KEGG   Mus musculus (mouse): 12675Help
Entry
12675             CDS       T01002                                 

Gene name
Chuk, AI256658, Chuk1, Fbx24, Fbxo24, IKBKA, IKK_alpha, IKK1, Ikka, NFKBIKA
Definition
(RefSeq) conserved helix-loop-helix ubiquitous kinase
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01523  Antifolate resistance
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04062  Chemokine signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04068  FoxO signaling pathway
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04380  Osteoclast differentiation
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04622  RIG-I-like receptor signaling pathway
mmu04623  Cytosolic DNA-sensing pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04657  IL-17 signaling pathway
mmu04658  Th1 and Th2 cell differentiation
mmu04659  Th17 cell differentiation
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04668  TNF signaling pathway
mmu04920  Adipocytokine signaling pathway
mmu05135  Yersinia infection
mmu05142  Chagas disease (American trypanosomiasis)
mmu05145  Toxoplasmosis
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05200  Pathways in cancer
mmu05212  Pancreatic cancer
mmu05215  Prostate cancer
mmu05220  Chronic myeloid leukemia
mmu05221  Acute myeloid leukemia
mmu05222  Small cell lung cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    12675 (Chuk)
   04010 MAPK signaling pathway
    12675 (Chuk)
   04064 NF-kappa B signaling pathway
    12675 (Chuk)
   04668 TNF signaling pathway
    12675 (Chuk)
   04068 FoxO signaling pathway
    12675 (Chuk)
   04151 PI3K-Akt signaling pathway
    12675 (Chuk)
   04150 mTOR signaling pathway
    12675 (Chuk)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    12675 (Chuk)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    12675 (Chuk)
   04621 NOD-like receptor signaling pathway
    12675 (Chuk)
   04622 RIG-I-like receptor signaling pathway
    12675 (Chuk)
   04623 Cytosolic DNA-sensing pathway
    12675 (Chuk)
   04625 C-type lectin receptor signaling pathway
    12675 (Chuk)
   04660 T cell receptor signaling pathway
    12675 (Chuk)
   04658 Th1 and Th2 cell differentiation
    12675 (Chuk)
   04659 Th17 cell differentiation
    12675 (Chuk)
   04657 IL-17 signaling pathway
    12675 (Chuk)
   04662 B cell receptor signaling pathway
    12675 (Chuk)
   04062 Chemokine signaling pathway
    12675 (Chuk)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    12675 (Chuk)
  09158 Development
   04380 Osteoclast differentiation
    12675 (Chuk)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    12675 (Chuk)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    12675 (Chuk)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    12675 (Chuk)
   05221 Acute myeloid leukemia
    12675 (Chuk)
   05220 Chronic myeloid leukemia
    12675 (Chuk)
   05215 Prostate cancer
    12675 (Chuk)
   05222 Small cell lung cancer
    12675 (Chuk)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    12675 (Chuk)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    12675 (Chuk)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    12675 (Chuk)
   05170 Human immunodeficiency virus 1 infection
    12675 (Chuk)
   05162 Measles
    12675 (Chuk)
   05164 Influenza A
    12675 (Chuk)
   05161 Hepatitis B
    12675 (Chuk)
   05160 Hepatitis C
    12675 (Chuk)
   05168 Herpes simplex virus 1 infection
    12675 (Chuk)
   05163 Human cytomegalovirus infection
    12675 (Chuk)
   05167 Kaposi sarcoma-associated herpesvirus infection
    12675 (Chuk)
   05169 Epstein-Barr virus infection
    12675 (Chuk)
   05165 Human papillomavirus infection
    12675 (Chuk)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    12675 (Chuk)
   05142 Chagas disease (American trypanosomiasis)
    12675 (Chuk)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    12675 (Chuk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    12675 (Chuk)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     12675 (Chuk)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   12675 (Chuk)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IKBKB_SDD Pkinase Pkinase_Tyr Pkinase_fungal Kdo TBK1_ULD
Motif
Other DBs
NCBI-GeneID: 12675
NCBI-ProteinID: NP_001155882
MGI: 99484
Ensembl: ENSMUSG00000025199
Vega: OTTMUSG00000029724
UniProt: Q3TPN9 Q8CBT3 E9Q605
LinkDB All DBs
Position
19 C3; 19 36.71 cM
AA seq 719 aa AA seqDB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCH
EIQIMKKLDHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQPRC
FALMDHILNLKIVHILNMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPPDHLYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGYSLEGTVTPPVSAWLPPTLADREHPLTCVRDVSTNDRRKSELSWPFKYYYS
NT seq 2160 nt NT seq  +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcggcccctgggagatgcgggaacgg
cttggcaccggcggtttcgggaacgtcagtctgtaccagcaccgggaacttgatctcaaa
atagcaattaagtcttgtcgtttagagctaagttccaaaaacagagagcgatggtgccat
gaaatccagatcatgaaaaagttggaccatgcgaatgttgtaaaggcctgtgatgtccct
gaggaattgaactttttaattaacgatgtgcctcttctggcaatggagtactgttctgga
ggggacctccggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactgagtgacataggatctgggatccgatatctgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaatatagttcttcaagatgttggtgggaagacaata
cataaaataattgatttgggttatgccaaagatgttgatcaaggaagtctctgtacatct
tttgtgggaacattgcagtatttggccccagagctctttgaaaataagccgtacacagcc
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaagatccaaag
tgtatatttgcatgtgaagagatgactggagaagttcggtttagtagccatttacctcag
ccaaacagcctttgtagtttaatagtagagccaatggaaagctggctccaattgatgctg
aattgggacccacagcagagagggggacctattgatcttactttgaagcagccaagatgt
tttgcattaatggatcacattctcaatttaaagatagtgcacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatgtgatgaaagtcttcattcactacagtctcga
attgagcgtgaaacaggaataaatacaggttctcaggagcttctgtcagagacagggatt
tctctggatcctcggaaaccagcctctcagtgtgttctagatggagttagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgtacaagacagcaaaatacaactgccaatt
atacagctgcggaaagtatgggctgaagcagtgcactacgtatctgggctaaaggaagac
tacagcaggctcttccagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcgaaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgttaaaagcatggaaagaaatggaagaaaaggccattcac
tattctgaggttggtgtcattggttatcttgaggatcaaattatgtctttgcacactgaa
atcatggagctgcagaagagcccctatggacgacgccagggagacttgatggagtctctg
gagcagcgtgccattgatctctataagcagctaaagcacagacctcctgatcacttgtac
agcgacagcacagagatggtgaagatcatcgtgcacaccgtgcagagtcaggaccgtgtt
ctcaaggagctgtttggtcacctgagcaagttgttgggctgcaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatttggcacctccttaaaattgcctgtacacag
agttctgcccgctctcttgtaggatacagtctagaaggcacagtaacccctccagtatca
gcatggctgccccctacattagcagaccgtgaacatcctctgacatgtgtgagagacgtt
agcacaaatgatagaagaaaatctgaactgtcttggccatttaagtactattattcgtga

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