Entry |
|
Symbol |
Raf1, 6430402F14Rik, Craf1, D830050J10Rik, Raf-1, c-Raf, cRaf, v-Raf
|
Name |
(RefSeq) v-raf-leukemia viral oncogene 1
|
KO |
K04366 | RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] |
|
Organism |
mmu Mus musculus (house mouse)
|
Pathway |
mmu01521 | EGFR tyrosine kinase inhibitor resistance |
mmu04072 | Phospholipase D signaling pathway |
mmu04270 | Vascular smooth muscle contraction |
mmu04550 | Signaling pathways regulating pluripotency of stem cells |
mmu04613 | Neutrophil extracellular trap formation |
mmu04625 | C-type lectin receptor signaling pathway |
mmu04650 | Natural killer cell mediated cytotoxicity |
mmu04660 | T cell receptor signaling pathway |
mmu04662 | B cell receptor signaling pathway |
mmu04664 | Fc epsilon RI signaling pathway |
mmu04666 | Fc gamma R-mediated phagocytosis |
mmu04810 | Regulation of actin cytoskeleton |
mmu04914 | Progesterone-mediated oocyte maturation |
mmu04919 | Thyroid hormone signaling pathway |
mmu04928 | Parathyroid hormone synthesis, secretion and action |
mmu04935 | Growth hormone synthesis, secretion and action |
mmu05022 | Pathways of neurodegeneration - multiple diseases |
mmu05163 | Human cytomegalovirus infection |
mmu05167 | Kaposi sarcoma-associated herpesvirus infection |
mmu05170 | Human immunodeficiency virus 1 infection |
mmu05207 | Chemical carcinogenesis - receptor activation |
mmu05208 | Chemical carcinogenesis - reactive oxygen species |
mmu05230 | Central carbon metabolism in cancer |
mmu05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
110157 (Raf1)
04012 ErbB signaling pathway
110157 (Raf1)
04014 Ras signaling pathway
110157 (Raf1)
04015 Rap1 signaling pathway
110157 (Raf1)
04370 VEGF signaling pathway
110157 (Raf1)
04371 Apelin signaling pathway
110157 (Raf1)
04630 JAK-STAT signaling pathway
110157 (Raf1)
04068 FoxO signaling pathway
110157 (Raf1)
04072 Phospholipase D signaling pathway
110157 (Raf1)
04071 Sphingolipid signaling pathway
110157 (Raf1)
04024 cAMP signaling pathway
110157 (Raf1)
04022 cGMP-PKG signaling pathway
110157 (Raf1)
04151 PI3K-Akt signaling pathway
110157 (Raf1)
04150 mTOR signaling pathway
110157 (Raf1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
110157 (Raf1)
09143 Cell growth and death
04210 Apoptosis
110157 (Raf1)
04218 Cellular senescence
110157 (Raf1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
110157 (Raf1)
04540 Gap junction
110157 (Raf1)
04550 Signaling pathways regulating pluripotency of stem cells
110157 (Raf1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
110157 (Raf1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
110157 (Raf1)
04625 C-type lectin receptor signaling pathway
110157 (Raf1)
04650 Natural killer cell mediated cytotoxicity
110157 (Raf1)
04660 T cell receptor signaling pathway
110157 (Raf1)
04662 B cell receptor signaling pathway
110157 (Raf1)
04664 Fc epsilon RI signaling pathway
110157 (Raf1)
04666 Fc gamma R-mediated phagocytosis
110157 (Raf1)
04062 Chemokine signaling pathway
110157 (Raf1)
09152 Endocrine system
04910 Insulin signaling pathway
110157 (Raf1)
04929 GnRH secretion
110157 (Raf1)
04912 GnRH signaling pathway
110157 (Raf1)
04915 Estrogen signaling pathway
110157 (Raf1)
04914 Progesterone-mediated oocyte maturation
110157 (Raf1)
04917 Prolactin signaling pathway
110157 (Raf1)
04921 Oxytocin signaling pathway
110157 (Raf1)
04926 Relaxin signaling pathway
110157 (Raf1)
04935 Growth hormone synthesis, secretion and action
110157 (Raf1)
04919 Thyroid hormone signaling pathway
110157 (Raf1)
04928 Parathyroid hormone synthesis, secretion and action
110157 (Raf1)
04916 Melanogenesis
110157 (Raf1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
110157 (Raf1)
09156 Nervous system
04726 Serotonergic synapse
110157 (Raf1)
04720 Long-term potentiation
110157 (Raf1)
04730 Long-term depression
110157 (Raf1)
04722 Neurotrophin signaling pathway
110157 (Raf1)
09158 Development and regeneration
04360 Axon guidance
110157 (Raf1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
110157 (Raf1)
05206 MicroRNAs in cancer
110157 (Raf1)
05205 Proteoglycans in cancer
110157 (Raf1)
05207 Chemical carcinogenesis - receptor activation
110157 (Raf1)
05208 Chemical carcinogenesis - reactive oxygen species
110157 (Raf1)
05230 Central carbon metabolism in cancer
110157 (Raf1)
05231 Choline metabolism in cancer
110157 (Raf1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
110157 (Raf1)
09162 Cancer: specific types
05210 Colorectal cancer
110157 (Raf1)
05212 Pancreatic cancer
110157 (Raf1)
05225 Hepatocellular carcinoma
110157 (Raf1)
05226 Gastric cancer
110157 (Raf1)
05214 Glioma
110157 (Raf1)
05221 Acute myeloid leukemia
110157 (Raf1)
05220 Chronic myeloid leukemia
110157 (Raf1)
05218 Melanoma
110157 (Raf1)
05211 Renal cell carcinoma
110157 (Raf1)
05219 Bladder cancer
110157 (Raf1)
05215 Prostate cancer
110157 (Raf1)
05213 Endometrial cancer
110157 (Raf1)
05224 Breast cancer
110157 (Raf1)
05223 Non-small cell lung cancer
110157 (Raf1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
110157 (Raf1)
05161 Hepatitis B
110157 (Raf1)
05160 Hepatitis C
110157 (Raf1)
05164 Influenza A
110157 (Raf1)
05163 Human cytomegalovirus infection
110157 (Raf1)
05167 Kaposi sarcoma-associated herpesvirus infection
110157 (Raf1)
05165 Human papillomavirus infection
110157 (Raf1)
09171 Infectious disease: bacterial
05132 Salmonella infection
110157 (Raf1)
05152 Tuberculosis
110157 (Raf1)
09164 Neurodegenerative disease
05010 Alzheimer disease
110157 (Raf1)
05022 Pathways of neurodegeneration - multiple diseases
110157 (Raf1)
09165 Substance dependence
05034 Alcoholism
110157 (Raf1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
110157 (Raf1)
01522 Endocrine resistance
110157 (Raf1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:mmu01001]
110157 (Raf1)
Enzymes [BR:mmu01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
110157 (Raf1)
Protein kinases [BR:mmu01001]
Serine/threonine kinases: TKL group
RAF family [OT]
110157 (Raf1)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
6:complement(115595530..115653596)
|
AA seq |
648 aa
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYE
LMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF |
NT seq |
1947 nt +upstreamnt +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggctttggactcaaagatgcg
gtgtttgatggctccagctgcatctcccctaccattgttcagcagtttggctatcagcgc
cgggcctcagatgatggcaagctcacggattcttctaagacaagcaatactatccgggtt
ttcttgccgaataagcaaaggactgtggtcaatgtgcggaatggaatgagcttacatgac
tgccttatgaaagctctgaaggtgagaggcctgcagccagagtgctgtgcagtgttcaga
cttctccaggaacacaaaggtaagaaagcacgcttagattggaacaccgatgccgcctct
ctgattggagaagaactgcaagtggattttttggatcatgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gttggtgacagtggagtcccagcaccaccttctttcccaatgcgtcggatgcgagaatct
gtttcccggatgcctgctagttcccagcacagatactctacaccccatgccttcactttc
aacacctccagcccttcctcagaaggttccctgtcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccctgcatgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagcccaaacaacctg
agtccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagcgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagactcgagttat
tactgggaaatagaagccagtgaggtgatgctgtctactcggatcgggtcaggttccttt
ggcactgtgtacaagggcaagtggcatggagatgttgcagtaaagatcctaaaggtggtt
gacccaactccagagcaacttcaggccttcaggaacgaggtggctgttttgcgcaaaaca
cggcatgttaacatcctgctgttcatggggtacatgacaaaggacaacctggcgattgtg
actcagtggtgtgaaggcagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccactggctctgtgctgtggatggccccagaagtaatccggatgcag
gatgacaacccgttcagcttccagtccgacgtgtactcgtacggcatcgtgctgtacgag
ctgatggctggggagcttccctacgcccacatcaacaaccgagaccagatcatcttcatg
gtaggccgtgggtatgcatcccctgatctcagcaggctctacaagaactgccccaaggca
atgaagaggttggtggctgactgtgtgaagaaagtcaaagaagagagacctttgtttccc
cagatcctgtcttccatcgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccttccctgcatcgggcagctcacactgaggacatcaatgcttgcacgctgact
acatccccaaggctaccagtcttctag |