Mus musculus (mouse): 14083
Entry
14083 CDS
T01002
Gene name
Ptk2, FADK_1, FAK, FRNK, Fadk, p125FAK
Definition
(RefSeq) PTK2 protein tyrosine kinase 2
KO
K05725
focal adhesion kinase 1 [EC:
2.7.10.2
]
Organism
mmu
Mus musculus (mouse)
Pathway
mmu01522
Endocrine resistance
mmu04012
ErbB signaling pathway
mmu04062
Chemokine signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04360
Axon guidance
mmu04370
VEGF signaling pathway
mmu04510
Focal adhesion
mmu04670
Leukocyte transendothelial migration
mmu04810
Regulation of actin cytoskeleton
mmu05100
Bacterial invasion of epithelial cells
mmu05135
Yersinia infection
mmu05146
Amoebiasis
mmu05163
Human cytomegalovirus infection
mmu05165
Human papillomavirus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05200
Pathways in cancer
mmu05202
Transcriptional misregulation in cancer
mmu05205
Proteoglycans in cancer
mmu05222
Small cell lung cancer
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
14083 (Ptk2)
04370 VEGF signaling pathway
14083 (Ptk2)
04151 PI3K-Akt signaling pathway
14083 (Ptk2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
14083 (Ptk2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
14083 (Ptk2)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
14083 (Ptk2)
04062 Chemokine signaling pathway
14083 (Ptk2)
09158 Development
04360 Axon guidance
14083 (Ptk2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
14083 (Ptk2)
05202 Transcriptional misregulation in cancer
14083 (Ptk2)
05205 Proteoglycans in cancer
14083 (Ptk2)
09162 Cancer: specific types
05222 Small cell lung cancer
14083 (Ptk2)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
14083 (Ptk2)
09171 Infectious disease: bacterial
05135 Yersinia infection
14083 (Ptk2)
05100 Bacterial invasion of epithelial cells
14083 (Ptk2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
14083 (Ptk2)
05163 Human cytomegalovirus infection
14083 (Ptk2)
05165 Human papillomavirus infection
14083 (Ptk2)
09174 Infectious disease: parasitic
05146 Amoebiasis
14083 (Ptk2)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
14083 (Ptk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
14083 (Ptk2)
01009 Protein phosphatases and associated proteins [BR:
mmu01009
]
14083 (Ptk2)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
14083 (Ptk2)
Protein kinases [BR:
mmu01001
]
Non-receptor tyrosine kinases
FAK family
14083 (Ptk2)
Protein phosphatases and associated proteins [BR:
mmu01009
]
Protein Ser/ Thr phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
14083 (Ptk2)
SSDB
Motif
Pfam:
Pkinase_Tyr
Focal_AT
Pkinase
FERM_N_2
FERM_M
Haspin_kinase
FERM_F2
Kinase-like
Other DBs
NCBI-GeneID:
14083
NCBI-ProteinID:
NP_032008
MGI:
95481
Ensembl:
ENSMUSG00000022607
UniProt:
P34152
LinkDB
Structure
PDB:
1K40
6BZ3
5F28
Position
15 D3; 15 33.94 cM
AA seq
1052 aa
MAAAYLDPNLNHTPSSSTKTHLGTGMERSPGAMERVLKVFHYFESSSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMQEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGIPAMAGSIYQGQASLLDQTELWNHRPQE
MSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPALPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
NT seq
3159 nt
+upstream
nt +downstream
nt
atggcagctgcttatcttgacccaaacttgaatcacacaccaagttcgagtactaagact
cacctgggtactggcatggaacggtcccctggtgcaatggaacgagtattaaaggtcttt
cattattttgaaagcagtagtgagccaaccacctgggccagtattatcaggcatggagat
gctactgatgtcaggggcatcattcagaagatagtggacagtcacaaagtaaagcacgtg
gcctgctatggatttcgcctcagtcacctgcgatcggaggaggtgcactggctgcacgtg
gacatgggtgtctccagtgtgagggagaaatatgaactcgcccacccaccagaggagtgg
aaatatgagttgagaattcgttacttgccaaaaggatttctaaaccagtttactgaagat
aagccaacattgaatttcttctatcaacaggtgaagagtgactacatgcaagaaatagct
gatcaagtagaccaagaaatagctttgaagttgggttgtttggaaattaggcgatcctat
tgggagatgaggggtaatgccctagagaagaagtccaactatgaagtattagaaaaagat
gttggtttaaagcgattttttcctaagagtttactggattctgtcaaggccaaaacacta
agaaagctgatccagcaaacattcaggcagtttgccaaccttaatagagaagaaagcatc
ctgaaattctttgagattctttctcctgtgtacagatttgacaaagagtgcttcaagtgt
gcccttgggtcaagttggatcatttctgtggaattggcaatcggcccagaagaagggatc
agttacctgacagacaaaggctgcaatcccacacacctagcagactttaaccaagtgcag
accatccagtactcaaacagtgaagacaaagacaggaaaggaatgctacaactcaaaatc
gctggtgctcctgagcctctgaccgtgacggcaccatccctaaccattgccgagaacatg
gccgacctgattgatggatactgccggctggtgaatggagccacacaatctttcatcatc
agaccccagaaagaaggtgaacgggcgttgccatcaataccaaagttggccaacagtgaa
aagcaaggcatgcggacacatgcagtctctgtgtcagagacagatgactatgcagagatc
atcgatgaggaagacacatacaccatgccctcgaccagggattatgagattcagagagaa
agaatagaacttggacgctgtattggagaaggtcagtttggagatgtacatcaaggcgtg
tacctgagcccagagaatccagctttggctgttgcaatcaaaacatgtaaaaactgtact
tcggacagcgtgagagagaagttccttcaagaagccttaacaatgcgtcagtttgaccat
cctcacatcgtgaagctgattggagtcattacagagaaccctgtctggataatcatggag
ttgtgcacacttggagagctgaggtcatttttgcaagtaagaaaatacagcttggacctg
gcatctttgatattatatgcctatcagcttagtacagcactcgcgtatctggagagcaaa
agatttgttcacagggacattgctgctcggaatgttctggtgtcttcaaatgattgtgta
aaattgggagactttggattatctcgatatatggaagacagtacttactataaagcttcc
aaaggaaaattacctattaaatggatggctccagagtcaatcaattttcgacgttttacc
tcagctagtgacgtgtggatgtttggtgtgtgtatgtgggagatactgatgcatggcgtg
aagccttttcaaggagtgaagaacaatgatgtgatcggtcgaattgaaaatggggaaaga
ttaccaatgcctccaaattgtcctcccaccctctacagccttatgacgaaatgttgggcc
tatgaccccagcaggcggcccaggtttactgaactaaaagctcagctcagcacaatcctg
gaggaggagaaggtgcagcaagaagaacggatgaggatggaatccagaagacaggctacc
gtgtcctgggactctggagggtctgatgaagcaccacccaagcccagcagacctggttat
cctagcccgagatccagtgaaggattttatcccagcccacagcacatggtccagaccaat
cactaccaggtctctggctacccgggttcccatggaatcccagccatggctggcagcatt
taccaaggtcaggcatctcttctggaccagacagaattgtggaatcacagacctcaggag
atgtccatgtggcagcccagtgtggaggattcggcagctttggaccttcgagggatggga
caggtgcttccccctcacctgatggaagagcggctaatccgacagcagcaggaaatggaa
gaagaccagcgctggctggagaaggaagagcgattcctgaaacctgatgtgaggctctct
cgaggcagcatcgacagggaagacgggagttttcagggtccgactggaaaccaacacatc
tatcagcctgtggggaagccagatcctgcagctccaccaaagaaacctcctcgccctgga
gcacctggccacctaagcaacctgtccagcatcagcagccctgcagacagctacaatgag
ggtgtcaagcttcagccccaggaaatcagcccccctcccactgccaaccttgaccggtcc
aatgacaaggtatatgaaaatgtgacaggcctagtgaaggctgtcatcgagatgtccagc
aaaatccagccagctcctccagaagagtacgtccctatggtgaaggaagttggcctggcc
ctgcggaccttactagccacggtggatgagaccattcctgctcttccagccagcactcat
cgagagatcgagatggcacagaagctgctgaactccgacttaggcgagctcatcagcaag
atgaagctggcgcagcagtacgtcatgaccagcctgcagcaggagtataagaagcagatg
ctgacagctgctcacgccctggctgtggatgccaagaacctacttgatgttattgatcaa
gcaagactgaaaatgctagggcagacacggccacactga
DBGET
integrated database retrieval system
