KEGG   PATHWAY: mgp04115
Entry
mgp04115                    Pathway                                

Name
p53 signaling pathway - Meleagris gallopavo (turkey)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
mgp04115  p53 signaling pathway
mgp04115

Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100540368  serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100540056  serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
100543068  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
100542484  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100547861  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100550141  GORAB; RAB6-interacting golgin [KO:K19748]
100546889  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100544420  MDM4; protein Mdm4 isoform X1 [KO:K10127]
104914505  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100539759  CCND1; LOW QUALITY PROTEIN: G1/S-specific cyclin-D1 [KO:K04503]
104909362  G1/S-specific cyclin-D2 [KO:K10151]
100546832  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
100539044  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100545829  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
104913010  G1/S-specific cyclin-E1-like [KO:K06626]
100542044  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100544986  SFN; 14-3-3 protein sigma [KO:K06644]
100542909  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100549676  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100540601  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
104915137  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100549398  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
100550139  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100546092  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
664712  TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b precursor [KO:K04722]
100539605  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04722]
100541513  caspase-8 [KO:K04398] [EC:3.4.22.61]
100541666  caspase-8-like [KO:K04398] [EC:3.4.22.61]
100548073  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
104914820  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100539573  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100545008  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100545625  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
100544313  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
100538951  SHISA5; protein shisa-5 [KO:K10135]
100549869  p53 apoptosis effector related to PMP-22-like [KO:K10136]
100550023  p53 apoptosis effector related to PMP-22-like [KO:K10136]
100547023  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
100549528  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
100549365  CYC; cytochrome c [KO:K08738]
100549497  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100550410  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100548182  CASP3; LOW QUALITY PROTEIN: caspase-3 [KO:K02187] [EC:3.4.22.56]
100543413  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
100539598  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
104911603  insulin-like growth factor I [KO:K05459]
678666  insulin-like growth factor I precursor [KO:K05459]
100540586  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
100545881  CD82; CD82 antigen [KO:K06509]
100542373  THBS1; thrombospondin-1 [KO:K16857]
100546549  SERPINB5; serpin B5 isoform X2 [KO:K10139]
100548596  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100550737  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100550027  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
100545569  SESN1; sestrin-1 isoform X2 [KO:K10141]
100546334  SESN3; sestrin-3 [KO:K10141]
104912103  sestrin-3-like [KO:K10141]
100541251  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100542960  TSC2; tuberin isoform X3 [KO:K07207]
100548600  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
100542481  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
104910570  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
100541216  CCNG1; cyclin-G1 [KO:K10145]
100550997  CCNG2; cyclin-G2 [KO:K10146]
100541630  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
100545037  TP73; tumor protein p73 isoform X1 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
mgp04110  Cell cycle
mgp04210  Apoptosis
mgp04218  Cellular senescence
KO pathway
ko04115   
LinkDB

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