaacggaccgattgactggagt
ggagacatgcctctctcttgtagtctttctcagggtcttcaggcactgcttaccccagtt
cttgcaaacatacttgaagctgatcaggagaagtgctggggttttgaccagttctttgca
gagactagtgatgtgcttcaccgaatggtaatccatgtcttctcgctacaacacatgacg
gcgcttaagatttacattcatagctataacactgctgctgtgttccatgaactggtctat
aaacaaaccaagattgtttcctcaaatcaagaacttatctacgaaggacgacgcttagtc
ctagaacttggaagactagcccagcattttcctaaaaccacagaggaaaatcctatcttt
gtcacgagccgggaacaactcaattccgtaggactgagatatgaaaaaatttccctccct
aagatacacccgcgctatgatctggacggggacgccagcatggccaaggcagtgacgggg
gtcgtgtgctacgcctgcagaactgccagtaccctgctgctctatcaagaattgatgcgc
aagggggtgcggtggctgattgaactggttaaggatgactacaaagagaccgtccacaag
aagacggaggtagtgatcaccctggatttctgcatcaggaacattgagaagactgtgaaa
gtgtatgagaagttgatgagggtcaacctggaagccgcagagctgggtgagatttcagac
atacacaccaagctgctgagactttccagttctcagggaacaatagaaagcagccttcag
gacatcagcaacaggctgtctccagggggcttgctggctgacacctgggcacatcaagaa
ggcacgcatccaagagacaggaatgtagaaaaactgcaagtcctgttgaactgcatcaca
gagatttactatcagttcaaaaaagacaaagcagaacgcagactagcttataatgaagaa
cagatccacaaatttgataagcaaaaattgtattaccatgcaacaaaagcaatgagccac
ttttcagaagaatgtgttagaaagtatgaagcgtttaaagataagtcggaagagtggatg
agaaagatgcttctccttaggaagcagttgttatcgctaactaatcagtgtttcgatatc
gaagaggaagtgtccaagtatcaagactatactaacgagttacaagaaactctgcctcag
aaaatgctcgcagcctccggtggagtcaagcacgccatggccccgatctaccccagctct
aacacattagtggagatgactcttggtatgaagaagttaaaggaggagatggaaggcgtg
gttaaggagctggccgagaacaatcatattttagaaaggtttgggtctttaacaatggac
agtggccttcgcaatgtggactgtctttag

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