Mus musculus (mouse): 13866
Entry
13866 CDS
T01002
Gene name
Erbb2, Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, l11Jus8, mKIAA3023
Definition
(RefSeq) erb-b2 receptor tyrosine kinase 2
KO
K05083
receptor tyrosine-protein kinase erbB-2 [EC:
2.7.10.1
]
Organism
mmu
Mus musculus (mouse)
Pathway
mmu01521
EGFR tyrosine kinase inhibitor resistance
mmu01522
Endocrine resistance
mmu01524
Platinum drug resistance
mmu04010
MAPK signaling pathway
mmu04012
ErbB signaling pathway
mmu04020
Calcium signaling pathway
mmu04066
HIF-1 signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04510
Focal adhesion
mmu04520
Adherens junction
mmu04530
Tight junction
mmu05200
Pathways in cancer
mmu05205
Proteoglycans in cancer
mmu05206
MicroRNAs in cancer
mmu05212
Pancreatic cancer
mmu05213
Endometrial cancer
mmu05215
Prostate cancer
mmu05219
Bladder cancer
mmu05223
Non-small cell lung cancer
mmu05224
Breast cancer
mmu05226
Gastric cancer
mmu05230
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
13866 (Erbb2)
04012 ErbB signaling pathway
13866 (Erbb2)
04066 HIF-1 signaling pathway
13866 (Erbb2)
04020 Calcium signaling pathway
13866 (Erbb2)
04151 PI3K-Akt signaling pathway
13866 (Erbb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
13866 (Erbb2)
04520 Adherens junction
13866 (Erbb2)
04530 Tight junction
13866 (Erbb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
13866 (Erbb2)
05206 MicroRNAs in cancer
13866 (Erbb2)
05205 Proteoglycans in cancer
13866 (Erbb2)
05230 Central carbon metabolism in cancer
13866 (Erbb2)
09162 Cancer: specific types
05212 Pancreatic cancer
13866 (Erbb2)
05226 Gastric cancer
13866 (Erbb2)
05219 Bladder cancer
13866 (Erbb2)
05215 Prostate cancer
13866 (Erbb2)
05213 Endometrial cancer
13866 (Erbb2)
05224 Breast cancer
13866 (Erbb2)
05223 Non-small cell lung cancer
13866 (Erbb2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
13866 (Erbb2)
01524 Platinum drug resistance
13866 (Erbb2)
01522 Endocrine resistance
13866 (Erbb2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
13866 (Erbb2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mmu04147
]
13866 (Erbb2)
04090 CD molecules [BR:
mmu04090
]
13866 (Erbb2)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
13866 (Erbb2)
Protein kinases [BR:
mmu01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
13866 (Erbb2)
Exosome [BR:
mmu04147
]
Exosomal proteins
Exosomal proteins of breast cancer cells
13866 (Erbb2)
CD molecules [BR:
mmu04090
]
Proteins
13866 (Erbb2)
SSDB
Motif
Pfam:
Pkinase_Tyr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
Haspin_kinase
APH
EphA2_TM
Other DBs
NCBI-GeneID:
13866
NCBI-ProteinID:
NP_001003817
MGI:
95410
Ensembl:
ENSMUSG00000062312
Vega:
OTTMUSG00000002711
UniProt:
P70424
LinkDB
Position
11 61.75 cM; 11 D
AA seq
1256 aa
MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNR
DPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQL
APVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQ
CAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTC
PYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSD
NIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESF
QDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNT
VPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQE
CVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVAR
CPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVV
GVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETE
LRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS
PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEV
RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF
THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW
MIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVD
AEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSE
GAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEY
VNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAP
RAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV
NT seq
3771 nt
+upstream
nt +downstream
nt
atggagctggcggcctggtgccgttgggggttcctcctcgccctcctgtcccccggagcc
gcgggtacccaagtgtgtaccggtaccgacatgaagttgcgactccctgccagtcctgag
acccacctggacatgcttcgccacctctaccagggctgtcaggtggtgcagggcaatttg
gagcttacctacctgcccgccaatgccagcctctcattcctgcaggacatccaggaagtc
cagggatacatgctcatcgctcacaaccgagtgaaacacgtcccactgcagaggttgcgc
atcgtgagagggactcagctctttgaggacaagtatgccctggctgtgctagacaaccga
gaccctttggacaacgtcaccaccgccgccccaggcagaaccccagaagggctgcgggag
ctgcagcttcgaagtctcacagagatcttgaagggaggagttttgatccgtgggaaccct
cagctctgctaccaggacatggttttgtggaaggatgtcctccgtaagaataaccagctg
gctcctgtcgacatggacaccaatcgttcccgggcctgtccaccttgtgccccaacctgc
aaagacaatcactgttggggtgagagtcctgaagactgtcagatcttgactggcaccatc
tgtactagtggctgtgcccggtgcaagggccggctgcccactgactgttgccatgagcag
tgtgctgcaggctgcacgggtcccaagcattctgactgcctggcctgcctccacttcaat
catagtggtatctgtgagctgcactgcccggccctcatcacctacaacacagacaccttc
gagtccatgctcaaccctgagggtcgctacacctttggtgccagctgtgtgaccacctgc
ccctacaactacctctccacggaagtgggatcctgcactctggtctgtcccccgaacaac
caagaggtcacagctgaggacggaacacagcggtgtgagaaatgcagcaagccctgtgct
ggagtatgctatggtctgggcatggagcacctccgaggggcgagggccatcaccagtgac
aatatccaggagtttgctggctgcaagaagatctttgggagcctggcatttttgccggag
agctttgatgggaacccctcctccggcgttgccccactgaagccagagcatctccaagtg
ttcgaaaccctggaggagatcacaggttacctatacatttcagcatggccagagagcttc
caagacctcagtgtcttccagaaccttcgggtcattcggggacggattctccatgatggt
gcttactcattgacgttgcaaggcctggggattcactcactggggctacgctcactgcgg
gagctgggcagtggattggctctcattcaccgcaacacccatctctgctttgtaaacact
gtaccttgggaccagctcttccggaacccgcaccaggccctactccacagtgggaaccgg
ccagaagaggcatgtggtcttgagggcttggtctgtaactcactgtgtgcccgtgggcac
tgctgggggccagggcccacccagtgtgtcaactgcagtcagttcctccggggccaggag
tgtgtggaggagtgccgagtatggaaggggctccccagggagtatgtgaggggcaagcac
tgtctgccatgccaccccgagtgtcagcctcaaaacagctcggagacctgctatggatcg
gaggctgaccagtgtgaggcttgtgcccactacaaggactcatcttcctgtgtggctcgc
tgccccagtggtgtgaagccagacctctcctacatgcctatctggaagtacccggatgag
gagggcatatgtcagccatgccccatcaactgcacccactcatgtgtggacctggacgaa
cgaggctgcccagcagagcagagagccagcccagtgacattcatcattgcaactgtggtg
ggcgtcctgttgttcctgatcatagtggtggtcattggaatcctaatcaaacgaaggcga
cagaagatccggaagtataccatgcgtaggctgctgcaggagaccgagctggtggagccg
ctgacgcccagtggagctgtgcccaaccaggctcagatgcggatcctaaaggagacagag
ctaaggaagctgaaggtgcttgggtcaggagccttcggcactgtctacaagggcatctgg
atcccagatggggagaacgtgaaaatccccgtggccatcaaggtgttgagggaaaacaca
tctcctaaagctaacaaagaaatcctagatgaagcgtacgtcatggctggtgtgggttct
ccatatgtgtcccgcctcctgggcatctgcctgacatccacagtgcagctggtgacacag
cttatgccctatggctgccttctggaccatgtccgagaacaccgaggtcgcttaggctcc
caggacctgctcaactggtgtgttcagattgccaaggggatgagctacctggaggaagtt
cggcttgttcacagggacctagctgcccgaaacgtgctagtcaagagtcccaaccacgtc
aagattaccgacttcgggctggcacggctgctggacattgatgagactgaataccatgca
gatgggggcaaggtgcccatcaagtggatggcattggaatctattctcagacgccggttc
acccatcagagtgatgtgtggagctatggtgtgactgtgtgggagctgatgacctttggg
gccaaaccttacgatgggatcccagctcgggagatccctgatttgctggagaagggagaa
cgcctacctcagcctccaatctgcaccatcgacgtctacatgatcatggtcaaatgttgg
atgattgactccgaatgtcgcccgagattccgggagttggtatcagaattctcccgtatg
gcaagggacccccagcgctttgtggtcatccagaacgaggacttaggcccctccagcccc
atggacagcaccttctaccgttcactgctggaggatgatgacatgggggagctggtcgat
gctgaagagtacctggtaccccagcagggattcttctccccagaccctgccctaggtact
gggagcacagcccaccgcagacaccgcagctcgtcggccaggagtggcggtggtgagctg
acactgggcctggagccctcggaagaagagccccccagatctccactggctccctccgaa
ggggctggctccgatgtgtttgatggtgacctggcagtgggggtaaccaaaggactgcag
agcctctctccacatgacctcagccctctacagcggtacagtgaggatcccacattacct
ctgccccccgagactgatggctacgttgctcccctggcctgcagcccccagcccgagtat
gtgaaccagccagaggttcggcctcagtctcccttgaccccagagggtcctccgcctccc
atccgacctgctggtgctactctagaaagacccaagactctctctcctgggaaaaatggg
gttgtcaaagacgtttttgcctttgggggtgctgtggagaaccctgaatacttagcaccc
agagcaggcactgcctctcagccccacccttctcctgccttcagcccagcctttgacaac
ctctattactgggaccagaactcatcggagcagggtcctccaccaagtacctttgaaggg
acccccactgcagagaaccctgagtacctaggcctggatgtgccagtatga
DBGET
integrated database retrieval system
