Macaca mulatta (rhesus monkey): 698830 Help Entry 698830            CDS       T01028                                  Gene name HRAS Definition (RefSeq) GTPase HRas   KO K02833   GTPase HRas Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc01522   Endocrine resistance mcc04010   MAPK signaling pathway mcc04012   ErbB signaling pathway mcc04014   Ras signaling pathway mcc04015   Rap1 signaling pathway mcc04062   Chemokine signaling pathway mcc04068   FoxO signaling pathway mcc04071   Sphingolipid signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04144   Endocytosis mcc04150   mTOR signaling pathway mcc04151   PI3K-Akt signaling pathway mcc04210   Apoptosis mcc04211   Longevity regulating pathway mcc04213   Longevity regulating pathway - multiple species mcc04218   Cellular senescence mcc04360   Axon guidance mcc04370   VEGF signaling pathway mcc04371   Apelin signaling pathway mcc04510   Focal adhesion mcc04540   Gap junction mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04625   C-type lectin receptor signaling pathway mcc04630   JAK-STAT signaling pathway mcc04650   Natural killer cell mediated cytotoxicity mcc04660   T cell receptor signaling pathway mcc04662   B cell receptor signaling pathway mcc04664   Fc epsilon RI signaling pathway mcc04714   Thermogenesis mcc04720   Long-term potentiation mcc04722   Neurotrophin signaling pathway mcc04725   Cholinergic synapse mcc04726   Serotonergic synapse mcc04730   Long-term depression mcc04810   Regulation of actin cytoskeleton mcc04910   Insulin signaling pathway mcc04912   GnRH signaling pathway mcc04915   Estrogen signaling pathway mcc04916   Melanogenesis mcc04917   Prolactin signaling pathway mcc04919   Thyroid hormone signaling pathway mcc04921   Oxytocin signaling pathway mcc04926   Relaxin signaling pathway mcc04929   GnRH secretion mcc04933   AGE-RAGE signaling pathway in diabetic complications mcc04935   Growth hormone synthesis, secretion and action mcc05010   Alzheimer disease mcc05022   Pathways of neurodegeneration - multiple diseases mcc05034   Alcoholism mcc05132   Salmonella infection mcc05160   Hepatitis C mcc05161   Hepatitis B mcc05163   Human cytomegalovirus infection mcc05165   Human papillomavirus infection mcc05166   Human T-cell leukemia virus 1 infection mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05170   Human immunodeficiency virus 1 infection mcc05200   Pathways in cancer mcc05203   Viral carcinogenesis mcc05205   Proteoglycans in cancer mcc05206   MicroRNAs in cancer mcc05210   Colorectal cancer mcc05211   Renal cell carcinoma mcc05213   Endometrial cancer mcc05214   Glioma mcc05215   Prostate cancer mcc05216   Thyroid cancer mcc05218   Melanoma mcc05219   Bladder cancer mcc05220   Chronic myeloid leukemia mcc05221   Acute myeloid leukemia mcc05223   Non-small cell lung cancer mcc05224   Breast cancer mcc05225   Hepatocellular carcinoma mcc05226   Gastric cancer mcc05230   Central carbon metabolism in cancer mcc05231   Choline metabolism in cancer mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     698830 (HRAS)    04012 ErbB signaling pathway     698830 (HRAS)    04014 Ras signaling pathway     698830 (HRAS)    04015 Rap1 signaling pathway     698830 (HRAS)    04370 VEGF signaling pathway     698830 (HRAS)    04371 Apelin signaling pathway     698830 (HRAS)    04630 JAK-STAT signaling pathway     698830 (HRAS)    04068 FoxO signaling pathway     698830 (HRAS)    04072 Phospholipase D signaling pathway     698830 (HRAS)    04071 Sphingolipid signaling pathway     698830 (HRAS)    04151 PI3K-Akt signaling pathway     698830 (HRAS)    04150 mTOR signaling pathway     698830 (HRAS)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     698830 (HRAS)    04140 Autophagy - animal     698830 (HRAS)    04137 Mitophagy - animal     698830 (HRAS)   09143 Cell growth and death    04210 Apoptosis     698830 (HRAS)    04218 Cellular senescence     698830 (HRAS)   09144 Cellular community - eukaryotes    04510 Focal adhesion     698830 (HRAS)    04540 Gap junction     698830 (HRAS)    04550 Signaling pathways regulating pluripotency of stem cells     698830 (HRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     698830 (HRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     698830 (HRAS)    04650 Natural killer cell mediated cytotoxicity     698830 (HRAS)    04660 T cell receptor signaling pathway     698830 (HRAS)    04662 B cell receptor signaling pathway     698830 (HRAS)    04664 Fc epsilon RI signaling pathway     698830 (HRAS)    04062 Chemokine signaling pathway     698830 (HRAS)   09152 Endocrine system    04910 Insulin signaling pathway     698830 (HRAS)    04929 GnRH secretion     698830 (HRAS)    04912 GnRH signaling pathway     698830 (HRAS)    04915 Estrogen signaling pathway     698830 (HRAS)    04917 Prolactin signaling pathway     698830 (HRAS)    04921 Oxytocin signaling pathway     698830 (HRAS)    04926 Relaxin signaling pathway     698830 (HRAS)    04935 Growth hormone synthesis, secretion and action     698830 (HRAS)    04919 Thyroid hormone signaling pathway     698830 (HRAS)    04916 Melanogenesis     698830 (HRAS)   09156 Nervous system    04725 Cholinergic synapse     698830 (HRAS)    04726 Serotonergic synapse     698830 (HRAS)    04720 Long-term potentiation     698830 (HRAS)    04730 Long-term depression     698830 (HRAS)    04722 Neurotrophin signaling pathway     698830 (HRAS)   09158 Development and regeneration    04360 Axon guidance     698830 (HRAS)   09149 Aging    04211 Longevity regulating pathway     698830 (HRAS)    04213 Longevity regulating pathway - multiple species     698830 (HRAS)   09159 Environmental adaptation    04714 Thermogenesis     698830 (HRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     698830 (HRAS)    05206 MicroRNAs in cancer     698830 (HRAS)    05205 Proteoglycans in cancer     698830 (HRAS)    05203 Viral carcinogenesis     698830 (HRAS)    05230 Central carbon metabolism in cancer     698830 (HRAS)    05231 Choline metabolism in cancer     698830 (HRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     698830 (HRAS)   09162 Cancer: specific types    05210 Colorectal cancer     698830 (HRAS)    05225 Hepatocellular carcinoma     698830 (HRAS)    05226 Gastric cancer     698830 (HRAS)    05214 Glioma     698830 (HRAS)    05216 Thyroid cancer     698830 (HRAS)    05221 Acute myeloid leukemia     698830 (HRAS)    05220 Chronic myeloid leukemia     698830 (HRAS)    05218 Melanoma     698830 (HRAS)    05211 Renal cell carcinoma     698830 (HRAS)    05219 Bladder cancer     698830 (HRAS)    05215 Prostate cancer     698830 (HRAS)    05213 Endometrial cancer     698830 (HRAS)    05224 Breast cancer     698830 (HRAS)    05223 Non-small cell lung cancer     698830 (HRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     698830 (HRAS)    05022 Pathways of neurodegeneration - multiple diseases     698830 (HRAS)   09165 Substance dependence    05034 Alcoholism     698830 (HRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     698830 (HRAS)   09171 Infectious disease: bacterial    05132 Salmonella infection     698830 (HRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     698830 (HRAS)    05170 Human immunodeficiency virus 1 infection     698830 (HRAS)    05161 Hepatitis B     698830 (HRAS)    05160 Hepatitis C     698830 (HRAS)    05163 Human cytomegalovirus infection     698830 (HRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     698830 (HRAS)    05165 Human papillomavirus infection     698830 (HRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     698830 (HRAS)    01522 Endocrine resistance     698830 (HRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mcc04131]     698830 (HRAS)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mcc04147]     698830 (HRAS)    04031 GTP-binding proteins [BR:mcc04031]     698830 (HRAS) Membrane trafficking [BR:mcc04131]  Endocytosis   Macropinocytosis    Ras GTPases     698830 (HRAS) Exosome [BR:mcc04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    698830 (HRAS)   Exosomal proteins of colorectal cancer cells    698830 (HRAS) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     698830 (HRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA G-alpha ATP_bind_1 Septin Ldh_1_N AAA_25 AAA_16 Motif Other DBs NCBI-GeneID:  698830 NCBI-ProteinID:  NP_001253350 Ensembl:  ENSMMUG00000021659 UniProt:  F7F5K9 G7NBC9 LinkDB All DBs Position 14 AA seq 189 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG CMSCKCVLS NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atgacggaatataagctcgtggtggtgggcgccggcggtgtgggcaagagtgcgctgacc atccagctgatccagaaccacttcgtggacgaatacgaccccaccatagaggactcctac cggaaacaggtggtcattgatggggagacgtgcctgttggacatcctggacacggccggc caagaggagtacagcgccatgcgggaccagtacatgcgcacgggggaaggcttcctgtgt gtgtttgccatcaacaacaccaagtcctttgaggacatccaccagtacagggagcagatc aagcgggtgaaggactcagacgacgtgcccatggtgctggtggggaacaagtgtgacctg gctgcacgcaccgtggagtctcggcaggctcaggacctcgcccgaagctatggtatcccc tacattgagacctcggccaagacgcgacagggagtagaggatgccttttacacattggtg cgtgagattcggcagcataagctgcggaagctgaaccctcctgatgagagtggccccggc tgcatgagctgcaagtgtgtgctctcctga

Macaca mulatta (rhesus monkey): 699700 Help Entry 699700            CDS       T01028                                  Gene name RRAS2 Definition (RefSeq) ras-related protein R-Ras2   KO K07830   Ras-related protein R-Ras2 Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc04010   MAPK signaling pathway mcc04014   Ras signaling pathway mcc04024   cAMP signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04218   Cellular senescence mcc04371   Apelin signaling pathway mcc04625   C-type lectin receptor signaling pathway mcc04810   Regulation of actin cytoskeleton mcc05205   Proteoglycans in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     699700 (RRAS2)    04014 Ras signaling pathway     699700 (RRAS2)    04371 Apelin signaling pathway     699700 (RRAS2)    04072 Phospholipase D signaling pathway     699700 (RRAS2)    04024 cAMP signaling pathway     699700 (RRAS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     699700 (RRAS2)    04137 Mitophagy - animal     699700 (RRAS2)   09143 Cell growth and death    04218 Cellular senescence     699700 (RRAS2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     699700 (RRAS2)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     699700 (RRAS2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     699700 (RRAS2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mcc04147]     699700 (RRAS2)    04031 GTP-binding proteins [BR:mcc04031]     699700 (RRAS2) Exosome [BR:mcc04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    699700 (RRAS2)   Exosomal proteins of bladder cancer cells    699700 (RRAS2) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     699700 (RRAS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase ATP_bind_1 DUF2075 Motif Other DBs NCBI-GeneID:  699700 NCBI-ProteinID:  NP_001247489 Ensembl:  ENSMMUG00000000664 UniProt:  A0A1D5QAR1 LinkDB All DBs Position 14 AA seq 204 aa AA seqDB search MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE QECPPSPEPTRKEKDKKGCHCVIF NT seq 615 nt NT seq  +upstreamnt  +downstreamnt atggccgcggccggctggcgggacggctccggccaggagaagtaccggctcgtggtggtc ggcgggggtggcgtgggcaagtcggcgctcaccatccagttcatccagtcctattttgta acagattatgatccaaccattgaagattcttacacaaagcagtgtgtgatagatgacaga gcagcccggctagatattttggatacagcaggacaagaagagtttggagccatgagagaa cagtatatgaggactggcgagggcttcctgttggtcttttcagtcacagatagaggcagt tttgaagaaatctataagtttcaaagacagattctcagagtaaaggatcgtgatgagttc ccaatgattttaattggtaataaagcagatctggatcatcaaagacaggtaacacaggaa gaaggacagcagttagcacggcaacttaaggtaacatacatggaggcatcagcaaaaatt aggatgaatgtagatcaagctttccatgaacttgtccgggttatcaggaaatttcaagag caggaatgtcctccttcaccagaaccaacacggaaagaaaaagacaagaaaggctgccat tgtgtcattttctag

Macaca mulatta (rhesus monkey): 707977 Help Entry 707977            CDS       T01028                                  Gene name KRAS Definition (RefSeq) GTPase KRas   KO K07827   GTPase KRas Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc01522   Endocrine resistance mcc04010   MAPK signaling pathway mcc04012   ErbB signaling pathway mcc04014   Ras signaling pathway mcc04015   Rap1 signaling pathway mcc04062   Chemokine signaling pathway mcc04068   FoxO signaling pathway mcc04071   Sphingolipid signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04150   mTOR signaling pathway mcc04151   PI3K-Akt signaling pathway mcc04210   Apoptosis mcc04211   Longevity regulating pathway mcc04213   Longevity regulating pathway - multiple species mcc04218   Cellular senescence mcc04360   Axon guidance mcc04370   VEGF signaling pathway mcc04371   Apelin signaling pathway mcc04540   Gap junction mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04625   C-type lectin receptor signaling pathway mcc04650   Natural killer cell mediated cytotoxicity mcc04660   T cell receptor signaling pathway mcc04662   B cell receptor signaling pathway mcc04664   Fc epsilon RI signaling pathway mcc04714   Thermogenesis mcc04720   Long-term potentiation mcc04722   Neurotrophin signaling pathway mcc04725   Cholinergic synapse mcc04726   Serotonergic synapse mcc04730   Long-term depression mcc04810   Regulation of actin cytoskeleton mcc04910   Insulin signaling pathway mcc04912   GnRH signaling pathway mcc04914   Progesterone-mediated oocyte maturation mcc04915   Estrogen signaling pathway mcc04916   Melanogenesis mcc04917   Prolactin signaling pathway mcc04919   Thyroid hormone signaling pathway mcc04921   Oxytocin signaling pathway mcc04926   Relaxin signaling pathway mcc04929   GnRH secretion mcc04933   AGE-RAGE signaling pathway in diabetic complications mcc04935   Growth hormone synthesis, secretion and action mcc04960   Aldosterone-regulated sodium reabsorption mcc05010   Alzheimer disease mcc05022   Pathways of neurodegeneration - multiple diseases mcc05034   Alcoholism mcc05160   Hepatitis C mcc05161   Hepatitis B mcc05163   Human cytomegalovirus infection mcc05165   Human papillomavirus infection mcc05166   Human T-cell leukemia virus 1 infection mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05170   Human immunodeficiency virus 1 infection mcc05200   Pathways in cancer mcc05203   Viral carcinogenesis mcc05205   Proteoglycans in cancer mcc05206   MicroRNAs in cancer mcc05210   Colorectal cancer mcc05211   Renal cell carcinoma mcc05212   Pancreatic cancer mcc05213   Endometrial cancer mcc05214   Glioma mcc05215   Prostate cancer mcc05216   Thyroid cancer mcc05218   Melanoma mcc05219   Bladder cancer mcc05220   Chronic myeloid leukemia mcc05221   Acute myeloid leukemia mcc05223   Non-small cell lung cancer mcc05224   Breast cancer mcc05225   Hepatocellular carcinoma mcc05226   Gastric cancer mcc05230   Central carbon metabolism in cancer mcc05231   Choline metabolism in cancer mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     707977 (KRAS)    04012 ErbB signaling pathway     707977 (KRAS)    04014 Ras signaling pathway     707977 (KRAS)    04015 Rap1 signaling pathway     707977 (KRAS)    04370 VEGF signaling pathway     707977 (KRAS)    04371 Apelin signaling pathway     707977 (KRAS)    04068 FoxO signaling pathway     707977 (KRAS)    04072 Phospholipase D signaling pathway     707977 (KRAS)    04071 Sphingolipid signaling pathway     707977 (KRAS)    04151 PI3K-Akt signaling pathway     707977 (KRAS)    04150 mTOR signaling pathway     707977 (KRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     707977 (KRAS)    04137 Mitophagy - animal     707977 (KRAS)   09143 Cell growth and death    04210 Apoptosis     707977 (KRAS)    04218 Cellular senescence     707977 (KRAS)   09144 Cellular community - eukaryotes    04540 Gap junction     707977 (KRAS)    04550 Signaling pathways regulating pluripotency of stem cells     707977 (KRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     707977 (KRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     707977 (KRAS)    04650 Natural killer cell mediated cytotoxicity     707977 (KRAS)    04660 T cell receptor signaling pathway     707977 (KRAS)    04662 B cell receptor signaling pathway     707977 (KRAS)    04664 Fc epsilon RI signaling pathway     707977 (KRAS)    04062 Chemokine signaling pathway     707977 (KRAS)   09152 Endocrine system    04910 Insulin signaling pathway     707977 (KRAS)    04929 GnRH secretion     707977 (KRAS)    04912 GnRH signaling pathway     707977 (KRAS)    04915 Estrogen signaling pathway     707977 (KRAS)    04914 Progesterone-mediated oocyte maturation     707977 (KRAS)    04917 Prolactin signaling pathway     707977 (KRAS)    04921 Oxytocin signaling pathway     707977 (KRAS)    04926 Relaxin signaling pathway     707977 (KRAS)    04935 Growth hormone synthesis, secretion and action     707977 (KRAS)    04919 Thyroid hormone signaling pathway     707977 (KRAS)    04916 Melanogenesis     707977 (KRAS)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     707977 (KRAS)   09156 Nervous system    04725 Cholinergic synapse     707977 (KRAS)    04726 Serotonergic synapse     707977 (KRAS)    04720 Long-term potentiation     707977 (KRAS)    04730 Long-term depression     707977 (KRAS)    04722 Neurotrophin signaling pathway     707977 (KRAS)   09158 Development and regeneration    04360 Axon guidance     707977 (KRAS)   09149 Aging    04211 Longevity regulating pathway     707977 (KRAS)    04213 Longevity regulating pathway - multiple species     707977 (KRAS)   09159 Environmental adaptation    04714 Thermogenesis     707977 (KRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     707977 (KRAS)    05206 MicroRNAs in cancer     707977 (KRAS)    05205 Proteoglycans in cancer     707977 (KRAS)    05203 Viral carcinogenesis     707977 (KRAS)    05230 Central carbon metabolism in cancer     707977 (KRAS)    05231 Choline metabolism in cancer     707977 (KRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     707977 (KRAS)   09162 Cancer: specific types    05210 Colorectal cancer     707977 (KRAS)    05212 Pancreatic cancer     707977 (KRAS)    05225 Hepatocellular carcinoma     707977 (KRAS)    05226 Gastric cancer     707977 (KRAS)    05214 Glioma     707977 (KRAS)    05216 Thyroid cancer     707977 (KRAS)    05221 Acute myeloid leukemia     707977 (KRAS)    05220 Chronic myeloid leukemia     707977 (KRAS)    05218 Melanoma     707977 (KRAS)    05211 Renal cell carcinoma     707977 (KRAS)    05219 Bladder cancer     707977 (KRAS)    05215 Prostate cancer     707977 (KRAS)    05213 Endometrial cancer     707977 (KRAS)    05224 Breast cancer     707977 (KRAS)    05223 Non-small cell lung cancer     707977 (KRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     707977 (KRAS)    05022 Pathways of neurodegeneration - multiple diseases     707977 (KRAS)   09165 Substance dependence    05034 Alcoholism     707977 (KRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     707977 (KRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     707977 (KRAS)    05170 Human immunodeficiency virus 1 infection     707977 (KRAS)    05161 Hepatitis B     707977 (KRAS)    05160 Hepatitis C     707977 (KRAS)    05163 Human cytomegalovirus infection     707977 (KRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     707977 (KRAS)    05165 Human papillomavirus infection     707977 (KRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     707977 (KRAS)    01522 Endocrine resistance     707977 (KRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mcc04131]     707977 (KRAS)   09183 Protein families: signaling and cellular processes    04031 GTP-binding proteins [BR:mcc04031]     707977 (KRAS) Membrane trafficking [BR:mcc04131]  Endocytosis   Macropinocytosis    Ras GTPases     707977 (KRAS) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     707977 (KRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 MeaB G-alpha FeoB_N ATP_bind_1 Septin NPR1_interact AAA_25 Motif Other DBs NCBI-GeneID:  707977 NCBI-ProteinID:  NP_001248441 Ensembl:  ENSMMUG00000015381 UniProt:  I0FRK8 LinkDB All DBs Position 11 AA seq 188 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK SKTKCVIM NT seq 567 nt NT seq  +upstreamnt  +downstreamnt atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg atacagctaattcagaatcattttgtggacgaatatgatccaacaatagaggattcctac aggaagcaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaatt aaaagagttaaggactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttacggaattcct tttattgaaacatcagcaaagacaagacagggtgttgatgatgccttctatacattagtt cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag tcaaagacaaagtgtgtaattatgtaa

Macaca mulatta (rhesus monkey): 709089 Help Entry 709089            CDS       T01028                                  Gene name NRAS Definition (RefSeq) GTPase NRas   KO K07828   GTPase NRas Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc01522   Endocrine resistance mcc04010   MAPK signaling pathway mcc04012   ErbB signaling pathway mcc04014   Ras signaling pathway mcc04015   Rap1 signaling pathway mcc04062   Chemokine signaling pathway mcc04068   FoxO signaling pathway mcc04071   Sphingolipid signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04150   mTOR signaling pathway mcc04151   PI3K-Akt signaling pathway mcc04210   Apoptosis mcc04211   Longevity regulating pathway mcc04213   Longevity regulating pathway - multiple species mcc04218   Cellular senescence mcc04360   Axon guidance mcc04370   VEGF signaling pathway mcc04371   Apelin signaling pathway mcc04540   Gap junction mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04625   C-type lectin receptor signaling pathway mcc04650   Natural killer cell mediated cytotoxicity mcc04660   T cell receptor signaling pathway mcc04662   B cell receptor signaling pathway mcc04664   Fc epsilon RI signaling pathway mcc04714   Thermogenesis mcc04720   Long-term potentiation mcc04722   Neurotrophin signaling pathway mcc04725   Cholinergic synapse mcc04726   Serotonergic synapse mcc04730   Long-term depression mcc04810   Regulation of actin cytoskeleton mcc04910   Insulin signaling pathway mcc04912   GnRH signaling pathway mcc04915   Estrogen signaling pathway mcc04916   Melanogenesis mcc04917   Prolactin signaling pathway mcc04919   Thyroid hormone signaling pathway mcc04921   Oxytocin signaling pathway mcc04926   Relaxin signaling pathway mcc04929   GnRH secretion mcc04933   AGE-RAGE signaling pathway in diabetic complications mcc04935   Growth hormone synthesis, secretion and action mcc05010   Alzheimer disease mcc05022   Pathways of neurodegeneration - multiple diseases mcc05034   Alcoholism mcc05160   Hepatitis C mcc05161   Hepatitis B mcc05163   Human cytomegalovirus infection mcc05165   Human papillomavirus infection mcc05166   Human T-cell leukemia virus 1 infection mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05170   Human immunodeficiency virus 1 infection mcc05200   Pathways in cancer mcc05203   Viral carcinogenesis mcc05205   Proteoglycans in cancer mcc05206   MicroRNAs in cancer mcc05210   Colorectal cancer mcc05211   Renal cell carcinoma mcc05213   Endometrial cancer mcc05214   Glioma mcc05215   Prostate cancer mcc05216   Thyroid cancer mcc05218   Melanoma mcc05219   Bladder cancer mcc05220   Chronic myeloid leukemia mcc05221   Acute myeloid leukemia mcc05223   Non-small cell lung cancer mcc05224   Breast cancer mcc05225   Hepatocellular carcinoma mcc05226   Gastric cancer mcc05230   Central carbon metabolism in cancer mcc05231   Choline metabolism in cancer mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     709089 (NRAS)    04012 ErbB signaling pathway     709089 (NRAS)    04014 Ras signaling pathway     709089 (NRAS)    04015 Rap1 signaling pathway     709089 (NRAS)    04370 VEGF signaling pathway     709089 (NRAS)    04371 Apelin signaling pathway     709089 (NRAS)    04068 FoxO signaling pathway     709089 (NRAS)    04072 Phospholipase D signaling pathway     709089 (NRAS)    04071 Sphingolipid signaling pathway     709089 (NRAS)    04151 PI3K-Akt signaling pathway     709089 (NRAS)    04150 mTOR signaling pathway     709089 (NRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     709089 (NRAS)    04137 Mitophagy - animal     709089 (NRAS)   09143 Cell growth and death    04210 Apoptosis     709089 (NRAS)    04218 Cellular senescence     709089 (NRAS)   09144 Cellular community - eukaryotes    04540 Gap junction     709089 (NRAS)    04550 Signaling pathways regulating pluripotency of stem cells     709089 (NRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     709089 (NRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     709089 (NRAS)    04650 Natural killer cell mediated cytotoxicity     709089 (NRAS)    04660 T cell receptor signaling pathway     709089 (NRAS)    04662 B cell receptor signaling pathway     709089 (NRAS)    04664 Fc epsilon RI signaling pathway     709089 (NRAS)    04062 Chemokine signaling pathway     709089 (NRAS)   09152 Endocrine system    04910 Insulin signaling pathway     709089 (NRAS)    04929 GnRH secretion     709089 (NRAS)    04912 GnRH signaling pathway     709089 (NRAS)    04915 Estrogen signaling pathway     709089 (NRAS)    04917 Prolactin signaling pathway     709089 (NRAS)    04921 Oxytocin signaling pathway     709089 (NRAS)    04926 Relaxin signaling pathway     709089 (NRAS)    04935 Growth hormone synthesis, secretion and action     709089 (NRAS)    04919 Thyroid hormone signaling pathway     709089 (NRAS)    04916 Melanogenesis     709089 (NRAS)   09156 Nervous system    04725 Cholinergic synapse     709089 (NRAS)    04726 Serotonergic synapse     709089 (NRAS)    04720 Long-term potentiation     709089 (NRAS)    04730 Long-term depression     709089 (NRAS)    04722 Neurotrophin signaling pathway     709089 (NRAS)   09158 Development and regeneration    04360 Axon guidance     709089 (NRAS)   09149 Aging    04211 Longevity regulating pathway     709089 (NRAS)    04213 Longevity regulating pathway - multiple species     709089 (NRAS)   09159 Environmental adaptation    04714 Thermogenesis     709089 (NRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     709089 (NRAS)    05206 MicroRNAs in cancer     709089 (NRAS)    05205 Proteoglycans in cancer     709089 (NRAS)    05203 Viral carcinogenesis     709089 (NRAS)    05230 Central carbon metabolism in cancer     709089 (NRAS)    05231 Choline metabolism in cancer     709089 (NRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     709089 (NRAS)   09162 Cancer: specific types    05210 Colorectal cancer     709089 (NRAS)    05225 Hepatocellular carcinoma     709089 (NRAS)    05226 Gastric cancer     709089 (NRAS)    05214 Glioma     709089 (NRAS)    05216 Thyroid cancer     709089 (NRAS)    05221 Acute myeloid leukemia     709089 (NRAS)    05220 Chronic myeloid leukemia     709089 (NRAS)    05218 Melanoma     709089 (NRAS)    05211 Renal cell carcinoma     709089 (NRAS)    05219 Bladder cancer     709089 (NRAS)    05215 Prostate cancer     709089 (NRAS)    05213 Endometrial cancer     709089 (NRAS)    05224 Breast cancer     709089 (NRAS)    05223 Non-small cell lung cancer     709089 (NRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     709089 (NRAS)    05022 Pathways of neurodegeneration - multiple diseases     709089 (NRAS)   09165 Substance dependence    05034 Alcoholism     709089 (NRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     709089 (NRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     709089 (NRAS)    05170 Human immunodeficiency virus 1 infection     709089 (NRAS)    05161 Hepatitis B     709089 (NRAS)    05160 Hepatitis C     709089 (NRAS)    05163 Human cytomegalovirus infection     709089 (NRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     709089 (NRAS)    05165 Human papillomavirus infection     709089 (NRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     709089 (NRAS)    01522 Endocrine resistance     709089 (NRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mcc04131]     709089 (NRAS)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mcc04147]     709089 (NRAS)    04031 GTP-binding proteins [BR:mcc04031]     709089 (NRAS) Membrane trafficking [BR:mcc04131]  Endocytosis   Macropinocytosis    Ras GTPases     709089 (NRAS) Exosome [BR:mcc04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    709089 (NRAS)   Exosomal proteins of other body fluids (saliva and urine)    709089 (NRAS)   Exosomal proteins of breast cancer cells    709089 (NRAS)   Exosomal proteins of colorectal cancer cells    709089 (NRAS) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     709089 (NRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin ParA Ldh_1_N Motif Other DBs NCBI-GeneID:  709089 NCBI-ProteinID:  XP_015004311 Ensembl:  ENSMMUG00000049105 UniProt:  A0A1D5QQS3 G7MIK1 LinkDB All DBs Position 1 AA seq 189 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG CMGLPCVVM NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atgactgagtacaaactggtggtggttggagcaggtggtgttgggaaaagcgcactgaca atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac agaaaacaggtggttatagatggtgaaacctgtttgttggacatactggatacagctgga caagaagagtacagtgccatgagagaccaatacatgaggacaggcgaaggcttcctctgt gtatttgccatcaataatagcaagtcatttgcggatattaacctctacagggagcagatt aagcgagtaaaagactcagatgatgtacctatggtgctagtgggaaacaagtgtgatttg ccaacaaggacagttgatacaaaacaagcccacgaactggccaagagttacgggattcca ttcattgaaacctcagccaagaccagacagggtgttgaagatgctttttacacactggta agagaaatacgccagtaccgaatgaaaaaactcaacagcagtgatgatgggactcagggt tgtatgggattaccatgtgtggtgatgtaa

Macaca mulatta (rhesus monkey): 716352 Help Entry 716352            CDS       T01028                                  Gene name MRAS Definition (RefSeq) ras-related protein M-Ras   KO K07831   Ras-related protein M-Ras Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc04010   MAPK signaling pathway mcc04014   Ras signaling pathway mcc04015   Rap1 signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04218   Cellular senescence mcc04371   Apelin signaling pathway mcc04625   C-type lectin receptor signaling pathway mcc04810   Regulation of actin cytoskeleton mcc05205   Proteoglycans in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     716352 (MRAS)    04014 Ras signaling pathway     716352 (MRAS)    04015 Rap1 signaling pathway     716352 (MRAS)    04371 Apelin signaling pathway     716352 (MRAS)    04072 Phospholipase D signaling pathway     716352 (MRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     716352 (MRAS)    04137 Mitophagy - animal     716352 (MRAS)   09143 Cell growth and death    04218 Cellular senescence     716352 (MRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     716352 (MRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     716352 (MRAS)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     716352 (MRAS)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04031 GTP-binding proteins [BR:mcc04031]     716352 (MRAS) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     716352 (MRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc GTP_EFTU Arf RsgA_GTPase MMR_HSR1 ATP_bind_1 AAA_16 MMR_HSR1_Xtn Gtr1_RagA Motif Other DBs NCBI-GeneID:  716352 NCBI-ProteinID:  NP_001247498 Ensembl:  ENSMMUG00000007756 UniProt:  A0A1D5QV11 G7MJP0 LinkDB All DBs Position 2 AA seq 208 aa AA seqDB search MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP EKSQKKKKKTKWRGDRATGTHKLQCVIL NT seq 627 nt NT seq  +upstreamnt  +downstreamnt atggcaaccagcgccgtccccagtgacaacctccccacatacaagctggtggtggtgggg gatgggggcgtgggcaaaagtgccctcaccatccagtttttccaaaagatctttgtgcct gactatgaccccaccattgaagactcctacctgaaacatacagagattgacaatcagtgg gccatcttggacgttttggacacagccgggcaggaggaattcagcgccatgcgggagcag tacatgcgcacgggggatggcttcctcatcgtctactccgtcaccgacaaggccagcttc gagcacgtggaccgtttccaccagctcatcctgcgtgtcaaagacagggagtcattcccg atgatcctcgtggccaacaaggtcgatttgatgcacttaaggaaaatcaccagggagcaa ggaaaagaaatggcgaccaaacacaatattccgtacatagaaaccagtgccaaggaccca cctctcaatgtcgacaaagccttccatgacctcgtgagagtaattaggcaacagattccg gaaaaaagccagaagaagaagaagaaaaccaaatggcggggagaccgggccacaggcacg cacaaactgcaatgtgtgatcttgtga

Macaca mulatta (rhesus monkey): 718939 Help Entry 718939            CDS       T01028                                  Gene name RRAS Definition (RefSeq) ras-related protein R-Ras   KO K07829   Ras-related protein R-Ras Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc04010   MAPK signaling pathway mcc04014   Ras signaling pathway mcc04015   Rap1 signaling pathway mcc04024   cAMP signaling pathway mcc04072   Phospholipase D signaling pathway mcc04137   Mitophagy - animal mcc04140   Autophagy - animal mcc04218   Cellular senescence mcc04360   Axon guidance mcc04371   Apelin signaling pathway mcc04625   C-type lectin receptor signaling pathway mcc04810   Regulation of actin cytoskeleton mcc05132   Salmonella infection mcc05205   Proteoglycans in cancer Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     718939 (RRAS)    04014 Ras signaling pathway     718939 (RRAS)    04015 Rap1 signaling pathway     718939 (RRAS)    04371 Apelin signaling pathway     718939 (RRAS)    04072 Phospholipase D signaling pathway     718939 (RRAS)    04024 cAMP signaling pathway     718939 (RRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     718939 (RRAS)    04137 Mitophagy - animal     718939 (RRAS)   09143 Cell growth and death    04218 Cellular senescence     718939 (RRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     718939 (RRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     718939 (RRAS)   09158 Development and regeneration    04360 Axon guidance     718939 (RRAS)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     718939 (RRAS)   09171 Infectious disease: bacterial    05132 Salmonella infection     718939 (RRAS)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04031 GTP-binding proteins [BR:mcc04031]     718939 (RRAS) GTP-binding proteins [BR:mcc04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     718939 (RRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU ATP_bind_1 MMR_HSR1 AAA_22 Ribosomal_S30AE Motif Other DBs NCBI-GeneID:  718939 NCBI-ProteinID:  XP_001115362 Ensembl:  ENSMMUG00000028733 UniProt:  H9EPG6 LinkDB All DBs Position 19 AA seq 218 aa AA seqDB search MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG KLFTQILRVKDRDDFPVVLVGNKADLEAQRQVPRSEASAFGASHHVAYFEASAKLRLNVD EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL NT seq 657 nt NT seq  +upstreamnt  +downstreamnt atgagcagcggggcggcgtccgggacagggcgggggcggccccggggcgggggacctggg cccggggaccccccgcccagcgagacacacaagctggtggtcgtgggcggcggcggcgtg ggcaagagcgcgctgaccatccagttcatccagtcctacttcgtgtctgactacgacccc actattgaggactcctacacgaagatctgcagtgtggatgggatcccggcccggctggac atcctggacactgcgggccaggaggagttcggggccatgagagagcagtacatgcgtgcc ggccacggcttcctgctggtgtttgccattaacgaccggcagagtttcaacgaggtgggc aagctcttcacgcagattctccgggtcaaggaccgcgatgacttcccggtcgtgttggtc gggaacaaggcggatctggaggcacagcgccaggtcccccgatcagaagcatctgccttc ggcgcctcccaccacgtggcctactttgaggcctcggccaaactgcgtctcaacgtggac gaggcttttgagcagctggtgcgggctgtccggaaataccaggaacaagagctcccaccc agccctcccagtgcccccaggaagaagggcgggggctgcccctgcgtcctcctgtag

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