Mus musculus (mouse): 12370
Entry
12370 CDS
T01002
Gene name
Casp8, CASP-8, FLICE, MACH, Mch5
Definition
(RefSeq) caspase 8
KO
K04398
caspase 8 [EC:
3.4.22.61
]
Organism
mmu
Mus musculus (mouse)
Pathway
mmu01524
Platinum drug resistance
mmu04115
p53 signaling pathway
mmu04210
Apoptosis
mmu04215
Apoptosis - multiple species
mmu04217
Necroptosis
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04668
TNF signaling pathway
mmu04932
Non-alcoholic fatty liver disease (NAFLD)
mmu05010
Alzheimer disease
mmu05016
Huntington disease
mmu05134
Legionellosis
mmu05142
Chagas disease (American trypanosomiasis)
mmu05145
Toxoplasmosis
mmu05152
Tuberculosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05200
Pathways in cancer
mmu05203
Viral carcinogenesis
mmu05416
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
12370 (Casp8)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
12370 (Casp8)
04215 Apoptosis - multiple species
12370 (Casp8)
04217 Necroptosis
12370 (Casp8)
04115 p53 signaling pathway
12370 (Casp8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
12370 (Casp8)
04621 NOD-like receptor signaling pathway
12370 (Casp8)
04622 RIG-I-like receptor signaling pathway
12370 (Casp8)
04625 C-type lectin receptor signaling pathway
12370 (Casp8)
04657 IL-17 signaling pathway
12370 (Casp8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
12370 (Casp8)
05203 Viral carcinogenesis
12370 (Casp8)
09164 Neurodegenerative disease
05010 Alzheimer disease
12370 (Casp8)
05016 Huntington disease
12370 (Casp8)
09166 Cardiovascular disease
05416 Viral myocarditis
12370 (Casp8)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease (NAFLD)
12370 (Casp8)
09171 Infectious disease: bacterial
05134 Legionellosis
12370 (Casp8)
05152 Tuberculosis
12370 (Casp8)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
12370 (Casp8)
05162 Measles
12370 (Casp8)
05164 Influenza A
12370 (Casp8)
05161 Hepatitis B
12370 (Casp8)
05160 Hepatitis C
12370 (Casp8)
05168 Herpes simplex virus 1 infection
12370 (Casp8)
05163 Human cytomegalovirus infection
12370 (Casp8)
05167 Kaposi sarcoma-associated herpesvirus infection
12370 (Casp8)
05169 Epstein-Barr virus infection
12370 (Casp8)
05165 Human papillomavirus infection
12370 (Casp8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
12370 (Casp8)
05142 Chagas disease (American trypanosomiasis)
12370 (Casp8)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
12370 (Casp8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
mmu01002
]
12370 (Casp8)
Enzymes [BR:
mmu01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.61 caspase-8
12370 (Casp8)
Peptidases and inhibitors [BR:
mmu01002
]
Cysteine peptidases
Family C14: caspase family
12370 (Casp8)
SSDB
Motif
Pfam:
Peptidase_C14
DED
PYRIN
Other DBs
NCBI-GeneID:
12370
NCBI-ProteinID:
NP_001073595
MGI:
1261423
Ensembl:
ENSMUSG00000026029
Vega:
OTTMUSG00000047216
UniProt:
O89110
Q3U607
LinkDB
Position
1 C1.3; 1 29.19 cM
AA seq
480 aa
MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLS
FLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSF
KFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYER
SSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLI
INNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEG
YQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQ
ACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNG
TWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP
NT seq
1443 nt
+upstream
nt +downstream
nt
atggatttccagagttgtctttatgctattgctgaagaactgggcagtgaagacctggct
gccctcaagttcctgtgcttggactacatcccacacaagaagcaggagaccatcgaggat
gcccagaagctatttctgaggctgcgggaaaaggggatgttggaggaaggcaatctgtct
ttcctgaaagagctgcttttccacatcagtcggtgggacctgctggtcaacttcctagac
tgcaaccgagaggagatggtgagagagctgcgggatccagacaatgcccagatttctccc
tacagggtcatgctctttaagctctcagaagaagtgagcgagttggaattgagatctttt
aagttccttttgaacaatgagatccccaaatgtaagctggaagatgacttgagcctgctt
gaaatttttgtagaaatggagaagaggaccatgctggcagaaaataacttggaaacccta
aaatcaatctgtgaccaggtcaacaagagcctgctggggaagatcgaggattatgaaaga
tcaagcacagagagaagaatgagccttgaaggaagggaagagttgccaccttcagttttg
gatgagatgagcctcaaaatggcggaactgtgtgactcgccaagagaacaagacagtgag
tcacggacttcagacaaagtttaccaaatgaagaacaaacctcggggatactgtctgatc
atcaacaatcatgatttcagcaaggcccgggaagacataacccaactccgaaaaatgaag
gacagaaaaggaacagactgtgataaagaggctctgagtaagacctttaaggagcttcat
tttgagatagtatcttacgacgactgcactgcaaatgaaatccacgagattctagaaggc
taccaaagcgcagaccacaagaacaaagactgcttcatctgctgtatcctatcccacggt
gacaagggtgtcgtctatggaacggatgggaaggaggcctccatctatgacctgacatct
tacttcactggttcaaagtgcccttccctgtctgggaaacccaagatctttttcattcag
gcttgccaaggaagtaacttccagaaaggagtgcctgatgaggcaggcttcgagcaacag
aaccacactttagaagtggattcatcatctcacaagaactatattccggatgaggcagac
tttctgctgggaatggctacggtgaagaactgcgtttcctaccgagatcctgtgaatgga
acctggtatattcagtcactttgccagagcctgagggaaagatgtcctcaaggagatgac
attcttagcatcctgactggcgtgaactatgacgtgagcaataaagacgacaggaggaac
aagggaaagcagatgccacagcccaccttcacactacggaagaagctcttcttccctccc
taa
DBGET
integrated database retrieval system
