Mus caroli (Ryukyu mouse): 110310364
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Entry
110310364 CDS
T05910
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mcal
Mus caroli (Ryukyu mouse)
Pathway
mcal05012
Parkinson disease
mcal05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mcal00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
110310364 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
110310364 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mcal01001
]
110310364 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mcal04131
]
110310364 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mcal04147
]
110310364 (Lrrk2)
Enzymes [BR:
mcal01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
110310364 (Lrrk2)
Protein kinases [BR:
mcal01001
]
Serine/threonine kinases: TKL group
LRRK family
110310364 (Lrrk2)
Membrane trafficking [BR:
mcal04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
110310364 (Lrrk2)
Exosome [BR:
mcal04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
110310364 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR
Ras
LRR_1
Arf
LRR_9
Ank_2
ABC_tran
MMR_HSR1
WD40_like
AAA_22
G-alpha
PduV-EutP
GTP_EFTU
Ank_3
T2SSE
TniB
HEAT_EZ
AAA_16
AAA_7
nSTAND3
Gtr1_RagA
Arm
Kdo
SRPRB
NACHT
MobB
AAA_29
cobW
ResIII
FtsK_SpoIIIE
TrwB_AAD_bind
AAA_33
Septin
SRP54
AAA_23
LRR_6
Motif
Other DBs
NCBI-GeneID:
110310364
NCBI-ProteinID:
XP_021038912
Ensembl:
MGP_CAROLIEiJ_G0020185
UniProt:
A0A6P5R2M9
LinkDB
All DBs
Position
15:85529097..85670777
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGACQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEDK
NFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQNLIGPQDIGNDWEVLGIHRLI
LKMLTVHHTNVNLSIVGLKALDLLLDSGKLTLLILDEECDVFLLIFDAMHRYSANDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSN
VEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLLQKLTLGNFFNILVLNEVHVCVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDREKLFWLEPCYKALM
RHRKDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAHEPEVAESGCKMLSHLFEGSNPSLD
TMAAVVPKILTVMKAHGMSLSVQLEALRAILHFVVPGLSEESREDSQCRPNVLRKQCFRT
DIHKLVLAALNRFIGNPGIQKCGLKVISSLAHLPDAIETLSLQGAVDSVLHTLQMYPDDQ
EIQCLGLHLMGCLMTKKNFCIGTGHLLAKILVSTLQRFKDVAEVQTTGLQTTLSILELSV
SFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQN
NSIMVECLLLLGADANQVKGVTSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRRLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLA
RKVLRYQMRNTLQEGVASGSDGNFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSES
SFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLR
SSRLPSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQ
NSLTSFPQQLCETLKCLIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAV
KCPSLKQLNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRS
LDMSHNNIECLPGPAHWKSLNLRELIFSKNQISTLDFSEDPHVWSRVEKLHLSHNKLKEI
PPEIGRLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELSTQGATVGIDVRDWSFQI
RGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLRLVNEH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK
HPKGIISRRDVEKFLSKKKRFPKNYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNL
NSKSATLWLGCGNTEKGQLSLFDLNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQ
SGTLLVINVEEETKRHTLEKMTDSVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFEDKAV
KCKGAAPLKTLHIGDISTPLMCLSESLNSSERHITWGGCGTKVFSFSNDFTIQKLIETKT
NQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKAEKLCELIDCVHFLKEVMVKL
NKEWKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAT
AQLGSLKNVMLVLGYKRKSTEGIQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADK
MRKTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcgcctgtcagggctgcgaagaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaataatgtccaggaaggcaagcagatcgagacgttgcttcagctc
ctggaggacatgctggtgttcacctactcggaccgcgcctccaagttatttgaagataaa
aatttccacgtgcctctgttgattgtcctggactcctacatgagagttgccagtgtacag
caggcagggtggtcacttctgtgcaaattgatagaagtctgcccggggacattgcaaaac
ttaataggaccccaggatattggaaatgattgggaagtccttggtattcaccggctgatt
cttaagatgttaactgttcatcacaccaatgtcaacctgtcaatagttggactaaaagcc
ttagatctcctcctagattcaggtaaactcaccttgctgatactggatgaagaatgtgat
gttttcttgttaatttttgatgccatgcacagatattcagccaatgatgaagtccaaaag
ctcggatgcaaagctttacacgtgctttttgagagagtttccgaggaacagctgactgag
tttgtggagaacaaagattacacgatactgctgagtacgtttggcagcttcagaagggac
aaggagattgtgtaccacgtactttgctgcttgcattccctggcggttacttgcagcaat
gtagaggtcctcatgagtgggaatgtcaggtgctacaatcttgtggtggaggccatgaaa
gccttccccaccaatgaaaacatccaagaggtgagctgctccttgctccagaagcttaca
ttaggtaactttttcaacatcctggtgttgaacgaagtgcatgtctgtgtggtgaaagcg
gtccgacagtatcctgagaacgcagccttacagatctctgcactcagctgtttagcgctc
ctcactgagactattttcttaaaccaagatttggaggaaagaagtgagactcaggagcag
agtgaagaggaagaccgtgagaagcttttctggctggaaccctgctataaagccctgatg
cgccatcgaaaggacaaacacgtgcaggaggctgcctgctgggcactgaataacctcctt
atgtaccagaacagtttgcatgagaagatcggagatgaagatggccagttccctgcgcac
agggaagtgatgctgtctatgctgatgcactcgtcttccaaagatgtcttccaagcagct
gcacatgctctgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtatacctgaatgtcttggaattgatgcagaggcacgcccatgagcctgaggtg
gcagagagtggctgcaagatgctgagtcacctgtttgaaggaagtaacccttctctggat
acaatggcagcggtggtccctaaaatactaacagtgatgaaagcccacgggatgtctctg
tcagtccagctggaggcgctgcgagctatcttgcattttgtagtgccaggactatcggaa
gaatccagggaggactctcaatgcagaccaaacgtgctcagaaaacagtgtttcaggact
gacatccacaagctggttctagccgctttgaacaggttcattgggaatcctgggattcag
aaatgtggattgaaagtaatctcttctctcgcgcaccttcctgatgccatagagacattg
tccctgcaaggagcagttgactcagtcctccacactttacagatgtatccagatgaccaa
gaaattcagtgtctgggcttacaccttatgggatgcctgatgacaaagaagaatttctgc
atagggacagggcacctcctggcaaaaattctggtttccactttgcagcgctttaaagat
gttgctgaggtgcagactacaggattacagacaaccctgtcaatacttgagctgtcagta
tctttctccaagctgctagtgcactattcctttgatgtggtgatatttcatcagatgtct
tccagtgttgtagaacaaaaggatgagcagttcctcaatctatgttgcaaatgctttgca
aaagtggccgtggatgatgagctgaaaaacaccatgctagagagagcctgcgatcagaat
aacagcatcatggtcgaatgtttgctcctcttgggagctgatgccaaccaagtgaagggg
gtaacttctttaatctatcaggtatgtgagaaagagagcagtcctaaattggtggaactg
ttgcttaatggtggttgtcgtgaacaagatgtacggaaagccctgaccgtaagcatccaa
aagggcgacagccaggtcatcagcttgctcctcaggagacttgccctggacctggccaac
aacagcatttgccttggaggatttggcataggaaaaattgatccttcttggcttggtcct
ttatttccagataagtcatccaatttaaggaaacaaacaaacacaggatctgtcctagca
aggaaagtgctccggtatcagatgagaaacacccttcaagaaggcgtggcctcaggcagt
gatggcaacttctctgaagatgcgctggcgaaatttggagaatggacctttattcccgac
tcttctatggacagtgtgtttggccagagcgatgatctggatagcgaaggcagcgagagc
tcctttctcgtgaagaggaagtccaactcaattagtgtaggagaagtttacagagatcta
gctctgcagcgctgctcaccaaatgctcagaggcattccaattcgctgggtcctgttttt
gaccatgaagacttactgagacgaaaaagaaaaatactgtcttcagatgagtctctcagg
tcctcaaggctgccgtcccatatgaggcaatcagatagctcttcttccctggcttctgag
agagaacacatcacgtcgttagacctatctgccaacgaactcaaagatattgatgctctg
agccagaagtgttgcctcagtagccacctggagcatctcaccaaactggaacttcaccag
aattcactcaccagcttcccacagcagctgtgtgagactctgaagtgtttgatacacttg
gatttgcacagtaacaaattcacctcatttccctctttcgtgttgaaaatgccacgtatc
accaacctagatgcctctcgaaatgacatcgggccaacagtagttttagaccctgcggta
aagtgtccaagcctcaaacagttgaatctgtcctataaccagctctcttcaatcccagag
aaccttgcccaagtggtggagaaacttgagcagctcctactggaaggaaataaaatatcc
gggatttgctctcccttgagcctgaaggaactgaagattttaaatcttagtaaaaatcac
attccatccctacctggagattttcttgaggcttgttcaaaagtagagagtttcagtgct
cgcatgaattttcttgctgcaatgcctgccttaccttcttccataacgagcttaaaattg
tctcagaactctttcacgtgcattccagaagcgattttcagtcttccacacttgcggtcc
ttggatatgagccacaacaacattgaatgtctgccgggacctgcacattggaagtctctg
aacttaagggaactcatttttagcaagaatcagatcagcaccttagactttagcgaagac
ccacacgtatggtcaagagtagagaagctgcatctctctcataataaactgaaagagatt
cctccagaaattggccgccttgaaaatttgacatctctggatgtcagttacaacttggaa
ctgaggtcctttccaaatgaaatggggaagttgagcaagatatgggatcttcccttggat
ggactgcatctgaattttgactttaagcacgtaggatgcaaagccaaagacatcataagg
tttctacaacaacgtctgaaaaaggctgtaccctacaaccgaatgaagctcatgattgtg
ggaaatacggggagtggtaagaccactttactgcaacaactcatgaaaatgaagaaacca
gaacttagcacgcagggcgccacggtcggcatagacgtgcgagactggtccttccaaata
cggggcaaaaggaaaaaggacctggttctaaacgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcacccccacttcatgacccagagagctctctacctggctgtctatgat
ctcagcaaggggcaggcagaggtggacgccatgaagccctggctcttcaatatcaaggct
cgtgcctcttcttccccggtgattctggtgggcacacatttggatgtttctgatgagaag
cagcggaaagcctgcataagcaaaatcacgaaggaactcctaaataagcgaggattcccc
accatccgggactaccactttgtgaatgccaccgaggagtcagatgcgctggcaaagctt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgtggttggg
cagctaattccagattgctacgtagaactggagaaaatcattttatcagagcgtaaagct
gtgccgaccgagtttcctgtgattaaccggaaacacctgttacggctcgtgaacgaacat
cagctgcagctggatgagaacgagctcccacacgccgttcacttcctaaatgagtcggga
gttcttctgcattttcaagaccctgccttgcagctaagtgacctgtactttgtggaaccc
aagtggctttgtaaagtcatggcacagatcttgacagtgaaggtggacggctgtctgaaa
catcccaagggcatcatttcccggagagatgtggaaaagttcctttcaaagaaaaagcga
ttcccgaagaactacatgatgcaatactttaaactattagaaaaatttcagatcgcattg
ccaataggggaagaatatcttctggttccaagcagcttgtctgaccacaggccagtgata
gagctcccccactgtgagaactccgagatcatcatccggctgtacgaaatgccatacttt
cccatgggattttggtcaagattgattaaccgattacttgaaatctcacccttcatgctt
tctggccgagagagagcactacgcccaaacaggatgtattggcggcaaggcatctacttg
aattggtctccagaagcatactgtctggtaggctctgaagtcttagacaatcgccctgag
agtttcttgaaaatcacggttccatcctgtagaaaaggttgtattcttctgggccgagtt
gtggatcatattgactcactcatggaagaatggtttcctgggttactagagattgacatt
tgtggggaaggagaaactctgttgaaaaaatgggcattgtacagttttaatgacggtgaa
gaacatcagaagatcttgcttgatgagttgatgaagaaggctgaagaaggagacctgtta
ataaatccagaccaaccaaggctcactattccaatatcccagattgctccggacttgatc
ttggctgacctgcctagaaatatcatgctgaacaatgatgagcttgaatttgaggaagca
cctgagtttctcttaggcgatggaagttttggatccgtttatcgagctgcctacgaagga
gaggaggtggctgtgaagatttttaataagcacacatctcttaggctgttaagacaagag
ttggtggtcctttgtcaccttcaccaccccagcctgatatccttgctggcggctggaatt
cgtcctcggatgttggtaatggagttggcctccaaaggttccttggatcgcctactgcag
caggacaaagccagcctcaccagaaccctccagcacaggatcgcattgcatgtggccgac
ggcctgaggtatctccactcagccatgattatttaccgtgacctgaagccccacaacgtg
ctgctttttaccctgtatcccaatgctgccatcattgcgaagattgcagactatgggatt
gcacagtactgctgcaggatgggaataaagacatcagagggcaccccagggttccgggca
cctgaagttgccagggggaatgtcatttataaccaacaggccgatgtttattcttttggc
ttactacttcacgatatttggacaactgggagtaggattatggagggtttgaggttccca
aatgagtttgatgagttagccatacaagggaagttgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattacaaagtgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcggctgaattaatttgcctc
atgcgacacattttaatacctaagaacatcattgttgaatgcatggttgccacaaatctc
aatagcaagagtgcgactctctggttgggatgcgggaacacggaaaaaggacagctttcc
ttatttgacttaaacacggaaagatacagctatgaggaagttactgatagtagaatacta
tgcttggctttggtgcatctcgctgctgagaaagagagctgggttgtgtgcgggacacag
tctggaactctcctggtcatcaatgttgaagaggagacaaagagacacaccctggaaaag
atgactgattctgtcacttgtttgcattgcaattcccttgccaagcagagcaagcaaagt
aactttcttttggtgggaactgctgatggtaacttaatgatatttgaagataaagccgtt
aagtgtaaaggagctgcccccttgaagacactacacataggcgacatcagtacgcccctg
atgtgcctgagcgagtccctgaattcatctgaaagacacatcacatggggagggtgtggc
acaaaggtcttctccttttccaatgatttcaccattcagaaactcatcgagacaaaaacc
aaccagctgttttcttatgcggctttcagcgattctaacatcatagcgctggcagtagac
acagccctctatattgccaagaaaaacagccctgtcgtcgaggtgtgggacaagaaagca
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaacta
aacaaggaatggaaacatcagctgtcctactctgggagggtgaaggccctctgcctgcag
aagaacacggctctctggatcggaactggaggaggccacatcttactcctggatctttct
actcggcgagttatccgcaccattcacaatttctgtgattctgtgagagccatggccaca
gcacaattaggaagccttaagaatgtcatgctggttttggggtacaagcggaagagtaca
gagggtatccaagaacaaaaagagatacaatcttgtttgtctatttgggacctcaatctt
ccacacgaagtgcaaaatttagaaaaacacattgaagtaagaacagaattagctgataaa
atgaggaaaacatctgttgaatag
DBGET
integrated database retrieval system
