KEGG   Macaca mulatta (rhesus monkey): 712044
Entry
712044            CDS       T01028                                 

Gene name
PTPN11
Definition
(RefSeq) tyrosine-protein phosphatase non-receptor type 11
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc04014  Ras signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04360  Axon guidance
mcc04625  C-type lectin receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04650  Natural killer cell mediated cytotoxicity
mcc04670  Leukocyte transendothelial migration
mcc04722  Neurotrophin signaling pathway
mcc04920  Adipocytokine signaling pathway
mcc04931  Insulin resistance
mcc05168  Herpes simplex virus 1 infection
mcc05205  Proteoglycans in cancer
mcc05211  Renal cell carcinoma
mcc05220  Chronic myeloid leukemia
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    712044 (PTPN11)
   04630 JAK-STAT signaling pathway
    712044 (PTPN11)
   04072 Phospholipase D signaling pathway
    712044 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    712044 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    712044 (PTPN11)
   04670 Leukocyte transendothelial migration
    712044 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    712044 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    712044 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    712044 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    712044 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    712044 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    712044 (PTPN11)
   05211 Renal cell carcinoma
    712044 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    712044 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    712044 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mcc01009]
    712044 (PTPN11)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     712044 (PTPN11)
Protein phosphatases and associated proteins [BR:mcc01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    712044 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 712044
NCBI-ProteinID: NP_001248038
Ensembl: ENSMMUG00000013253
UniProt: H9Z053
LinkDB
Position
11
AA seq 593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcggaaaacctactg
ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac
ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gattactatgacctgtatggaggggagaaatttgccactttggcagagttggtccagtat
tacatggaacatcacgggcaattaaaagagaagaatggagatgttattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacacctctctgggaaa
gaagcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagc
cagagccaccctggagattttgttctctctgtgcgcactggtgatgacaaaggggagagc
aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatatgac
gttggcggaggagaacggtttgattctttgacagatcttgtggaacattacaagaagaat
cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt
ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctgtacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa
aacatcctgccctttgatcataccagggttgtcctacatgatggtgatcccaatgagcct
gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgcctgcagaacacagtgaacgac
ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat
ggcgtcatgcgtgttaggaatgtcaaagaaagtgctgctcatgactatacgctaagagaa
cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt
cggacctggccggaccacggagtgcccagcgaccccgggggcgtgctggacttcctggag
gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt
gctggaattggccggacagggacattcattgtgattgatattcttattgacatcatcaga
gagaaaggtgttgactgcgacattgacgttcccaaaaccatccagatggtgcggtctcag
aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat
tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcat
gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccccctc
ccgccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctat
gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga

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