KEGG   PATHWAY: mcc04540
Entry
mcc04540                    Pathway                                

Name
Gap junction - Macaca mulatta (rhesus monkey)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcc04540  Gap junction
mcc04540

Other DBs
GO: 0005921
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
714344  GJA1; gap junction alpha-1 protein [KO:K07372]
697250  GJD2; gap junction delta-2 protein [KO:K07373]
709208  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
699310  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
703780  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
708940  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
698830  HRAS; GTPase HRas [KO:K02833]
707977  KRAS; GTPase KRas [KO:K07827]
709089  NRAS; GTPase NRas [KO:K07828]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100424131  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
711672  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
702837  MAPK7; mitogen-activated protein kinase 7 isoform X4 [KO:K04464] [EC:2.7.11.24]
574194  TUBA1A; tubulin alpha-1A chain [KO:K07374]
702583  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
707215  tubulin alpha-3 chain [KO:K07374]
710378  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
718034  TUBA3E; tubulin alpha-3E chain [KO:K07374]
722506  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
709643  TUBA1B; tubulin alpha-1B chain [KO:K07374]
710110  tubulin alpha-1C chain isoform X1 [KO:K07374]
574113  TUBB; tubulin beta chain [KO:K07375]
693889  TUBB1; tubulin beta-1 chain [KO:K07375]
708415  TUBB2B; tubulin beta-2B chain [KO:K07375]
709331  TUBB8; tubulin beta-8 chain [KO:K07375]
712533  tubulin beta-8 chain-like [KO:K07375]
722929  tubulin beta-2A chain [KO:K07375]
100425863  TUBB4B; tubulin beta-4B chain [KO:K07375]
699231  uncharacterized protein LOC699231 [KO:K07375]
703019  TUBB4A; tubulin beta-4A chain [KO:K07375]
114673745  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
722862  tubulin beta-8 chain [KO:K07375]
720677  tubulin beta-8 chain-like isoform X1 [KO:K07375]
708952  tubulin beta-8 chain-like [KO:K07375]
106996033  tubulin beta-8 chain-like [KO:K07375]
719479  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
699269  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
720550  TJP1; tight junction protein ZO-1 isoform X6 [KO:K05701]
100426598  ADRB1; beta-1 adrenergic receptor [KO:K04141]
697796  DRD1; D(1A) dopamine receptor [KO:K04144]
694289  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
100424899  neuroendocrine secretory protein 55 [KO:K04632]
694181  DRD2; D(2) dopamine receptor [KO:K04145]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
613032  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
711808  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
708141  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
698736  GRM1; metabotropic glutamate receptor 1 precursor [KO:K04603]
705445  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
721649  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
699365  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X2 [KO:K12318] [EC:4.6.1.2]
706615  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100424944  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
114673584  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
703356  PRKG1; cGMP-dependent protein kinase 1 isoform X2 [KO:K07376] [EC:2.7.11.12]
696308  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04060  Cytokine-cytokine receptor interaction
mcc04070  Phosphatidylinositol signaling system
mcc04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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