Mus musculus (mouse): 12370
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Entry
12370 CDS
T01002
Gene name
Casp8, CASP-8, Casp, FLI, FLICE, MAC, MACH, Mch5
Definition
(RefSeq) caspase 8
KO
K04398
caspase 8 [EC:
3.4.22.61
]
Organism
mmu
Mus musculus (mouse)
Pathway
mmu01524
Platinum drug resistance
mmu04115
p53 signaling pathway
mmu04210
Apoptosis
mmu04215
Apoptosis - multiple species
mmu04217
Necroptosis
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04668
TNF signaling pathway
mmu04932
Non-alcoholic fatty liver disease
mmu05010
Alzheimer disease
mmu05016
Huntington disease
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05132
Salmonella infection
mmu05134
Legionellosis
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05152
Tuberculosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05200
Pathways in cancer
mmu05203
Viral carcinogenesis
mmu05416
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
12370 (Casp8)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
12370 (Casp8)
04215 Apoptosis - multiple species
12370 (Casp8)
04217 Necroptosis
12370 (Casp8)
04115 p53 signaling pathway
12370 (Casp8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
12370 (Casp8)
04621 NOD-like receptor signaling pathway
12370 (Casp8)
04622 RIG-I-like receptor signaling pathway
12370 (Casp8)
04625 C-type lectin receptor signaling pathway
12370 (Casp8)
04657 IL-17 signaling pathway
12370 (Casp8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
12370 (Casp8)
05203 Viral carcinogenesis
12370 (Casp8)
09164 Neurodegenerative disease
05010 Alzheimer disease
12370 (Casp8)
05016 Huntington disease
12370 (Casp8)
05022 Pathways of neurodegeneration - multiple diseases
12370 (Casp8)
09166 Cardiovascular disease
05416 Viral myocarditis
12370 (Casp8)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
12370 (Casp8)
09171 Infectious disease: bacterial
05132 Salmonella infection
12370 (Casp8)
05134 Legionellosis
12370 (Casp8)
05152 Tuberculosis
12370 (Casp8)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
12370 (Casp8)
05161 Hepatitis B
12370 (Casp8)
05160 Hepatitis C
12370 (Casp8)
05164 Influenza A
12370 (Casp8)
05162 Measles
12370 (Casp8)
05168 Herpes simplex virus 1 infection
12370 (Casp8)
05163 Human cytomegalovirus infection
12370 (Casp8)
05167 Kaposi sarcoma-associated herpesvirus infection
12370 (Casp8)
05169 Epstein-Barr virus infection
12370 (Casp8)
05165 Human papillomavirus infection
12370 (Casp8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
12370 (Casp8)
05142 Chagas disease
12370 (Casp8)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
12370 (Casp8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
mmu01002
]
12370 (Casp8)
Enzymes [BR:
mmu01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.61 caspase-8
12370 (Casp8)
Peptidases and inhibitors [BR:
mmu01002
]
Cysteine peptidases
Family C14: caspase family
12370 (Casp8)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Peptidase_C14
DED
PYRIN
Motif
Other DBs
NCBI-GeneID:
12370
NCBI-ProteinID:
NP_001073595
MGI:
1261423
Ensembl:
ENSMUSG00000026029
Vega:
OTTMUSG00000047216
UniProt:
O89110
Q3U607
LinkDB
All DBs
Position
1 C1.3; 1 29.19 cM
AA seq
480 aa
AA seq
DB search
MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLS
FLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSF
KFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYER
SSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLI
INNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEG
YQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQ
ACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNG
TWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP
NT seq
1443 nt
NT seq
+upstream
nt +downstream
nt
atggatttccagagttgtctttatgctattgctgaagaactgggcagtgaagacctggct
gccctcaagttcctgtgcttggactacatcccacacaagaagcaggagaccatcgaggat
gcccagaagctatttctgaggctgcgggaaaaggggatgttggaggaaggcaatctgtct
ttcctgaaagagctgcttttccacatcagtcggtgggacctgctggtcaacttcctagac
tgcaaccgagaggagatggtgagagagctgcgggatccagacaatgcccagatttctccc
tacagggtcatgctctttaagctctcagaagaagtgagcgagttggaattgagatctttt
aagttccttttgaacaatgagatccccaaatgtaagctggaagatgacttgagcctgctt
gaaatttttgtagaaatggagaagaggaccatgctggcagaaaataacttggaaacccta
aaatcaatctgtgaccaggtcaacaagagcctgctggggaagatcgaggattatgaaaga
tcaagcacagagagaagaatgagccttgaaggaagggaagagttgccaccttcagttttg
gatgagatgagcctcaaaatggcggaactgtgtgactcgccaagagaacaagacagtgag
tcacggacttcagacaaagtttaccaaatgaagaacaaacctcggggatactgtctgatc
atcaacaatcatgatttcagcaaggcccgggaagacataacccaactccgaaaaatgaag
gacagaaaaggaacagactgtgataaagaggctctgagtaagacctttaaggagcttcat
tttgagatagtatcttacgacgactgcactgcaaatgaaatccacgagattctagaaggc
taccaaagcgcagaccacaagaacaaagactgcttcatctgctgtatcctatcccacggt
gacaagggtgtcgtctatggaacggatgggaaggaggcctccatctatgacctgacatct
tacttcactggttcaaagtgcccttccctgtctgggaaacccaagatctttttcattcag
gcttgccaaggaagtaacttccagaaaggagtgcctgatgaggcaggcttcgagcaacag
aaccacactttagaagtggattcatcatctcacaagaactatattccggatgaggcagac
tttctgctgggaatggctacggtgaagaactgcgtttcctaccgagatcctgtgaatgga
acctggtatattcagtcactttgccagagcctgagggaaagatgtcctcaaggagatgac
attcttagcatcctgactggcgtgaactatgacgtgagcaataaagacgacaggaggaac
aagggaaagcagatgccacagcccaccttcacactacggaagaagctcttcttccctccc
taa
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