Macaca mulatta (rhesus monkey): 677689 Help Entry 677689            CDS       T01028                                  Gene name JAK1 Definition (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc04151   PI3K-Akt signaling pathway mcc04217   Necroptosis mcc04380   Osteoclast differentiation mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04621   NOD-like receptor signaling pathway mcc04630   JAK-STAT signaling pathway mcc04658   Th1 and Th2 cell differentiation mcc04659   Th17 cell differentiation mcc05140   Leishmaniasis mcc05145   Toxoplasmosis mcc05152   Tuberculosis mcc05160   Hepatitis C mcc05161   Hepatitis B mcc05162   Measles mcc05163   Human cytomegalovirus infection mcc05164   Influenza A mcc05165   Human papillomavirus infection mcc05166   Human T-cell leukemia virus 1 infection mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05168   Herpes simplex virus 1 infection mcc05169   Epstein-Barr virus infection mcc05171   Coronavirus disease - COVID-19 mcc05200   Pathways in cancer mcc05203   Viral carcinogenesis mcc05212   Pancreatic cancer mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     677689 (JAK1)    04151 PI3K-Akt signaling pathway     677689 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     677689 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     677689 (JAK1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     677689 (JAK1)    04658 Th1 and Th2 cell differentiation     677689 (JAK1)    04659 Th17 cell differentiation     677689 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     677689 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     677689 (JAK1)    05203 Viral carcinogenesis     677689 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     677689 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     677689 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     677689 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     677689 (JAK1)    05161 Hepatitis B     677689 (JAK1)    05160 Hepatitis C     677689 (JAK1)    05171 Coronavirus disease - COVID-19     677689 (JAK1)    05164 Influenza A     677689 (JAK1)    05162 Measles     677689 (JAK1)    05168 Herpes simplex virus 1 infection     677689 (JAK1)    05163 Human cytomegalovirus infection     677689 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     677689 (JAK1)    05169 Epstein-Barr virus infection     677689 (JAK1)    05165 Human papillomavirus infection     677689 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     677689 (JAK1)    05140 Leishmaniasis     677689 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     677689 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mcc01001]     677689 (JAK1) Enzymes [BR:mcc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      677689 (JAK1) Protein kinases [BR:mcc01001]  Non-receptor tyrosine kinases   JAK family [OT]    677689 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2 Motif Other DBs NCBI-GeneID:  677689 NCBI-ProteinID:  NP_001244838 Ensembl:  ENSMMUG00000018566 UniProt:  F6YLX1 LinkDB All DBs Position 1 AA seq 1154 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEVPEPGVEVIFYMSDREPLRLGSGEYTAEEL CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHSNDSGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEQGQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRIFKKDLVQGEHLGRGTRTHIYSG TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT SFQNLIEGFEALLK NT seq 3465 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagactgaggtgaacctggaggtccctgagccaggggtggaagtgatcttc tatatgtcggacagggagcccctccggctgggcagtggagagtatacagcagaggaactg tgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctctttgccctg tatgatgagaacaccaagctctggtatgctccaaatcgcactatcaccgttgatgacaag atgtccctccgactccactaccggatgaggttctatttcaccaattggcacggaaccaac gacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctacgagaaa aaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctgtttgct cagggacagtatgatttggtgaaatgcctggctcccattcgagaccccaagaccgagcag gatgggcatgatattgaaaacgagtgtctggggatggctgtcctggccatctcacactat gccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgacagcagc gtgtccacgcatgacctgaaggtgaaatacttggctaccttggaaactttgacaaaacat tatggcgctgaaatatttgagacttccatgttgctgatttcatcagaaaatgagatgaat tggtttcattcgaatgacagtggaaacgttctgtactatgaagtgatggtgactgggaat cttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaaaataaa ctgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaagatccgg gaagagtggaataatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctgtcttcccatgag gaggccttgtcctttgtgtcactggtagatggctacttccggctcaccgcagacgcccat cattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaatggctgt catggtccaatctgtacagaatatgccatcaataaattgcggcaagaaggaagcgaggag gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgaccgtcacc tgctttgagaagtctgagcaggggcagggtgcccagaagcagttcaagaactttcagatc gaggtgcagaagggccgctacagcctgcatggttcagaccgcagcttccccagcttggga gacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttcatgttg aaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctactaagaaa gcccaggagtggcagcccgtctaccccatgagccagctgagttttgatcggattttcaag aaggatctggtgcagggcgagcaccttgggagaggcacgagaacacacatctactctggg accctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaagtgatc ctcaaagtcttagaccctagccacagggatatttccctggccttcttcgaggcagccagc atgatgagacaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgcgac gtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttcatgcac cggaaaagcgatgtccttactacaccctggaaattcaaagttgccaaacagctggccagt gccctgagctacttggaagataaagacctggtccatggaaatgtgtgtactaaaaacctc ctcctggcccgtgagggcatcgacagcgagtgtggtccgttcatcaagctcagtgaccct ggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccgtggattgct cccgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagctttgga actacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagacactgatt gagaaagagagattctatgaaagccggtgcaggccagtgacaccatcatgtaaggagctg gctgacctcatgacccgctgcatgaactacgaccccaatcagaggcccttcttccgagcc atcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaaaaaaag ccagcaactgaagtggaccccacgcattttgagaagcgcttcctaaagaggatccgtgac ttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggggacaat acaggggagcaggtggctgtcaaatctctgaagcctgagagtggaggtaaccacatagct gatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtgaagtac aaaggaatctgcacggaagacggaggaaatggtattaagctcatcatggaatttctgcct tcgggaagccttaaggagtatcttccaaagaataagaacaaaattaacctcaaacagcag ctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatatgtt caccgtgacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattgga gacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaaggatgac cgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattttatatc gcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgtgactca gattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccagatgaca gtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccgcctaactgt ccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaatcggaca agctttcagaaccttattgaaggatttgaagcacttttaaaataa

Macaca mulatta (rhesus monkey): 694184 Help Entry 694184            CDS       T01028                                  Gene name JAK2 Definition (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc04062   Chemokine signaling pathway mcc04151   PI3K-Akt signaling pathway mcc04217   Necroptosis mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04630   JAK-STAT signaling pathway mcc04658   Th1 and Th2 cell differentiation mcc04659   Th17 cell differentiation mcc04725   Cholinergic synapse mcc04917   Prolactin signaling pathway mcc04920   Adipocytokine signaling pathway mcc04933   AGE-RAGE signaling pathway in diabetic complications mcc04935   Growth hormone synthesis, secretion and action mcc05140   Leishmaniasis mcc05145   Toxoplasmosis mcc05152   Tuberculosis mcc05161   Hepatitis B mcc05164   Influenza A mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05168   Herpes simplex virus 1 infection mcc05200   Pathways in cancer mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     694184 (JAK2)    04151 PI3K-Akt signaling pathway     694184 (JAK2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     694184 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     694184 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     694184 (JAK2)    04659 Th17 cell differentiation     694184 (JAK2)    04062 Chemokine signaling pathway     694184 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     694184 (JAK2)    04917 Prolactin signaling pathway     694184 (JAK2)    04935 Growth hormone synthesis, secretion and action     694184 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     694184 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     694184 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     694184 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     694184 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     694184 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     694184 (JAK2)    05164 Influenza A     694184 (JAK2)    05168 Herpes simplex virus 1 infection     694184 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     694184 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     694184 (JAK2)    05140 Leishmaniasis     694184 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     694184 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mcc01001]     694184 (JAK2) Enzymes [BR:mcc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      694184 (JAK2) Protein kinases [BR:mcc01001]  Non-receptor tyrosine kinases   JAK family [OT]    694184 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like Motif Other DBs NCBI-GeneID:  694184 NCBI-ProteinID:  NP_001252830 Ensembl:  ENSMMUG00000014558 UniProt:  A0A5F8ATC5 LinkDB All DBs Position 15 AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKENDQTPLAIYNSISYKTFLPECIRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSDESRVVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI RNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL ANLINNCMDYEPDFRPSFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNLRPSFRDLALRVDQIRDNMAG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcctgccttactatgacagaaatggagggaacatccacatcttctatatat cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagtccttcag gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt cctcgttggtattgcagcggcagcaacagagcctatcggcatggaatatctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaatgatcaaaccccactggccatc tataattctatcagctacaagacattcttaccagaatgtattcgagcaaagatccaagac tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcagttc agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaacc ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcagatgaaagccga gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat cattacctctgtaaagaagtagcacctccaacagtgcttgaaaatatacaaagcaactgt catggcccaatttcgatggattttgccattagtaaactgaagaaagcaggtaatcagact ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt taccagatggaaaccgttcgctcagacaatataattttccagtttactaagtgctgtccc ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgatgta ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc agaaatgaagatttgatatttaatgaaagccttggccaaggcactttcacaaagattttt aaaggcatacgaagagaagtaggagactatggtcaacttcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggagtttgtaaaatttggatcactagatacatacctgaaaaag aataaaaattgtataaatatattatggaaacttgaagttgcgaaacagttggcatgggcc atgcattttctagaagaaaacacccttattcatgggaatgtgtgcgccaaaaatattcta cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataaacctctaagtgccctggattctcaa agaaagctgcaattttatgaagataggcaccagcttcctgcaccaaagtgggcagaatta gcaaaccttataaataattgtatggattatgaacccgatttcaggccttctttcagagcc gtcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagacagggat cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaacttt gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct gtaaaaaagcttcagcatagtactgaagagcacctgagagactttgaaagggaaattgaa atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaga aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa tttatgcgcatgattggcaatgataaacaaggacagatgatcgtgttccatttgatagaa cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatatg atcatgacagaatgctggaacaataatgtaaatctacgcccctcctttagagatctagct cttcgagtggatcaaataagggataacatggctggatga

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