Mannheimia haemolytica D171: J450_03215
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Entry
J450_03215 CDS
T02747
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
mham
Mannheimia haemolytica D171
Pathway
mham00260
Glycine, serine and threonine metabolism
mham00261
Monobactam biosynthesis
mham00270
Cysteine and methionine metabolism
mham00300
Lysine biosynthesis
mham01100
Metabolic pathways
mham01110
Biosynthesis of secondary metabolites
mham01120
Microbial metabolism in diverse environments
mham01230
Biosynthesis of amino acids
Module
mham_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
mham_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
mham_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
mham00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
J450_03215 (thrA)
00270 Cysteine and methionine metabolism
J450_03215 (thrA)
00300 Lysine biosynthesis
J450_03215 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
J450_03215 (thrA)
Enzymes [BR:
mham01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
J450_03215 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
J450_03215 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
ACT_7
ACT
Sacchrp_dh_NADP
DUF1131
DapB_N
DUF4781
Motif
Other DBs
NCBI-ProteinID:
AGQ38187
LinkDB
All DBs
Position
709236..711692
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AA seq
818 aa
AA seq
DB search
MRVLKFGGTSLANPERFMQAAEIIEKAHLADQAAGVLSAPAKITNHLVAIVDKAIAGESF
QSNLSEATEIFHNIINGLYATNNHFAKEALLALVEAELNQIQQVAAEAAQTKSLSDKIAA
TIHCRGEKLSIAMMQAWFEAKGYEVTRIDPVEKLLAHGSYLESSVDIAESTKRVDAGSIP
KKNIVLMAGFTAGNEQGELVLLGRNGSDYSAACLAACLKADVCEIWTDVDGVYTCDPRLV
PDAVCLETMSYQEAMELSYFGAKVIHPRTIGPLVPLNIPCLIKNTGNPDGKGTLIDGNVA
NDNLKVKGITNLDNVAMFNVSGSGMQGMVGMAARVFSTMSKAGISVILITQSSSEYSISF
CVPAKSAEKALAALNTEFAQELSENLLDPIDIIKDLSIVSVVGDGMRTAKGIAARFFSAL
AQANISIVAIAQGSSERSISAVVPLNKAIEAVKATHKSLFNSKRVVDMFLVGVGGVGSEL
IEQVKQQKEFLAKKDIEIRVCALANSDKMLLNENGLNLDNWKEDLEKAIQPSDFDVLLSF
IKFHHVVNPVFVDCTSAQSVANLYARALKEGFHVVTPNKKANTSGYDYYLEMRENARQSQ
HKFLYETNVGAGLPVIENLQNLLAAGDEVEKFEGILSGSLSFIFGKLEEGLTLSQATLIA
KEKGFTEPDPRDDLSGADVARKLLILVRETGLPLEFEDIEIEGVLPKGFSEGMSRDEFLQ
ALPSLDEEFSKRVEAAKAEGKVLRYVGSITGDKCRVAIEAVDENHPLYKVKDGENALAFL
TRYYNPIPLLLRGYGAGNSVTAAGIFADILRTLQGGVN
NT seq
2457 nt
NT seq
+upstream
nt +downstream
nt
atgcgagttcttaaatttggaggcacttctcttgccaaccctgaacgctttatgcaagcg
gcagagattatcgagaaagctcatttggcagatcaagctgccggcgtattatccgcccca
gccaaaattaccaatcatcttgtcgctattgtagataaagcgattgccggtgaatcattt
caatctaacctttccgaagctaccgagattttccacaacatcattaacggcttatatgct
acaaataatcactttgctaaagaagcactgttagccttagtggaagcggaattaaaccaa
attcagcaagtggcagcagaagcagctcaaactaaatcgttgtcagataaaattgctgcc
actattcactgccgtggtgaaaaactctctattgcgatgatgcaagcgtggttcgaggca
aaaggctatgaagtcactcgtatcgaccctgttgaaaaattattggctcacggcagctat
ttggaatcttcggtcgatattgccgaatccaccaagcgagttgatgcaggttcaattcca
aagaaaaatatcgtgctaatggctggttttaccgcaggtaatgagcaaggcgaactggtg
ttattagggcgtaacggttcagattattctgccgcttgtttggcagcgtgtttaaaagcc
gatgtttgtgaaatctggacggacgtagatggcgtttacacctgcgaccctcgtttggtg
cctgatgcagtatgcttagaaacaatgagctatcaagaggcaatggagctttcctacttt
ggggcgaaagtgatccaccctcgcaccatcgggccattagtgccgctcaatattccttgt
ttaatcaaaaataccggcaatccggacggaaaaggcacattaattgatggcaatgtggcg
aacgataatctcaaagtaaaagggattaccaaccttgataacgtggcgatgttcaacgtt
tcaggttcaggaatgcagggaatggtgggcatggctgcccgtgtgttctcgacgatgtca
aaagccggtatttcggtgattttaattacccaatcatcatcagaatatagcatcagcttc
tgcgtgccggcaaaatcggcagaaaaagcgttagcggctctaaatactgaatttgcacaa
gagttatctgaaaacttacttgacccgattgatattattaaagatttatccattgtttcg
gtggtgggtgatggtatgcgtaccgccaaaggaattgcggctcgcttcttctctgcccta
gcccaagccaacatcagtattgtggcaattgcacagggttcatctgagcgttccatttct
gctgtcgtgccgttaaacaaagcgattgaagcagtaaaagcaactcacaaatcgctattt
aacagtaaacgtgtggtggatatgtttttagtgggtgtaggcggtgtgggtagcgaactc
atcgagcaagtcaaacaacaaaaggagtttttggcaaagaaggatattgagatccgtgtg
tgtgctttagctaattctgataaaatgttactcaacgaaaacggcttaaatttagacaac
tggaaagaagatttagaaaaagcaattcagccgtcagactttgatgtattgctttctttc
atcaaattccaccacgtggtaaacccagtatttgtagattgcacttcggcacaatcggtg
gcgaacctgtacgcacgagccttaaaagagggcttccacgtggtaacaccaaacaaaaaa
gccaatacatcaggttacgattactacttagaaatgcgtgaaaacgcccgccaaagccag
cacaaattcctctacgaaactaatgtaggggcaggtttaccggtaattgaaaacttacaa
aacctattagctgccggtgacgaagtagagaaatttgaagggattttatccggttcgctc
tctttcattttcggcaaattagaagaaggtttaaccctttcgcaagcaactttaatcgcc
aaagaaaaaggctttaccgagccagatccacgagatgatttatccggtgcagatgttgct
cgtaaactcttaattcttgttcgtgaaaccggcttaccgcttgaatttgaagatattgaa
attgaaggcgtattgccaaaaggcttctcggaaggaatgagtcgtgatgagtttttacaa
gctctaccgtctttagacgaagaattcagcaagcgtgtagaagctgccaaggctgaaggc
aaagtgttgcgttatgtgggctcgatcacaggtgataaatgccgagttgccattgaagcc
gtggacgaaaaccacccactttacaaagttaaagacggcgaaaatgcccttgcttttctc
acacgttactacaaccctattccattattattgcgtgggtatggtgcgggcaatagcgta
accgctgccggtatctttgcagatattctgcgtactttacaaggaggagtgaactaa
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