KEGG   PATHWAY: mjv04630
Entry
mjv04630                    Pathway                                

Name
JAK-STAT signaling pathway - Manis javanica (Malayan pangolin)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04630  JAK-STAT signaling pathway
mjv04630

Other DBs
GO: 0007259
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383567  IL2; interleukin-2 [KO:K05429]
108392856  interleukin-3-like [KO:K04736]
108390065  IL4; interleukin-4 [KO:K05430]
108404046  IL5; interleukin-5 isoform X1 [KO:K05428]
108398622  IL6; interleukin-6 [KO:K05405]
108398928  IL7; interleukin-7 isoform X1 [KO:K05431]
108391238  IL9; interleukin-9 [KO:K05432]
108403017  IL10; interleukin-10 [KO:K05443]
108388693  IL11; interleukin-11 [KO:K05417]
108409113  IL12A; interleukin-12 subunit alpha [KO:K05406]
108409190  IL12B; interleukin-12 subunit beta [KO:K05425]
108390063  IL13; interleukin-13 [KO:K05435]
108385980  IL15; interleukin-15 isoform X1 [KO:K05433]
108403291  IL17D; LOW QUALITY PROTEIN: interleukin-17D [KO:K05492]
108403018  IL19; interleukin-19 [KO:K05444]
108403021  IL20; interleukin-20 [KO:K22667]
108383569  IL21; interleukin-21 [KO:K05434]
108406572  IL22; interleukin-22 [KO:K05445]
108402233  IL23A; interleukin-23 subunit alpha [KO:K05426]
108403020  IL24; interleukin-24 [KO:K22668]
108397409  interferon alpha-2-like [KO:K05414]
108388277  interferon alpha-1/13-like [KO:K05414]
108402531  IFNB1; interferon beta [KO:K05415]
108384008  IFNG; interferon gamma [KO:K04687]
108408540  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
108399095  IFNK; interferon kappa [KO:K05441]
108394700  interferon lambda-1-like [KO:K05447]
108391987  interferon lambda-1-like [KO:K05447]
108408539  interferon omega-2-like [KO:K05440]
108397407  interferon omega-2-like [KO:K05440]
108397408  interferon omega-1-like [KO:K05440]
108396879  OSM; oncostatin-M [KO:K05418]
108396861  LIF; leukemia inhibitory factor [KO:K05419]
108407980  TSLP; thymic stromal lymphopoietin [KO:K05436]
108385437  CTF1; LOW QUALITY PROTEIN: cardiotrophin-1 [KO:K05422]
108385428  cardiotrophin-2 [KO:K24382]
108392857  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
108398074  CNTF; ciliary neurotrophic factor [KO:K05420]
108385153  CSF3; granulocyte colony-stimulating factor [KO:K05423]
108409376  EPO; erythropoietin [KO:K05437]
108403155  somatotropin isoform X1 [KO:K05438]
108395315  LEP; leptin [KO:K05424]
108395274  THPO; thrombopoietin isoform X1 [KO:K06854]
108385400  PRL; prolactin [KO:K05439]
108408073  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108384839  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
108392662  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
108403309  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
108389002  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
108405149  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
108390628  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
108393946  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
108406858  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
108402039  IL9R; interleukin-9 receptor [KO:K05073]
108390189  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
108409506  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
108395551  GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056]
108383562  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
108404889  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
108386976  interleukin-13 receptor subunit alpha-1-like [KO:K05076]
108394461  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
108399808  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
108407553  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
108410302  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
108393777  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
108405151  IL21R; interleukin-21 receptor [KO:K05075]
108387774  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
108410305  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
108404887  IL23R; interleukin-23 receptor [KO:K05065]
108403518  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
108393228  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
108396596  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108409505  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108410304  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
108385993  IFNGR2; interferon gamma receptor 2 [KO:K05133]
108387775  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
108401571  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108404133  LIFR; leukemia inhibitory factor receptor [KO:K05058]
108389086  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
108395488  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
108389965  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
108389768  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
108392655  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
108400801  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108398989  EPOR; erythropoietin receptor [KO:K05079]
108400493  GHR; growth hormone receptor [KO:K05080]
108406161  LEPR; leptin receptor isoform X1 [KO:K05062]
108407017  MPL; thrombopoietin receptor [KO:K05082]
108405848  PRLR; prolactin receptor isoform X1 [KO:K05081]
108406292  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
108385741  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108405993  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108388836  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108395333  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
108388002  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
108397113  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
108400080  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108402236  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108386068  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108400081  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
108388330  signal transducer and activator of transcription 5B-like [KO:K11224]
108385818  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
108402880  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
108405554  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
108400461  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
108407802  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
108396005  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
108387701  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
108385429  SOCS6; LOW QUALITY PROTEIN: suppressor of cytokine signaling 6 [KO:K04699]
108396412  SOCS7; LOW QUALITY PROTEIN: suppressor of cytokine signaling 7 [KO:K04699]
108385222  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
108403236  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
108393091  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108395749  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
108399996  MYC; myc proto-oncogene protein [KO:K04377]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108403976  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108405335  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108385913  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108391579  AOX1; aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
108391580  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
108391581  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
108403678  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
108404506  signal transducing adapter molecule 2 [KO:K04705]
108403202  signal transducing adapter molecule 2-like [KO:K04705]
108406768  tyrosine-protein phosphatase non-receptor type 2-like [KO:K18026] [EC:3.1.3.48]
108384835  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
108391263  IRF9; interferon regulatory factor 9 [KO:K04693]
108394315  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108395362  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108406656  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
108400380  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
108408312  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
108396286  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
108405695  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
108409005  LOW QUALITY PROTEIN: growth factor receptor-bound protein 2-like [KO:K04364]
108388820  growth factor receptor-bound protein 2-like [KO:K04364]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 [KO:K03099]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108395975  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390746  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
108399184  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Related
pathway
mjv04010  MAPK signaling pathway
mjv04060  Cytokine-cytokine receptor interaction
mjv04110  Cell cycle
mjv04120  Ubiquitin mediated proteolysis
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
KO pathway
ko04630   
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