Manis javanica (Malayan pangolin): 108407248
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Entry
108407248 CDS
T06054
Gene name
PLCG1
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
mjv
Manis javanica (Malayan pangolin)
Pathway
mjv00562
Inositol phosphate metabolism
mjv01100
Metabolic pathways
mjv01521
EGFR tyrosine kinase inhibitor resistance
mjv04012
ErbB signaling pathway
mjv04014
Ras signaling pathway
mjv04015
Rap1 signaling pathway
mjv04020
Calcium signaling pathway
mjv04062
Chemokine signaling pathway
mjv04064
NF-kappa B signaling pathway
mjv04066
HIF-1 signaling pathway
mjv04070
Phosphatidylinositol signaling system
mjv04072
Phospholipase D signaling pathway
mjv04360
Axon guidance
mjv04370
VEGF signaling pathway
mjv04613
Neutrophil extracellular trap formation
mjv04650
Natural killer cell mediated cytotoxicity
mjv04658
Th1 and Th2 cell differentiation
mjv04659
Th17 cell differentiation
mjv04660
T cell receptor signaling pathway
mjv04664
Fc epsilon RI signaling pathway
mjv04666
Fc gamma R-mediated phagocytosis
mjv04670
Leukocyte transendothelial migration
mjv04722
Neurotrophin signaling pathway
mjv04750
Inflammatory mediator regulation of TRP channels
mjv04919
Thyroid hormone signaling pathway
mjv04933
AGE-RAGE signaling pathway in diabetic complications
mjv04935
Growth hormone synthesis, secretion and action
mjv05012
Parkinson disease
mjv05022
Pathways of neurodegeneration - multiple diseases
mjv05135
Yersinia infection
mjv05167
Kaposi sarcoma-associated herpesvirus infection
mjv05170
Human immunodeficiency virus 1 infection
mjv05171
Coronavirus disease - COVID-19
mjv05200
Pathways in cancer
mjv05205
Proteoglycans in cancer
mjv05206
MicroRNAs in cancer
mjv05214
Glioma
mjv05223
Non-small cell lung cancer
mjv05225
Hepatocellular carcinoma
mjv05231
Choline metabolism in cancer
mjv05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
mjv_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
mjv00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
108407248 (PLCG1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
108407248 (PLCG1)
04014 Ras signaling pathway
108407248 (PLCG1)
04015 Rap1 signaling pathway
108407248 (PLCG1)
04370 VEGF signaling pathway
108407248 (PLCG1)
04064 NF-kappa B signaling pathway
108407248 (PLCG1)
04066 HIF-1 signaling pathway
108407248 (PLCG1)
04020 Calcium signaling pathway
108407248 (PLCG1)
04070 Phosphatidylinositol signaling system
108407248 (PLCG1)
04072 Phospholipase D signaling pathway
108407248 (PLCG1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
108407248 (PLCG1)
04650 Natural killer cell mediated cytotoxicity
108407248 (PLCG1)
04660 T cell receptor signaling pathway
108407248 (PLCG1)
04658 Th1 and Th2 cell differentiation
108407248 (PLCG1)
04659 Th17 cell differentiation
108407248 (PLCG1)
04664 Fc epsilon RI signaling pathway
108407248 (PLCG1)
04666 Fc gamma R-mediated phagocytosis
108407248 (PLCG1)
04670 Leukocyte transendothelial migration
108407248 (PLCG1)
04062 Chemokine signaling pathway
108407248 (PLCG1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
108407248 (PLCG1)
04919 Thyroid hormone signaling pathway
108407248 (PLCG1)
09156 Nervous system
04722 Neurotrophin signaling pathway
108407248 (PLCG1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
108407248 (PLCG1)
09158 Development and regeneration
04360 Axon guidance
108407248 (PLCG1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108407248 (PLCG1)
05206 MicroRNAs in cancer
108407248 (PLCG1)
05205 Proteoglycans in cancer
108407248 (PLCG1)
05231 Choline metabolism in cancer
108407248 (PLCG1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
108407248 (PLCG1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
108407248 (PLCG1)
05214 Glioma
108407248 (PLCG1)
05223 Non-small cell lung cancer
108407248 (PLCG1)
09164 Neurodegenerative disease
05012 Parkinson disease
108407248 (PLCG1)
05022 Pathways of neurodegeneration - multiple diseases
108407248 (PLCG1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
108407248 (PLCG1)
09171 Infectious disease: bacterial
05135 Yersinia infection
108407248 (PLCG1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
108407248 (PLCG1)
05171 Coronavirus disease - COVID-19
108407248 (PLCG1)
05167 Kaposi sarcoma-associated herpesvirus infection
108407248 (PLCG1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108407248 (PLCG1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mjv04131
]
108407248 (PLCG1)
Enzymes [BR:
mjv01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
108407248 (PLCG1)
Membrane trafficking [BR:
mjv04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
108407248 (PLCG1)
Endocytosis
Macropinocytosis
Phospholipase C
108407248 (PLCG1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
PH
SH3_9
SH3_2
PH_12
GDPD
PH_9
Motif
Other DBs
NCBI-GeneID:
108407248
NCBI-ProteinID:
XP_017531906
LinkDB
All DBs
Position
Unknown
AA seq
1329 aa
AA seq
DB search
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEEEVNMWIKGLTWLMEDTSQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFMEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMFSFLRDPLREIEEPHFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPASVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSG
SAELHSNEKWFHGKLGAGRDGRHIAERLLTEYCVETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICVEVLGARHLPKNGRGIVCPFVELEVAGAEYDSAKQKTEFVVDNGLNPVW
PAKSFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDIFPAKQENGDLSPFGGASLRERGLDASGQLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERSGVITKTLAPHSWRDTSAQSLGRGAAGVIGHVGCSALSGTGWG
WEEKQSLFW
NT seq
3990 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctccgacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaaatcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgggaaatcaaggag
atccgcccagggaagacctcacgagattttgatcgctaccaggaggaccctgctttccga
ccggaccaatcacactgctttgttatcctgtatggaatggaattccgcctgaagaccctg
agcctgcaagctacatctgaggaggaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacatcacaggcggccacacccctgcagattgagaggtggctgcggaagcag
ttctactcagtggatcggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactatcgggtccccaacatgcgcttcctccgagagcggctgacagac
ctggagcagcgcagcagtgacatcacctatgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcatggaagccagtgcgctgagggca
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttcctccttgag
taccagggggagctatgggctgttgaccggctccaggtgcaggagttcatgttcagcttc
ctccgggacccactgcgagagattgaggagccgcacttcttcctggacgagtttgtcacc
ttcctgttctccaaagagaacagcgtatggaactcgcagctagatgcagtgtgcccagat
accatgaacaaccctctctcccactactggatttcctcctcgcacaatacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggattgttgggacggccctgatgggatgccagtcatttaccac
gggcacacccttaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcat
gcctttgtggcctcggagtacccagttatcctgtctatcgaggaccactgcagcatcgcc
cagcagaggaacatggcccagtacttcaagaaggtactcggggacacactgctcaccaag
cctgtggacattgctgccgatgggctcccctcacccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgcctgcatccgtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggacccc
gtgaaccatgagtggtatccccactacttcgtcctgaccagcagcaagatctactactct
gaggaaaccagcagtgaccagggcaacgaggatgaagaggaacccaaggaggtcagcggc
agcgcagagctgcactccaatgagaagtggttccacgggaagcttggggccggacgggat
gggcgtcacattgctgagcgcctgctcactgagtactgcgttgagactggggcccccgac
ggctccttcctggtgcgcgagagcgagaccttcgtgggcgactacaccctctctttctgg
cggaacggcaaagtccagcactgccgcatccactctcggcaagacgccgggacccccaag
ttcttcctgacagacaacctggtctttgactcactctatgaccttatcacacactaccag
caagttcccctgcgctgcaacgaatttgagatgcgcctctcggagcctgtcccacagacc
aatgcccacgagagcaaagagtggtaccacgccagcctaacccgagcgcaagccgagcat
atgctgatgcgtgttccccgggatggggccttcctggtgcgaaaacgcaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcattgccgtgtccagcaggag
ggccagacagtaatgctgggcaactcggagtttgacagcctggttgacctcatcagctat
tacgagaagcatccgctgtaccgtaaaatgaagctgcgctatcccatcaacgaggaggcg
ctggagaagatcggcactgctgagcctgactacggagccctgtatgagggacgcaaccct
ggattctacgtggaggcaaaccctatgccgactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagagaggatgagctgactttcaccaagagtgccattatccagaat
gtggagaagcaggagggaggctggtggcggggggactatggcggaaagaaacagctatgg
ttcccatctaactacgtggaagagatggtcagccctgcagccctggagcctgagagggag
cacttggacgagaacagccccctaggggacttgctgaggggggtcttggatgtgccagct
tgtcagattgccatccgccctgagggcaagaacagccggctcttcgtcttctccatcagc
atggcgtcggtggcgcactggtccctggatgttgctgctgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcgcagactgcagatgccaggctcactgagggg
aagatgatggaacggaggaagaagatcgccctggagctctcggagcttgtcgtctactgc
cggcctgtgccctttgacgaagagaagattggcacagagcgtgcctgctaccgggacatg
tcatcgttcccggaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaaattc
ctccagtacaaccggctgcagctgtcccgcatctaccccaagggccagcgtctggactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctggtggccctcaacttc
cagactccagataagcccatgcagatgaaccaggccctcttcatggctggcgggcactgt
ggctacgtgttgcagccgagcaccatgcgggacgaggccttcgacccatttgacaagagc
agcctccgcgggctggagccatgtgctatctgcgtcgaggtgctgggggcccggcatctg
ccaaagaatggccggggcattgtgtgtcctttcgtggagcttgaggtggctggagcagag
tatgacagtgccaagcagaagacagagtttgtggtggacaatggactgaaccccgtgtgg
ccggccaagtccttccacttccagatcagtaacccggaattcgccttcctgcgctttgtg
gtatatgaggaagacatgtttagtgaccagaacttcctggctcaggctactttcccagtg
aaaggcctgaagacaggatacagagctgtgcctttgaagaacaactacagtgaggacctg
gagctggcctccctgctcgtcaagatagacattttccctgccaagcaggagaacggcgac
ctcagccccttcggtggtgcgtccctgcgggagcgtggcctagatgcttcgggccagctg
tttcacggccgggcccgggaaggctcctttgaagctcgctaccagcagccatttgaggac
ttccgcatctcccaggagcatctggcagaccattttgatagtcgggaacgaagtggtgtc
ataactaagacattggctcctcactcttggagggacacctcagcacagagcctcggacgg
ggagcggcaggtgtcatcggccacgtgggctgttcagcactgtcaggaacggggtgggga
tgggaagagaagcaaagcctattctggtga
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integrated database retrieval system
