Macaca mulatta (rhesus monkey): 694965 Help Entry 694965            CDS       T01028                                  Gene name TSC2 Definition (RefSeq) tuberin isoform X7   KO K07207   tuberous sclerosis 2 Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc04072   Phospholipase D signaling pathway mcc04115   p53 signaling pathway mcc04140   Autophagy - animal mcc04150   mTOR signaling pathway mcc04151   PI3K-Akt signaling pathway mcc04152   AMPK signaling pathway mcc04211   Longevity regulating pathway mcc04218   Cellular senescence mcc04714   Thermogenesis mcc04910   Insulin signaling pathway mcc04919   Thyroid hormone signaling pathway mcc05163   Human cytomegalovirus infection mcc05165   Human papillomavirus infection mcc05168   Herpes simplex virus 1 infection mcc05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     694965 (TSC2)    04151 PI3K-Akt signaling pathway     694965 (TSC2)    04152 AMPK signaling pathway     694965 (TSC2)    04150 mTOR signaling pathway     694965 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     694965 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     694965 (TSC2)    04218 Cellular senescence     694965 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     694965 (TSC2)    04919 Thyroid hormone signaling pathway     694965 (TSC2)   09149 Aging    04211 Longevity regulating pathway     694965 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     694965 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     694965 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     694965 (TSC2)    05163 Human cytomegalovirus infection     694965 (TSC2)    05165 Human papillomavirus infection     694965 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:mcc01009]     694965 (TSC2) Protein phosphatases and associated proteins [BR:mcc01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      694965 (TSC2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP Telomere_reg-2 Cnd1 Motif Other DBs NCBI-GeneID:  694965 NCBI-ProteinID:  XP_001083256 Ensembl:  ENSMMUG00000002808 LinkDB All DBs Position 20 AA seq 1944 aa AA seqDB search MLRSGRGATCCSFSPPGRRGLLPTPPRSSPGSQAPVPRQHPGAQGVHAGLLRTTHPGGPR GPRHVTQGSPAFPLEGCLELQLPAGSVAALRAAPLPEVRVPLPAASGARGVRLSPRRGGP ARGGAAREGCSGASWPTMAKPASKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAE ILRELSVECGLSNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLA LLKAIIQGQGERLGVLRALFFKVIKDYPSNEDLHERLDVFKALTDNGRHITYLEEELADF VLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLD AVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDR AYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSIT RLIKKYRKELQVVTWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGS QERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRI KVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHH FNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHA TRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPY CVCDYMEPERGSEKKASGPLSPPTGPPGPAPAGPAVRLGSLPYSLLFRVLLQCLKQESDW KVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLH LAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIMIKAL PVLVVKLTHISATASMAVPLLEFLSTLARLPQLYRNFAAEQYASVFAISLPYTNPSKFNQ YIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNER PKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSA DENSVAQADDSLKSLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGMNVRQTKEAPAKLESQAGQQVSRG ARDRVRSMSGGHGLRVGALDVPASQFPGSAASPGPQTAPAAKPEKASAGARLPVQEKTNL AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE HRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEG SPGEVPVPVEPPGLEDFEAALGVDRRTDAYSRSSSTSSQEEKSFHAEELVAGGIPIERAV SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGIL DGESAAWPASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGRRVERDAFKSR ATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTH KIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGED GQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIK GQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMAS QVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHTKGPAQTPAE PTPGYEMGQRKRLISSVEDFTEFV NT seq 5835 nt NT seq  +upstreamnt  +downstreamnt atgctccggtcagggcgcggcgctacctgctgcagcttctcccctccggggaggcgcggg ctcctccccacacccccgcggtccagccctgggtcccaggctccggttccgcgtcagcat cctggcgctcaaggagttcatgccggactcctgcggactacacatcccggcggcccacgc ggcccccgtcacgtgacgcaaggatcgccggcctttccgctagagggctgcctagaacta caactcccagcaggctccgtggcggccctccgcgcggcaccgctgccggaagtgcgggtc ccgcttccggcagcgtccggggccaggggggttcgcctttctccgcgtcggggcggcccg gcgcgcggtggcgcggcgagggaggggtgttctggtgcgtcctggcccaccatggccaaa ccagcaagcaaagattcaggcttgaaggagaagtttaggattctgtttggactgggaaca ccgaggccaaatcccaggtctgcagagggcaaacagacggaatttatcatcaccgccgaa atcctgagagagctgagtgtggaatgcggcctcagcaatcgcatccggatgatagggcag atttgtgaagtcgcaaaaaccaagaaatttgaagagcacgcagtggaagcactctggaag gcggttgcggatctgttgcagccagaacggccgctggaggcccggcacgcggtgctggct ctgctgaaggccatcattcaggggcagggcgagcgtttgggggtcctcagggccctcttc tttaaggtcatcaaggattacccttccaacgaagacctccacgagaggctggacgttttc aaggccctcacagacaatgggagacacatcacctacttggaggaagagctggcggacttt gtcctgcagtggatggatgtcggcttgtcctcggaattccttctggtgctggtgaacttg gtcaaattcaacagctgttacctcgatgagtacatcgcaaggatggttcagatgatctgc ctgctctgcgtccggaccgcatcctctgtggacatagaggtctccctgcaggtgctggac gccgtggtctgctacaactgcctgccggctgagagcctcccgctgttcatcgtcaccctg tgccgcaccatcaatgtcaaggagctctgcgagccttgctggaagctgatgcggaacctc cttggcacccacctgggccacagtgccatctacaacatgtgccacctcatggaggacaga gcctatatggaggacgcgcccctgctgagaggagccgtgttttttgtgggcatggctctc tggggagcccaccggctctattctctcaggaactcgccgacatcggtgctgccatcattt taccaggccatggcatgtccgaacgaggtggtgtcctatgagatcgtcctgtccatcacc aggctcatcaagaagtataggaaggagctccaggtggtgacgtgggacattctgctgaac atcatcgaacggctccttcagcagctccagaccttggacagcccggagctcaggaccatc gtccatgacctgctgaccacggtggaggagctgtgtgaccagaatgagttccacgggtct caggagagatactttgaactggtggagagatgtgcagaccagaggcctgagtcctccctc ctgaacctgatctcctacagagcgcagtccattcacccggccaaggacggctggattcag aacctgcaggcgctgatggagagattcttcaggagcgagtcccgaggcgccgtgcgcatc aaggtgctggatgtgctgtcctttgtgctgctcatcaacaggcagttctacgaggaggag ctgattaactcagtggtcatctctcagctctcccacatccccgaggataaagaccatcag gtccgaaagctggccacccagttgctggtggacctggcagagggctgccacacacaccac ttcaacagtctgctggacatcatcgagaaggtgatggcccgctccctctccccacccccg gagttggaagaaagggatgtggccgcgtactcggcgtccttggaggatgtgaagacagct gtcctggggcttctggtcatccttcagactaagctgtacaccctgcctgcgagccatgcc acgcgcgtttatgagatgctggtcagccacattcagctccactacaagcacagctacacc ctgccaatcgccagcagcatccggctgcaggcctttgacttcctgttgctgctgcgggcc gactcactgcaccgcctcggcctgcccaacaaggatggggtcgtgcggttcagcccctac tgcgtctgcgactacatggagccggagagaggctctgagaagaaggccagcggccccctt tctcctcccacagggccacctggcccggcgcctgcaggcccggctgtgcggctgggctcc ctgccctactccctgctcttccgcgtcctgctgcagtgcttgaagcaggagtctgactgg aaggtgctgaagctggttctgggcaggctgcctgagtccctgcgctacaaagtactcatc tttacctccccttgcagtgtggaccagctgtgctctgctctctgctccatgctttcaggc ccaaagacactggagcggctccgaggcgccccggaaggcttctccagaactgacctgcac ctggctgtggttccagtgctgacggcattaatctcttaccataactacctggacaaaacc aaacagcgcgagatggtctactgcctggagcagggcctcatccaccgctgtgccagccag tgcgtcgtagccttgtccatctgcagcgtggagatgcctgacatcatgatcaaggcgctg cccgtcctggtggtgaagctcacacacatctcggccacagccagcatggccgtcccgctg ctggagttcctgtccactctggccaggctgccgcagctctacaggaacttcgccgcggag cagtatgccagtgtgttcgccatctcactgccgtacaccaacccctccaagtttaatcag tacatcgtgtgtctggcccatcacgtcatagccatgtggtttatcaggtgccgcctgccc ttccggaaggattttgtccctttcatcactaagggcctgcggtccaatgtcctcttgtct tttgatgacacccccgagaaggacagcttcagggcccggagtactagtctcaacgagagg cccaagagtctgaggatagccagaccccccaaacaaggcttgaataactctccacccgtg aaagaattcaaggagagctctgcagccgaggccttccggtgccgcagcatcagtgtgtct gaacatgtggtccgcagcaggatacagacgtccctcaccagtgccagcctggggtctgca gacgagaactccgtggcccaggctgacgatagcctgaaaagcctccatctggagctcacg gaaacctgtctggacatgatggcccgatacgtcttctccaacttcacagctgtcccgaag aggtctcctgtgggcgagttcctcctggcgggtggcaggaccaaaacctggctggttggg aacaagcttgtcactgtgacgacgagtgtgggaaccgggacccggtcgttactaggcctg gactcgggggagctgcagtccggcccggagtcgagctccagccccggcatgaatgtgaga cagacgaaggaggcgccagccaagctggagtcccaggctgggcagcaggtgtcccgtggg gcccgggaccgggtccgttctatgtcagggggccatggtcttcgagttggcgccctggat gtgccggcctcccagttcccgggcagtgccgcttctccaggaccacagactgcaccagcc gcgaagcctgagaaggcctcggccggcgcccggcttcctgtgcaggagaagacgaacctg gccgcctacgtgcccctgctgacccagggctgggcggagatcctggtccggaggcccaca gggaacaccagctggctgatgagcctggagaacccgctcagccctttctcctcggacatc aacaacatgcccctgcaggagctgtccaacgccctcatggcagctgagcgcttcaaggag caccgggacacagccctgtacaagtcgctgtcggtgccagcagccagcacggccaaaccc cctcctctgcctcgctccaacacagtggcctctttctcctccctgtaccagtccagctgc caaggacagctgcacaggagcgtttcctgggcagactccgccgtggtcatggaggaggga agtcctggcgaggttcctgtgccagtggagcccccaggattggaggactttgaggcggcg ctaggcgtggacaggcgcacagacgcctacagcaggtcgtcctcaacctccagccaggag gagaagtcattccacgcagaggagctggttgccgggggaatccccattgaacgagccgtc tcctcggagggtggccggccctctgtggacctctccttccagccctcacagcccctgagc aagtctagctcctctcctgagctgcagaccctgcaggacatcctcggggaccctggggac aaggctgacgtgggccggctgagccctgaggttaaggcccgttcacagtcagggatcctg gacggggaaagtgctgcctggccagcctcgggcgaagacagtcggggccagcccgagggt cccttgccttccagctccccccgctcacccagtggcctccggccccgcggttacaccatc tccgactcggccccatcacgcaggggcaggagggtagaaagggatgcctttaagagcaga gccacagcttccaatgcagagaaagtgccaggcatcaaccccagtttcgtgttcctgcag ctctaccattcgcctttctttggcgacgagtcaaacaagccaatcctgctgcccaatgag tcacagtcctttgagcggtcggtgcagctcctcgaccagatcccatcatacgacacccac aagatcgccgtcctgtatgtgggagaaggccagagcaacagtgagctcgccatcctgtcc aatgagcatggctcctacaggtacacggagttcctgacgggcctgggccggctcatcgag ctcaaggactgccagccagacaaggtgtacctgggcggcctggacgtgtgtggtgaggac ggccagttcacctactgctggcacgacgacatcatgcaagccgtcttccacatcgccacc ctgatgcccaccaaggacgtggacaagcatcgttgcgacaagaagcgccacctgggcaac gatttcgtgtccattgtctacaatgactctggcgaggacttcaagctcggcaccatcaag ggccagttcaactttgtccacgtgatcatcaccccgctggattatgagtgcaacctggtg tccctgcagtgcaggaaagacatggagggccttgtggacaccagcgtggccaagatcgtg tctgaccgcaacctgccttttgtggcccgtcagatggccctgcatgcaaacatggcctca caggtgcaccacagccgctccaaccccaccgacatctacccctccaagtggattgcccgg ctccgccacatcaagagactccgccagcggatctgcgaggaagccgcctactccaacccc agcctgcctctggtgcaccccccatcccataccaaagggcctgcacagactccagccgag cccacgcctggctacgagatgggccagcggaagcgcctcatctcctctgtggaggacttc accgagttcgtgtga

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