Entry
Name
Nucleotide excision repair - Manis javanica (Malayan pangolin)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Manis javanica (Malayan pangolin) [GN:
mjv ]
Gene
108388647 DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140 ]
108400073 XPC; DNA repair protein complementing XP-C cells isoform X1 [KO:K10838 ]
108399666 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839 ]
108397088 LOW QUALITY PROTEIN: UV excision repair protein RAD23 homolog B-like [KO:K10839 ]
108407477 POLR2C; DNA-directed RNA polymerase II subunit RPB3 isoform X1 [KO:K03011 ]
108388790 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 [KO:K03013 ]
108392689 DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014 ]
108395273 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 [KO:K03016 ]
108400990 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like [KO:K03016 ]
108396957 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 [KO:K03017 ]
118971133 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
108394018 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009 ]
108396067 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009 ]
108404724 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009 ]
108383780 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008 ]
118971667 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit GRINL1A-like [KO:K21987 ]
108387328 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 [KO:K10843 ] [EC:5.6.2.4 ]
108391018 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 [KO:K10844 ] [EC:5.6.2.3 ]
108389688 LOW QUALITY PROTEIN: general transcription factor IIH subunit 5-like [KO:K10845 ]
108405101 GTF2H1; general transcription factor IIH subunit 1 isoform X1 [KO:K03141 ]
108409887 GTF2H4; general transcription factor IIH subunit 4 isoform X1 [KO:K03144 ]
108395667 XPA; DNA repair protein complementing XP-A cells isoform X1 [KO:K10847 ]
108391811 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466 ]
108389751 RPA2; replication protein A 32 kDa subunit isoform X1 [KO:K10739 ]
108403621 ERCC4; DNA repair endonuclease XPF isoform X1 [KO:K10848 ] [EC:3.1.-.-]
Reference
Authors
Sugasawa K.
Title
[Molecular mechanism of mammalian nucleotide excision repair]
Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
Authors
Nakatsu Y.
Title
[Transcription-coupled repair and Cockayne syndrome]
Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
Authors
Nakagawa N, Masui R, Kuramitsu S.
Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Journal
Reference
Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Journal
Reference
Authors
Sugasawa K.
Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
Authors
Ito S, Ando D, Tanaka K.
Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related pathway
KO pathway
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