KEGG   Macaca mulatta (rhesus monkey): 694725
Entry
694725            CDS       T01028                                 

Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01521  EGFR tyrosine kinase inhibitor resistance
mcc01522  Endocrine resistance
mcc04010  MAPK signaling pathway
mcc04012  ErbB signaling pathway
mcc04014  Ras signaling pathway
mcc04015  Rap1 signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04024  cAMP signaling pathway
mcc04062  Chemokine signaling pathway
mcc04068  FoxO signaling pathway
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04140  Autophagy - animal
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04218  Cellular senescence
mcc04270  Vascular smooth muscle contraction
mcc04360  Axon guidance
mcc04370  VEGF signaling pathway
mcc04371  Apelin signaling pathway
mcc04510  Focal adhesion
mcc04540  Gap junction
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04613  Neutrophil extracellular trap formation
mcc04625  C-type lectin receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04650  Natural killer cell mediated cytotoxicity
mcc04660  T cell receptor signaling pathway
mcc04662  B cell receptor signaling pathway
mcc04664  Fc epsilon RI signaling pathway
mcc04666  Fc gamma R-mediated phagocytosis
mcc04720  Long-term potentiation
mcc04722  Neurotrophin signaling pathway
mcc04726  Serotonergic synapse
mcc04730  Long-term depression
mcc04810  Regulation of actin cytoskeleton
mcc04910  Insulin signaling pathway
mcc04912  GnRH signaling pathway
mcc04914  Progesterone-mediated oocyte maturation
mcc04915  Estrogen signaling pathway
mcc04916  Melanogenesis
mcc04917  Prolactin signaling pathway
mcc04919  Thyroid hormone signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04926  Relaxin signaling pathway
mcc04928  Parathyroid hormone synthesis, secretion and action
mcc04929  GnRH secretion
mcc04935  Growth hormone synthesis, secretion and action
mcc05010  Alzheimer disease
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05034  Alcoholism
mcc05132  Salmonella infection
mcc05152  Tuberculosis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05163  Human cytomegalovirus infection
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05170  Human immunodeficiency virus 1 infection
mcc05200  Pathways in cancer
mcc05205  Proteoglycans in cancer
mcc05206  MicroRNAs in cancer
mcc05210  Colorectal cancer
mcc05211  Renal cell carcinoma
mcc05212  Pancreatic cancer
mcc05213  Endometrial cancer
mcc05214  Glioma
mcc05215  Prostate cancer
mcc05218  Melanoma
mcc05219  Bladder cancer
mcc05220  Chronic myeloid leukemia
mcc05221  Acute myeloid leukemia
mcc05223  Non-small cell lung cancer
mcc05224  Breast cancer
mcc05225  Hepatocellular carcinoma
mcc05226  Gastric cancer
mcc05230  Central carbon metabolism in cancer
mcc05231  Choline metabolism in cancer
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    694725 (RAF1)
   04012 ErbB signaling pathway
    694725 (RAF1)
   04014 Ras signaling pathway
    694725 (RAF1)
   04015 Rap1 signaling pathway
    694725 (RAF1)
   04370 VEGF signaling pathway
    694725 (RAF1)
   04371 Apelin signaling pathway
    694725 (RAF1)
   04630 JAK-STAT signaling pathway
    694725 (RAF1)
   04068 FoxO signaling pathway
    694725 (RAF1)
   04072 Phospholipase D signaling pathway
    694725 (RAF1)
   04071 Sphingolipid signaling pathway
    694725 (RAF1)
   04024 cAMP signaling pathway
    694725 (RAF1)
   04022 cGMP-PKG signaling pathway
    694725 (RAF1)
   04151 PI3K-Akt signaling pathway
    694725 (RAF1)
   04150 mTOR signaling pathway
    694725 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    694725 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    694725 (RAF1)
   04218 Cellular senescence
    694725 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    694725 (RAF1)
   04540 Gap junction
    694725 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    694725 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    694725 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    694725 (RAF1)
   04625 C-type lectin receptor signaling pathway
    694725 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    694725 (RAF1)
   04660 T cell receptor signaling pathway
    694725 (RAF1)
   04662 B cell receptor signaling pathway
    694725 (RAF1)
   04664 Fc epsilon RI signaling pathway
    694725 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    694725 (RAF1)
   04062 Chemokine signaling pathway
    694725 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    694725 (RAF1)
   04929 GnRH secretion
    694725 (RAF1)
   04912 GnRH signaling pathway
    694725 (RAF1)
   04915 Estrogen signaling pathway
    694725 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    694725 (RAF1)
   04917 Prolactin signaling pathway
    694725 (RAF1)
   04921 Oxytocin signaling pathway
    694725 (RAF1)
   04926 Relaxin signaling pathway
    694725 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    694725 (RAF1)
   04919 Thyroid hormone signaling pathway
    694725 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    694725 (RAF1)
   04916 Melanogenesis
    694725 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    694725 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    694725 (RAF1)
   04720 Long-term potentiation
    694725 (RAF1)
   04730 Long-term depression
    694725 (RAF1)
   04722 Neurotrophin signaling pathway
    694725 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    694725 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    694725 (RAF1)
   05206 MicroRNAs in cancer
    694725 (RAF1)
   05205 Proteoglycans in cancer
    694725 (RAF1)
   05230 Central carbon metabolism in cancer
    694725 (RAF1)
   05231 Choline metabolism in cancer
    694725 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    694725 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    694725 (RAF1)
   05212 Pancreatic cancer
    694725 (RAF1)
   05225 Hepatocellular carcinoma
    694725 (RAF1)
   05226 Gastric cancer
    694725 (RAF1)
   05214 Glioma
    694725 (RAF1)
   05221 Acute myeloid leukemia
    694725 (RAF1)
   05220 Chronic myeloid leukemia
    694725 (RAF1)
   05218 Melanoma
    694725 (RAF1)
   05211 Renal cell carcinoma
    694725 (RAF1)
   05219 Bladder cancer
    694725 (RAF1)
   05215 Prostate cancer
    694725 (RAF1)
   05213 Endometrial cancer
    694725 (RAF1)
   05224 Breast cancer
    694725 (RAF1)
   05223 Non-small cell lung cancer
    694725 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    694725 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    694725 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    694725 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    694725 (RAF1)
   05152 Tuberculosis
    694725 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    694725 (RAF1)
   05161 Hepatitis B
    694725 (RAF1)
   05160 Hepatitis C
    694725 (RAF1)
   05164 Influenza A
    694725 (RAF1)
   05163 Human cytomegalovirus infection
    694725 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    694725 (RAF1)
   05165 Human papillomavirus infection
    694725 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    694725 (RAF1)
   01522 Endocrine resistance
    694725 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    694725 (RAF1)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     694725 (RAF1)
Protein kinases [BR:mcc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   694725 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 694725
NCBI-ProteinID: NP_001253231
Ensembl: ENSMMUG00000007450
UniProt: F6SWC0
LinkDB
Position
2
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaatactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtacgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggccttcaaccagagtgctgtgcagtgttcaga
cttctccatgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcctct
ttgattggggaagaacttcaagtagatttcctggatcatgttccgctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacaggtattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctttcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacacccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggcaaatggcacggagacgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggccta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcagatgtctactcctatggcatcgtattgtatgag
ctgatgacgggggaacttccttactctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgagggtatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acatccccgaggctgcctgtcttctag

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