KEGG   PATHWAY: mcc04622
Entry
mcc04622                    Pathway                                

Name
RIG-I-like receptor signaling pathway - Macaca mulatta (rhesus monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
mcc04622  RIG-I-like receptor signaling pathway
mcc04622

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
704638  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:3.6.4.13]
702024  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
709116  DHX58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:3.6.4.13]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
700942  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
705275  AZI2; 5-azacytidine-induced protein 2 [KO:K12651]
693913  TBKBP1; TANK-binding kinase 1-binding protein 1 isoform X1 [KO:K12652]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
710751  interferon alpha-17-like [KO:K05414]
694631  interferon alpha-1/13-like [KO:K05414]
710487  interferon alpha-14 [KO:K05414]
710528  interferon alpha-1/13 [KO:K05414]
710568  interferon alpha-4-like [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
711088  interferon alpha-17-like [KO:K05414]
106992322  interferon alpha-17 [KO:K05414]
710848  interferon alpha-17 [KO:K05414]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
114672663  interferon alpha-17-like [KO:K05414]
114672664  interferon alpha-17-like [KO:K05414]
711414  IFNB1; interferon beta precursor [KO:K05415]
711329  interferon omega-1 [KO:K05440]
114675730  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
106993736  IFNE; interferon epsilon [KO:K05442]
707234  IFNK; interferon kappa [KO:K05441]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708013  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
701295  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
710979  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
715467  TNF; tumor necrosis factor [KO:K03156]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
574243  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
712588  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
695652  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
706726  RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1 [KO:K12170] [EC:2.3.2.27]
700141  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
696874  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
696765  ATG12; LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
703981  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
694353  TMEM173; stimulator of interferon genes protein [KO:K12654]
711927  OTUD5; OTU domain-containing protein 5 isoform X1 [KO:K12655] [EC:3.4.19.12]
708999  SIKE1; suppressor of IKBKE 1 [KO:K12656]
706891  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:3.6.4.13]
711095  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
694117  TKFC; triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Related
pathway
mcc04010  MAPK signaling pathway
mcc04120  Ubiquitin mediated proteolysis
mcc04210  Apoptosis
mcc04630  JAK-STAT signaling pathway
KO pathway
ko04622   
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