Mus musculus (house mouse): 15486
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Entry
15486 CDS
T01002
Symbol
Hsd17b2
Name
(RefSeq) hydroxysteroid (17-beta) dehydrogenase 2
KO
K13368
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:
1.1.1.62
1.1.1.239
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00140
Steroid hormone biosynthesis
mmu01100
Metabolic pathways
mmu04913
Ovarian steroidogenesis
Module
mmu_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
15486 (Hsd17b2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
15486 (Hsd17b2)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.62 17beta-estradiol 17-dehydrogenase
15486 (Hsd17b2)
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
15486 (Hsd17b2)
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Motif
Pfam:
adh_short
adh_short_C2
DUF1776
KR
Epimerase
NmrA
Motif
Other DBs
NCBI-GeneID:
15486
NCBI-ProteinID:
NP_032316
MGI:
1096386
Ensembl:
ENSMUSG00000031844
UniProt:
P51658
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Position
8:118427752..118485767
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AA seq
381 aa
AA seq
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MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFL
LSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGP
GAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGEL
IPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAAL
TMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDY
VHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLL
DYVIKKGFYPQPTPRALRTVH
NT seq
1146 nt
NT seq
+upstream
nt +downstream
nt
atgagcccgtttgcctctgagtcagcatggctctgcttggctgccgctgcagtgctgggg
ggcacgcttctctgcggatgccggagtggcaggcagctgcggagccaggcggtgtgtctc
gctggcctctggggaggtgcctgcctgctcagtctgtccctcctctgcaccttgttcctc
ttatccgtggcctgcttccttcttctgtatatgagttcatctgaccaagacttgttacct
gtggatcaaaaggccgtgctggtgacaggtgctgattccggtttcggtcacggtttggcc
aagcacctggacaagctgggtttcacagtgtttgctggagtgctggacaaagagggcccg
ggagcagaggaactgagaaaacactgctctgagcgtctttcagtgctccagatggatgtc
accaagccagagcagataaaagatgctcacagcaaagtcacagagaagatacaagacaaa
ggactgtgggccgtggttaacaatgccggggtcttccacttacctatcgacggggaactc
atacccatgagcatctacagaaaatgcatggccgtgaacttcttcggaactgtcgaggtc
accaaggcgtttctgcctctacttagaaagtccaaggggaggctggtgaacgtcagcagc
atgggaggcacggttccacttcaaatgacatcagcttatgcagccacaaaggcagctcta
accatgttctcaacaatcatcagacaggagcttgacaaatggggagttaaagttgtgacc
atcaaacccggaggcttcaaaacaaacatcacaggctcacaggacatttgggataaaatg
gagaaggaaatcctggaccacttttccaaagatattcaggagaactatggccaggactac
gtccatacacagaagctcatcatcccgaccttgaaagagaggtccaacccggacatcacc
cctgtgcttcgggacatccagcatgccatttctgcaaggaacccctcttccttttattac
ccagggcgaatggcttacctgtgggtctgcttagcagcctactgccccaccagcttactt
gactatgttataaaaaaaggtttttatccacaacccacgccgagagctttaaggacagtg
cactag
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