KEGG   Macaca mulatta (rhesus monkey): 114669853
Entry
114669853         CDS       T01028                                 

Definition
(RefSeq) LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3-like
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc04062  Chemokine signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04217  Necroptosis
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc05161  Hepatitis B
mcc05162  Measles
mcc05166  Human T-cell leukemia virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05223  Non-small cell lung cancer
mcc05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    114669853
   04151 PI3K-Akt signaling pathway
    114669853
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    114669853
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    114669853
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    114669853
   04659 Th17 cell differentiation
    114669853
   04062 Chemokine signaling pathway
    114669853
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114669853
   05203 Viral carcinogenesis
    114669853
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    114669853
  09163 Immune disease
   05340 Primary immunodeficiency
    114669853
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114669853
   05161 Hepatitis B
    114669853
   05162 Measles
    114669853
   05169 Epstein-Barr virus infection
    114669853
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    114669853
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     114669853
Protein kinases [BR:mcc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   114669853
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo Kinase-like APH SH2 LRR_RI_capping
Other DBs
NCBI-GeneID: 114669853
NCBI-ProteinID: XP_028698656
LinkDB
Position
19
AA seq 1124 aa
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARXPGPPQRLSFSFGDHLAEDLCVQAAKA
SGILPVYHSLFALXTEDLSYWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLDKCHRFGL
RKDLASAILDLPVLEHLFAQHRGDLVSGRLRCGLSLKEQGECLSLAVLDLARMAREQAQR
PGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMTKYIM
DLERLDPAGAAETFHVSLPGVPGGQDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQTP
LGPDYKGCLIRRSPTGSFFLVGLSRSHSSLRELLAACWDGGLHVDGVTVTLTSCCIPRPK
EKSNLIVVQRGRSPPTSSLVQPQSQCQLSQMIFHKIPADSLEWHENLGHGSFTKIYRGCR
HEVVDGESRKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQ
EFVHLGAIDTYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGT
DGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLRKAQTLSLEADKWGFGATVWEVFS
GVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSL
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSTLGPQLDMLWSGSRGCETHAFTAHPEGKPHSLSFL
NT seq 3375 nt   +upstreamnt  +downstreamnt
atggcacctccgagtgaggagacacccctgatccctcagcgctcctgcagcctcttgtcc
acggaggctggtgccctgcacgtgctactgcccgctcggngcccggggcccccccagcgc
ctatctttctcctttggggaccacttggctgaggacctgtgcgtgcaggctgccaaggcc
agcggcatcctgcctgtgtaccactccctctttgctttgngcacggaggacctgtcctac
tggttccccccgagccacatcttctccgtggaggatgccagcacccaagtcctgctctac
aggattcgtttttacttccccaattggtttgggctggacaagtgccaccgcttcgggcta
cgcaaggatttggccagcgctatccttgacctgccagtcctggagcacctctttgcccag
caccgcggtgacctggtgagtgggcgccttcgctgtggcctcagcctcaaggagcagggt
gagtgtctcagcctggcagtgctggacctggcccggatggcgcgagagcaggcccagcgg
ccaggagagctgctgaagactgtcagctacaaggcctgcctgcccccaagcctgcgcgac
ctgatccagggcctgagcttcgtgacgcggaggcgtattcggaggacagtgcgcagggcc
ctgcgccgcgtggccgcctgccaggccgaccggcactcgctcatgaccaagtacattatg
gatctggagcggctggatccggctggggccgccgagaccttccacgtgagcctccctggg
gtccctggtggccaggacgggctggggctgctccgcgtggctggtgacggaggaatcgcc
tggacccagggagaacaggaggtcctccagcccttctgcgactttccagaaatcgtagac
attagcatcaagcaggccccgcgcgttggcccggccggggagcaccgcctggtcactgtc
accaggacagacaaccagattttggaggccgagttcccggggctgcccgaggctctgtct
ttcgtggcgctcgtggacggctacttccggctgaccacagactcccagcacttcttctgc
aaggaggtggcaccgccgaggctgctggaggaggtggcagagcagtgccacggccccatc
actctggactttgccataaacaagcttaagactgggggctcacgtcctggctcctatgtt
ctccgccgcagcccccaggactttgacagcttcctcctcactgtctgtgtacagaccccc
cttggtcctgattataagggttgcctcattcggcgcagccccacagggagcttctttctg
gttggcctcagccgatcccacagcagtcttcgagagctcctggcagcctgctgggatggg
gggctgcacgtagatggggtcacagtgaccctcacctcctgctgtatccccagacccaaa
gaaaagtccaacttgatcgtggtccagagaggtcgcagcccacccacgtcctccctggtt
cagccccaatcccaatgccagctgagtcagatgatatttcacaagatccccgctgacagc
ctagagtggcatgagaacctgggccatggatccttcaccaagatttaccggggctgtcgc
cacgaggtggtggatggggagtcccgaaagacagaggtgctgctaaaagtgatggatgct
aagcacaagaactgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtcg
taccggcatctcgtgctgctccacggcgtgtgcatggctggagacagcaccatggtgcaa
gaatttgtacacctgggggcgatagacacgtatctgcgaaaacgtggccacctggtgcca
gccagctggaagctgcaggtggtcaaacagctggcctacgccctcaactatctggaggac
aaaggcctcccccatggcaatgtctccgcccggaaggtgctcctggctcgggagggcact
gatgggagcccgcccttcatcaagctaagtgaccctggggtcagccccgctgtgttaagc
ctggagatgctcaccgacaggatcccctgggtggctcccgagtgtcttcggaaggcccag
acacttagcttggaagctgacaagtggggcttcggcgccacggtctgggaggtgtttagt
ggcgtcaccatgcccatcagcgccctggatcctgctaagaaactccaattttatgaggac
cggcagcagctgccagcccccaagtggacagagctggccctgctaattcaacagtgcatg
gcctatgagccagtccagaggccctccttccgagccgtcattcgtgacctcaacagcctc
atctcttcagactatgagctcctctcagaccccacacctggtgccctggcacctcgtgat
gggctgtggaatggtgcccagctctatgcctgccaagaccccacgatcttcgaggagaga
cacctcaagtacatctcacagctgggcaagggcaactttggcagcgtggagctgtgccgc
tatgacccgctaggtgacaacacaggtgccctggtggccgtgaaacagctgcagcacagc
gggccagaccagcagagggacttccagcgggagattcagatcctcaaagcactgcacagt
gatttcattgtcaagtatcgtggtgtcagctacggcccgggccgccagagcctgcggctg
gtcatggagtacctgcccagcggctgcttgcgcgacttcctgcagcggcaccgcgcgcgc
ctggatgccagccgcctcctgctctactcctcgcagatctgcaagggcatggagtacctg
ggctcccgccgctgcgtgcaccgcgacctggccgcccgaaatatcctggtggagagcgag
gcacacgtcaagatcgctgacttcggcctagctaagctgctgccgcttgacaaagactac
tacgtggtccgcgagccgggccagagccccattttctggtatgcccccgaatccctctcg
gacaacatcttctctcgccagtcagacgtctggagcttcggggtcgtcctgtacgagctc
ttcacctactgcgacaaaagctgcagcccctcggccgagtttctgcggatgatgggatgt
gagcgggatgtccccgccctctgccgcctcctggaactgctggaggagggccagaggctg
ccggcgcctcctgcctgccctgctgaggttcacgagctcatgaagctgtgctgggcccct
agcccacaggaccgcccatcattcagcaccctgggcccccagctggacatgctatggagc
ggaagccgggggtgtgagactcacgccttcactgctcacccagagggcaaaccacactcc
ctgtcctttttatag

KEGG   Macaca mulatta (rhesus monkey): 574130
Entry
574130            CDS       T01028                                 

Gene name
TYK2
Definition
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc04217  Necroptosis
mcc04380  Osteoclast differentiation
mcc04621  NOD-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc05145  Toxoplasmosis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05162  Measles
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05168  Herpes simplex virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    574130 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    574130 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    574130 (TYK2)
   04658 Th1 and Th2 cell differentiation
    574130 (TYK2)
   04659 Th17 cell differentiation
    574130 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    574130 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    574130 (TYK2)
   05160 Hepatitis C
    574130 (TYK2)
   05171 Coronavirus disease - COVID-19
    574130 (TYK2)
   05164 Influenza A
    574130 (TYK2)
   05162 Measles
    574130 (TYK2)
   05168 Herpes simplex virus 1 infection
    574130 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    574130 (TYK2)
   05169 Epstein-Barr virus infection
    574130 (TYK2)
   05165 Human papillomavirus infection
    574130 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    574130 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    574130 (TYK2)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     574130 (TYK2)
Protein kinases [BR:mcc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   574130 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo RIO1 APH
Other DBs
NCBI-GeneID: 574130
NCBI-ProteinID: XP_028695770
Ensembl: ENSMMUG00000003110
LinkDB
Position
19
AA seq 1190 aa
MPLRHRGTTRGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRMRFYFRNWHGMNPQEL
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHFK
NESLGMAFLHLCHLALCRGVPLEEVAKKTSFKDCIPLSFRRQIRQHSALTRLRLRNVFRR
FLQDFQPDRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGEAP
TDPGPESAARPPTHEVLVTGTGGIQWWPVQEEVNKEEGSSGGSGRNPQASLSGKKAKAHK
AIGQPADRLREPLWAYFCDFRDITHVVLKECCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIQDGIHGPLLEPFVQAKLRPEDGLYLIQWSTSHP
YRLILTVAQRSQAPDGTQSLRLRKFPIEQQAGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRRCLPQPGETSNLIIMRGARASTRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHVHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWMA
PECLPGGPNSLSIAMDKWGFGATLLEICFDGEAPLQSRSSSEKEHFYQRQHRLPEPSCPE
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHTLPDLADVLIVNPDSSASDPTVFHKRYL
KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIEILRTLYHE
HIVKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQ
HYIHRDLAARNVLLDNDKLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK
FYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGITQGQMTVLRLTELLERGERLPRP
DKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
NT seq 3573 nt   +upstreamnt  +downstreamnt
atgcctctgcgccatcgggggacgaccaggggcagcaagcccgttggggatggagcccag
cccatggctgccatgggaggcctgaaggtgcttctgcactgggctggtccaggcggcgga
gagccctgggtcactttcagcgagtcatcgctgacagctgaggaagtctgcatccacatt
gcacataaagtcggtatcactcctccttgtttcaatctcttcgccctcttcgatgctcag
gcccaagtctggttgcccccaaaccacatcctagagatccccagagatgcaagcctgatg
ctgtatttccgcatgaggttttatttccggaactggcatggcatgaatcctcaggagctg
gctgtgtaccgttgtgggcccccaggaaccgaggcatcctcagatcagacagcacagggg
atgcaactcctggacccagcctcatttgagtacctctttgagcagggcaagcatgagttt
gtgaatgacgtggcatcactgtgggagctatcgagcgaggaggagatccaccactttaag
aatgagagcctgggcatggcctttctgcacctctgtcacctcgctctctgccgtggtgtc
cccctggaggaggtggccaagaaaaccagcttcaaggactgtatcccgctctccttccgt
cggcagatccggcagcacagcgccctgacccggctgcgccttcggaacgtcttccgcagg
ttcctgcaggacttccagccggacagactctcccagcagatggtcatggtcaaatacctg
gccacactcgaacggctggcaccccgctttggcacagagcgtgtgcccgtgtgccacctg
aggctgctggcccaggcagagggagagccctgctacatccgggacagtggggaggcccct
acagaccctggccctgagtctgctgctagacccccaacccatgaggtgctggtgacaggc
actggtggcatccagtggtggccagtacaggaggaggtgaacaaggaggagggttctagt
ggcggcagcggcaggaacccccaagccagcctgtctgggaagaaggccaaggctcacaag
gcaatcggccagccggcggacaggctgcgggagccactgtgggcctacttctgtgacttc
cgggacatcacccacgtggtgctgaaagagtgctgtgtcagcatccaccggcaggacaac
aagtgcctggagctgagcctgccttcccgggctgcagcgctgtccttcgtgtcgctggtg
gacggctatttccgcctgacggccgactccagccactacctgtgccacgaggtggctccc
ccacggctggtgatgagcatccaggatgggatccatggacccctgctggagccgtttgtg
caggccaagctgcggcccgaggacggcctgtacctcattcagtggagcaccagccacccc
taccgcctgatcctcacagtggcccagcgtagccaggcaccagacggcacacagagcttg
cggctccggaagttccccattgagcagcaggccggggcctttgtgctggagggctggggc
cggtccttccccagcgttcgggaacttggggccgccttgcagggctgcttgctgagggcc
ggggacgactgcttctctctgcgtcgccgttgcctgccccaaccaggagaaacctccaac
ctcatcatcatgcggggggctcgggccagcaccaggacactcaacctcagccagctcagc
ttccaccgggttgaccagaaggagatcacccagctgtcccacttgggccagggcacaagg
accaacgtgtacgagggccgcctgcgagtggagggcagtggggaccctgaggagggcaag
atggacgatgaggaccccctcgtgcctggaagggaccgtgggcaggagctacgagtggtg
ctcaaagtgctggacccgagtcaccatgacatcgccctggccttctatgagacagccagc
ctcatgagccaggtctcccacgtgcacctggccttcgtgcacggcgtctgtgtgcgaggc
cctgaaaatatcatggtgacagagtacgtggagcacggacccctggacgtgtggctgcgg
agggagcggggccatgtgcccatggcttggaagatggtggtggcccagcagctagccagc
gccctcagctacctggagaacaagaacctggtacatggtaatgtgtgtggccggaacatc
ctgctggctcggctggggctggcagagggcacgagccccttcatcaagctgagtgatccc
ggcgtgggcctcggcgccctctccagggaggagcgggtggagcggatcccctggatggcc
cccgaatgcctcccaggtgggcccaacagcctaagcattgccatggacaagtgggggttt
ggtgccaccctcctggagatctgctttgatggagaggccccgctgcagagccgcagctcc
tccgagaaggagcatttctaccagaggcagcaccggctgcccgagccctcctgcccagag
ctggccacactcaccagccagtgtctgacctatgagccaacccagaggccttcattccgc
accatcctgcgtgacctcacccggctgcagccccacactcttccagatcttgctgatgtc
ttgattgtgaacccggactcatcggcgtcagaccctacggttttccacaagcgctatttg
aaaaagatccgagatctgggcgagggtcacttcggcaaggtcagtttgtactgctacgat
ccgaccaacgacggcactggcgagatggtggcggtgaaagcccttaaggcagactgcggc
ccccagcaccgctcgggctggaagcaggagattgagattctgcgcacgctctatcacgag
cacatcgtcaagtacaagggctgctgcgaggatcaaggcgagaagtcgctgcagctggtc
atggagtacgtgcccctgggcagcctccgagactacctgccccggcacagcgtcgggctg
gcccagctgctgctcttcgcccagcagatctgcgagggcatggcctatctgcacgcgcag
cactacatccaccgagacctagccgcgcgcaacgtgctgctggacaacgacaagctggtc
aagatcggggactttggcctagccaaggccgtgcccgaaggccacgagtactaccgcgtg
cgcgaggatggggacagccccgtgttctggtatgccccagagtgcctgaaagagtataag
ttctactatgcgtccgatgtctggtccttcggggtgaccctgtatgagctgctgacgcac
tgtgactccagccagagcccccccacgaaattccttgagctcataggcatcacccagggt
cagatgacagttctgagactcaccgagttgctggaacgaggggagaggctgccacgacct
gacaaatgtccctgtgaggtctatcatctcatgaagaactgctgggagacagaggcgtcc
ttccgcccaaccttcgagaacctcatacccatcctgaagacagtccatgagaagtaccaa
ggccaggccccttccgtgttcagtgtgtgctga

KEGG   Macaca mulatta (rhesus monkey): 677689
Entry
677689            CDS       T01028                                 

Gene name
JAK1
Definition
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01521  EGFR tyrosine kinase inhibitor resistance
mcc04151  PI3K-Akt signaling pathway
mcc04217  Necroptosis
mcc04380  Osteoclast differentiation
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04621  NOD-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc05140  Leishmaniasis
mcc05145  Toxoplasmosis
mcc05152  Tuberculosis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05162  Measles
mcc05163  Human cytomegalovirus infection
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05166  Human T-cell leukemia virus 1 infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05168  Herpes simplex virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05171  Coronavirus disease - COVID-19
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05212  Pancreatic cancer
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    677689 (JAK1)
   04151 PI3K-Akt signaling pathway
    677689 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    677689 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    677689 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    677689 (JAK1)
   04658 Th1 and Th2 cell differentiation
    677689 (JAK1)
   04659 Th17 cell differentiation
    677689 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    677689 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    677689 (JAK1)
   05203 Viral carcinogenesis
    677689 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    677689 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    677689 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    677689 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    677689 (JAK1)
   05161 Hepatitis B
    677689 (JAK1)
   05160 Hepatitis C
    677689 (JAK1)
   05171 Coronavirus disease - COVID-19
    677689 (JAK1)
   05164 Influenza A
    677689 (JAK1)
   05162 Measles
    677689 (JAK1)
   05168 Herpes simplex virus 1 infection
    677689 (JAK1)
   05163 Human cytomegalovirus infection
    677689 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    677689 (JAK1)
   05169 Epstein-Barr virus infection
    677689 (JAK1)
   05165 Human papillomavirus infection
    677689 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    677689 (JAK1)
   05140 Leishmaniasis
    677689 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    677689 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    677689 (JAK1)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     677689 (JAK1)
Protein kinases [BR:mcc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   677689 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2
Other DBs
NCBI-GeneID: 677689
NCBI-ProteinID: NP_001244838
Ensembl: ENSMMUG00000018566
UniProt: F6YLX1
LinkDB
Position
1
AA seq 1154 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEVPEPGVEVIFYMSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDSGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQGQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRIFKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
NT seq 3465 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagactgaggtgaacctggaggtccctgagccaggggtggaagtgatcttc
tatatgtcggacagggagcccctccggctgggcagtggagagtatacagcagaggaactg
tgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg
tatgatgagaacaccaagctctggtatgctccaaatcgcactatcaccgttgatgacaag
atgtccctccgactccactaccggatgaggttctatttcaccaattggcacggaaccaac
gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa
aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct
cagggacagtatgatttggtgaaatgcctggctcccattcgagaccccaagaccgagcag
gatgggcatgatattgaaaacgagtgtctggggatggctgtcctggccatctcacactat
gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgacagcagc
gtgtccacgcatgacctgaaggtgaaatacttggctaccttggaaactttgacaaaacat
tatggcgctgaaatatttgagacttccatgttgctgatttcatcagaaaatgagatgaat
tggtttcattcgaatgacagtggaaacgttctgtactatgaagtgatggtgactgggaat
cttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaaaataaa
ctgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgg
gaagagtggaataatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctgtcttcccatgag
gaggccttgtcctttgtgtcactggtagatggctacttccggctcaccgcagacgcccat
cattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgt
catggtccaatctgtacagaatatgccatcaataaattgcggcaagaaggaagcgaggag
gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgaccgtcacc
tgctttgagaagtctgagcaggggcagggtgcccagaagcagttcaagaactttcagatc
gaggtgcagaagggccgctacagcctgcatggttcagaccgcagcttccccagcttggga
gacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttcatgttg
aaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaa
gcccaggagtggcagcccgtctaccccatgagccagctgagttttgatcggattttcaag
aaggatctggtgcagggcgagcaccttgggagaggcacgagaacacacatctactctggg
accctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatc
ctcaaagtcttagaccctagccacagggatatttccctggccttcttcgaggcagccagc
atgatgagacaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgcgac
gtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcac
cggaaaagcgatgtccttactacaccctggaaattcaaagttgccaaacagctggccagt
gccctgagctacttggaagataaagacctggtccatggaaatgtgtgtactaaaaacctc
ctcctggcccgtgagggcatcgacagcgagtgtggtccgttcatcaagctcagtgaccct
ggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccgtggattgct
cccgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagctttgga
actacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacactgatt
gagaaagagagattctatgaaagccggtgcaggccagtgacaccatcatgtaaggagctg
gctgacctcatgacccgctgcatgaactacgaccccaatcagaggcccttcttccgagcc
atcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaag
ccagcaactgaagtggaccccacgcattttgagaagcgcttcctaaagaggatccgtgac
ttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaat
acaggggagcaggtggctgtcaaatctctgaagcctgagagtggaggtaaccacatagct
gatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtgaagtac
aaaggaatctgcacggaagacggaggaaatggtattaagctcatcatggaatttctgcct
tcgggaagccttaaggagtatcttccaaagaataagaacaaaattaacctcaaacagcag
ctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatatgtt
caccgtgacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattgga
gacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgac
cgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatatc
gcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgactca
gattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgaca
gtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccgcctaactgt
ccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggaca
agctttcagaaccttattgaaggatttgaagcacttttaaaataa

KEGG   Macaca mulatta (rhesus monkey): 694184
Entry
694184            CDS       T01028                                 

Gene name
JAK2
Definition
(RefSeq) tyrosine-protein kinase JAK2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01521  EGFR tyrosine kinase inhibitor resistance
mcc04062  Chemokine signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04217  Necroptosis
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc04725  Cholinergic synapse
mcc04917  Prolactin signaling pathway
mcc04920  Adipocytokine signaling pathway
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04935  Growth hormone synthesis, secretion and action
mcc05140  Leishmaniasis
mcc05145  Toxoplasmosis
mcc05152  Tuberculosis
mcc05161  Hepatitis B
mcc05164  Influenza A
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05168  Herpes simplex virus 1 infection
mcc05200  Pathways in cancer
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    694184 (JAK2)
   04151 PI3K-Akt signaling pathway
    694184 (JAK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    694184 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    694184 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    694184 (JAK2)
   04659 Th17 cell differentiation
    694184 (JAK2)
   04062 Chemokine signaling pathway
    694184 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    694184 (JAK2)
   04917 Prolactin signaling pathway
    694184 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    694184 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    694184 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    694184 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    694184 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    694184 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    694184 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    694184 (JAK2)
   05164 Influenza A
    694184 (JAK2)
   05168 Herpes simplex virus 1 infection
    694184 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    694184 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    694184 (JAK2)
   05140 Leishmaniasis
    694184 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    694184 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    694184 (JAK2)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     694184 (JAK2)
Protein kinases [BR:mcc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   694184 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like
Other DBs
NCBI-GeneID: 694184
NCBI-ProteinID: NP_001252830
Ensembl: ENSMMUG00000014558
UniProt: A0A5F8ATC5
LinkDB
Position
15
AA seq 1132 aa
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPECIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSDESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNLRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcctgccttactatgacagaaatggagggaacatccacatcttctatatat
cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagtccttcag
gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg
gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt
cctcgttggtattgcagcggcagcaacagagcctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat
tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaatgatcaaaccccactggccatc
tataattctatcagctacaagacattcttaccagaatgtattcgagcaaagatccaagac
tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcagttc
agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaacc
ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt
cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcagatgaaagccga
gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg
gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccaacagtgcttgaaaatatacaaagcaactgt
catggcccaatttcgatggattttgccattagtaaactgaagaaagcaggtaatcagact
ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa
gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt
taccagatggaaaccgttcgctcagacaatataattttccagtttactaagtgctgtccc
ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgatgta
ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaaggcactttcacaaagattttt
aaaggcatacgaagagaagtaggagactatggtcaacttcatgaaacagaagttctttta
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagag
gagaatattctggttcaggagtttgtaaaatttggatcactagatacatacctgaaaaag
aataaaaattgtataaatatattatggaaacttgaagttgcgaaacagttggcatgggcc
atgcattttctagaagaaaacacccttattcatgggaatgtgtgcgccaaaaatattcta
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataaacctctaagtgccctggattctcaa
agaaagctgcaattttatgaagataggcaccagcttcctgcaccaaagtgggcagaatta
gcaaaccttataaataattgtatggattatgaacccgatttcaggccttctttcagagcc
gtcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagacagggat
cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaacttt
gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct
gtaaaaaagcttcagcatagtactgaagagcacctgagagactttgaaagggaaattgaa
atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat
cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaga
aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa
tttatgcgcatgattggcaatgataaacaaggacagatgatcgtgttccatttgatagaa
cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatatg
atcatgacagaatgctggaacaataatgtaaatctacgcccctcctttagagatctagct
cttcgagtggatcaaataagggataacatggctggatga

KEGG   Macaca mulatta (rhesus monkey): 720040
Entry
720040            CDS       T01028                                 

Gene name
JAK3
Definition
(RefSeq) LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc04062  Chemokine signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04217  Necroptosis
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc05161  Hepatitis B
mcc05162  Measles
mcc05166  Human T-cell leukemia virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05223  Non-small cell lung cancer
mcc05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    720040 (JAK3)
   04151 PI3K-Akt signaling pathway
    720040 (JAK3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    720040 (JAK3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    720040 (JAK3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    720040 (JAK3)
   04659 Th17 cell differentiation
    720040 (JAK3)
   04062 Chemokine signaling pathway
    720040 (JAK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    720040 (JAK3)
   05203 Viral carcinogenesis
    720040 (JAK3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    720040 (JAK3)
  09163 Immune disease
   05340 Primary immunodeficiency
    720040 (JAK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    720040 (JAK3)
   05161 Hepatitis B
    720040 (JAK3)
   05162 Measles
    720040 (JAK3)
   05169 Epstein-Barr virus infection
    720040 (JAK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    720040 (JAK3)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     720040 (JAK3)
Protein kinases [BR:mcc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   720040 (JAK3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo Kinase-like APH LRR_RI_capping
Other DBs
NCBI-GeneID: 720040
NCBI-ProteinID: XP_028694975
Ensembl: ENSMMUG00000010996
LinkDB
Position
19
AA seq 1169 aa
MTVAQETKGPTQEGAEWDFPLAASRLCSPFEGPGSLPARQVALMAPPSEETPLXPQRSCS
LLSTEAGXLHVLLPARGPGPPXRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATED
LSYWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLDKCHRFGLRKDLASAILDLPVLEHL
FAQHRGDLVSGRLAVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPS
LRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVS
LPGVPGGQDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRL
VTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCH
GPSRKNLLDFAITSLRLGLTSWLYVLRRSPQDFDSFXLTVCVQTPLGPDYKGCLIRRSPT
GSFFLVGLSRSHSSLREXLAACWDGGLHVDGVTVTLTSCCIPRPKEKSNLIVVQRGRSPP
TSSLVQPQSNASXVRXYFHKIPADSLEWHMKPGHGSFTKIYRGLSPRGGGWESRKTEVLL
KVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDTYLRKR
GHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGTDGSPPFIKLSDPGVS
PAVLSLEMLTDRIPWVAPECLRKAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKL
QFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGA
LAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVK
QLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ
RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLP
LDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFL
RMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSTLGPQL
DMLWSGSRGCETHAFTAHPEGKPHSLSFL
NT seq 3510 nt   +upstreamnt  +downstreamnt
atgacagtggctcaggaaaccaaggggcccacacaggaaggagccgagtgggactttcct
ctcgctgcctcccggctctgctctcccttcgaaggtccagggtccctgcctgctaggcaa
gttgcactcatggcacctccaagtgaggagacacccctgnatcctcagcgctcctgcagc
ctcttgtccacggaggctggtngcctgcacgtgctactgcccgctcggggcccgggaccc
cccnagcgcctatctttctcctttggggaccacttggctgaggacctgtgcgtgcaggct
gccaaggccagcggcatcctgcctgtgtaccactccctctttgctttggccacggaggac
ctgtcctactggttccccccgagccacatcttctccgtggaggatgccagcacccaagtc
ctgctctacaggattcgtttttacttccccaattggtttgggctggacaagtgccaccgc
ttcgggctacgcaaggatttggccagcgctatccttgacctgccagtcctggagcacctc
tttgcccagcaccgcggtgacctggtgagtgggcgccttgctgtgggcctcagcctcaag
gagcagggtgagtgtctcagcctggccgtgctggacctggcccggatggcgcgagagcag
gcccagcggccaggagagctgctgaagactgtcagctacaaggcctgcctgcccccaagc
ctgcgcgacctgatccagggcctgagcttcgtgacgcggaggcgtattcggaggacagtg
cgcagggccctgcgccgcgtggccgcctgccaggccgaccggcactcgctcatggccaag
tacattatggatctggagcggctggatccggctggggccgccgagaccttccacgtgagc
ctccctggggtccctggtggccaggacgggctggggctgctccgcgtggctggtgacgga
ggaatcgcctggacccagggagaacaggaggtcctccagcccttctgcgactttccagaa
atcgtagacattagcatcaagcaggccccgcgcgttggcccggccggggagcaccgcctg
gtcactgtcaccaggacagacaaccagattttggaggccgagttcccggggctgcccgag
gctctgtctttcgtggcgctcgtggacggctacttccggctgaccacagactcccagcac
ttcttctgcaaggaggtggcaccgccgaggctgctggaggaggtggcagagcagtgccac
ggcccatcacgtaagaaccttctggactttgccataacaagcttaagactggggctcacg
tcctggctctatgttctccgccgcagcccccaggactttgacagcttcntcctcactgtc
tgtgtacagaccccccttggtcctgattataagggttgcctcattcggcgcagccccaca
gggagcttctttctggttggcctcagccgatcccacagcagtcttcgagagnctctggca
gcctgctgggatggggggctgcacgtagatggggtcacagtgaccctcacctcctgctgt
atccccagacccaaagaaaagtccaacttgatcgtggtccagagaggtcgcagcccaccc
acgtcctccctggttcagccccaatccaatgccagctgagtcagatgatatttccacaag
atccccgctgacagcctagagtggcacatgaaacctggccatggatccttcaccaagatt
taccgggggctgtcgccacgaggtggtggatgggagtcccgaaagacagaggtgctgcta
aaagtgatggatgctaagcacaagaactgcatggagtcattcctggaagcagcgagcttg
atgagccaagtgtcgtaccggcatctcgtgctgctccacggcgtgtgcatggctggagac
agcaccatggtgcaagaatttgtacacctgggggcgatagacacatatctgcgaaaacgt
ggccacctggtgccagccagctggaagctgcaggtggtcaaacagctggcctacgccctc
aactatctggaggacaaaggcctcccccatggcaatgtctccgcccggaaggtgctcctg
gctcgggagggcactgatgggagcccgcccttcatcaagctaagtgaccctggggtcagc
cccgctgtgttaagcctggagatgctcaccgacaggatcccctgggtggctcccgagtgt
cttcggaaggcccagacccttagcttggaagctgacaagtggggcttcggcgccacggtc
tgggaggtgtttagtggcgtcaccatgcccatcagcgccctggatcctgctaagaaactc
caattttatgaggaccggcagcagctgccagcccccaagtggacagagctggccctgcta
attcaacagtgcatggcctatgagccagtccagaggccctccttccgagccgtcattcgt
gacctcaacagcctcatctcttcagactatgagctcctctcagaccccacacctggtgcc
ctggcacctcgtgatgggctgtggaatggtgcccagctctatgcctgccaagaccccacg
atcttcgaggagagacacctcaagtacatctcacagctgggcaagggcaactttggcagc
gtggagctgtgccgctatgacccgctaggcgacaacacaggtgccctggtggccgtgaaa
cagctgcagcacagcgggccagaccagcagagggacttccagcgggagattcagatcctc
aaagcactgcacagtgatttcattgtcaagtatcgtggtgtcagctacggcccgggccgc
cagagcctgcggctggtcatggagtacctgcccagcggctgcttgcgcgacttcctgcag
cggcaccgcgcgcgcctggatgccagccgcctcctgctctactcctcgcagatctgcaag
ggcatggagtacctgggctcccgccgctgcgtgcaccgcgacctggccgcccgaaatatc
ctggtggagagcgaggcacacgtcaagatcgctgacttcggcctagctaagctgctgccg
cttgacaaagactactacgtggtccgcgagccgggccagagccccattttctggtatgcc
cccgaatccctctcggacaacatcttctctcgccagtcagacgtatggagcttcggggtc
gtcctgtacgagctcttcacctactgcgacaaaagctgcagcccctcggccgagtttctg
cggatgatgggatgtgagcgggatgtccccgccctctgccgcctcctggaactgctggag
gagggccagaggctgccggcgcctcctgcctgccctgctgaggttcacgagctcatgaag
ctgtgctgggcccctagcccacaggaccgcccatcattcagcaccctgggcccccagctg
gacatgctatggagcggaagccgggggtgtgagactcacgccttcactgctcacccagag
ggcaaaccacactccctgtcctttttatag

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