KEGG   Macaca mulatta (rhesus monkey): 706921
Entry
706921            CDS       T01028                                 

Gene name
NOS2
Definition
(RefSeq) nitric oxide synthase, inducible
  KO
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00220  Arginine biosynthesis
mcc00330  Arginine and proline metabolism
mcc01100  Metabolic pathways
mcc04020  Calcium signaling pathway
mcc04066  HIF-1 signaling pathway
mcc04146  Peroxisome
mcc04371  Apelin signaling pathway
mcc04926  Relaxin signaling pathway
mcc05010  Alzheimer disease
mcc05014  Amyotrophic lateral sclerosis
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05133  Pertussis
mcc05140  Leishmaniasis
mcc05142  Chagas disease
mcc05145  Toxoplasmosis
mcc05146  Amoebiasis
mcc05152  Tuberculosis
mcc05200  Pathways in cancer
mcc05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    706921 (NOS2)
   00330 Arginine and proline metabolism
    706921 (NOS2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    706921 (NOS2)
   04066 HIF-1 signaling pathway
    706921 (NOS2)
   04020 Calcium signaling pathway
    706921 (NOS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    706921 (NOS2)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    706921 (NOS2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    706921 (NOS2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    706921 (NOS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    706921 (NOS2)
   05014 Amyotrophic lateral sclerosis
    706921 (NOS2)
   05022 Pathways of neurodegeneration - multiple diseases
    706921 (NOS2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    706921 (NOS2)
   05152 Tuberculosis
    706921 (NOS2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    706921 (NOS2)
   05145 Toxoplasmosis
    706921 (NOS2)
   05140 Leishmaniasis
    706921 (NOS2)
   05142 Chagas disease
    706921 (NOS2)
Enzymes [BR:mcc01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     706921 (NOS2)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 NAD_binding_6
Other DBs
NCBI-GeneID: 706921
NCBI-ProteinID: XP_014974372
Ensembl: ENSMMUG00000010083
LinkDB
Position
16
AA seq 1153 aa
MACPWKFLFKTKFHQYTMTGGKDINNNMEKAACATSSLVTQDDLQYHSLSKQQNESPQPL
VGTGKKSPESLVKPDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARNCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQADGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYSLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELTNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSSVTWDPHHYRLVQDSQPLDL
SKALSNVHAKNVFTMRLKSRQNLQSLTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPAPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEATERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTQDGQGPLHHGVCSTWLNSLKPRDPVPCF
IRNASGFHLPEDPSHPCILVGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHEEPGHLY
VCGDVRMAWDVAHTLKQLVAAKLNLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDG
AAVQPGSLEMSAL
NT seq 3462 nt   +upstreamnt  +downstreamnt
atggcctgtccttggaaatttctgttcaagaccaaattccaccagtatacaatgactggg
ggaaaagacatcaacaacaacatggagaaagccgcctgtgccacctccagtctagtgaca
caggatgaccttcagtatcacagcctcagcaagcagcagaatgagtccccgcagcccctc
gtggggacaggaaagaagtctccagaatctctggtcaagccggatgcaaccccattgtcc
tccccacggcacgtgaggatcaaaaactggggcagcgggatgactttccaggacacactt
caccacaaggccaaagggattttgacttgcaggtccaaatcttgcttggggtccattatg
actcccaaaagtttgaccagaggacccagggacaagcctacccctccagatgagcttcta
cctcaagctatcgaatttgtcaaccaatattacggctccttcaaagaggcaaaaatagag
gaacatctggccagggtggaagcggtaacaaaggagatagaaacaacaggaacctaccaa
ctgacgggagatgagctcatcttcgccaccaagcaggcctggcgcaatgccccacgctgc
attgggaggatccagtggtccaacctgcaggtcttcgatgcccgcaactgttccaccgcc
cgggaaatgtttgaacacatctgcagacacgtgcgttactccaccaacaatggcaacatc
aggtcggccatcaccgtgttcccccagcggagcgatggtaagcacgacttccgggtgtgg
aatgctcagctcatccgctacgcgggctaccagatgccagatggcagcatcagaggggat
cctgccaacgtggaattcactcagctgtgcatcgacctgggctggaagcccaagtatggc
cgcttcgatgtggtccccctggtcctacaggctgacggccgtgaccctgagctcttcgaa
atcccacctgaccttgtgcttgaggtggccatggaacatcccaaatatgagtggtttcgg
gaactggagctaaagtggtacgccctgcctgcagtggccaacatgctgctcgaggtgggc
ggcctggagttcccagggtgccccttcaatggctggtacatgggcacagagatcggagtc
cgagacttctgtgacgtccaacgctacaacatcctggaggaagtgggcaggagaatgggc
ttggaaacgcacaagctggcctcgctctggaaagaccaggctgtcgttgagatcaacatt
gctgtgctccatagtttccagaagcaaaacgtgaccatcatggaccaccactcagctgca
gaatccttcatgaagtacatgcaaaatgaataccggtcccgtgggggctgcccggcagac
tggatttggctggtccctcccatgtctgggagcatcactcccgtgtttcaccaggagatg
ctgaactacgtcctgtcccctttctactactatcaggtagaggcctggaaaacccatgtc
tggcaggacgagaagcggagacccaagagaagagagattccgttgaaagtcttggtcaaa
gctgtgctctttgcctgtatgctgatgcgcaagacgatggcgtcccgagtcagagtcact
atcctctttgcgacagagacaggaaaatcagaggcgctggcctgggacctgggggccttg
tttagctgtgccttcaaccccaaggttgtctgcatggataagtacagtctgagctgcctg
gaggaggagcggctgctgttggtggtgaccagtacgtttggcaatggagactgccccggc
aatggagagaaactgaagaaatcactcttcatgctgaaagagctcaccaacaaattcagg
tatgccgtgtttggccttggctccagcatgtaccctcggttctgcgcctttgctcatgac
atcgatcagaagctgtcccacctgggggcctctcagctcacccctatgggagaaggggac
gaactcagtgggcaggaggacgccttccgcagctgggccgtgcaaaccttcaaggcagcc
tgtgagacatttgatgtccgaggcaaacagcacattcagatccccaagctctacacctcc
agtgtgacctgggacccacaccactacaggctcgtgcaggactcacagcctttggacctc
agcaaagccctcagcaacgtgcacgccaagaacgtgttcaccatgaggctcaaatctcgg
cagaatctacagagtctgacatccagccgtgccaccatcctggtggaactctcctgtgag
gacggccaaggcctgaactacttgccgggggagcacctcggggtttgtccaggcaaccag
cccgccctggtccaaggcatcctggagcgagtggtggacggccccgcaccccaccagaca
gtgcgcctggaggccctggacgagagcggcagctactgggtcagtgacaagaggctgccc
ccctgctcgctcagccaggccctcacctacttcctggatatcaccacccccccaacccag
ctgctgctccaaaagctggcccaggtggccacagaagcgactgagagacagaggctggag
gccctgtgccagccctcagagtacagcaagtggaagttcaccaacagccccacgttcctg
gaggtgctggaggagttcccatccctgcgggtgtctgctggcttcctgctctcccagctc
cccattctgaagcccaggttctactccatcagctcctcccgggatcacacgcccacggag
atccacctgactgtggccgtggtcacgtaccacacccaagatggccagggtcccctgcac
cacggcgtctgcagcacatggctcaacagcctgaagccccgagacccagtgccctgcttc
atacgaaacgccagcggcttccacctccccgaggacccctcccatccttgcatcctggtc
gggcctggcacaggcatcgcccccttccgcagtttctggcagcagcggctccatgactcc
cagcacaagggagtgcggggaggccgcatgaccttggtgtttgggtgccgccgcccagat
gaggaccacatctaccaggaggagatgctggagatggcccagaagggggtgctgcatgcg
gtgcacacagcctattctcgcctgcctggcaagcccaaggtctatgttcaggacatcctg
cggcagcagctggccagcgaggtgctccgtgtgctccacgaggagccgggccacctctat
gtttgcggggatgtgcgcatggcctgggatgtggcccacaccctgaagcagctggtggct
gccaagctgaacttgaatgaggagcaggtcgaggactatttctttcagctcaagagccag
aagcgctatcatgaagatatctttggtgctgtatttccctacgaggcgaagaaggacggg
gcggcagtgcagcccgggagcctggagatgtcagccctctga

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