KEGG   MODULE: M00744
Entry
M00744            Signature Module                                 

Name
Cationic antimicrobial peptide (CAMP) resistance, protease PgtE
Definition
K07637 K07660 K08477
Diagram
M00744

Orthology
K07637  
phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] [COG:COG0642] [GO:0000155]
K07660  
phoP; two-component system, OmpR family, response regulator PhoP [COG:COG0745] [GO:0000156]
K08477  
pgtE; outer membrane protease E [EC:3.4.21.-] [COG:COG4571]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: cleavage of peptides
Reference
  Authors
Guina T, Yi EC, Wang H, Hackett M, Miller SI
  Title
A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides.
  Journal
J Bacteriol 182:4077-86 (2000)
DOI:10.1128/JB.182.14.4077-4086.2000
Reference
  Authors
Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Shi Y
  Title
The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide.
  Journal
J Biol Chem 286:5529-39 (2011)
DOI:10.1074/jbc.M110.200352
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