Macaca mulatta (rhesus monkey): 697069
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Entry
697069 CDS
T01028
Gene name
PLCG1
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
mcc
Macaca mulatta (rhesus monkey)
Pathway
mcc00562
Inositol phosphate metabolism
mcc01100
Metabolic pathways
mcc01521
EGFR tyrosine kinase inhibitor resistance
mcc04012
ErbB signaling pathway
mcc04014
Ras signaling pathway
mcc04015
Rap1 signaling pathway
mcc04020
Calcium signaling pathway
mcc04062
Chemokine signaling pathway
mcc04064
NF-kappa B signaling pathway
mcc04066
HIF-1 signaling pathway
mcc04070
Phosphatidylinositol signaling system
mcc04072
Phospholipase D signaling pathway
mcc04360
Axon guidance
mcc04370
VEGF signaling pathway
mcc04613
Neutrophil extracellular trap formation
mcc04650
Natural killer cell mediated cytotoxicity
mcc04658
Th1 and Th2 cell differentiation
mcc04659
Th17 cell differentiation
mcc04660
T cell receptor signaling pathway
mcc04664
Fc epsilon RI signaling pathway
mcc04666
Fc gamma R-mediated phagocytosis
mcc04670
Leukocyte transendothelial migration
mcc04722
Neurotrophin signaling pathway
mcc04750
Inflammatory mediator regulation of TRP channels
mcc04919
Thyroid hormone signaling pathway
mcc04933
AGE-RAGE signaling pathway in diabetic complications
mcc04935
Growth hormone synthesis, secretion and action
mcc05012
Parkinson disease
mcc05022
Pathways of neurodegeneration - multiple diseases
mcc05135
Yersinia infection
mcc05167
Kaposi sarcoma-associated herpesvirus infection
mcc05170
Human immunodeficiency virus 1 infection
mcc05171
Coronavirus disease - COVID-19
mcc05200
Pathways in cancer
mcc05205
Proteoglycans in cancer
mcc05206
MicroRNAs in cancer
mcc05214
Glioma
mcc05223
Non-small cell lung cancer
mcc05225
Hepatocellular carcinoma
mcc05231
Choline metabolism in cancer
mcc05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
mcc_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
mcc00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
697069 (PLCG1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
697069 (PLCG1)
04014 Ras signaling pathway
697069 (PLCG1)
04015 Rap1 signaling pathway
697069 (PLCG1)
04370 VEGF signaling pathway
697069 (PLCG1)
04064 NF-kappa B signaling pathway
697069 (PLCG1)
04066 HIF-1 signaling pathway
697069 (PLCG1)
04020 Calcium signaling pathway
697069 (PLCG1)
04070 Phosphatidylinositol signaling system
697069 (PLCG1)
04072 Phospholipase D signaling pathway
697069 (PLCG1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
697069 (PLCG1)
04650 Natural killer cell mediated cytotoxicity
697069 (PLCG1)
04660 T cell receptor signaling pathway
697069 (PLCG1)
04658 Th1 and Th2 cell differentiation
697069 (PLCG1)
04659 Th17 cell differentiation
697069 (PLCG1)
04664 Fc epsilon RI signaling pathway
697069 (PLCG1)
04666 Fc gamma R-mediated phagocytosis
697069 (PLCG1)
04670 Leukocyte transendothelial migration
697069 (PLCG1)
04062 Chemokine signaling pathway
697069 (PLCG1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
697069 (PLCG1)
04919 Thyroid hormone signaling pathway
697069 (PLCG1)
09156 Nervous system
04722 Neurotrophin signaling pathway
697069 (PLCG1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
697069 (PLCG1)
09158 Development and regeneration
04360 Axon guidance
697069 (PLCG1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
697069 (PLCG1)
05206 MicroRNAs in cancer
697069 (PLCG1)
05205 Proteoglycans in cancer
697069 (PLCG1)
05231 Choline metabolism in cancer
697069 (PLCG1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
697069 (PLCG1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
697069 (PLCG1)
05214 Glioma
697069 (PLCG1)
05223 Non-small cell lung cancer
697069 (PLCG1)
09164 Neurodegenerative disease
05012 Parkinson disease
697069 (PLCG1)
05022 Pathways of neurodegeneration - multiple diseases
697069 (PLCG1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
697069 (PLCG1)
09171 Infectious disease: bacterial
05135 Yersinia infection
697069 (PLCG1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
697069 (PLCG1)
05171 Coronavirus disease - COVID-19
697069 (PLCG1)
05167 Kaposi sarcoma-associated herpesvirus infection
697069 (PLCG1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
697069 (PLCG1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mcc04131
]
697069 (PLCG1)
Enzymes [BR:
mcc01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
697069 (PLCG1)
Membrane trafficking [BR:
mcc04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
697069 (PLCG1)
Endocytosis
Macropinocytosis
Phospholipase C
697069 (PLCG1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
PH
SH3_9
SH3_2
PH_12
GDPD
PH_9
Motif
Other DBs
NCBI-GeneID:
697069
NCBI-ProteinID:
XP_015004490
Ensembl:
ENSMMUG00000005905
UniProt:
A0A1D5R8E9
LinkDB
All DBs
Position
10
AA seq
1291 aa
AA seq
DB search
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLQTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRVSQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq
3876 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgccgcatccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatagagggggccattgatattcgagaaatcaaggag
attcgcccagggaagacctcacgagactttgatcgctatcaagaggaccccgctttccgg
ccggaccagtcacactgctttgtcattctctatggaatggaattccgtctgaagacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctaaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctaacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaatagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccccctttcccactattggatctcctcctcacacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcaaaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcggcacatcgctgagcgcctgctcactgagtactgcatcgagaccggggcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcacggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgactttcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctgatgcgtgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgaaggcaagatcaagcattgccgtgtccagcaagag
ggccagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaagcacccgctataccgcaagatgaagctgcgctatccaatcaatgaggaggcg
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagggaggatgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccagagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagatcgccctggagctctctgaacttgttgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggctctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctgttgaggtgctgggtgcccgacatttg
ccaaagaatggccgaggcattgtgtgcccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccggccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcgtctcccaggagcatcttgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag
DBGET
integrated database retrieval system
