Macaca mulatta (rhesus monkey): 712911 Help Entry 712911            CDS       T01028                                  Gene name NF1 Definition (RefSeq) neurofibromin isoform X1   KO K08052   neurofibromin 1 Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc04010   MAPK signaling pathway mcc04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     712911 (NF1)    04014 Ras signaling pathway     712911 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     712911 (NF1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGAP CRAL_TRIO_2 CRAL_TRIO MOR2-PAG1_C MIF4G_like_2 Motif Other DBs NCBI-GeneID:  712911 NCBI-ProteinID:  XP_014974489 Ensembl:  ENSMMUG00000008605 LinkDB All DBs Position 16 AA seq 2849 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN STFKHGLGTASALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAQTLTFKE KVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLV QLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQM LSSTEILKWLREILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEEL LRTPGASLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCF RHLCEEADIRCGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPT AGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSD TDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVNERKGSMISVMSSEGNADTP VSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQ VLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQ IKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQ ASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGR KRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQG TEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSR HLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVIT SSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQ ATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKK PPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKTNFDAARRFFLDIASDCPTSD AVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPE HKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVA RRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFA YDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAAT LALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEE ICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDV PGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVS ISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQR VTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEV MADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSF NNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLR LSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALL EIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRI LSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNL YSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFAL VGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVR SRCSLKHRKSLLLTDVSMENVPMDTYPIHHGDPTYRTLKETQPWSSPKGSEGYLAATYPT VGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMR RVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYT TDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVY HEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEET SEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNS GRTRHGSASQVQKQRSAGSFKRNSIKKIV NT seq 8550 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacacataccaaagtcagtactgagcacaacaag gaatgtctaatcaatatttccaaatacaagttttctttggttataagcggcctcactact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat ctctctcagttgattattttggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt cttcacacctgtcgtgaaggaaaccagcatgcagctgaacttcggaattctgcctctggg gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgcatttctaccagg ttacaggaattaactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa tttaaagccctaaagaaggttgcacagttagcagttataaatagcctggaaaaggcattt tggaactgggtagaaaattatccagatgaatttacaaaactataccagatcccacagact gatatggctgaatgtgcagaaaagctgtttgacttggtggatggttttgctgaaagcacc aaacgtaaagcagcagtttggccactacaaatcattctccttatcttgtgtccagaaata atccaggatatatccaaggatgtggttgatgaaaacaacatgaataagaagttatttctg gacagtctacgaaaagctcttgctggccatggaggaagtaggcagctgacagaaagtgct gcaattgcctgtgtcaaactgtgtaaagcaagtacttacatcaactgggaagataactct gtcattttcctacttgttcagtccatggtggttgatcttaagaacctgctttttaatcca agtaagccattctcaagaggcagtcagcctgcagatgtggatctaatgattgactgcctt gtttcttgctttcgtataagtcctcacaacaaccaacactttaagatctgcctggctcag aattcaccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat agcactttcaagcatggacttggcactgcttcggcattggattggtggcctaagattgat gctgtgtattgtcactcggttgaacttcgaaatatgtttggtgaaacacttcataaagca gtgcaaggttgtggagcacacccagcaatacgaatggcacagactcttacatttaaagaa aaagtaacaagccttaaatttaaagaaaaacctacagacctggagacaagaagctataag tatcttcttttgtccatggtgaaactaattcatgcagatccaaagctcttgctttgtaat ccaagaaaacaggggcccgaaacccaaggcagtacagcagagttaattacagggctcgtc caactagtccctcagtcacacatgccagagattgcgcaggaagcaatggaggctctgctg gttcttcatcagttagatagcattgatttgtggaatcctgatgctcctgtagaaacattt tgggagattagctcacaaatgcttttttacatctgcaagaaattaactagtcatcaaatg cttagtagcacagaaattctcaagtggttgcgggaaattttgatctgcaggaataaattt cttcttaaaaataagcaggcagatagaagttcctgtcactttctccttttttatggggta ggatgtgatattccttctagtggaaataccagtcaaatgtccatggatcatgaagaatta ctacgtactcctggagcctctctccggaagggaaaagggaactcctctatggatagtgca gcaggatgcagcggaacccccccgatttgccgacaagcccagaccaaactagaagtggcc ctgtacatgtttctgtggaaccctgacactgaagctgttctggttgccatgtcctgtttc cgccacctctgtgaggaagcagatatccggtgtggggtggatgaagtgtcagtgcataac ctcttgcccaactataacacattcatggagtttgcctctgtcagcaatatgatgtcaaca ggaagagcagcacttcagaaaagagtgatggcactgctgaggcgcattgagcatcccact gcaggaaacactgaggcttgggaagatacacatgcaaaatgggaacaagcaacaaaacta atccttaactatccaaaagccaaaatggaagatggccaggctgctgaaagccttcacaag accattgttaagaggcgaatgtcccatgtgagtggaggaggatccatagatttgtctgac acagactccctacaggaatggatcaacatgactggcttcctttgtgcccttgggggagtg tgcctccagcagagaagcaattctggcctggcaacctatagcccacccatgggtccagtc aatgaacgtaagggttccatgatttcagtgatgtcctcagagggaaacgcagatacacct gtcagcaaatttatggatcggctcttgtccttaatggtgtgtaaccatgagaaagtggga cttcaaatacggaccaatgttaaggatctggtgggtctagaattgagtcctgctctgtat ccaatgctatttaacaaattgaagaataccatcagcaagttttttgactcccaaggacag gttttattgaccgataccaatactcagtttgtagaacaaaccatagctataatgaagaac ttgctagataatcataccgaaggcagctctgaacatctggggcaagctagcattgaaaca atgatgttaaatctggtcaggtatgttcgtgtgcttgggaatatggtccatgcaattcaa ataaaaacgaaactgtgtcagttagttgaagtaatgatggcaaggagagatgacctctca ttttgccaagagatgaaatttaggaataagatggtagaatacctgacagactgggttatg ggaacatcaaaccaagcagcggatgatgatgtaaagtgtcttacaagagatttggaccag gcaagcatggaagcagtagtttcacttctagctggtctccctctgcagcctgaagaagga gatggtgtggaattgatggaagccaaatcacagttatttcttaaatacttcacattattt atgaaccttttgaatgactgcagtgaagttgaagatgaaaatgcacaaacaggtggcagg aaacgtggcatgtctcggaggctggcatcactgaggcactgtacagtccttgcaatgtca aacttactcaatgccaacgtagacagtggtctcatgcactccataggcttaggttaccac aaagatctccagacaagagctacatttatggaagttctgacaaaaatccttcaacaaggc acagaatttgacacacttgcagaaacggtattggctgatcggtttgagagattggtggaa ctggtcacaatgatgggtgatcaaggagaactccctatagcgatggctctggccaatgtg gttccttgttctcagtgggatgaactagctcgagttctggttactctgtttgattctcgg catttactctaccaactgctctggaacatgttttctaaagaagtagaattggcagactcc atgcagactctcttccgaggcaacagcttggccagtaaaataatgacgttctgtttcaag gtatatggtgctacctatctacagaaactcctggatcctttattacgaattgtgatcaca tcctctgattggcaacatgttagctttgaagtggatcctaccagattagaaccatcagag agccttgaggaaaaccagcggaacctccttcagatgactgaaaagttcttccatgccatc atcagttcttcctcagaattcccccctcaacttcgaagtgtgtgccactgtttataccag gcaacttgccactccctactgaataaagctacagtaaaagaaaaaaaggaaaacaaaaaa tcagtggttagccagcgtttccctcagaacagcatcggtgcagtaggaagtgccatgttc ctcagatttatcaatcctgccattgtctcaccatatgaagcagggattttagataaaaag ccaccacctagaatcgaaaggggcttgaagttaatgtcaaagatacttcagagtatcgcc aatcatgttctcttcacaaaagaagaacatatgcggcctttcaacgattttgtgaaaacc aactttgatgcagcacgaaggtttttccttgatatagcatctgattgtcctacaagtgat gcagtaaatcatagtctttccttcatcagtgacggcaatgtgcttgctttacatcgtcta ctctggaacaatcaggagaaaatcggccagtatctgtccagcaacagggatcataaagct gttggaagacgaccttttgataagatggcaacacttcttgcgtacctgggtcctccagag cacaaacctgtggcagatacacactggtccagccttaaccttaccagttcaaagtttgag gaatttatgactaggcatcaggtacatgaaaaagaagaattcaaggctttgaaaacgtta agtattttctaccaagctgggacttccaaagctgggaatcctattttttattatgttgca cggaggttcaaaactggtcaaatcaatggtgatttgctgatataccatgtcttactgact ttaaagccatattatgcaaagccatatgaaattgtagtggaccttacccataccgggcct agcaatcgctttaaaacagactttctctctaagtggtttgttgtttttcctggctttgct tacgacaacgtctccgcagtctatatctataactgtaactcctgggtcagggagtacacc aagtaccatgagcggctgctgactggcctcaaaggtagcaaaaggcttgttttcatagac tgtcctgggaaactggctgagcacatagagcatgaacaacagaaactacctgctgccacc ttggctttagaagaggacctgaaggtattccacaatgctctcaagctagctcacaaagat accaaagtttctattaaagttggttctactgctgtccaagtaacctcagcagagcgaaca aaagtcctaggacaatcagtctttttaaatgacatctattatgcttcggaaattgaagaa atctgcctagtagatgagaaccagttcaccttaaccattgcaaaccagggcacgccgctc accttcatgcaccaggagtgtgaagccattgtccagtctatcattcatatccggacccgc tgggagctgtcacagcccgactctatcccacaacacaccaagattcggccaaaagatgtc cctgggacactgcttaatatcgcattacttaatttaggcagttctgacccgagtttacgg tcagctgcctataatcttctgtgtgccttaacttgtacctttaatttaaaaatcgagggc cagttactagagacatcaggtttatgtatccctgccaacaacaccctctttattgtctct attagtaagacactggcagccaatgagccacacctcacgttagaatttttggaagagtgt atttctggatttagcaaatctagtattgaattgaaacacctttgtttggaatacatgact ccatggctgtcaaatctagttcgtttttgcaagcataatgatgatgccaaacgacaaaga gtcactgctattcttgacaagctgataacaatgaccatcaatgaaaaacagatgtaccca tctattcaagcaaaaatatggggaagccttgggcagattacagatctgcttgatgttgta ctagacagtttcatcaaaaccagtgcaacaggtggcttgggatcaataaaagctgaggtg atggcagatactgctgtagctttggcttctggaaatgtgaaattggtttcaagcaaggtt attggaaggatgtgcaaaataattgacaagacatgcttatctccaactcctactttagaa caacatcttatgtgggatgatattgctattttagcacgctacatgctgatgctgtccttc aacaattcccttgatgtggcagctcatcttccctacctcttccacgttgttactttctta gtagccacaggtccgctctcccttagagcttccacacatggactagtcattaatatcatt cactctctgtgtacttgttcacagcttcattttagtgaagagaccaagcaagttttgaga ctcagtctgacagaattctcattacccaaattttacttgctgtttggcattagcaaagtc aagtcagctgctgtcattgccttccgttccagttaccgggacaggtcattctctcctggc tcctatgagagagagacttttgctttgacatccttggaaacagtcacagaagctttattg gagatcatggaggcatgcatgagagatattccaacgtgcaagtggctggaccagtggaca gaactagctcaaagatttgcattccagtataatccatccctgcaaccaagagctcttgtt gtctttgggtgtattagcaaacgagtgtctcatgggcagataaagcagattatccgtatt cttagcaaggcacttgagagttgcttaaaaggacctgatacttacaacagtcaagttctg atagaagctacagtaatagcactaaccaaattacagccacttcttaataaggactcacct ctgcacaaagccctcttttgggtagctgtggctgtgctgcagcttgatgaagtcaacttg tattcagcaggcacggcacttcttgaacaaaacctgcatactttagatagtctccgtata ttcaatgacaagagtccagaggaagtatttatggcaatccggaatcctctggagtggcac tgcaagcaaatggatcattttgttggactcaatttcaactctaactttaactttgcattg gttggacaccttttaaaagggtacaggcatccttcacctgccattgttgcaagaacagtc agaattttacatacactactaactctggttaacaaacacaggaattgtgacaaatttgaa gtgaatacacagagcgtggcctacttagcagctttacttacagtgtctgaagaagttcga agtcgctgcagcctaaaacatagaaagtcacttcttcttactgatgtttcaatggaaaat gttcctatggatacatatcccattcatcatggtgatcctacctataggacactaaaggag actcagccatggtcctctcccaaaggttctgaaggataccttgcagccacctatccaact gtcggccagaccagtccccgagccaggaaatccatgagcttggacatggggcagccttct caggccaacactaagaagttgcttggaacaaggaaaagttttgatcacttgatatcagac acaaaggctcctaaaaggcaagaaatggaatcagggatcacaacaccccccaaaatgagg agagtagcagaaactgattatgaaatggaaactcagaggatttcctcatcacaacagcat ccacatttacgtaaggtttcggtgtctgaatcaaatgttctcttggatgaagaagtactt actgatccaaaaatccaggcgctgcttcttactgttctagctacactggtaaaatatacc acagatgagtttgatcaacgaattctttatgaatacttagcagaggccagtgttgtgttt cccaaagtatttcctgttgtgcataatttgttggactctaagatcaacaccctgttatca ctgtgccaagatccaaatctgttaaatccaatccatggaattgtgcagagtgtggtgtac catgaagaatccccaccacaataccaaacatcttacctgcaaagttttggttttaatggc ttgtggcggtttgcaggacccttttcaaagcaaacacaaattccagactatgctgagctt attgttaagtttcttgatgccttgattgacacgtacctgcctggaattgatgaagaaacc agtgaggaatccctcctgacacccacatctccttaccctcctgcactgcagagccagctt agtatcactgccaaccttaacctctctaattccatgacctcacttgcaacttcccagcat tccccaggaatcgacaaggagaacgttgaactctcccctaccactggccactgtaacagt ggacgaactcgccacggatccgcaagccaagtgcagaagcaaagaagcgctggcagtttc aaacgtaatagcattaagaagatcgtgtga

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