KEGG T06054: 108385046

KEGG Orthology (KO) [BR:mjv00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108385046 (MAP2K2)
   04012 ErbB signaling pathway
    108385046 (MAP2K2)
   04014 Ras signaling pathway
    108385046 (MAP2K2)
   04015 Rap1 signaling pathway
    108385046 (MAP2K2)
   04370 VEGF signaling pathway
    108385046 (MAP2K2)
   04371 Apelin signaling pathway
    108385046 (MAP2K2)
   04066 HIF-1 signaling pathway
    108385046 (MAP2K2)
   04068 FoxO signaling pathway
    108385046 (MAP2K2)
   04072 Phospholipase D signaling pathway
    108385046 (MAP2K2)
   04071 Sphingolipid signaling pathway
    108385046 (MAP2K2)
   04024 cAMP signaling pathway
    108385046 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    108385046 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    108385046 (MAP2K2)
   04150 mTOR signaling pathway
    108385046 (MAP2K2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108385046 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    108385046 (MAP2K2)
   04218 Cellular senescence
    108385046 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    108385046 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    108385046 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108385046 (MAP2K2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    108385046 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    108385046 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    108385046 (MAP2K2)
   04660 T cell receptor signaling pathway
    108385046 (MAP2K2)
   04662 B cell receptor signaling pathway
    108385046 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    108385046 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108385046 (MAP2K2)
   04929 GnRH secretion
    108385046 (MAP2K2)
   04912 GnRH signaling pathway
    108385046 (MAP2K2)
   04915 Estrogen signaling pathway
    108385046 (MAP2K2)
   04917 Prolactin signaling pathway
    108385046 (MAP2K2)
   04921 Oxytocin signaling pathway
    108385046 (MAP2K2)
   04926 Relaxin signaling pathway
    108385046 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    108385046 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    108385046 (MAP2K2)
   04916 Melanogenesis
    108385046 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    108385046 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    108385046 (MAP2K2)
   04730 Long-term depression
    108385046 (MAP2K2)
   04722 Neurotrophin signaling pathway
    108385046 (MAP2K2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108385046 (MAP2K2)
   05206 MicroRNAs in cancer
    108385046 (MAP2K2)
   05205 Proteoglycans in cancer
    108385046 (MAP2K2)
   05230 Central carbon metabolism in cancer
    108385046 (MAP2K2)
   05231 Choline metabolism in cancer
    108385046 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108385046 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108385046 (MAP2K2)
   05225 Hepatocellular carcinoma
    108385046 (MAP2K2)
   05226 Gastric cancer
    108385046 (MAP2K2)
   05214 Glioma
    108385046 (MAP2K2)
   05216 Thyroid cancer
    108385046 (MAP2K2)
   05221 Acute myeloid leukemia
    108385046 (MAP2K2)
   05220 Chronic myeloid leukemia
    108385046 (MAP2K2)
   05218 Melanoma
    108385046 (MAP2K2)
   05211 Renal cell carcinoma
    108385046 (MAP2K2)
   05219 Bladder cancer
    108385046 (MAP2K2)
   05215 Prostate cancer
    108385046 (MAP2K2)
   05213 Endometrial cancer
    108385046 (MAP2K2)
   05224 Breast cancer
    108385046 (MAP2K2)
   05223 Non-small cell lung cancer
    108385046 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108385046 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    108385046 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    108385046 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108385046 (MAP2K2)
   05135 Yersinia infection
    108385046 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108385046 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    108385046 (MAP2K2)
   05161 Hepatitis B
    108385046 (MAP2K2)
   05160 Hepatitis C
    108385046 (MAP2K2)
   05164 Influenza A
    108385046 (MAP2K2)
   05163 Human cytomegalovirus infection
    108385046 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108385046 (MAP2K2)
   05165 Human papillomavirus infection
    108385046 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108385046 (MAP2K2)
   01522 Endocrine resistance
    108385046 (MAP2K2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108385046 (MAP2K2)
Enzymes [BR:mjv01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     108385046 (MAP2K2)
Protein kinases [BR:mjv01001]
Serine/threonine kinases: STE group
  STE7 family
   108385046 (MAP2K2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like APH Seadorna_VP7 Kdo

Other DBs

NCBI-GeneID:

108385046

NCBI-ProteinID:

XP_017497810

LinkDB

Position

Unknown

AA seq 374 aa
MLALLANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVV
TKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYP
IPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRPPGRPISGHGMDSRPAMAIFELLDYIV
NEPPPKLPSGIFTQDFQEFVNKCLIKNPAERADLKMLMNHTFIKRSEAEEVDFAGWLCKT
LRLNQPSTPTRAAV

NT seq 1125 nt +upstreamnt +downstreamnt
atgttggcccttctagccaacttggtggacctccagaagaagctagaggagctggaactc
gatgagcagcagaagaagcggctagaagctttcctcacccagaaggccaaggtcggggag
ctcaaggatgatgacttcgagcggatctcagagctgggagctgggaacggcggggtggtc
accaaggtccagcatagaccttcgggcctcatcatggcaaggaagttgattcacctggag
atcaagccggccatccggaaccagatcatccgagagctacaggtgctgcacgagtgtaac
tcgccgtacatcgtgggcttctacggggccttctacagcgacggggagatcagcatctgc
atggagcacatggacggcggctctctggaccaggtgttgaaagaagccaagagaattccc
gaggagatcctgggcaaggtcagcatcgcggtcctgcggggcttggcgtatctccgggaa
aagcaccagatcatgcaccgagacgtgaaaccgtcgaacatcctcgtcaactcccgaggg
gagatcaagctgtgcgattttggggtgagcgggcaactcattgactcaatggccaactcc
ttcgtgggaacgcggtcctacatgtctccagagcggttgcaaggtactcactactccgtg
cagtcagacatctggagcatgggcctgtccctggtggagctgtccatcggaaggtacccc
atccccccaccagatgccaaggagctggaagccatatttggccggcccatggtcgatggg
gcggaaggagagccacacagcatctcgccacggccgagaccccccggacgccccatcagc
ggtcacgggatggacagccggccggccatggctatcttcgagctgctggactatattgtg
aatgagccacctcccaagctgcccagcggcattttcacccaggacttccaggagtttgta
aataaatgcctgattaagaacccagcagagcgagccgatctgaagatgctcatgaaccac
accttcatcaaacggtccgaggcggaagaagtcgattttgccggctggttgtgtaaaacg
ctgcggctgaaccagcccagcacgcccacacgcgctgccgtgtga

Manis javanica (Malayan pangolin): 108392139

Entry

108392139 CDS T06054

Gene name

MAP2K1

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 1

K04368

mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

Organism

mjv Manis javanica (Malayan pangolin)

Pathway

mjv01521

EGFR tyrosine kinase inhibitor resistance

mjv01522

Endocrine resistance

mjv04010

MAPK signaling pathway

mjv04012

ErbB signaling pathway

mjv04014

Ras signaling pathway

mjv04015

Rap1 signaling pathway

mjv04022

cGMP-PKG signaling pathway

mjv04024

cAMP signaling pathway

mjv04062

Chemokine signaling pathway

mjv04066

HIF-1 signaling pathway

mjv04068

FoxO signaling pathway

mjv04071

Sphingolipid signaling pathway

mjv04072

Phospholipase D signaling pathway

mjv04114

Oocyte meiosis

mjv04140

Autophagy - animal

mjv04150

mTOR signaling pathway

mjv04151

PI3K-Akt signaling pathway

mjv04210

Apoptosis

mjv04218

Cellular senescence

mjv04270

Vascular smooth muscle contraction

mjv04370

VEGF signaling pathway

mjv04371

Apelin signaling pathway

mjv04380

Osteoclast differentiation

mjv04510

Focal adhesion

mjv04540

Gap junction

mjv04550

Signaling pathways regulating pluripotency of stem cells

mjv04613

Neutrophil extracellular trap formation

mjv04620

Toll-like receptor signaling pathway

mjv04650

Natural killer cell mediated cytotoxicity

mjv04660

T cell receptor signaling pathway

mjv04662

B cell receptor signaling pathway

mjv04664

Fc epsilon RI signaling pathway

mjv04666

Fc gamma R-mediated phagocytosis

mjv04668

TNF signaling pathway

mjv04720

Long-term potentiation

mjv04722

Neurotrophin signaling pathway

mjv04725

Cholinergic synapse

mjv04726

Serotonergic synapse

mjv04730

Long-term depression

mjv04810

Regulation of actin cytoskeleton

mjv04910

Insulin signaling pathway

mjv04912

GnRH signaling pathway

mjv04914

Progesterone-mediated oocyte maturation

mjv04915

Estrogen signaling pathway

mjv04916

Melanogenesis

mjv04917

Prolactin signaling pathway

mjv04919

Thyroid hormone signaling pathway

mjv04921

Oxytocin signaling pathway

mjv04926

Relaxin signaling pathway

mjv04928

Parathyroid hormone synthesis, secretion and action

mjv04929

GnRH secretion

mjv04934

Cushing syndrome

mjv04935

Growth hormone synthesis, secretion and action

mjv05010

Alzheimer disease

mjv05022

Pathways of neurodegeneration - multiple diseases

mjv05034

Alcoholism

mjv05132

Salmonella infection

mjv05135

Yersinia infection

mjv05160

Hepatitis C

mjv05161

Hepatitis B

mjv05163

Human cytomegalovirus infection

mjv05164

Influenza A

mjv05165

Human papillomavirus infection

mjv05166

Human T-cell leukemia virus 1 infection

mjv05167

Kaposi sarcoma-associated herpesvirus infection

mjv05170

Human immunodeficiency virus 1 infection

mjv05200

Pathways in cancer

mjv05205

Proteoglycans in cancer

mjv05206

MicroRNAs in cancer

mjv05210

Colorectal cancer

mjv05211

Renal cell carcinoma

mjv05212

Pancreatic cancer

mjv05213

Endometrial cancer

mjv05214

Glioma

mjv05215

Prostate cancer

mjv05216

Thyroid cancer

mjv05218

Melanoma

mjv05219

Bladder cancer

mjv05220

Chronic myeloid leukemia

mjv05221

Acute myeloid leukemia

mjv05223

Non-small cell lung cancer

mjv05224

Breast cancer

mjv05225

Hepatocellular carcinoma

mjv05226

Gastric cancer

mjv05230

Central carbon metabolism in cancer

mjv05231

Choline metabolism in cancer

mjv05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:mjv00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108392139 (MAP2K1)
   04012 ErbB signaling pathway
    108392139 (MAP2K1)
   04014 Ras signaling pathway
    108392139 (MAP2K1)
   04015 Rap1 signaling pathway
    108392139 (MAP2K1)
   04370 VEGF signaling pathway
    108392139 (MAP2K1)
   04371 Apelin signaling pathway
    108392139 (MAP2K1)
   04668 TNF signaling pathway
    108392139 (MAP2K1)
   04066 HIF-1 signaling pathway
    108392139 (MAP2K1)
   04068 FoxO signaling pathway
    108392139 (MAP2K1)
   04072 Phospholipase D signaling pathway
    108392139 (MAP2K1)
   04071 Sphingolipid signaling pathway
    108392139 (MAP2K1)
   04024 cAMP signaling pathway
    108392139 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    108392139 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    108392139 (MAP2K1)
   04150 mTOR signaling pathway
    108392139 (MAP2K1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108392139 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    108392139 (MAP2K1)
   04210 Apoptosis
    108392139 (MAP2K1)
   04218 Cellular senescence
    108392139 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108392139 (MAP2K1)
   04540 Gap junction
    108392139 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    108392139 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108392139 (MAP2K1)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    108392139 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    108392139 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    108392139 (MAP2K1)
   04660 T cell receptor signaling pathway
    108392139 (MAP2K1)
   04662 B cell receptor signaling pathway
    108392139 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    108392139 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    108392139 (MAP2K1)
   04062 Chemokine signaling pathway
    108392139 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108392139 (MAP2K1)
   04929 GnRH secretion
    108392139 (MAP2K1)
   04912 GnRH signaling pathway
    108392139 (MAP2K1)
   04915 Estrogen signaling pathway
    108392139 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    108392139 (MAP2K1)
   04917 Prolactin signaling pathway
    108392139 (MAP2K1)
   04921 Oxytocin signaling pathway
    108392139 (MAP2K1)
   04926 Relaxin signaling pathway
    108392139 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    108392139 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    108392139 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    108392139 (MAP2K1)
   04916 Melanogenesis
    108392139 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    108392139 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    108392139 (MAP2K1)
   04726 Serotonergic synapse
    108392139 (MAP2K1)
   04720 Long-term potentiation
    108392139 (MAP2K1)
   04730 Long-term depression
    108392139 (MAP2K1)
   04722 Neurotrophin signaling pathway
    108392139 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    108392139 (MAP2K1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108392139 (MAP2K1)
   05206 MicroRNAs in cancer
    108392139 (MAP2K1)
   05205 Proteoglycans in cancer
    108392139 (MAP2K1)
   05230 Central carbon metabolism in cancer
    108392139 (MAP2K1)
   05231 Choline metabolism in cancer
    108392139 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108392139 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108392139 (MAP2K1)
   05212 Pancreatic cancer
    108392139 (MAP2K1)
   05225 Hepatocellular carcinoma
    108392139 (MAP2K1)
   05226 Gastric cancer
    108392139 (MAP2K1)
   05214 Glioma
    108392139 (MAP2K1)
   05216 Thyroid cancer
    108392139 (MAP2K1)
   05221 Acute myeloid leukemia
    108392139 (MAP2K1)
   05220 Chronic myeloid leukemia
    108392139 (MAP2K1)
   05218 Melanoma
    108392139 (MAP2K1)
   05211 Renal cell carcinoma
    108392139 (MAP2K1)
   05219 Bladder cancer
    108392139 (MAP2K1)
   05215 Prostate cancer
    108392139 (MAP2K1)
   05213 Endometrial cancer
    108392139 (MAP2K1)
   05224 Breast cancer
    108392139 (MAP2K1)
   05223 Non-small cell lung cancer
    108392139 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108392139 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    108392139 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    108392139 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    108392139 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108392139 (MAP2K1)
   05135 Yersinia infection
    108392139 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108392139 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    108392139 (MAP2K1)
   05161 Hepatitis B
    108392139 (MAP2K1)
   05160 Hepatitis C
    108392139 (MAP2K1)
   05164 Influenza A
    108392139 (MAP2K1)
   05163 Human cytomegalovirus infection
    108392139 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108392139 (MAP2K1)
   05165 Human papillomavirus infection
    108392139 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108392139 (MAP2K1)
   01522 Endocrine resistance
    108392139 (MAP2K1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108392139 (MAP2K1)
Enzymes [BR:mjv01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     108392139 (MAP2K1)
Protein kinases [BR:mjv01001]
Serine/threonine kinases: STE group
  STE7 family
   108392139 (MAP2K1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like Seadorna_VP7 NAD_binding_6

Other DBs

NCBI-GeneID:

108392139

NCBI-ProteinID:

XP_017507679

LinkDB

Position

Unknown

AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

NT seq 1182 nt +upstreamnt +downstreamnt
atgcctaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgccgtc
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcgccttgaggccttcctcacccagaagcagaaggtc
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggttttcaaagtctcccacaagccatccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaattcggaaccagatcataagggagctgcaggttctgcatgag
tgcaactccccctacatcgtgggcttctacggtgctttctacagtgatggcgaaatcagt
atctgcatggagcacatggatgggggttcattggatcaggttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaagggcctgacatatctg
agagagaagcacaagattatgcatagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactctttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcactac
tcggtgcagtcagacatctggagcatggggctctctctggttgagatggcagttgggagg
tatcccattcctcctccagatgccaaggagctggagctcatgtttgggtgccaggtggaa
ggagatgcggctgagacaccacccaggccaaggacccctggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattatatagtcaatgaa
cctcctccaaaactgcccagcggagtattcagtctggaatttcaagattttgttaataag
tgcttaataaaaaaccctgcagagagagcagatctaaagcagctcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggctggctctgctccaccattggc
cttaaccagcccagcacaccaacccacgcagctggcgtctaa

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