KEGG   MODULE: M00718
Entry
M00718            Signature Module                                 

Name
Multidrug resistance, efflux pump MexAB-OprM
Definition
K18131 K03585+K18138+K18139
Diagram
M00718

Orthology
K18131  
mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
K03585  
acrA; membrane fusion protein, multidrug efflux system
K18138  
acrB; multidrug efflux pump
K18139  
oprM; outer membrane protein, multidrug efflux system
Class
Signature modules; Gene set; Drug resistance
Reference
  Authors
Evans K, Adewoye L, Poole K
  Title
MexR repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa: identification of MexR binding sites in the mexA-mexR intergenic region.
  Journal
J Bacteriol 183:807-12 (2001)
DOI:10.1128/JB.183.3.807-812.2001
Reference
  Authors
Boutoille D, Corvec S, Caroff N, Giraudeau C, Espaze E, Caillon J, Plesiat P, Reynaud A
  Title
Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing beta-lactam resistance.
  Journal
FEMS Microbiol Lett 230:143-6 (2004)
DOI:10.1016/S0378-1097(03)00882-6
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