KEGG   Macaca mulatta (rhesus monkey): 702781
Entry
702781            CDS       T01028                                 

Gene name
CASP8
Definition
(RefSeq) caspase-8 isoform X1
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01524  Platinum drug resistance
mcc04115  p53 signaling pathway
mcc04210  Apoptosis
mcc04215  Apoptosis - multiple species
mcc04217  Necroptosis
mcc04620  Toll-like receptor signaling pathway
mcc04621  NOD-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04625  C-type lectin receptor signaling pathway
mcc04657  IL-17 signaling pathway
mcc04668  TNF signaling pathway
mcc04932  Non-alcoholic fatty liver disease
mcc05010  Alzheimer disease
mcc05016  Huntington disease
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05132  Salmonella infection
mcc05134  Legionellosis
mcc05142  Chagas disease
mcc05145  Toxoplasmosis
mcc05152  Tuberculosis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05162  Measles
mcc05163  Human cytomegalovirus infection
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05168  Herpes simplex virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05170  Human immunodeficiency virus 1 infection
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    702781 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    702781 (CASP8)
   04215 Apoptosis - multiple species
    702781 (CASP8)
   04217 Necroptosis
    702781 (CASP8)
   04115 p53 signaling pathway
    702781 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    702781 (CASP8)
   04621 NOD-like receptor signaling pathway
    702781 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    702781 (CASP8)
   04625 C-type lectin receptor signaling pathway
    702781 (CASP8)
   04657 IL-17 signaling pathway
    702781 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    702781 (CASP8)
   05203 Viral carcinogenesis
    702781 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    702781 (CASP8)
   05016 Huntington disease
    702781 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    702781 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    702781 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    702781 (CASP8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    702781 (CASP8)
   05134 Legionellosis
    702781 (CASP8)
   05152 Tuberculosis
    702781 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    702781 (CASP8)
   05161 Hepatitis B
    702781 (CASP8)
   05160 Hepatitis C
    702781 (CASP8)
   05164 Influenza A
    702781 (CASP8)
   05162 Measles
    702781 (CASP8)
   05168 Herpes simplex virus 1 infection
    702781 (CASP8)
   05163 Human cytomegalovirus infection
    702781 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    702781 (CASP8)
   05169 Epstein-Barr virus infection
    702781 (CASP8)
   05165 Human papillomavirus infection
    702781 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    702781 (CASP8)
   05142 Chagas disease
    702781 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    702781 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mcc01002]
    702781 (CASP8)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     702781 (CASP8)
Peptidases and inhibitors [BR:mcc01002]
 Cysteine peptidases
  Family C14: caspase family
   702781 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED PYRIN
Other DBs
NCBI-GeneID: 702781
NCBI-ProteinID: XP_014966130
Ensembl: ENSMMUG00000031296
LinkDB
Position
12
AA seq 496 aa
MVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALM
LFQRLQEKRMLEENNLSFLKELLFRINRLDLLTTYLNTRKEEMERELQAPGRAQISAYRV
MLYQISEEVGRSELRSFKFLLQEEISKCKLDDDMNLLDIFVEMEKRVILGEGKLDILKRV
CAQVNKSLLKIINDYEEFSRERTRSLEGSPEEGSNGEELCGLMTISDSPREQDSESQTLD
KVYQMKSKPRGYCLIINNYDFTKAREKVPKLHSIRDRNGTHLDAEALTATFEELHFEIQH
HNDCTVEKIYKILKTYQLMDHSNKDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGL
KCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM
ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQM
PQPTFTLRKKLVFPSD
NT seq 1491 nt   +upstreamnt  +downstreamnt
atggtgccaggaaagggtggagcggattatattctgctgccttttgaagagatggacttc
aacagaaatctttatgatattggggaacaactggacagtgaagagctggcctccctcaag
ttcctgagcctggactgcatcccacaaaggaagcaagaacccatcaaagatgccttgatg
ttattccagagactccaggaaaagagaatgttggaggaaaacaatctgtccttcctgaag
gagctgctcttccgaattaatagactggatttgctcactacttacctaaacactagaaag
gaggagatggaaagggaacttcaggcaccaggcagggctcagatttctgcctacagggtc
atgctctatcagatttcagaagaggtgggcagatcagaattgaggtcttttaagtttctt
ctgcaagaggagatctccaaatgcaaactggatgatgacatgaacctgctggatattttc
gtagagatggagaagagggtcatcctgggagaaggcaagttggacatcctgaagagagtc
tgtgcccaagtcaacaagagcctgctgaagataatcaatgactatgaagaattcagcaga
gagagaacaaggagccttgaaggaagtcctgaggaaggttcaaatggggaggagttgtgt
gggctaatgacaatctcggactctccaagagaacaggatagtgaatcacagactttggac
aaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaacaattacgat
tttacgaaagcacgggagaaagtgcccaaacttcacagcattagggacaggaatggaaca
cacttggatgcagaggctttgaccgcgacctttgaagagcttcattttgagatccagcac
cacaatgactgcacagtagagaaaatctataagattttgaaaacctaccaactcatggac
cacagtaacaaggattgcttcatctgctgtatcctctcccatggagacaagggcatcatc
tatggcactgatggacaggaggcccccatctatgagctgacatctcagttcactggtttg
aagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgtcagggggat
aactaccagaaaggtatacctgttgagactgattcagaggagcaaccctatttggaaatg
gatttatcatcacctcaaacgagatatatcccggatgaggctgactttctgctggggatg
gccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctggtacatccag
tcactttgccagagcctgagagaacgatgtcctcgaggcgatgatattctcaccatcctg
actgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatggggaaacagatg
ccgcagccaactttcacactaagaaaaaaacttgtcttcccttctgattga

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